Treatment
Metformin clinical trials
We’re tracking 152 recruiting studies that include Metformin, each written for real people, not researchers, below.
Recruiting studies
- NCT06537843RecruitingPhase 2
Venetoclax, cytarabine and metformin for AML
This trial tests a combination of three drugs – venetoclax, cytarabine, and metformin – for adults with AML who cannot receive standard high-dose chemotherapy. It aims to see if this gentler mix can help control the leukemia with fewer side effects.
BelémAges 18 years+ - NCT06545526RecruitingPhase 3
Celecoxib and metformin for familial adenomatous polyposis
This trial tests whether a combination of two drugs, celecoxib and metformin, can prevent the growth of polyps in the colon or duodenum (the first part of the small intestine) in people with familial adenomatous polyposis (FAP). FAP is a condition that causes many polyps to form, raising the risk of cancer. If you have FAP, are between 20 and 55, and have at least 5 polyps that are 2mm or larger, this study may be for you.
SeoulAges 20–55 - NCT06576375RecruitingPhase 3
Dapagliflozin vs metformin for PCOS and infertility
This trial compares two medicines, dapagliflozin and metformin, to see which works better for women with PCOS who are trying to get pregnant. Both are pills that can help with hormone balance and ovulation.
GizaAges 18–40 - NCT06686043RecruitingPhase 2
HPV vaccine, imiquimod, and metformin for advanced cervical or vulvar cancer
This trial tests a combination of an HPV vaccine, an immune cream (imiquimod), and a diabetes drug (metformin) together with standard chemoradiation. The goal is to see if this mix helps treat advanced cervical, vaginal, or vulvar cancers better than standard care alone.
Houston, TexasAges 18–64 - NCT06687265RecruitingPhase 2
Metformin for reducing liver pressure in cirrhosis
This trial tests if metformin can lower the pressure in the liver's blood vessels (portal hypertension) in people with cirrhosis. The goal is to see if it can help reduce complications like swelling or bleeding.
Clichy, FranceAges 18 years+ - NCT06687876RecruitingPhase 2
Metformin before chemoradiation for esophageal cancer
This trial tests if taking metformin (a diabetes pill) before standard chemoradiation can make esophageal cancer respond better. You take metformin for 2 weeks before starting standard treatment, and doctors will check your tumor with two endoscopies to see how it changes.
AmsterdamAges 18 years+ - NCT06707012RecruitingPhase 4
Metformin plus antidepressants for depression in obesity
This trial tests whether adding metformin (a diabetes medicine) to usual antidepressant treatment can help improve depression in people who are overweight or obese. It is for adults age 18–44 who are newly diagnosed with depression and do not have diabetes.
Karachi, SindhAges 18–45 - NCT06742710RecruitingPhase 4
Liraglutide for obese infertility in PCOS
This trial tests if liraglutide, a weight-loss medication, can help obese women with PCOS who have a frozen embryo achieve pregnancy. It aims to improve fertility outcomes by aiding weight loss before embryo transfer.
Beijing, Beijing MunicipalityAges 20–40 - NCT06781775RecruitingPhase 4
Metformin vs insulin for gestational diabetes
This trial compares two medicines—metformin pills and insulin shots—to see which works better for controlling blood sugar in gestational diabetes. You may be able to join if you have gestational diabetes that needs treatment and are willing to take either medicine.
Charlottesville, VirginiaAges 18–50 - NCT06845540RecruitingPhase 1/Phase 2
Metformin pills for melasma in Latin American women
This study tests if taking metformin pills can help treat melasma (dark patches on the skin) in Latin American women. It may be a new option for those whose melasma hasn't improved with other treatments.
San Juan, PRAges 21 years+ - NCT06862739RecruitingPhase 4
Testing a 3-drug combination for better blood sugar control
This study tests a combination of three diabetes medicines (empagliflozin, linagliptin, and metformin) to see if it helps control blood sugar in people with type 2 diabetes. It may be an option if your current treatment isn't working well enough.
Faisalabad, Punjab ProvinceAges 18–80 - NCT06924658RecruitingPhase 2
Metformin for gout patients study
This trial tests if metformin, a common diabetes drug, can help people with gout. It aims to see if the drug is safe and effective for reducing gout symptoms.
