Clinical trials
Amputation clinical trials
Below are recruiting amputation clinical trials, each written for real people, not researchers. We’re tracking 141 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06987019Recruiting
Testing balance in people with one-sided below-knee amputation
This study tests a new way to measure balance in people who have a below-knee amputation on one leg. It uses special sensors to see how well the legs work together during movement, which could help improve prosthetic fit and rehabilitation.
New York, New YorkAges 18 years+ - NCT06160882Recruiting
Powered prosthetic leg for bone-anchored amputees
This study tests a high-tech powered knee and foot for people who have a leg amputation above the knee and have (or are candidates for) a bone-anchored implant. The goal is to see if the powered prosthesis helps with walking and daily activities.
Chicago, IllinoisAges 18–70 - NCT06648798Recruiting
Comparing a new fast-fit prosthetic leg to your current one
This trial is testing a new quick-to-make, custom below-knee prosthetic leg (called the UniLeg). It compares how well it works for daily walking versus your current prosthetic. The goal is to see if the new leg can be made faster and fit better, helping you stay active.
La Jolla, CaliforniaAges 18–75 - NCT07645729Recruiting
Testing a Powered Ankle Prosthesis with Neural Control
This study tests a new powered ankle prosthesis (an artificial foot with a motor) that you control using signals from your nerves and receive feedback through gentle stimulation on your skin. The goal is to see if it helps you walk more naturally and perform daily activities with better balance and control.
Cambridge, MassachusettsAges 18–70 - NCT06025253Recruiting
Negative pressure dressing after leg amputation
This trial tests a special wound dressing that applies gentle suction to the incision after major leg amputation. It aims to reduce wound complications and help the stump heal better.
Dublin, DublinAges 18 years+ - NCT07489820Recruiting
Vacuum dressing for healing after rectal cancer surgery
This trial is testing whether a special vacuum-type wound dressing (called negative pressure therapy) helps the surgical area heal better after removal of the rectum and anus for rectal cancer. If you've had chemotherapy and radiation before surgery, this study may help improve your recovery.
AmiensAges 18 years+ - NCT07706452Recruiting
Balance Training for People with a Prosthetic Leg
This study tests a special balance training program for people who use a prosthetic leg after losing a leg due to injury. The program combines balance exercises with a second task (like talking or counting) to improve walking and stability in daily life.
Gaza, Gaza StripAges 18 years+ - NCT03400345Recruiting
Follow-up for transplanted arm patients
This study follows people who received a transplanted arm (or both arms) to learn from their ongoing care. You may be asked for small tissue samples (biopsies) and to continue an immunotherapy plan to help protect the transplant.
Baltimore, MarylandAges 18–100 - NCT03409133Recruiting
Neural feedback training for people with leg amputations
This study tests whether a nerve-based “feedback” system can help people with below-knee or above-knee amputations during standing and walking. It focuses on whether the training and device setup are safe and workable for participants over the study period.
Cleveland, OhioAges 18 years+ - NCT04063592Recruiting
Surgery plan for pain or skin problems in a healed leg stump
This study looks at a surgical approach for people who already had an above-knee or below-knee amputation and now have ongoing pain or skin/stump problems that haven’t improved. It aims to improve comfort and how well the stump area heals, assuming you’re healthy enough for surgery under standard anesthesia.
Bethesda, MarylandAges 18–65 - NCT04164641Recruiting
Test software-guided walking analysis to help prevent foot ulcers
This study checks whether a computer system that analyzes your walking can help change gait (how you walk) to reduce the chance of diabetic foot ulcers coming back or leading to amputation. It is meant for adults who have had a healed diabetic foot ulcer before.
Baltimore, MarylandAges 18–90 - NCT04635436Recruiting
Split-walking training for one-sided leg weakness when walking hurts
This trial tests whether a “split gait” walking training method can improve walking balance and how you move when you have one-sided leg problems and pain or limitations when walking. It may help reduce walking difficulties by training your stepping pattern safely.
