Clinical trials
Advanced clinical trials
Below are recruiting advanced clinical trials, each written for real people, not researchers. We’re tracking 3,902 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04824014RecruitingPhase 2
PET imaging for ER+ advanced breast cancer
This trial uses a special PET scan called 4FMFES-PET to take detailed pictures of ER-positive breast cancer that has spread. It helps doctors see where the cancer is and how active it is, which may guide treatment decisions.
Sherbrooke, QuebecAges 18 years+ - NCT04852328RecruitingPhase 2
Testing CUE-101 schedules before treatment for HPV16 throat cancer
This Phase 2 trial studies different timing “schedules” of CUE-101 given before surgery or before chemoradiation for HPV16-positive oropharyngeal throat cancer. The goal is to see if CUE-101 can help the body respond better and potentially improve outcomes.
St Louis, MissouriAges 18 years+ - NCT04811703RecruitingPhase 1
Testing aerosol chemotherapy through the belly for advanced ovarian cancer
This Phase 1 study tests a new way to deliver chemotherapy inside the abdomen (belly) using a pressurized aerosol during a procedure, along with standard blood (IV) chemotherapy. It may help people with advanced ovarian cancer whose tumors have not progressed but are not removable with surgery yet.
LilleAges 18–75 - NCT04802759RecruitingPhase 1/Phase 2
Testing drug combinations for recurrent or advanced ER-positive breast cancer
This early-phase trial tests several combinations of cancer medicines to slow or control ER-positive breast cancer that has returned or progressed. It also checks safety and whether tumor or blood biomarkers can help match the right treatment to the right person.
Duarte, CaliforniaAges 18 years+ - NCT04686682RecruitingPhase 1/Phase 2
Study drug for adults with advanced cancers or AML
This early study (Phase 1/2) tests a new medicine (JAB-8263) in adults with advanced solid tumors or recurrent/refractory AML. It aims to find a safe dose and see whether it can shrink tumors or control the cancer.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT04708587Recruiting
Choosing the right anti-platelet duration for advanced kidney disease
This study looks at the best length of anti-platelet medicine (which helps prevent stent clots) after a new type of heart stent. It specifically focuses on people with advanced chronic kidney disease, where bleeding and clot risks can be higher.
SeoulAges 19–84 - NCT04703101RecruitingPhase 1
Short radiation plus chemo for stage II–III rectal cancer
This trial tests a short course of radiation therapy combined with chemotherapy for people with stage II or III rectal cancer. It’s designed to see whether this approach is safe and effective before or around cancer surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT04768322Recruiting
LVAD versus standard heart failure medicines in advanced patients
This trial compares an LVAD device (a pump placed in the chest) plus medicines versus medicines alone for people with advanced, end-stage heart failure. It aims to see which approach works better to help patients live and stay out of the hospital.
BesançonAges 18 years+ - NCT04729114RecruitingPhase 1
Safety and dose test of PRL-02 shot for advanced prostate cancer
This Phase 1 study tests how safe PRL-02 depot (an injection) is and finds the best dose for men with advanced prostate cancer. It may help determine a new treatment option for cancers that have spread or are getting worse despite standard care.
Tucson, ArizonaAges 18 years+ - NCT04613596RecruitingPhase 2/Phase 3
Adagrasib for KRAS G12C lung cancer, alone or with pembrolizumab
This trial studies adagrasib (an anti-cancer drug) either alone or with pembrolizumab (an immunotherapy) in people with advanced lung cancer that has a KRAS G12C mutation. It aims to shrink tumors and improve outcomes, including for people without urgent brain treatment needs.
Goodyear, ArizonaAges 18 years+ - NCT04683250RecruitingPhase 1/Phase 2
RET-targeting drug study for advanced cancers with RET changes
This trial tests an “RET-inhibitor” medicine (TAS0953/HM06) for advanced solid tumors that have RET gene changes. It may help shrink tumors by blocking cancer growth signals from the RET gene.
Orange, CaliforniaAges 18 years+ - NCT04606914RecruitingPhase 2
Carboplatin plus mirvetuximab for advanced ovarian cancer after chemo
This Phase 2 study tests adding mirvetuximab to carboplatin for people with advanced, high-grade serous ovarian cancer who will first receive “neoadjuvant” chemotherapy. It is designed for tumors that strongly show FRα, which mirvetuximab targets, to see if this improves outcomes.
