Treatment
Metformin clinical trials
We’re tracking 148 recruiting studies that include Metformin, each written for real people, not researchers, below.
Recruiting studies
- NCT04500756RecruitingPhase 2
Metformin to slow abdominal aortic aneurysm growth
This trial tests whether metformin, a common diabetes medicine, can slow the growth of an abdominal aortic aneurysm (a bulging area in the main artery in your belly). If you have a small aneurysm, this medicine might help keep it from getting bigger and reduce your risk of needing surgery.
Stanford, CaliforniaAges 50–95 - NCT07193069Recruiting
Metformin overdose in the ICU – signs and dapagliflozin effects
This study looks at patients who are in the ICU after taking too much metformin (a diabetes drug), sometimes along with another drug called dapagliflozin (Farxiga). The goal is to understand how overdose affects the body and what signs doctors should watch for.
Saint-Denis, FranceAges 18 years+ - NCT07188740RecruitingPhase 1
Metformin to target leukemia-related mutation during remission
This trial tests if metformin can reduce a specific mutation (DNMT3A R882) in people with acute leukemia who are in remission. The goal is to see if it helps prevent relapse.
Tianjin, Tianjin MunicipalityAges 14 years+ - NCT07179042Enrolling by invitationEarly Phase 1
Metformin for hip fracture recovery in older adults
This study tests whether the diabetes drug metformin can help older adults recover better after hip fracture surgery. To join, you need to be 60+, have had a low-energy hip fracture fixed within 3 days, and be generally healthy without diabetes or kidney issues.
Salt Lake City, UtahAges 60–90 - NCT07129473RecruitingPhase 1/Phase 2
Metformin to lower risk of severe morning sickness
This trial tests if taking metformin before pregnancy can reduce the chance of severe morning sickness (hyperemesis gravidarum) in women who had it before. You would take a daily pill and be followed closely.
Birmingham, AlabamaAges 18–49 - NCT07131384Recruiting
Nitrate supplement and metformin for prediabetes
This trial tests whether adding a nitrate supplement to metformin helps people with prediabetes. It looks at how the two treatments interact, especially when you start exercising. The study might help you if you have prediabetes, are between 18 and 60 years old, and don't exercise much.
Charlottesville, VirginiaAges 18–60 - NCT07120971RecruitingEarly Phase 1
Metformin study for premature babies with lung disease
This study tests whether metformin, a medicine used for diabetes, can help premature babies with chronic lung disease (bronchopulmonary dysplasia, or BPD) breathe better. It may reduce the need for breathing machines.
Milwaukee, WisconsinAges 1 week–6 months - NCT07108075Recruiting
Testing metformin and carvedilol for cirrhosis with variceal bleeding
This trial tests whether adding metformin to carvedilol (a standard drug) lowers liver pressure more than carvedilol alone in people with cirrhosis who have had variceal bleeding. The goal is to prevent future bleeding.
New Delhi, National Capital Territory of DelhiAges 18–75 - NCT05917587RecruitingEarly Phase 1
Metformin for blood-vessel function after pregnancy diabetes
This early study tests whether metformin can improve how small blood vessels work after gestational diabetes (pregnancy diabetes). It may help some people who feel long-term effects after delivery by improving blood-vessel-related function.
Iowa City, IowaAges 18–45 - NCT07098299RecruitingPhase 1
Metformin with chemotherapy or immunotherapy for advanced solid tumors
This trial tests if adding metformin, a common diabetes drug, to standard chemotherapy or immunotherapy can help treat advanced solid tumors. It may be an option for people who are already eligible for chemo or immunotherapy.
Bay City, MichiganAges 18 years+ - NCT07093476RecruitingPhase 3
Adding empagliflozin to improve blood sugar control
This trial tests whether adding empagliflozin (a diabetes pill) to your current medicines (alogliptin and metformin) helps manage blood sugar better. It may be an option if your blood sugar is not well controlled with your current treatment.
SeoulAges 19 years+ - NCT06937294RecruitingPhase 4
Metformin for diabetes from chronic pancreatitis
This trial tests if metformin is safe and effective for people who developed diabetes after being diagnosed with chronic pancreatitis. You must not have taken any diabetes medication before.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07045142RecruitingPhase 3
Metformin for blood sugar issues from statins in schizophrenia
This trial tests whether metformin can help prevent or manage blood sugar problems that may arise when people with schizophrenia take statins (cholesterol-lowering drugs). If you have schizophrenia, are on a stable medication routine, and have high cholesterol but not diabetes, this study might be an option.
