Clinical trials
ACL clinical trials
Below are recruiting acl clinical trials, each written for real people, not researchers. We’re tracking 130 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06505525Recruiting
ACL reconstruction: adding extra support vs standard surgery
This trial compares two surgical techniques for ACL reconstruction. The standard method repairs the ACL inside the knee joint, while the new method also adds extra support outside the joint. The study aims to see which approach gives better stability and recovery for people with specific risk factors, like being a young athlete or having a chronic ACL tear.
São Paulo, São PauloAges 14–40 - NCT06524869Recruiting
Muscle and function after ACL reconstruction
This study looks at how muscle strength, power, and control relate to daily function after ACL reconstruction. It may help you understand your recovery progress and guide your rehabilitation.
CaenAges 18–40 - NCT06635668Recruiting
ACL injury risk screening study for athletes
This study screens healthy athletes aged 10 to 65 to understand what normal ACL injury risk looks like. It helps set a baseline so doctors can better identify those at higher risk.
Fargo, North DakotaAges 10–65 - NCT07683247Recruiting
Energy use during ACL reconstruction surgery
This study measures how much energy your body uses during ACL reconstruction surgery. It uses a special vest to track your heart rate and breathing, which may help surgeons understand how your body handles the operation.
LecceAges 16–49 - NCT06858930Recruiting
Navigation system for ACL reconstruction
This trial tests a special computer navigation system to help surgeons place the new ACL graft more precisely during knee reconstruction. If you have a torn ACL and are between 18 and 80, this study might help improve your surgery outcomes.
Beijing, Beijing MunicipalityAges 18–80 - NCT06875427RecruitingPhase 3
Nerve block vs no block for ACL surgery in kids
This trial tests whether a nerve block (a numbing shot) before ACL reconstruction helps young patients have less pain and better recovery compared to no block.
Hamilton, OntarioAges 10–18 - NCT06955026Recruiting
Hockey slideboard and blood flow restriction for ACL rehab
This trial tests if using a hockey slideboard with blood flow restriction (a special band that limits blood flow during exercise) helps recovery after ACL surgery. It may improve muscle strength and function faster.
Odorheiu Secuiesc, RomaniaAges 18–45 - NCT06974526RecruitingPhase 2
Hormone implant for ACL surgery recovery
This trial tests a small implant that slowly releases the hormone oxandrolone to help you recover strength and function faster after ACL reconstruction surgery. It is for people who are already active and have no major health problems that could interfere with the medicine.
Fortaleza, CearáAges 18–60 - NCT07030764Recruiting
Comparing rehab with and without a digital app after ACL surgery
This trial tests whether adding a digital therapy app to regular rehabilitation helps reduce thigh muscle weakness after ACL reconstruction. Participants will use the app on their smartphone alongside standard physical therapy.
Lyon, FranceAges 18 years+ - NCT07097077Recruiting
Brain changes after ACL surgery with special training
This study uses brain scans (fMRI) to see how a special type of movement training affects the brain after ACL surgery. If you've had an ACL repair and are active in sports, you may be eligible.
Bologna, BolognaAges 18–30 - NCT07158476RecruitingPhase 4
Steroid injection for pain after ACL repair
This trial tests whether a single dose of methylprednisolone (a steroid) can reduce pain after ACL knee surgery. You will be randomly assigned to receive either the steroid or a placebo, and your pain levels will be tracked.
St Louis, MissouriAges 13–50 - NCT07201597Recruiting
Readiness and knee function after ACL surgery
This study looks at how your mental readiness, knee function, and strength relate after ACL reconstruction using a specific type of tendon graft. It may help you understand if you're ready to return to sports.
Cairo, Cairo GovernorateAges 18–35 - NCT07475351Recruiting
Comparing two grafts for ACL reconstruction
This trial compares two types of grafts to rebuild the ACL in the knee, to see if one leads to better results. It is for active athletes with a recent ACL tear and healthy knees.
Granada, GranadaAges 12–40 - NCT06885372Enrolling by invitation
Long-term follow-up of ACL tear patients without surgery
This trial is for people with a torn ACL who are young (up to 25) and have certain risk factors for knee instability. It will follow them long-term to see how their knee does without surgery, focusing on those who are active in pivoting sports, have a loose knee joint, or have naturally loose joints.
Banff, AlbertaAges 14–25 - NCT06781021Enrolling by invitation
ACL surgery: Clearer view with medication or tourniquet?
This study compares two ways to control bleeding during ACL knee surgery: a medication called tranexamic acid (TXA) versus a tourniquet. The goal is to see which method gives surgeons a clearer view inside the knee, which may help them do a better job.
Kingston, JamaicaAges 18 years+ - NCT06006624Enrolling by invitationPhase 4
Exparel vs nerve block for ACL reconstruction pain
This trial compares two methods of pain control after ACL surgery: a long-lasting local anesthetic (Exparel) versus a nerve block. It aims to find which provides better pain relief and recovery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04956536Enrolling by invitation
ACL injury study using your pre-surgery MRI
This trial studies ACL (knee ligament) injuries and how the tibia (shin bone) shifts, using MRI scans taken before surgery. It may help doctors better understand knee instability and improve how ACL injuries are evaluated and treated.
BeijingAges 18 years+ - NCT03365908Enrolling by invitation
Pain Management After ACL Reconstruction Surgery
This study looks at ways to manage pain in adults who are getting surgery to repair a torn ACL (a knee ligament). It may help improve comfort and recovery after ACL reconstruction.
Sacramento, CaliforniaAges 18–45 - NCT05527171Recruiting
Virtual reality mindfulness after ACL knee surgery
This study uses a virtual-reality mindfulness meditation program to help improve fear and movement quality after ACL reconstruction. It may help you feel less afraid of movement and land more safely when you return to sports.
Chapel Hill, North CarolinaAges 14–25 - NCT07765173Recruiting
Muscle function after ACL reconstruction in active people
This study looks at how well your thigh muscles work after ACL reconstruction surgery. It aims to understand muscle power recovery in active people, which could help improve rehabilitation programs.
Challes-les-EauxAges 18–65 - NCT05527548RecruitingPhase 4
Alendronate for knee recovery after ACL surgery
This trial tests whether alendronate, a drug commonly used for bone health, can improve knee function and recovery after ACL surgery. It is for people having their first ACL repair.
ShatinAges 14 years+ - NCT06240780Enrolling by invitation
Incrediwear recovery study for ACL and MCL surgery
This trial tests whether wearing Incrediwear clothing helps you recover faster after arthroscopic knee surgery for ACL or MCL tears. It is designed for people about to have surgery and who want to improve their healing process.
Oklahoma City, OklahomaAges 18–65 - NCT06041763Recruiting
Bridge-enhanced ACL repair for meniscus repair
This study tests a special bridge implant to help heal a torn meniscus during surgery. It may help improve recovery and reduce the need for additional surgeries.
New York, New YorkAges 18–75 - NCT05972876Recruiting
Blood-flow restriction rehab after ACL surgery
This trial looks at how well your ACL graft (the repaired tissue) heals after ACL reconstruction when you use a specific rehab method called blood-flow restriction training. It may help your care team understand whether this rehab approach leads to better healing and function.
Sittard, LimburgAges 18–65
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Common questions
- Are there clinical trials for acl?
- Yes. Clin2 currently lists 130 recruiting acl studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acl trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acl trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.