Treatment
Intrathecal clinical trials
We’re tracking 102 recruiting studies that include Intrathecal, each written for real people, not researchers, below.
Recruiting studies
- NCT07559097RecruitingPhase 1/Phase 2
Methotrexate-loaded vesicles injected into spine fluid for lung cancer spread to brain membranes
This study tests a new way to deliver a cancer drug directly into the fluid around your brain and spinal cord to treat lung cancer that has spread to the membranes covering the brain. It may help patients whose cancer hasn't responded to standard treatments.
Zhengzhou, HenanAges 18 years+ - NCT07537062Recruiting
Virtual Reality to Reduce Anxiety During Cancer Chemotherapy in Children
This study tests whether wearing virtual reality headsets can help reduce anxiety and fear in children with cancer who need a spinal injection of chemotherapy (a needle procedure into the spine). The goal is to see if this distraction tool makes the experience less stressful for kids and their families.
KayseriAges 4–10 - NCT07448610RecruitingPhase 4
Real-world safety and effectiveness of gene therapy for spinal muscular atrophy
This study tracks how well the gene therapy ITVISMA works in everyday medical practice for people with spinal muscular atrophy (SMA). It aims to see if the treatment is safe and effective in a real-world setting.
New York, New YorkAges 2–100 - NCT07447557RecruitingPhase 1/Phase 2
Gene therapy study for Charcot-Marie-Tooth type 4J (CMT4J)
This trial tests a gene therapy medicine (ELP-02) given through a spinal tap for children and young adults with a specific genetic form of CMT (CMT4J). It aims to slow or stop the disease from getting worse.
Palo Alto, CaliforniaAges 3–20 - NCT07404982RecruitingPhase 2
Speeding Recovery from Spinal Anesthesia After Joint Surgery
This trial tests a way to make the leg numbness and weakness from spinal anesthesia wear off faster after joint replacement surgery. Researchers use a small tube (catheter) placed in your spine during the procedure to reverse the muscle block sooner.
Boston, MassachusettsAges Any age - NCT04903678Recruiting
Chemo into spinal fluid for advanced retinoblastoma spread
This trial studies giving chemotherapy directly into the spinal fluid to treat retinoblastoma that has spread to the central nervous system (brain/spinal cord). It may help by targeting tumor cells that are in the fluid around the brain and spinal cord.
ShanghaiAges Any age - NCT06541184Recruiting
Ziconotide via spine pump for chronic non-cancer pain
This study looks at a medicine called ziconotide, given through a pump in your spine (intrathecal delivery) to treat chronic pain that is not from cancer. It aims to learn how safe and effective this treatment is in real-world patients.
AubagneAges 18 years+ - NCT07290062RecruitingPhase 1
Gene therapy injection for ALS safety study
This trial tests a single injection of a gene therapy called INS1202 into the spinal fluid. It is for people with ALS, including those with a specific genetic form (SOD1 mutation). The goal is to see if it is safe and how it affects the body.
La Jolla, CaliforniaAges 18–79 - NCT05112549RecruitingPhase 1
PD-1 antibody placed into brain fluid for metastatic cancer
This early-phase study tests a PD-1 antibody delivered directly into the brain fluid (intrathecal space) to treat metastatic solid tumors that have spread to the lining around the brain/spinal cord (leptomeningeal disease). It aims to see whether this approach can better control cancer in that area and whether it’s safe.
BonnAges 18 years+ - NCT07203742Recruiting
Mandala drawing for anxiety before spinal chemo in kids with leukemia
This study tests whether drawing mandalas (circular patterns) can help children aged 4 to 12 with leukemia feel less anxious and scared before a spinal tap that delivers chemotherapy. It may offer a calming, non-drug way to cope with a stressful procedure.
IzmirAges 4–12 - NCT05018793RecruitingPhase 1
Testing stem cell injections for spinal cord injury safety
This early study tests whether two types of stem cells—made from your own fat cells versus from donated umbilical-cord cells—are safe when injected into the fluid around the spinal cord. It may help researchers find safer cell-based options for people with spinal cord injury.
St John'sAges Any age - NCT07153614Recruiting
Pain management after cancer surgery to start chemo sooner
This trial compares different methods of managing pain after cancer surgery to see which helps patients start chemotherapy sooner. It focuses on people having open abdominal surgery for certain cancers who are scheduled for chemotherapy afterward.
