Clinical trials
Amputation clinical trials
Below are recruiting amputation clinical trials, each written for real people, not researchers. We’re tracking 140 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06519175Recruiting
Study of leg problems in children
This study gathers information on children with leg bone or muscle problems (from birth or later) to better understand their conditions. It may help improve future care for kids with similar issues.
BolognaAges Up to 18 years - NCT06635655Recruiting
Testing a new prosthetic knee for mental ease
This study tests whether a new prosthetic knee system helps reduce mental effort while walking for people with above-knee amputations. If you use a prosthetic leg and are comfortable with a smartphone, you may be able to join.
Multiple LocationsAges 18–84 - NCT06645054Recruiting
Testing a smart hallway system in clinics
This trial tests a smart hallway system that may help monitor walking. It is for people who can walk a short distance on their own, have no major memory or thinking problems, and speak Slovenian.
LjubljanaAges 18 years+ - NCT06813937Recruiting
Magnetic stimulation for feeling in upper limb amputation
This study tests whether magnetic stimulation can improve sensation in people who have lost an upper limb. It may help restore feeling in the residual limb.
MoscowAges 18–65 - NCT06829212Recruiting
Wireless brain implant for device control
This trial tests a wireless brain implant that lets you control external devices like a computer or wheelchair just by thinking. It's designed for people with paralysis or double arm amputations who want to regain some independence.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06830876Recruiting
Testing muscle stimulator for pain and function after leg amputation
This trial tests if a noninvasive electrical stimulator (NMES) placed on the residual leg can reduce pain and improve muscle and function in people with a below-knee amputation. It aims to offer a drug-free option for managing chronic limb pain.
Pittsburgh, PennsylvaniaAges 18–100 - NCT06915662RecruitingPhase 2
A nerve cap for pain after finger amputation
This trial tests a small nerve cap, called Tulavi Allay, placed on the end of a cut nerve during finger amputation surgery. The cap is meant to reduce pain and protect the nerve ending. It is for people who have lost one or more fingers in an accident.
Boston, MassachusettsAges 22 years+ - NCT07075198Recruiting
Testing the Caesar running foot for people with below-knee amputations
This trial tests a new running foot called Caesar for people with below-knee amputations who want to run but don't have a running blade yet. You'll try the foot at home and give feedback on how it works.
Austin, TexasAges 18 years+ - NCT07139483Recruiting
Preventing chronic phantom limb pain with mirror therapy and brain stimulation
This study tests whether combining mirror therapy (looking at a reflection of your healthy limb) with a gentle brain stimulation technique called tDCS can prevent phantom limb pain from becoming long-lasting. It is for people who recently had a limb amputated and are already starting to feel phantom pain.
Raanana, IsraelAges 18 years+ - NCT07191795Recruiting
Using phantom sensations from socket changes as feedback while walking
This trial tests whether changing how your prosthetic socket fits can create helpful phantom limb sensations that improve your walking. It may help people with major lower-limb amputations walk more naturally.
NancyAges 18 years+ - NCT07216183RecruitingPhase 1
Skin sensor study for lower leg amputees
This study tests a new wireless skin sensor that sticks to your residual limb (the part of your leg below the knee where you wear your prosthetic). The goal is to track how your skin is doing inside the socket. If you qualify, you'll visit North Carolina State University to try the sensor and be photographed during research activities.
Raleigh, North CarolinaAges 18–75 - NCT06452186Recruiting
Study of a new leg prosthetic controller for improved balance
This study tests a new prosthetic leg controller that helps people with below-knee amputations walk more steadily and with better balance. You may be eligible if you have used a prosthetic leg for at least a year and are comfortable walking in the community.
Raleigh, North CarolinaAges 18–99 - NCT01894802Recruiting
Brain recording and stimulation to help control a computer
This study tests a brain-machine interface that records brain activity and uses stimulation to help people with severe hand/arm movement loss communicate or control tasks using a computer. It may help restore some control and reduce dependence on hands that cannot be used normally.
Chicago, IllinoisAges 22–70 - NCT01459107RecruitingPhase 2
Upper arm transplant study using immune treatment
This trial tests replacing a missing or non-working lower arm/hand with a donated upper limb (transplant). It also uses a special immune treatment plan and bone marrow infusion to help the body accept the new limb, aiming to improve hand function and quality of life.
Baltimore, MarylandAges 18–69 - NCT02476838Recruiting
Hand transplant for people missing part of a hand
This trial studies whether a transplanted hand can work safely and successfully for adults who are missing all or part of a hand and forearm. You may be considered if you’ve tried a prosthetic (artificial hand) or it hasn’t worked well for you.
New York, New YorkAges 18–60 - NCT07486063RecruitingEarly Phase 1
Motorized leg prosthetics for above-knee amputees
This study tests whether a motorized (powered) prosthetic knee and ankle can help people with above-knee amputations walk better. If you already use a mechanical or microprocessor-controlled leg, you may be able to try a new powered version.
Salt Lake City, UtahAges 18–80 - NCT07605754Recruiting
Nerve Surgery Results for Pain After Amputation
This study evaluates how well nerve surgery works for patients with severe, persistent pain in the area where a limb was amputated. Researchers will review outcomes to understand if this surgical approach helps reduce pain that hasn't responded to other treatments.
Leiden, South HollandAges 18 years+ - NCT07613840Recruiting
Personalized Blood Clot Prevention After Leg Artery Surgery
This study tests a personalized approach to prevent blood clots in patients who have had surgery to repair blocked arteries in their legs. Researchers want to find the best blood-thinning medication for each individual to reduce serious complications while keeping you safe.
Boston, MassachusettsAges 18 years+ - NCT07432685Enrolling by invitation
Can movement predict chronic pain after combat limb injuries?
This study is looking for people with combat-related arm or leg injuries to see if how they move can predict long-term pain. Researchers hope to better understand who might develop chronic pain and help improve treatment.
LvivAges 18–50 - NCT06956508Enrolling by invitation
VR therapy to prevent phantom limb pain after amputation
This study tests whether using virtual reality (VR) daily in the hospital after a major amputation can help prevent phantom limb pain. You'll use a VR headset to do simple exercises that may keep your brain from sending pain signals to the missing limb.
Charlotte, North CarolinaAges 13 years+
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Common questions
- Are there clinical trials for amputation?
- Yes. Clin2 currently lists 140 recruiting amputation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amputation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amputation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.