Clinical trials
Amputation clinical trials
Below are recruiting amputation clinical trials, each written for real people, not researchers. We’re tracking 145 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06138977Recruiting
Testing a smart bionic leg for different walking activities
This study tests a new type of bionic leg that can adjust to different walking speeds and activities. You may be able to join if you are a healthy adult or an adult with a leg amputation who can walk well.
Ann Arbor, MichiganAges 18–65 - NCT04839497RecruitingPhase 2
Safety and benefit of injecting fibroblast cells in leg amputees’ skin
This Phase 2 study tests whether injecting a patient’s own (autologous) fibroblast cells into the end of a transtibial (below-knee) amputation is safe and may improve outcomes. You may qualify if you have a certain type of prosthesis timing and healthy skin on the stump, and you can follow frequent visit and wound-care instructions.
Baltimore, MarylandAges 18–75 - NCT06106984Recruiting
Home rehab for phantom limb pain in veterans
This study tests a home-based rehabilitation program delivered by telehealth (video calls) to help veterans with phantom limb pain after a below-knee amputation. It aims to see if the program can reduce pain and improve function while taking part from home.
Minneapolis, MinnesotaAges 18–89 - NCT05888428Recruiting
Test of a smart arm prosthesis control system for arm amputees
This trial studies whether the MyoTrain system can help people with a below-elbow (trans-radial) arm amputation control a myoelectric prosthesis using muscle signals. It may help you practice and use a more “thought-to-movement” style control method if you meet the safety and participation requirements.
Grand Rapids, MichiganAges 18 years+ - NCT06043518Recruiting
Brain changes after losing an arm or hand
This study uses MRI scans to see how the brain changes in people born without a hand or who lost an arm. You might join as a participant with upper-limb loss or as a healthy volunteer for comparison.
Zurich, Canton of ZurichAges 18–75 - NCT06025253Recruiting
Negative pressure dressing after leg amputation
This trial tests a special wound dressing that applies gentle suction to the incision after major leg amputation. It aims to reduce wound complications and help the stump heal better.
Dublin, DublinAges 18 years+ - NCT05990062Recruiting
Better fitting prosthetic arms for amputees
This study is testing a new way to design prosthetic arms to make them fit better and work more naturally. It may help people who have used a prosthetic arm before and are looking for a more comfortable and functional device.
Pittsburgh, PennsylvaniaAges Any age - NCT05831696Recruiting
Compare walking effort with two types of prosthetic knees
This trial studies how much energy it takes to walk when using passive versus powered prosthetic knees. It may help people understand which knee type could make walking feel easier depending on their needs.
Loma Linda, CaliforniaAges 18–75 - NCT05716321Recruiting
Study of pain and function after limb amputation surgery
This study looks at pain and day-to-day functioning after someone has a limb removed due to surgery. The results may help doctors better understand what to expect and how to improve comfort and mobility after amputation.
Hershey, PennsylvaniaAges 18–89 - NCT05699174RecruitingPhase 3
Compare two antibiotic routes for infected broken bones after surgery
This Phase 3 trial tests whether giving antibiotics by mouth (PO) works as well as giving antibiotics through a vein (IV) for an infected fracture that has not healed after prior surgery. It may help you understand which approach is safer and more effective for getting the bone to heal.
Indianapolis, IndianaAges 18 years+ - NCT05601869Recruiting
Testing better footwear options for women with below-knee amputations
This study looks at whether improving what you can use for your prosthesis and footwear can improve comfort, balance, and daily activities. It focuses on women Veterans with below-knee (transtibial) amputations who already use a well-fitting prosthesis.
Minneapolis, MinnesotaAges 18–89 - NCT05548322Recruiting
Testing touch feedback for prosthetic limbs in healthy people
This study tests how well a prosthetic touch system can give realistic sensory feedback. It aims to improve how prosthetic users feel touch and movement, based on controlled testing in volunteers.
