Clinical trials
Amputation clinical trials
Below are recruiting amputation clinical trials, each written for real people, not researchers. We’re tracking 145 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07191795Recruiting
Using phantom sensations from socket changes as feedback while walking
This trial tests whether changing how your prosthetic socket fits can create helpful phantom limb sensations that improve your walking. It may help people with major lower-limb amputations walk more naturally.
NancyAges 18 years+ - NCT07175714Recruiting
Study of walking stumbles and slips
This study tests how well different methods can recreate stumbles and slips while walking. It may help people with and without prosthetic legs understand how to prevent falls.
ReykjavikAges 18 years+ - NCT07139483Recruiting
Preventing chronic phantom limb pain with mirror therapy and brain stimulation
This study tests whether combining mirror therapy (looking at a reflection of your healthy limb) with a gentle brain stimulation technique called tDCS can prevent phantom limb pain from becoming long-lasting. It is for people who recently had a limb amputated and are already starting to feel phantom pain.
Raanana, IsraelAges 18 years+ - NCT06813430Recruiting
Ultrasound vs standard care for fingertip wound healing
This study tests a special low-frequency ultrasound device to see if it helps fingertip injuries heal faster than a standard treatment. The ultrasound treatment does not touch your skin, so it may be gentler and help reduce pain or scarring.
Bethlehem, PennsylvaniaAges 18 years+ - NCT05425810Recruiting
Smart tool to help check prosthetic socket fit
This study tests an easy-to-use smart system (called ENABLE) that helps assess whether a prosthetic socket fits your leg well. It may help improve comfort and reduce skin problems by making sure the socket fit is assessed in a consistent, affordable way.
Raleigh, North CarolinaAges 18–99 - NCT05779852Recruiting
Hypnosis to ease new foot amputation wound pain
This trial tests whether auto-hypnosis (a self-guided calming technique) can reduce pain after a toe or multiple toes are removed. It is for adults who are newly after an amputation and have moderate pain soon after the first dressing.
RennesAges 18 years+ - NCT07075198Recruiting
Testing the Caesar running foot for people with below-knee amputations
This trial tests a new running foot called Caesar for people with below-knee amputations who want to run but don't have a running blade yet. You'll try the foot at home and give feedback on how it works.
Austin, TexasAges 18 years+ - NCT07032233Recruiting
Strength, Balance, and Function in Above-Knee Amputees
This study looks at how the length of the remaining part of your leg (residual limb) affects your strength, balance, and walking ability. If you have a transfemoral amputation (above the knee) and use a prosthesis, this trial may help researchers better understand your function.
Ankara, AnkaraAges 18–50 - NCT06987019Recruiting
Measuring balance in people with below-knee amputation
This study tests a new way to measure how well people with a below-knee amputation keep their balance while wearing their prosthesis. It aims to see if this measurement is reliable and accurate, which could help improve future care.
New York, New YorkAges 18 years+ - NCT06956508Enrolling by invitation
VR therapy to prevent phantom limb pain after amputation
This study tests whether using virtual reality (VR) daily in the hospital after a major amputation can help prevent phantom limb pain. You'll use a VR headset to do simple exercises that may keep your brain from sending pain signals to the missing limb.
Charlotte, North CarolinaAges 13 years+ - NCT06915662RecruitingPhase 2
A nerve cap for pain after finger amputation
This trial tests a small nerve cap, called Tulavi Allay, placed on the end of a cut nerve during finger amputation surgery. The cap is meant to reduce pain and protect the nerve ending. It is for people who have lost one or more fingers in an accident.
Boston, MassachusettsAges 22 years+ - NCT06753110Recruiting
Long-term safety of OPRA implant for arm amputees
This study checks the long-term safety and how well the OPRA implant (a bone-anchored prosthetic) works for people who have an arm amputation. It is for those who already have the implant and had their second surgery at least six months ago.
Melbourne, VictoriaAges Any age - NCT06853938Recruiting
Optimizing control of a prosthetic arm after osseointegration surgery
This study looks at a new way to control a prosthetic arm after you have had osseointegration surgery (where a metal implant is placed in your bone to attach the arm). It will help find the best settings for the muscle signals that control the arm.
Edmonton, AlbertaAges 18–65 - NCT06635655Recruiting
Testing a new prosthetic knee for mental ease
This study tests whether a new prosthetic knee system helps reduce mental effort while walking for people with above-knee amputations. If you use a prosthetic leg and are comfortable with a smartphone, you may be able to join.
Multiple LocationsAges 18–84 - NCT06645054Recruiting
Testing a smart hallway system in clinics
This trial tests a smart hallway system that may help monitor walking. It is for people who can walk a short distance on their own, have no major memory or thinking problems, and speak Slovenian.
LjubljanaAges 18 years+ - NCT06636136Recruiting
Bone-anchored implant for below-knee amputation
This trial tests a metal implant that connects directly to your shin bone, replacing the need for a socket. It's for people with below-knee amputations who have trouble using a regular prosthetic leg.
Bethesda, MarylandAges 22–65 - NCT06310239Recruiting
Microbiome Study for Adults Having Surgery
This study looks at how your body’s natural bacteria (called the microbiome) may change after surgery. Researchers want to learn about the gut and skin bacteria of adults who are having a procedure, which could help improve recovery in the future.
Bethesda, MarylandAges 18–75 - NCT06539936Recruiting
Testing a new control method for a bionic hand
This trial tests a new way to control a bionic hand for people who have a below-elbow amputation. The goal is to make the hand easier and more natural to use.
Redondo Beach, CaliforniaAges 18 years+ - NCT06519175Recruiting
Study of leg problems in children
This study gathers information on children with leg bone or muscle problems (from birth or later) to better understand their conditions. It may help improve future care for kids with similar issues.
BolognaAges Up to 18 years - NCT06471855Recruiting
Rehabilitation support for leg amputation due to diabetes
This study is for people with diabetes or blood vessel disease who are at risk for losing a leg, have already had a lower leg amputation, or use a prosthetic leg. It focuses on a rehabilitation program that helps with both physical and emotional adjustment.
Pavia, PVAges Up to 80 years - NCT06452186Recruiting
Study of a new leg prosthetic controller for improved balance
This study tests a new prosthetic leg controller that helps people with below-knee amputations walk more steadily and with better balance. You may be eligible if you have used a prosthetic leg for at least a year and are comfortable walking in the community.
Raleigh, North CarolinaAges 18–99 - NCT06210620Recruiting
Prosthetic outcome registry for lower limb loss
This study is gathering information from people with lower limb loss. It aims to understand how different prosthetic devices work in real life, which can help improve future devices.
Irvine, CaliforniaAges 18 years+ - NCT06308562Recruiting
Fuzzy sock after leg amputation to help healing
This trial tests a fuzzy compression sock worn on the leg after amputation below the knee (transtibial amputation). The goal is to see if it helps the wound heal better in people with peripheral artery disease.
Rochester, MinnesotaAges 18 years+ - NCT06275282Recruiting
Nerve surgery for better leg prosthetic control
This trial tests a new nerve surgery technique to help people with above-knee leg amputations have better control of their prosthetic leg. The goal is to improve how well the prosthesis responds to your movements.
Ann Arbor, MichiganAges 18–75
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Common questions
- Are there clinical trials for amputation?
- Yes. Clin2 currently lists 145 recruiting amputation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amputation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amputation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.