Treatment
Varenicline clinical trials
We’re tracking 23 recruiting studies that include Varenicline, each written for real people, not researchers, below.
Recruiting studies
- NCT07099638RecruitingPhase 2
Quitting smoking with medicine and a phone app
This study tests a combination of two medicines—varenicline (Chantix) and nicotine lozenges—plus a smartphone app to help people stop smoking. You will be asked to set a quit date within the next week or two and use the app to track your progress for about 6 months.
Oklahoma City, OklahomaAges 18 years+ - NCT04604509RecruitingPhase 4
Smoking quit plan using counseling and nicotine-free medicines
This trial tests whether a quit program that combines counseling with medicines (nicotine replacement, varenicline, or bupropion) helps people stop or cut down smoking. It’s also delivered through telehealth, with repeated check-ins to see how well the plan works and whether it’s safe for you.
Houston, TexasAges 18 years+ - NCT03495024RecruitingPhase 4
Varenicline for quitting smoking in people with schizophrenia
This trial tests whether varenicline helps people with schizophrenia or schizoaffective disorder stop smoking. It also looks at related nervous-system side effects that can happen with some anti-psychotic medicines.
Philadelphia, PennsylvaniaAges 18–75 - NCT07145866RecruitingPhase 4
Varenicline and TMS for quitting nicotine use
This study tests whether combining the medication varenicline (Chantix) with a special brain stimulation treatment (TMS) can help people quit vaping or smoking nicotine. If you're motivated to quit and use nicotine daily, you may be able to join.
Boston, MassachusettsAges 18–65 - NCT05257629RecruitingPhase 3
Aggressive smoking quit program after heart problems
This trial tests whether a strong quit plan using varenicline (a quit pill) plus nicotine e-cigarettes, along with counseling, helps people stop smoking after a recent heart-related event. It’s aimed at people who want to quit and can safely stay involved for about a year.
New Westminster, British ColumbiaAges 18 years+ - NCT06679374RecruitingPhase 2
Can varenicline help reduce falls in Parkinson disease?
This phase 2 trial tests a medicine called varenicline (brand name Chantix) to see if it can reduce falls in people with Parkinson disease who also have a specific brain change (loss of a chemical called acetylcholine in the back of the brain) and mild cognitive problems. The study will help determine if this medicine is safe and effective for this group.
Ann Arbor, MichiganAges 45 years+ - NCT06798324RecruitingPhase 4
Brain stimulation plus smoking cessation medication for quitting smoking
This trial tests whether combining brain stimulation (tDCS) with a smoking cessation medication (varenicline) helps people quit smoking. You would attend daily visits for two weeks.
Toronto, OntarioAges 18–85 - NCT06832085RecruitingPhase 4
Comparing stop-smoking medications for adult smokers in Ontario
This study compares three different stop-smoking treatments—nicotine patches, cytisine, or varenicline—to see which works best. If you want to quit or cut down in the next six months, this could help you find the right medication.
Ottawa, OntarioAges 18 years+ - NCT07040566RecruitingPhase 2
Varenicline to help stop vaping
This trial tests whether varenicline, a medicine that reduces cravings, can help people quit using e-cigarettes that contain nicotine. You must be a daily nicotine vaper and live in Connecticut or South Carolina.
New Haven, ConnecticutAges 18 years+ - NCT07596485RecruitingPhase 1/Phase 2
RP-008 Plus Varenicline for Trigeminal Neuralgia Pain
This trial tests a new drug called RP-008 combined with varenicline (a quit-smoking medication) to relieve severe facial pain from trigeminal neuralgia. If you've already tried standard pain medications without enough relief, this combination might help reduce your pain attacks.
SherbrookeAges 18–80 - NCT05703672RecruitingPhase 3
Switching smokers to e-cigarettes who do not want to quit
This study tests whether switching from regular cigarettes to e-cigarettes helps smokers who are not interested in quitting. You would also be offered varenicline and regular check-ins to compare outcomes over time.
Kansas City, MissouriAges 21 years+ - NCT06474299RecruitingPhase 4
Quit Smoking and Vaping With Patches and Pills
This study tests whether a combination of a nicotine patch plus a medication called varenicline can help people who both smoke and vape quit both. You'll get free medication and support to help you stop.
