Clinical trials · Boston, MA
Amyotrophic Lateral Sclerosis clinical trials in Boston
We’re tracking 20 recruiting amyotrophic lateral sclerosis studies with a site in or near Boston — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Boston
- NCT05137665Recruiting
Study tracks ALS and health markers over time at home
This study follows people with ALS and healthy volunteers to measure how specific body fluids, symptoms, and at-home tracking change over time. It may help researchers find early signs of disease changes and better ways to measure treatment effects.
Boston, MassachusettsAges 18 years+ - NCT04363684Recruiting
Study of frontotemporal dementia and related syndromes over time
This study follows people with frontotemporal dementia (FTLD) and related conditions, and collects health and (for some people) body fluid information, to understand how these illnesses change over time. It may help researchers track disease signs and find better ways to measure progression.
Boston, MassachusettsAges 18 years+ - NCT07161999RecruitingPhase 2/Phase 3
COYA 302 treatment for ALS
This study tests an experimental treatment called COYA 302 for ALS. It aims to see if it can slow down the worsening of muscle weakness and improve daily function. It might be an option for people in the earlier stages of ALS.
Boston, MassachusettsAges 18–80 - NCT06578195Recruiting
Assess all ALS study
This study follows people with ALS and healthy volunteers over time to understand the disease better. You can join from home using a smartphone or computer.
Boston, MassachusettsAges 18 years+ - NCT00912041Recruiting
Test of a brain-to-computer device for quadriplegia
This study tests whether a tiny brain computer interface can help people with quadriplegia (loss of movement in all four limbs) communicate or control technology. It’s mainly a feasibility study, meaning the goal is to see if the device can work safely and reliably in real life.
Boston, MassachusettsAges 18–80 - NCT07023835RecruitingPhase 2
Testing usnoflast for ALS
This trial tests an experimental oral medication called usnoflast for people with ALS. It aims to see if the drug can slow the disease's progression.
Boston, MassachusettsAges 18 years+ - NCT06581861Recruiting
Family study to prevent ALS and FTD
This study is for adults who have a strong family history of ALS or FTD (like a parent or sibling with the disease) to help researchers understand how to prevent these conditions. It involves following you for about a year to track your health.
Boston, MassachusettsAges 18 years+ - NCT07322003RecruitingPhase 3
Pridopidine for ALS: Phase 3 trial testing safety and effectiveness
This trial is testing if an oral medication called pridopidine can slow the progression of ALS. It is for people recently diagnosed with ALS who have mild to moderate breathing function and meet specific risk scores.
Boston, MassachusettsAges 18–80 - NCT07259980Recruiting
Long-term safety of tofersen for SOD-1 ALS
This study checks the long-term safety of the drug tofersen (also known as Qalsody) for people with a specific genetic type of ALS caused by SOD1 mutations. It aims to make sure the drug is safe over time by watching participants from registry networks.
Boston, MassachusettsAges 18 years+ - NCT07287397RecruitingPhase 1/Phase 2
Testing VTx-002 for safety in ALS patients
This trial tests a new drug called VTx-002 to see if it is safe and tolerable for people with ALS. You may be able to join if you have had symptoms for less than 18 months and have a caregiver who can help.
Boston, MassachusettsAges 18 years+ - NCT05724173Recruiting
Test of a brain-to-computer device for ALS hand paralysis
This study checks whether a brain-computer interface (a BrainGate2 system) is safe and workable for people with ALS. If you qualify, you may be asked to try the device and complete study tasks to help researchers learn how well it can support communication or control.
Boston, MassachusettsAges 18–80 - NCT07357428Recruiting
Brain-computer implant study for severe paralysis or speech loss
This study tests a brain-computer implant that might help people with severe paralysis or speech loss control a computer with their thoughts. It is for people who have trouble moving and speaking due to a progressive disease or injury.
Boston, MassachusettsAges 22–75 - NCT06649955Recruiting
Controlling nerve activity in ALS with brain stimulation
This study tests a non-invasive brain stimulation technique (called transcutaneous spinal direct current stimulation and transcranial magnetic stimulation) to see if it can calm overactive nerves in people with ALS. You may be a good fit if you have ALS that started less than 3 years ago and your breathing is still strong.
Boston, MassachusettsAges 18–80 - NCT06665165RecruitingPhase 1
Study of AMX0114 for people with ALS
This study tests an experimental drug called AMX0114 for people recently diagnosed with ALS. It is an early-phase trial to see if the drug is safe and how it affects the body.
Boston, MassachusettsAges 18 years+ - NCT07294144RecruitingPhase 2
Tofersen for ALS without SOD1 or FUS mutations
This trial tests if tofersen, a drug that targets a protein linked to ALS, can help people who have ALS but do not have mutations in the SOD1 or FUS genes. It aims to slow disease progression in those diagnosed within the last 2 years.
Boston, MassachusettsAges 18 years+ - NCT04220190RecruitingPhase 2/Phase 3
Study drug made from your immune cells for ALS
This trial tests RAPA-501, a treatment made using your own immune cells, to slow progression of ALS. It may help by changing how your immune system responds in ALS.
Boston, MassachusettsAges 18 years+ - NCT06491732Recruiting
Muscle Scan as an ALS Biomarker
This study tests a device called Myolex mScan that measures muscle health non-invasively in people with ALS. It aims to see if this can be a useful biomarker to track the disease progression.
Boston, MassachusettsAges 18 years+ - NCT05104710Recruiting
Testing brain–muscle coordination as a marker in ALS
This study measures how well your nerves and muscles work together to see if it can serve as an early sign (a “biomarker”) of ALS. It may help doctors track ALS more accurately, especially in people who already seem to have ALS based on nerve testing.
Boston, MassachusettsAges 20–90 - NCT06885918Recruiting
ALS Research Collaborative study
This study is a research collaborative that collects information from people with ALS or their families. It aims to better understand the disease and find markers that could help develop treatments.
Watertown, MassachusettsAges 18 years+ - NCT03127267RecruitingPhase 3
Test of masitinib versus placebo for ALS
This Phase 3 study tests whether masitinib works better than an inactive pill (placebo) to slow ALS progression and keep it safe. It is meant for people recently diagnosed with ALS who meet specific breathing and function score requirements.
Burlington, MassachusettsAges 18–81
Hear when a new Amyotrophic Lateral Sclerosis trial opens near Boston, MA
We’ll email you when one opens near Boston, MA — at most once a week, no account needed, unsubscribe anytime.
Amyotrophic Lateral Sclerosis trials in other cities
Where these studies are running near Boston
Institutions with a site for the recruiting amyotrophic lateral sclerosis studies listed above.
- Massachusetts General Hospital · 14 studies
- Beth Israel Deaconess Medical Center · 2 studies
- Mass General Brigham · 2 studies
- ALS Therapy Development Institute
- Lahey Hospital and Medical Center
- Providence VA Medical Center
- Zydus US010
What taking part in a amyotrophic lateral sclerosis study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting amyotrophic lateral sclerosis studies in Massachusetts.
Common questions
- Are there amyotrophic lateral sclerosis clinical trials near Boston?
- Yes. We're currently tracking 20 recruiting amyotrophic lateral sclerosis studies with a site near Boston, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a amyotrophic lateral sclerosis study near Boston?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Boston to take part?
- Not necessarily. These studies have a site near Boston, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a amyotrophic lateral sclerosis trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New amyotrophic lateral sclerosis studies open near Boston regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.