Clinical trials
Amputation clinical trials
Below are recruiting amputation clinical trials, each written for real people, not researchers. We’re tracking 140 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04936789Recruiting
Testing a new arm prosthesis with sensors in one arm
This study checks whether a new sensor-enabled prosthesis for people with a lower-arm (transradial) amputation can be safely fitted and used. It may help improve how well a prosthesis can read muscle signals to control a hand/arm replacement.
GlasgowAges 18–65 - NCT04839497RecruitingPhase 2
Safety and benefit of injecting fibroblast cells in leg amputees’ skin
This Phase 2 study tests whether injecting a patient’s own (autologous) fibroblast cells into the end of a transtibial (below-knee) amputation is safe and may improve outcomes. You may qualify if you have a certain type of prosthesis timing and healthy skin on the stump, and you can follow frequent visit and wound-care instructions.
Baltimore, MarylandAges 18–75 - NCT04725201RecruitingPhase 4
IV heparin study after finger or hand reattachment
This study looks at whether giving an IV blood thinner called unfractionated heparin after finger/hand reattachment and restoring blood flow improves healing and safety. If you were accepted into the CEVARMU replant/revascularization program, this trial may be testing a standard-after-surgery medicine approach.
Montreal, QuebecAges 14 years+ - NCT05601869Recruiting
Testing better footwear options for women with below-knee amputations
This study looks at whether improving what you can use for your prosthesis and footwear can improve comfort, balance, and daily activities. It focuses on women Veterans with below-knee (transtibial) amputations who already use a well-fitting prosthesis.
Minneapolis, MinnesotaAges 18–89 - NCT03135847Enrolling by invitation
Using feedback to improve prosthetic movement in amputees
This study tests whether movement “feedback” can help adults with arm or leg amputations control a prosthetic better. It may be most helpful if you can comfortably wear a prosthetic socket and can understand and consent to the study.
Ages 18–75 - NCT02994160Recruiting
DEFT hand control test for people with arm amputations
This study tests a special implanted system meant to help control a hand using nerve signals. It is for adult arm/hand amputees and may help improve hand/arm control and reduce pain impacts.
Dallas, TexasAges 18–95 - NCT07314099Recruiting
Study of the Breizh Fabribus program for assistive devices
This study looks at the Breizh Fabribus program, which helps people get personalized assistive devices. It aims to see if the program helps improve your daily life.
Brest, FinistèreAges Any age - NCT06210620Recruiting
Prosthetic outcome registry for lower limb loss
This study is gathering information from people with lower limb loss. It aims to understand how different prosthetic devices work in real life, which can help improve future devices.
Irvine, CaliforniaAges 18 years+ - NCT06214026Recruiting
Study of a new prosthetic foot for better walking
This study tests a new type of prosthetic foot designed to help people walk more naturally. If you use a prosthetic foot and can walk short distances, this trial may help you move better.
Tampa, FloridaAges 16 years+ - NCT02797457Recruiting
Evaluating outcomes of donated hand and forearm transplants
This trial looks at whether donated (allograft) hand and forearm transplants are worth it compared with artificial devices, including cost and real-world results. It is meant for adults with amputations of both forearms who may be medically and psychologically able to receive the transplant.
BerckAges 18–60 - NCT06753110Recruiting
Long-term safety of OPRA implant for arm amputees
This study checks the long-term safety and how well the OPRA implant (a bone-anchored prosthetic) works for people who have an arm amputation. It is for those who already have the implant and had their second surgery at least six months ago.
Melbourne, VictoriaAges Any age - NCT05990062Recruiting
Better fitting prosthetic arms for amputees
This study is testing a new way to design prosthetic arms to make them fit better and work more naturally. It may help people who have used a prosthetic arm before and are looking for a more comfortable and functional device.
Pittsburgh, PennsylvaniaAges Any age - NCT06310239Recruiting
Microbiome Study for Adults Having Surgery
This study looks at how your body’s natural bacteria (called the microbiome) may change after surgery. Researchers want to learn about the gut and skin bacteria of adults who are having a procedure, which could help improve recovery in the future.
Bethesda, MarylandAges 18–75 - NCT07175714Recruiting
Study of walking stumbles and slips
This study tests how well different methods can recreate stumbles and slips while walking. It may help people with and without prosthetic legs understand how to prevent falls.
ReykjavikAges 18 years+ - NCT06275282Recruiting
Nerve surgery for better leg prosthetic control
This trial tests a new nerve surgery technique to help people with above-knee leg amputations have better control of their prosthetic leg. The goal is to improve how well the prosthesis responds to your movements.
Ann Arbor, MichiganAges 18–75 - NCT07204912Recruiting
Testing a brain-controlled leg prosthesis in real-world tasks
This trial tests a new powered leg prosthesis that you control with your own neural signals. It aims to help people with above-knee amputations walk more naturally in everyday situations.
Cambridge, MassachusettsAges 18–70 - NCT07204925RecruitingPhase 1
Personalizing a computerized leg for above-knee amputees
This trial tests a new way to personalize a computerized prosthetic leg for people who have lost a leg above the knee. It uses smart learning technology to help the leg adjust to how you walk, which may make walking feel more natural.
Raleigh, North CarolinaAges 18–75 - NCT07195461RecruitingEarly Phase 1
Magnetic beads helping control a robotic leg
This trial tests a new system that uses tiny magnetic beads to help a robotic leg move more naturally. It aims to improve function for people who need a below-knee amputation or already have one that needs fixing.
Boston, MassachusettsAges 22–65 - NCT06636136Recruiting
Bone-anchored implant for below-knee amputation
This trial tests a metal implant that connects directly to your shin bone, replacing the need for a socket. It's for people with below-knee amputations who have trouble using a regular prosthetic leg.
Bethesda, MarylandAges 22–65 - NCT03947450RecruitingPhase 2
Injection of your own skin cells into below-knee amputation site
This Phase 2 study tests whether injecting a patient’s own fibroblast cells (skin-support cells) into the wound area after a below-knee amputation can help the stump skin heal and work better. It’s intended for people who already have (or are close to having) a prosthetic fitting.
Baltimore, MarylandAges 18–65 - NCT05888428Recruiting
Test of a smart arm prosthesis control system for arm amputees
This trial studies whether the MyoTrain system can help people with a below-elbow (trans-radial) arm amputation control a myoelectric prosthesis using muscle signals. It may help you practice and use a more “thought-to-movement” style control method if you meet the safety and participation requirements.
Grand Rapids, MichiganAges 18 years+ - NCT06813430Recruiting
Ultrasound vs standard care for fingertip wound healing
This study tests a special low-frequency ultrasound device to see if it helps fingertip injuries heal faster than a standard treatment. The ultrasound treatment does not touch your skin, so it may be gentler and help reduce pain or scarring.
Bethlehem, PennsylvaniaAges 18 years+ - NCT06471855Recruiting
Rehabilitation support for leg amputation due to diabetes
This study is for people with diabetes or blood vessel disease who are at risk for losing a leg, have already had a lower leg amputation, or use a prosthetic leg. It focuses on a rehabilitation program that helps with both physical and emotional adjustment.
Pavia, PVAges Up to 80 years - NCT06987019Recruiting
Testing balance in people with one-sided below-knee amputation
This study tests a new way to measure balance in people who have a below-knee amputation on one leg. It uses special sensors to see how well the legs work together during movement, which could help improve prosthetic fit and rehabilitation.
New York, New YorkAges 18 years+
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Common questions
- Are there clinical trials for amputation?
- Yes. Clin2 currently lists 140 recruiting amputation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amputation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amputation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.