Madison, WisconsinAges 21 years+ - NCT05413122RecruitingPhase 2/Phase 3
Smoking quit support for adults living with HIV in South Africa
This trial tests smoking-cessation interventions to help people living with HIV quit smoking or smoke less. You may be eligible if you smoke, are actively engaged in HIV treatment, and can follow the study for about a year.
Soweto, GautengAges 18 years+ - NCT07705893Recruiting
Treating contact lens discomfort with a nasal spray
This trial tests a nasal spray (varenicline) to see if it can relieve discomfort and dryness from contact lens wear. If you wear daily disposable soft contacts and experience end-of-day eye dryness, you may be eligible.
Houston, TexasAges 18–99 - NCT04725617Recruiting
Smoking-quit program for people with HIV and sleep issues
This study tests a wellness-based smoking-cessation program (including the stop-smoking medicine varenicline) for people living with HIV who want to quit. It aims to help you reduce or stop smoking while monitoring safety, sleep, and mental health during the program.
Phoenix, ArizonaAges 18–75 - NCT05642715Recruiting
HIV smoking reduction program with varenicline and online support
This study tests a harm-reduction approach to help people with HIV smoke fewer cigarettes and quit if they want, using an online tobacco program and varenicline (a quit-smoking medicine). You may be placed in one of two different study groups to compare how well the approaches work.
The Bronx, New YorkAges 40–79 - NCT05786547RecruitingPhase 3
Varenicline plus support to help quit tobacco in HIV care
This Phase 3 trial tests a quit-smoking program using varenicline (a medicine) plus additional support, for people with HIV who currently use tobacco. It may help you stop smoking or using tobacco and stay quit with safer, guided care.
Aurora, ColoradoAges 18 years+ - NCT06582888RecruitingEarly Phase 1
VR attention test for smoking cravings
This study tests whether a virtual reality (VR) program can measure how your brain pays attention to smoking cues. It also involves taking a medication called varenicline (Chantix) to see if it reduces cravings. You may be eligible if you are a daily smoker, have been smoking for at least 3 years, and are not ready to quit in the next month.
San Diego, CaliforniaAges 22 years+ - NCT06609369RecruitingPhase 2
Sleep and smoking relapse study
This study tests whether improving sleep can help people quit smoking and avoid relapse. It uses brain scans, a quitting medication, and counseling.
New Haven, ConnecticutAges 18–65 - NCT06688539RecruitingPhase 4
Quitting e-cigarettes in adults who also use cannabis
This trial tests if varenicline, a stop-smoking medication, can help people ages 18 to 40 quit e-cigarettes while also using cannabis. It's designed for regular e-cigarette users who want to quit and who use cannabis at least 10 days per month.
Charleston, South CarolinaAges 18–40 - NCT06883162RecruitingPhase 3
A study to help people stop smoking tobacco and reduce cannabis use
This study tests whether a medication called varenicline (or a placebo) can help people who use both tobacco and cannabis to quit or cut back. It takes place in South Carolina and lasts 12 weeks.
Charleston, South CarolinaAges 18 years+ - NCT07606625RecruitingPhase 4
Nasal spray for dry eye disease and tear film stability
This study tests whether a nasal spray can improve dry eye symptoms and tear production in people with mild to moderate meibomian gland dysfunction (a common cause of dry eye). You'll use the spray daily while the research team monitors your eye health and comfort over several weeks.
Berkeley, CaliforniaAges 18 years+ - NCT05694637Enrolling by invitationPhase 4
Support to help daily smokers with HIV stay abstinent
This Phase 4 study tests a smoking-quit support approach (reinforcement and coaching) to help people with HIV stop smoking and stay smoke-free. It may help improve smoking abstinence while you continue HIV care.
Francistown, Central DistrictAges 18 years+
What Varenicline is being studied for
Conditions with recruiting Varenicline studies.
Common questions
- Are there clinical trials studying Varenicline?
- Yes. Clin2 currently lists 23 recruiting studies that include Varenicline, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Varenicline trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Varenicline an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Varenicline or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.