Knoxville, TennesseeAges 18–80 - NCT05959720Recruiting
Teen-to-adult ALL study using a pediatric chemotherapy plan
This trial tests a treatment plan for newly diagnosed acute lymphoblastic leukemia (ALL) in people ages 16 to 50. It aims to see how well a “pediatric-style” regimen works, but it only fits certain genetic and health profiles.
São Paulo, São PauloAges 16–50 - NCT07123740Recruiting
Pain relief after liver donor surgery: two methods compared
This study compares two ways to control pain after surgery for living liver donors. It tests if one method works better than the other, which could help you recover more comfortably.
Altındağ, AnkaraAges 18–65 - NCT07122453RecruitingPhase 1
Study of CNTX-3001 for severe chronic low back pain
This trial tests a medicine called CNTX-3001, given as a spinal injection, for people with long-term, severe low back pain that hasn't improved with other treatments.
Napa, CaliforniaAges 18–75 - NCT07102524RecruitingPhase 1/Phase 2
Gene therapy for SLC13A5 citrate transporter disorder
This trial tests a new gene therapy (TSHA-105) given through a spinal tap to treat SLC13A5 citrate transporter disorder, a genetic condition that affects the brain and body. The goal is to see if it can help improve symptoms by delivering a working copy of the gene.
Dallas, TexasAges 2–20 - NCT07091123RecruitingPhase 4
Comparing two treatments for chronic back pain after surgery
This study compares two treatments for long-term back pain after surgery: a spinal cord stimulator (a device that sends mild electrical pulses to your spine) and a pump that delivers pain medicine directly to your spinal fluid. It will look at which treatment you prefer and how well it works over time.
Cleveland, OhioAges 30 years+ - NCT07078201RecruitingPhase 4
Comparing two pain meds in spinal anesthesia for leg surgery
This study compares two medicines (dexmedetomidine and fentanyl) added to a spinal numbing shot for people having planned leg or knee surgery. The goal is to see which one works better to keep your blood pressure stable, and to make the numbing last while keeping you comfortable.
Port SaidAges 20–60 - NCT07059975RecruitingEarly Phase 1
Improved monitoring and treatment for pediatric acute myeloid leukemia
This study tests a new way to monitor and treat AML in children and young adults after their first chemotherapy. It aims to improve outcomes by closely tracking the disease and adjusting treatment as needed.
Houston, TexasAges 1 month–30 years - NCT07054775RecruitingPhase 4
Comparing itching after two doses of spinal morphine in C-section
This study compares two low doses of morphine given during spinal anesthesia for planned cesarean sections, to see which causes less itching. It aims to find a safer way to manage pain after birth.
Khon KaenAges 18–45 - NCT06766994Recruiting
Pain relief methods after hysterectomy: a recovery comparison
This study compares two different ways to manage pain after abdominal hysterectomy surgery. The goal is to see which method helps you recover better and feel more comfortable.
Erzurum, YakutiyeAges 18–65 - NCT06971094RecruitingPhase 3
Gene therapy for type 2 spinal muscular atrophy
This trial tests a new gene therapy called GC101 given as a one-time injection into the spinal fluid for people with type 2 spinal muscular atrophy (SMA). It may help improve motor function.
BeijingAges 2–12 - NCT06895473RecruitingPhase 2
Spinal injection to prevent nerve side effects from CAR-T therapy
This trial tests if a spinal injection of three common chemotherapy drugs can reduce or prevent serious brain and nerve side effects in people receiving CAR-T cell therapy for cancer.
Portland, OregonAges 18 years+ - NCT06896110Enrolling by invitationPhase 1
Spinal chemo and immunotherapy for recurrent high-grade glioma
This trial tests a combination of two drugs—azacitidine and nivolumab—given directly into the spinal fluid for people whose high-grade glioma has come back after initial treatment. The goal is to see if this approach can safely target the tumor and slow its growth.
Iowa City, IowaAges 13 years+
Common questions
- Are there clinical trials studying Intrathecal?
- Yes. Clin2 currently lists 102 recruiting studies that include Intrathecal, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Intrathecal trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Intrathecal an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Intrathecal or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.