Milan, MIAges 18–70 - NCT05008185Recruiting
Nerve interface surgery to reduce hand pain nerve tumors
This trial tests a regenerative nerve device/surgery approach to reduce painful nerve growths (neuromas) after a finger or partial hand amputation. You may qualify if you’re an adult with confirmed, localized neuroma pain and have already tried a 6-week desensitization therapy plan.
Baltimore, MarylandAges 18 years+ - NCT05009394Recruiting
Surgery options for long-term pain after limb amputation
This trial studies different surgical approaches to reduce persistent pain in the leftover part of an amputated limb. You may be able to join if your post-amputation pain has lasted more than a year and your pain level stays high despite stable pain treatments and prosthesis use.
Chicago, IllinoisAges 18 years+ - NCT05425810Recruiting
Smart tool to help check prosthetic socket fit
This study tests an easy-to-use smart system (called ENABLE) that helps assess whether a prosthetic socket fits your leg well. It may help improve comfort and reduce skin problems by making sure the socket fit is assessed in a consistent, affordable way.
Raleigh, North CarolinaAges 18–99 - NCT05483816Recruiting
Sensory stimulation trial for nerve pain in people with neuropathy
This study tests a multi-sensory (multiple-sense) stimulation approach to see if it can help people with nerve-related pain in the legs/feet. You must be able to safely take part in MRI-related sessions and answer questions about pain and health history.
Zurich, Canton of ZurichAges 18–80 - NCT05548322Recruiting
Testing touch feedback for prosthetic limbs in healthy people
This study tests how well a prosthetic touch system can give realistic sensory feedback. It aims to improve how prosthetic users feel touch and movement, based on controlled testing in volunteers.
MarseilleAges 20–70 - NCT05699174RecruitingPhase 3
Compare two antibiotic routes for infected broken bones after surgery
This Phase 3 trial tests whether giving antibiotics by mouth (PO) works as well as giving antibiotics through a vein (IV) for an infected fracture that has not healed after prior surgery. It may help you understand which approach is safer and more effective for getting the bone to heal.
Indianapolis, IndianaAges 18 years+ - NCT05716321Recruiting
Study of pain and function after limb amputation surgery
This study looks at pain and day-to-day functioning after someone has a limb removed due to surgery. The results may help doctors better understand what to expect and how to improve comfort and mobility after amputation.
Hershey, PennsylvaniaAges 18–89 - NCT05818410Recruiting
Brain and tech training after below-knee leg loss
This study looks at how your brain works with assistive technology after losing a leg below the knee. It may help researchers improve how prosthetic devices feel and function by measuring brain and movement signals during training.
BrusselsAges 18–65 - NCT05931198Recruiting
Testing how well prosthetic arms feel like your own hand
This study looks at whether people with an upper-limb amputation can experience the “rubber hand illusion” when using different types of prostheses. It may help researchers understand which prosthesis types feel more natural, which could improve comfort and use.
ValentonAges 18 years+ - NCT06043518Recruiting
Brain changes after losing an arm or hand
This study uses MRI scans to see how the brain changes in people born without a hand or who lost an arm. You might join as a participant with upper-limb loss or as a healthy volunteer for comparison.
Zurich, Canton of ZurichAges 18–75 - NCT06106984Recruiting
Home rehab for phantom limb pain in Veterans
This study tests a home-based rehab program for Veterans with phantom limb pain after a below-knee amputation. It uses telehealth to help you manage pain without needing to travel to a clinic.
Minneapolis, MinnesotaAges 18–89 - NCT06308562Recruiting
Fuzzy sock after leg amputation to help healing
This trial tests a fuzzy compression sock worn on the leg after amputation below the knee (transtibial amputation). The goal is to see if it helps the wound heal better in people with peripheral artery disease.
Rochester, MinnesotaAges 18 years+
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Common questions
- Are there clinical trials for amputation?
- Yes. Clin2 currently lists 141 recruiting amputation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amputation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amputation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.