Clinical trials
Amputation clinical trials
Below are recruiting amputation clinical trials, each written for real people, not researchers. We’re tracking 145 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07840781Recruiting
Building a performance model for amputee football players
This study aims to understand what makes amputee football players perform well, so it can help improve training and performance. If you play amputee football regularly, you may be able to join and contribute to this research.
AdanaAges Any age - NCT04635436Recruiting
Split-walking training for one-sided leg weakness when walking hurts
This trial tests whether a “split gait” walking training method can improve walking balance and how you move when you have one-sided leg problems and pain or limitations when walking. It may help reduce walking difficulties by training your stepping pattern safely.
Milan, MIAges 18–70 - NCT04936789Recruiting
Testing a new arm prosthesis with sensors in one arm
This study checks whether a new sensor-enabled prosthesis for people with a lower-arm (transradial) amputation can be safely fitted and used. It may help improve how well a prosthesis can read muscle signals to control a hand/arm replacement.
GlasgowAges 18–65 - NCT05931198Recruiting
Testing how well prosthetic arms feel like your own hand
This study looks at whether people with an upper-limb amputation can experience the “rubber hand illusion” when using different types of prostheses. It may help researchers understand which prosthesis types feel more natural, which could improve comfort and use.
ValentonAges 18 years+ - NCT07706452Recruiting
Balance Training for People with a Prosthetic Leg
This study tests a special balance training program for people who use a prosthetic leg after losing a leg due to injury. The program combines balance exercises with a second task (like talking or counting) to improve walking and stability in daily life.
Gaza, Gaza StripAges 18 years+ - NCT07691957Recruiting
Nerve study for healthy and amputee volunteers
This study uses a special technique to measure how nerves in the arm send signals to the brain. It compares healthy volunteers and people with an upper-limb amputation to better understand sensation and potentially improve prosthetic devices.
Pisa, PisaAges 18–60 - NCT07645729Recruiting
Testing a Powered Ankle Prosthesis with Neural Control
This study tests a new powered ankle prosthesis (an artificial foot with a motor) that you control using signals from your nerves and receive feedback through gentle stimulation on your skin. The goal is to see if it helps you walk more naturally and perform daily activities with better balance and control.
Cambridge, MassachusettsAges 18–70 - NCT05483816Recruiting
Sensory stimulation trial for nerve pain in people with neuropathy
This study tests a multi-sensory (multiple-sense) stimulation approach to see if it can help people with nerve-related pain in the legs/feet. You must be able to safely take part in MRI-related sessions and answer questions about pain and health history.
Zurich, Canton of ZurichAges 18–80 - NCT06648798Recruiting
Comparing a new fast-fit prosthetic leg to your current one
This trial is testing a new quick-to-make, custom below-knee prosthetic leg (called the UniLeg). It compares how well it works for daily walking versus your current prosthetic. The goal is to see if the new leg can be made faster and fit better, helping you stay active.
La Jolla, CaliforniaAges 18–75 - NCT07613840Recruiting
Personalized Blood Clot Prevention After Leg Artery Surgery
This study tests a personalized approach to prevent blood clots in patients who have had surgery to repair blocked arteries in their legs. Researchers want to find the best blood-thinning medication for each individual to reduce serious complications while keeping you safe.
Boston, MassachusettsAges 18 years+ - NCT05008185Recruiting
Nerve interface surgery to reduce hand pain nerve tumors
This trial tests a regenerative nerve device/surgery approach to reduce painful nerve growths (neuromas) after a finger or partial hand amputation. You may qualify if you’re an adult with confirmed, localized neuroma pain and have already tried a 6-week desensitization therapy plan.
Baltimore, MarylandAges 18 years+ - NCT07605754Recruiting
Nerve Surgery Results for Pain After Amputation
This study evaluates how well nerve surgery works for patients with severe, persistent pain in the area where a limb was amputated. Researchers will review outcomes to understand if this surgical approach helps reduce pain that hasn't responded to other treatments.
