Treatment
Intrathecal clinical trials
We’re tracking 104 recruiting studies that include Intrathecal, each written for real people, not researchers, below.
Recruiting studies
- NCT07078201RecruitingPhase 4
Comparing two pain meds in spinal anesthesia for leg surgery
This study compares two medicines (dexmedetomidine and fentanyl) added to a spinal numbing shot for people having planned leg or knee surgery. The goal is to see which one works better to keep your blood pressure stable, and to make the numbing last while keeping you comfortable.
Port SaidAges 20–60 - NCT07465185RecruitingPhase 2
Testing a drug for cesarean delivery pain relief
This study compares a standard spinal anesthetic (bupivacaine) with or without an added drug (dexmedetomidine) to see which works better for pain relief during planned cesarean delivery. It may help find a safer or more effective option for mothers.
Banhā, Elqalyoubea,Ages 20–35 - NCT07447557RecruitingPhase 1/Phase 2
Gene therapy study for Charcot-Marie-Tooth type 4J (CMT4J)
This trial tests a gene therapy medicine (ELP-02) given through a spinal tap for children and young adults with a specific genetic form of CMT (CMT4J). It aims to slow or stop the disease from getting worse.
Palo Alto, CaliforniaAges 3–20 - NCT07102524RecruitingPhase 1/Phase 2
Gene therapy for SLC13A5 citrate transporter disorder
This trial tests a new gene therapy (TSHA-105) given through a spinal tap to treat SLC13A5 citrate transporter disorder, a genetic condition that affects the brain and body. The goal is to see if it can help improve symptoms by delivering a working copy of the gene.
Dallas, TexasAges 2–20 - NCT07091123RecruitingPhase 4
Comparing two treatments for chronic back pain after surgery
This study compares two treatments for long-term back pain after surgery: a spinal cord stimulator (a device that sends mild electrical pulses to your spine) and a pump that delivers pain medicine directly to your spinal fluid. It will look at which treatment you prefer and how well it works over time.
Cleveland, OhioAges 30 years+ - NCT07054775RecruitingPhase 4
Comparing itching after two doses of spinal morphine in C-section
This study compares two low doses of morphine given during spinal anesthesia for planned cesarean sections, to see which causes less itching. It aims to find a safer way to manage pain after birth.
Khon KaenAges 18–45 - NCT06666985RecruitingPhase 4
Spinal morphine for pain relief after major abdominal surgery
This trial tests whether a single injection of morphine into the fluid around the spine can provide better pain relief after planned laparoscopic or robotic abdominal surgery. If you are having one of several types of major abdominal surgery that lasts at least 2 hours and requires a hospital stay of at least 1 day, this study may be an option.
Guangzhou, GuangdongAges 18 years+ - NCT07404982RecruitingPhase 2
Speeding Recovery from Spinal Anesthesia After Joint Surgery
This trial tests a way to make the leg numbness and weakness from spinal anesthesia wear off faster after joint replacement surgery. Researchers use a small tube (catheter) placed in your spine during the procedure to reverse the muscle block sooner.
Boston, MassachusettsAges Any age - NCT06132698RecruitingPhase 2
Immunotherapy injected into spinal fluid for lung cancer that has spread to the brain lining
This trial tests giving an immunotherapy drug directly into the spinal fluid for people with non-small cell lung cancer that has spread to the lining of the brain or spinal cord. The goal is to see if this approach can help control the cancer while allowing you to continue other treatments you may already be taking.
Chengdu, SichuanAges 18–75 - NCT06895473RecruitingPhase 2
Spinal injection to prevent nerve side effects from CAR-T therapy
This trial tests if a spinal injection of three common chemotherapy drugs can reduce or prevent serious brain and nerve side effects in people receiving CAR-T cell therapy for cancer.
Portland, OregonAges 18 years+ - NCT06390319RecruitingPhase 2
Adding dasatinib or venetoclax for children with T-cell leukemia or lymphoma
This trial tests whether adding either dasatinib or venetoclax to standard chemotherapy can improve outcomes for children aged 1 to 18 with newly diagnosed T-cell acute lymphoblastic leukemia, lymphoblastic lymphoma, or mixed phenotype acute leukemia. It compares the effects of these added drugs to help doctors find better treatment options.
San Diego, CaliforniaAges 1–18 - NCT03715517Recruiting
Spinal anesthesia to improve recovery after liver surgery
This trial studies whether using spinal/epidural anesthesia during liver tumor removal surgery can help people recover better and with less pain. It compares this approach to standard general anesthesia care to see if recovery is smoother.