MarseilleAges 20–70 - NCT05505513Recruiting
Test micro-electrode nerve implants for hand signal feedback
This study looks at whether tiny implanted sensors in a nerve can record brain/nerve signals and use them to provide feedback for people with a transradial arm amputation. If it works, it could help improve control or awareness with a prosthetic hand or related devices.
Salt Lake City, UtahAges 18–65 - NCT04164641Recruiting
Test software-guided walking analysis to help prevent foot ulcers
This study checks whether a computer system that analyzes your walking can help change gait (how you walk) to reduce the chance of diabetic foot ulcers coming back or leading to amputation. It is meant for adults who have had a healed diabetic foot ulcer before.
Baltimore, MarylandAges 18–90 - NCT05376332Enrolling by invitation
Testing a new arm prosthesis control and training approach
This study is testing different ways to control an arm prosthesis for people missing a hand or lower arm (transradial amputation). It may help compare how well people can use a myoelectric (muscle-signal) prosthesis using either direct control or pattern recognition.
Fairfax, VirginiaAges 18–65 - NCT04750876Recruiting
Psychological and physical therapy follow-up after leg amputation
This trial tests whether adding both psychological support and physical therapy check-ins before and after leg amputation improves recovery and rehab planning. It may help patients feel better and regain function during the transition to rehabilitation care.
La Roche-sur-YonAges 18 years+ - NCT04725201RecruitingPhase 4
IV heparin study after finger or hand reattachment
This study looks at whether giving an IV blood thinner called unfractionated heparin after finger/hand reattachment and restoring blood flow improves healing and safety. If you were accepted into the CEVARMU replant/revascularization program, this trial may be testing a standard-after-surgery medicine approach.
Montreal, QuebecAges 14 years+ - NCT04063592Recruiting
Surgery plan for pain or skin problems in a healed leg stump
This study looks at a surgical approach for people who already had an above-knee or below-knee amputation and now have ongoing pain or skin/stump problems that haven’t improved. It aims to improve comfort and how well the stump area heals, assuming you’re healthy enough for surgery under standard anesthesia.
Bethesda, MarylandAges 18–65 - NCT03947450RecruitingPhase 2
Injection of your own skin cells into below-knee amputation site
This Phase 2 study tests whether injecting a patient’s own fibroblast cells (skin-support cells) into the wound area after a below-knee amputation can help the stump skin heal and work better. It’s intended for people who already have (or are close to having) a prosthetic fitting.
Baltimore, MarylandAges 18–65 - NCT03409133Recruiting
Neural feedback training for people with leg amputations
This study tests whether a nerve-based “feedback” system can help people with below-knee or above-knee amputations during standing and walking. It focuses on whether the training and device setup are safe and workable for participants over the study period.
Cleveland, OhioAges 18 years+ - NCT03400345Recruiting
Follow-up for transplanted arm patients
This study follows people who received a transplanted arm (or both arms) to learn from their ongoing care. You may be asked for small tissue samples (biopsies) and to continue an immunotherapy plan to help protect the transplant.
Baltimore, MarylandAges 18–100 - NCT03135847Enrolling by invitation
Using feedback to improve prosthetic movement in amputees
This study tests whether movement “feedback” can help adults with arm or leg amputations control a prosthetic better. It may be most helpful if you can comfortably wear a prosthetic socket and can understand and consent to the study.
Ages 18–75 - NCT02994160Recruiting
DEFT hand control test for people with arm amputations
This study tests a special implanted system meant to help control a hand using nerve signals. It is for adult arm/hand amputees and may help improve hand/arm control and reduce pain impacts.
Dallas, TexasAges 18–95 - NCT01894802Recruiting
Brain recording and stimulation to help control a computer
This study tests a brain-machine interface that records brain activity and uses stimulation to help people with severe hand/arm movement loss communicate or control tasks using a computer. It may help restore some control and reduce dependence on hands that cannot be used normally.
Chicago, IllinoisAges 22–70
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Common questions
- Are there clinical trials for amputation?
- Yes. Clin2 currently lists 145 recruiting amputation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amputation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amputation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.