Leiden, South HollandAges 18 years+ - NCT05009394Recruiting
Surgery options for long-term pain after limb amputation
This trial studies different surgical approaches to reduce persistent pain in the leftover part of an amputated limb. You may be able to join if your post-amputation pain has lasted more than a year and your pain level stays high despite stable pain treatments and prosthesis use.
Chicago, IllinoisAges 18 years+ - NCT07489820Recruiting
Vacuum dressing for healing after rectal cancer surgery
This trial is testing whether a special vacuum-type wound dressing (called negative pressure therapy) helps the surgical area heal better after removal of the rectum and anus for rectal cancer. If you've had chemotherapy and radiation before surgery, this study may help improve your recovery.
AmiensAges 18 years+ - NCT07486063RecruitingEarly Phase 1
Motorized leg prosthetics for above-knee amputees
This study tests whether a motorized (powered) prosthetic knee and ankle can help people with above-knee amputations walk better. If you already use a mechanical or microprocessor-controlled leg, you may be able to try a new powered version.
Salt Lake City, UtahAges 18–80 - NCT06813937Recruiting
Magnetic stimulation for feeling in upper limb amputation
This study tests whether magnetic stimulation can improve sensation in people who have lost an upper limb. It may help restore feeling in the residual limb.
MoscowAges 18–65 - NCT06830876Recruiting
Testing muscle stimulator for pain and function after leg amputation
This trial tests if a noninvasive electrical stimulator (NMES) placed on the residual leg can reduce pain and improve muscle and function in people with a below-knee amputation. It aims to offer a drug-free option for managing chronic limb pain.
Pittsburgh, PennsylvaniaAges 18–100 - NCT05818410Recruiting
Brain and tech training after below-knee leg loss
This study looks at how your brain works with assistive technology after losing a leg below the knee. It may help researchers improve how prosthetic devices feel and function by measuring brain and movement signals during training.
BrusselsAges 18–65 - NCT07314099Recruiting
Study of the Breizh Fabribus program for assistive devices
This study looks at the Breizh Fabribus program, which helps people get personalized assistive devices. It aims to see if the program helps improve your daily life.
Brest, FinistèreAges Any age - NCT06829212Recruiting
Wireless brain implant for device control
This trial tests a wireless brain implant that lets you control external devices like a computer or wheelchair just by thinking. It's designed for people with paralysis or double arm amputations who want to regain some independence.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06160882Recruiting
Powered prosthetic leg for bone-anchored amputees
This study tests a high-tech powered knee and foot for people who have a leg amputation above the knee and have (or are candidates for) a bone-anchored implant. The goal is to see if the powered prosthesis helps with walking and daily activities.
Chicago, IllinoisAges 18–70 - NCT07216183RecruitingPhase 1
Skin sensor study for lower leg amputees
This study tests a new wireless skin sensor that sticks to your residual limb (the part of your leg below the knee where you wear your prosthetic). The goal is to track how your skin is doing inside the socket. If you qualify, you'll visit North Carolina State University to try the sensor and be photographed during research activities.
Raleigh, North CarolinaAges 18–75 - NCT07204925RecruitingPhase 1
Personalizing a computerized leg for above-knee amputees
This trial tests a new way to personalize a computerized prosthetic leg for people who have lost a leg above the knee. It uses smart learning technology to help the leg adjust to how you walk, which may make walking feel more natural.
Raleigh, North CarolinaAges 18–75 - NCT07204912Recruiting
Testing a brain-controlled leg prosthesis in real-world tasks
This trial tests a new powered leg prosthesis that you control with your own neural signals. It aims to help people with above-knee amputations walk more naturally in everyday situations.
Cambridge, MassachusettsAges 18–70
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Common questions
- Are there clinical trials for amputation?
- Yes. Clin2 currently lists 145 recruiting amputation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amputation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amputation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.