Winnipeg, ManitobaAges 18 years+ - NCT03725670Recruiting
Gene therapy injection for metachromatic leukodystrophy (MLD)
This trial tests a direct gene-therapy injection into the body to treat MLD, a genetic brain condition. It may help replace a faulty gene so the disease process slows or changes.
Shenzhen, GuangdongAges 1 month–50 years - NCT03727555Recruiting
Lentiviral gene therapy for childhood cerebral X-ALD
This trial studies an experimental gene therapy given through infusion (IV) and into the spinal fluid (injection) for people with X-ALD affecting the brain. It aims to improve or slow down damage in the nervous system, and you must be able to do MRI scans and meet specific health and infection requirements.
Shenzhen, GuangdongAges 1–60 - NCT06289673RecruitingPhase 4
Collecting info to start treatment for new leukemia or lymphoma
This study gathers key health information at the start of treatment for children and teens newly diagnosed with certain types of leukemia or lymphoma. The goal is to find the best way to begin therapy right away, without waiting for extra tests.
San Diego, CaliforniaAges 1–18 - NCT04849455RecruitingPhase 4
Nerve-block catheters plus spinal morphine for liver surgery pain
This trial tests whether placing pain-relief catheters near the back muscle plus giving morphine into the spinal fluid can improve comfort during and after liver surgery. It may help reduce the need for stronger opioid pain medicines afterward.
San Diego, CaliforniaAges 18 years+ - NCT04903678Recruiting
Chemo into spinal fluid for advanced retinoblastoma spread
This trial studies giving chemotherapy directly into the spinal fluid to treat retinoblastoma that has spread to the central nervous system (brain/spinal cord). It may help by targeting tumor cells that are in the fluid around the brain and spinal cord.
ShanghaiAges Any age - NCT05018793RecruitingPhase 1
Testing stem cell injections for spinal cord injury safety
This early study tests whether two types of stem cells—made from your own fat cells versus from donated umbilical-cord cells—are safe when injected into the fluid around the spinal cord. It may help researchers find safer cell-based options for people with spinal cord injury.
St John'sAges Any age - NCT05112549RecruitingPhase 1
PD-1 antibody placed into brain fluid for metastatic cancer
This early-phase study tests a PD-1 antibody delivered directly into the brain fluid (intrathecal space) to treat metastatic solid tumors that have spread to the lining around the brain/spinal cord (leptomeningeal disease). It aims to see whether this approach can better control cancer in that area and whether it’s safe.
BonnAges 18 years+ - NCT05351229RecruitingPhase 4
Spinal morphine for pain control after lung surgery
This trial tests whether putting morphine into the spinal area during lung surgery can reduce pain after surgery for people having certain minimally invasive lung operations. It aims to improve comfort and possibly reduce the need for other pain medicines.
Chicago, IllinoisAges 18–80 - NCT05519579RecruitingPhase 2
Spinal chemotherapy to help protect the brain during blinatumomab
This trial studies giving medicine into the spinal fluid (intrathecal chemotherapy) to lower the risk of brain/nerve side effects from blinatumomab. It’s for adults with certain types of B-cell acute lymphoblastic leukemia (ALL) who are starting their first cycle.
Atlanta, GeorgiaAges 18 years+ - NCT05658640RecruitingPhase 1/Phase 2
Testing trametinib and steroid plus chemo for relapsed blood cancers
This early-phase trial tests whether adding trametinib and dexamethasone to standard chemotherapy can improve outcomes for children whose blood cancer has come back or did not respond. Because it is a Phase 1/2 study, the main goal is to see safety and learn the best way to treat your specific cancer type.
ViennaAges 1–21 - NCT05745714RecruitingPhase 1/Phase 2
Targeted triple-combination treatment for children with relapsed blood cancers
This Phase 1/2 study tests a multi-drug combination (ruxolitinib, venetoclax, dexamethasone, plus chemotherapy) for children whose blood cancer has come back or did not respond. It aims to reduce the cancer by targeting specific genetic changes and may offer a new option when standard treatments have not worked.
ViennaAges 1–21 - NCT05751044RecruitingPhase 1/Phase 2
Study of four medicines for children with difficult blood cancers
This Phase 1/2 trial tests a combination of medicines (dasatinib, venetoclax, dexamethasone, cyclophosphamide, and cytarabine) in children and teens whose blood cancer has come back or did not respond to treatment. It aims to see whether this approach can control the cancer while checking what doses are safe.
ViennaAges 1–21
Common questions
- Are there clinical trials studying Intrathecal?
- Yes. Clin2 currently lists 104 recruiting studies that include Intrathecal, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Intrathecal trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Intrathecal an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Intrathecal or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.