Birmingham, AlabamaAges 18 years+ - NCT04613583Recruiting
Study of fetal tissue collected during normal pregnancy
This study asks pregnant people with a normal ultrasound to join research where fetal tissue may be collected at an important point in pregnancy (7–20 weeks). It aims to better understand fetal development, and participation requires being able to understand the study in English.
AberdeenAges 16 years+ - NCT04611867Recruiting
Test “BetterEveryDay” patient-reported care for pancreatic or bile cancer
This study studies how a patient “reporting” program (called PRO) works for people with advanced pancreatic or bile-tract cancer. It may help teams understand symptoms and needs earlier to improve care and support during treatment.
HerlevAges 18 years+ - NCT04649125Recruiting
Single-shot versus multi-day palliative radiation for metastatic cancer
This trial compares a single treatment session (one-fraction radiation) versus the usual multiple sessions (multi-fraction radiation) to help relieve symptoms from metastatic cancer. It may help your care team find the most effective and practical schedule for symptom control.
Saint Leonards, New South WalesAges Any age - NCT04622423Recruiting
Advanced therapies for colon or pancreas liver metastases
This study tests advanced treatments for cancer that has spread to the liver, either from colon cancer or pancreatic cancer. It may help by targeting liver tumors using treatment plans and, for some participants, liver tissue samples.
Milan, MilanAges 18 years+ - NCT04580225Recruiting
Tested partial wrist fusion with or without bone removal
This study compares two surgical options for certain types of advanced wrist arthritis—one with partial wrist fusion alone, and one with partial wrist fusion plus removal of a small wrist bone. It may help find which approach works better for pain and function after surgery.
Calgary, AlbertaAges 18–75 - NCT04575935RecruitingPhase 3
Minimally invasive surgery after chemotherapy for advanced ovarian cancer
This trial studies whether doing surgery using smaller incisions after chemotherapy works as well as a more traditional approach for certain people with stage IIIC–IV ovarian, fallopian tube, or primary peritoneal cancer. It may help reduce surgical trauma while aiming for effective tumor removal.
Miami, FloridaAges 18 years+ - NCT04577014RecruitingPhase 1/Phase 2
Retifanlimab plus chemotherapy for advanced soft tissue sarcoma
This trial tests retifanlimab (an immunotherapy that helps your immune system recognize cancer) combined with gemcitabine and docetaxel chemotherapy. It’s for people with advanced soft tissue sarcoma that can’t be safely removed with surgery, aiming to shrink tumors and improve outcomes.
New York, New YorkAges 18 years+ - NCT04383119RecruitingPhase 2
Study for advanced leiomyosarcoma after prior chemo
This Phase 2 trial studies how well gemcitabine or trabectedin works for people with leiomyosarcoma that cannot be fully removed or has spread. It’s for tumors that have grown or worsened despite prior standard chemotherapy.
Bologna, BOAges 18 years+ - NCT04478006Recruiting
Translational research for childhood blood cancers
This study looks at childhood leukemia and related blood disorders. It may help researchers learn more about the diseases and how to improve treatments for children.
Hong Kong, HksarAges Up to 18 years - NCT04406662Recruiting
Study for people living with incurable cancer
This study enrolls adults with advanced, incurable cancer to better understand care and outcomes in everyday settings. It may help by guiding improvements for people receiving treatment for symptom relief (palliative care).
EdinburghAges 18 years+ - NCT04436965RecruitingPhase 3
Standard nutrition support for malnourished nasopharyngeal cancer patients
This Phase 3 study tests whether giving a standard nutrition plan can improve nutritional status and outcomes in people with locally advanced nasopharyngeal cancer who are malnourished. It mainly checks whether nutrition support helps you tolerate treatment and do better over time.
Guangzhou, GuangdongAges 18–65 - NCT04486833RecruitingPhase 1/Phase 2
Genetic-targeted drug plus gene medicine for EGFR lung cancer
This trial studies a gene-based treatment added to osimertinib (a targeted lung cancer pill) for advanced EGFR-mutant lung cancer that has started growing again on osimertinib. It may help by attacking the cancer with both its usual target treatment and an added genetic approach.
Los Angeles, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for advanced?
- Yes. Clin2 currently lists 3,902 recruiting advanced studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.