Clinical trials
ACL clinical trials
Below are recruiting acl clinical trials, each written for real people, not researchers. We’re tracking 129 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06974526RecruitingPhase 2
Study of a dissolvable implant for recovery after ACL surgery
This study tests whether a dissolvable implant that releases a medication called oxandrolone can improve recovery after ACL surgery. Oxandrolone may help strengthen the new ligament and speed up healing.
Fortaleza, CearáAges 18–60 - NCT06885372Enrolling by invitation
Long-term follow-up of ACL tear patients without surgery
This trial is for people with a torn ACL who are young (up to 25) and have certain risk factors for knee instability. It will follow them long-term to see how their knee does without surgery, focusing on those who are active in pivoting sports, have a loose knee joint, or have naturally loose joints.
Banff, AlbertaAges 14–25 - NCT06875427RecruitingPhase 3
Nerve block vs no block for ACL surgery in kids
This trial tests whether a nerve block (a numbing shot) before ACL reconstruction helps young patients have less pain and better recovery compared to no block.
Hamilton, OntarioAges 10–18 - NCT06781021Enrolling by invitation
ACL surgery: Clearer view with medication or tourniquet?
This study compares two ways to control bleeding during ACL knee surgery: a medication called tranexamic acid (TXA) versus a tourniquet. The goal is to see which method gives surgeons a clearer view inside the knee, which may help them do a better job.
Kingston, JamaicaAges 18 years+ - NCT06635668Recruiting
ACL injury risk screening study for athletes
This study screens healthy athletes aged 10 to 65 to understand what normal ACL injury risk looks like. It helps set a baseline so doctors can better identify those at higher risk.
Fargo, North DakotaAges 10–65 - NCT06603051Recruiting
Freezing a nerve before ACL surgery to cut opioid use
This study looks at freezing a nerve before ACL surgery to help reduce the amount of strong pain medicine you need afterward. If you're having ACL reconstruction with your own tendon and haven't been using opioids regularly, you may be able to join.
Burlington, New JerseyAges 14 years+ - NCT05342441Recruiting
Choosing the best ligament graft for ACL repair
This study looks at how different “grafts” (tissue used to rebuild the ACL) affect outcomes after first-time ACL reconstruction. It may help personalize graft choice for people who want to return to physical activity.
HvidovreAges 18–40 - NCT04295148Recruiting
Compare brace and rehab for ACL reconstruction
This study compares two ways of rehabilitating the knee after ACL rupture repair. It’s meant to see which approach helps people return to their prior sport more safely and effectively.
Stockholm, Stockholm CountyAges 16–40 - NCT06341192Recruiting
Comparing two ways to reconstruct the ACL
This trial compares two different techniques for ACL surgery (single bundle vs. double bundle) to see which one works better. If you're planning to have ACL surgery, you may be able to join.
Taoyuan, taoyuanAges 18 years+ - NCT06311513RecruitingPhase 4
Concentrated bone marrow injection during repeat ACL surgery
This study tests whether adding a concentrated bone marrow injection during repeat ACL surgery helps healing and recovery better than surgery alone. If you have had a previous ACL reconstruction that failed, you may be eligible.
Atlanta, GeorgiaAges 18–55 - NCT06178484Recruiting
Surgery versus rehabilitation for a torn ACL
This study compares two ways to treat a tear of the anterior cruciate ligament (ACL) near the top of the knee. It looks at whether having surgery is better than a non-surgical approach with physical therapy. You may be eligible if your tear is recent and you have no other knee injuries.
Lille, Choisir Une RégionAges 18 years+ - NCT06178497Recruiting
5-Year Check-In After ACL Repair
This study checks on people who had ACL (anterior cruciate ligament) repair surgery 5 years ago to see how well their knee is doing. It looks at a specific type of ACL tear (a 'proximal' tear) and helps doctors understand long-term results.
Lille, Choisir Une RégionAges 18 years+ - NCT05584020Recruiting
ACL repair vs. reconstruction for a recent tear
This study compares two ways to repair a torn ACL: stitching it back together (repair) versus using a graft from another tendon (reconstruction). It is for people who have a fresh, uncomplicated ACL tear and want to see which approach works better.
Hangzhou, ZhejiangAges 18 years+ - NCT03896464Recruiting
Quadriceps tendon vs hamstring tendon for ACL surgery in teens
This trial compares using a quadriceps tendon graft versus a hamstring graft during ACL reconstruction in children and teens whose growth plates are still open. It aims to see which graft works better after ACL injury while accounting for ongoing bone growth.
Hamilton, OntarioAges 10–18 - NCT03441165Recruiting
Measure knee looseness during ACL and meniscus surgery
This trial checks how loose the knee feels during surgery for ACL reconstruction, ACL revision, or meniscus transplantation. The goal is to better assess knee stability during the operation, which may help surgeons choose the best repair.
Bologna, ItaliaAges 14–65 - NCT06096259RecruitingPhase 2
Preventing knee arthritis after ACL injury
This trial tests whether metformin, a common diabetes medicine, can prevent arthritis after an ACL injury. If you are planning to have ACL surgery soon, you may be able to join.
Atlanta, GeorgiaAges 18–45 - NCT04390035Recruiting
Blood-flow training after ACL surgery for teens
This trial looks at whether a special exercise method that changes blood flow during physical therapy (called BFRT) can improve recovery after ACL reconstruction in teens. It may help strength and rehab progress, but you would need to meet several surgery and safety requirements and attend many PT visits.
Atlanta, GeorgiaAges 12–18 - NCT03096366Recruiting
Blood flow restriction rehab after ACL knee surgery
This trial studies whether a special exercise method that limits blood flow to the thigh (called blood flow restriction training) can improve quadriceps strength and function during recovery after arthroscopic ACL surgery. If you qualify, you would join a structured physical therapy program and follow the study’s rehab plan.
Houston, TexasAges 14–55 - NCT04607538Recruiting
Study of knee joint shape and patella dislocations in Faroese teens
This study looks at how knee joint shape differences may relate to repeated kneecap (patella) instability or near-dislocation, and what that means long-term. It specifically includes teens from the Faroe Islands and asks about symptoms and knee function over time.
HvidovreAges 15–20 - NCT07859397Recruiting
Pain relief options for knee ligament surgery
This study compares two nerve-block approaches to see which provides better pain relief after knee ligament reconstruction surgery. If you are having this surgery, joining could help manage your pain more effectively.
AnkaraAges 18–65 - NCT06195423Recruiting
Stopping knee arthritis after an ACL tear
This study tests a home exercise program to prevent knee arthritis after an ACL tear. If you had ACL surgery 9 to 36 months ago and still have some knee symptoms, this program may help protect your knee in the long run.
Vancouver, British ColumbiaAges 16–35 - NCT06442319Recruiting
PRP after ACL reconstruction
This trial tests if injecting platelet-rich plasma (a concentration of your own blood platelets) after ACL reconstruction helps with healing and reduces pain. It's for people who recently had ACL surgery and want to try an extra treatment to improve recovery.
TorunAges 18–45 - NCT06379308Recruiting
ACL revision surgery study in France
This study looks at people who need a second ACL surgery (revision). It helps doctors learn more about these procedures to improve care.
Saint-EtienneAges 18 years+ - NCT07765173Recruiting
Muscle function after ACL reconstruction in active people
This study looks at how well your thigh muscles work after ACL reconstruction surgery. It aims to understand muscle power recovery in active people, which could help improve rehabilitation programs.
Challes-les-EauxAges 18–65
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Common questions
- Are there clinical trials for acl?
- Yes. Clin2 currently lists 129 recruiting acl studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acl trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acl trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.