Zhumadian, HenanAges 18–65 - NCT06742710RecruitingPhase 4
Liraglutide for obese infertility in PCOS
This trial tests if liraglutide, a weight-loss medication, can help obese women with PCOS who have a frozen embryo achieve pregnancy. It aims to improve fertility outcomes by aiding weight loss before embryo transfer.
Beijing, Beijing MunicipalityAges 20–40 - NCT06972732RecruitingPhase 4
Comparing three diabetes drugs for type 2 diabetes
This trial tests a combination of three common diabetes medications (metformin, an SGLT2 inhibitor, and a TZD) to see how well they work together and if they are safe. It may help people with type 2 diabetes who need better blood sugar control.
Seoul, Seocho DistrictAges 19 years+ - NCT05065372RecruitingPhase 1
Metformin test with automated insulin in teens with type 1
This Phase 1 study tests how adding metformin affects blood flow in the kidneys, insulin sensitivity, and overall heart/metabolic health in young people with type 1 diabetes. It may help researchers understand whether this combo is safe and beneficial alongside automated or pump/shot insulin care.
Aurora, ColoradoAges 12–25 - NCT06948825RecruitingPhase 2
Lifestyle program vs. metformin for mothers after gestational diabetes
This study compares a lifestyle program (diet and exercise) with the medication metformin to see which better helps mothers who recently had gestational diabetes improve their health. You may be eligible if you had a single baby, are between 8 weeks and 12 months postpartum, and have a BMI of 25 to 45.
Washington D.C., District of ColumbiaAges 18–45 - NCT06924658RecruitingPhase 2
Metformin for gout patients study
This trial tests if metformin, a common diabetes drug, can help people with gout. It aims to see if the drug is safe and effective for reducing gout symptoms.
TantaAges 18–60 - NCT06862739RecruitingPhase 4
Testing a 3-drug combination for better blood sugar control
This study tests a combination of three diabetes medicines (empagliflozin, linagliptin, and metformin) to see if it helps control blood sugar in people with type 2 diabetes. It may be an option if your current treatment isn't working well enough.
Faisalabad, Punjab ProvinceAges 18–80 - NCT06846138Enrolling by invitation
Herbal supplement to help metformin work better and cause fewer side effects
This study tests a special herbal blend added to metformin to see if it helps reduce stomach problems and improves blood sugar control in people with type 2 diabetes. Researchers want to understand how the herbs affect the bacteria in your gut.
RigaAges 25–80 - NCT06687876RecruitingPhase 2
Metformin before chemoradiation for esophageal cancer
This trial tests if taking metformin (a diabetes pill) before standard chemoradiation can make esophageal cancer respond better. You take metformin for 2 weeks before starting standard treatment, and doctors will check your tumor with two endoscopies to see how it changes.
AmsterdamAges 18 years+ - NCT06829238RecruitingPhase 4
Metformin to boost immune function in people with a history of drug use
This study tests whether metformin, a common diabetes drug, can help restore immune system balance in people who have used injection drugs in the past. It includes both people living with HIV and those who are HIV-negative.
Birmingham, AlabamaAges 18–64 - NCT06763328RecruitingPhase 3
Metformin for insulin resistance after breast cancer chemo
This study tests if metformin, a common diabetes medicine, can help reduce insulin resistance in women who finished chemotherapy for early-stage breast cancer. It aims to improve long-term health and prevent future problems.
Duarte, CaliforniaAges 18 years+ - NCT06142656RecruitingPhase 2/Phase 3
Vildagliptin vs Metformin for PCOS
This trial compares two medicines, vildagliptin and metformin, to see which works better for women with Polycystic Ovary Syndrome (PCOS). The goal is to find a safe and effective treatment that may help manage PCOS symptoms.
GizaAges 18–50
Common questions
- Are there clinical trials studying Metformin?
- Yes. Clin2 currently lists 148 recruiting studies that include Metformin, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Metformin trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Metformin an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Metformin or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.