TantaAges 18–60 - NCT06937294RecruitingPhase 4
Metformin for diabetes from chronic pancreatitis
This trial tests if metformin is safe and effective for people who developed diabetes after being diagnosed with chronic pancreatitis. You must not have taken any diabetes medication before.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06948825RecruitingPhase 2
Lifestyle program vs. metformin for mothers after gestational diabetes
This study compares a lifestyle program (diet and exercise) with the medication metformin to see which better helps mothers who recently had gestational diabetes improve their health. You may be eligible if you had a single baby, are between 8 weeks and 12 months postpartum, and have a BMI of 25 to 45.
Washington D.C., District of ColumbiaAges 18–45 - NCT06972732RecruitingPhase 4
Comparing three diabetes drugs for type 2 diabetes
This trial tests a combination of three common diabetes medications (metformin, an SGLT2 inhibitor, and a TZD) to see how well they work together and if they are safe. It may help people with type 2 diabetes who need better blood sugar control.
Seoul, Seocho DistrictAges 19 years+ - NCT06995339RecruitingPhase 2
Metformin vs. Febuxostat for gout in obesity without diabetes
This study compares two medicines—metformin (usually for diabetes) and febuxostat (for gout)—in people who have both gout and obesity but not diabetes. The goal is to see which works better for controlling gout and related health markers.
Damietta, New DamiettaAges 18–65 - NCT07045142RecruitingPhase 3
Metformin for blood sugar issues from statins in schizophrenia
This trial tests whether metformin can help prevent or manage blood sugar problems that may arise when people with schizophrenia take statins (cholesterol-lowering drugs). If you have schizophrenia, are on a stable medication routine, and have high cholesterol but not diabetes, this study might be an option.
Zhumadian, HenanAges 18–65 - NCT07093476RecruitingPhase 3
Adding empagliflozin to improve blood sugar control
This trial tests whether adding empagliflozin (a diabetes pill) to your current medicines (alogliptin and metformin) helps manage blood sugar better. It may be an option if your blood sugar is not well controlled with your current treatment.
SeoulAges 19 years+ - NCT07108075Recruiting
Testing metformin and carvedilol for cirrhosis with variceal bleeding
This trial tests whether adding metformin to carvedilol (a standard drug) lowers liver pressure more than carvedilol alone in people with cirrhosis who have had variceal bleeding. The goal is to prevent future bleeding.
New Delhi, National Capital Territory of DelhiAges 18–75 - NCT07120971RecruitingEarly Phase 1
Metformin study for premature babies with lung disease
This study tests whether metformin, a medicine used for diabetes, can help premature babies with chronic lung disease (bronchopulmonary dysplasia, or BPD) breathe better. It may reduce the need for breathing machines.
Milwaukee, WisconsinAges 1 week–6 months - NCT07131384Recruiting
Nitrate supplement and metformin for prediabetes
This trial tests whether adding a nitrate supplement to metformin helps people with prediabetes. It looks at how the two treatments interact, especially when you start exercising. The study might help you if you have prediabetes, are between 18 and 60 years old, and don't exercise much.
Charlottesville, VirginiaAges 18–60 - NCT07193069Recruiting
Metformin overdose in the ICU – signs and dapagliflozin effects
This study looks at patients who are in the ICU after taking too much metformin (a diabetes drug), sometimes along with another drug called dapagliflozin (Farxiga). The goal is to understand how overdose affects the body and what signs doctors should watch for.
Saint-Denis, FranceAges 18 years+ - NCT07229651RecruitingPhase 2/Phase 3
Metformin for Parkinson's disease
This trial tests if metformin, a diabetes drug, can help people with Parkinson's disease. It may improve symptoms or slow progression.
TantaAges 50–70 - NCT07291297RecruitingPhase 2
Metformin plus standard therapy for soft tissue sarcoma
This trial tests adding metformin, a common diabetes drug, to the usual first cancer treatment for advanced soft tissue sarcoma. It may help the standard therapy work better.
Charlotte, North CarolinaAges 18 years+
Common questions
- Are there clinical trials studying Metformin?
- Yes. Clin2 currently lists 152 recruiting studies that include Metformin, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Metformin trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Metformin an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Metformin or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.