Clinical trials
Anterior Cruciate Ligament (ACL) Reconstruction clinical trials
Below are recruiting anterior cruciate ligament (acl) reconstruction clinical trials, each written for real people, not researchers. We’re tracking 115 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04650568Enrolling by invitation
Stem cell treatment after ACL ligament surgery
This trial studies whether adding mesenchymal stem cells during ACL (knee ligament) reconstruction helps the knee heal better. You might be eligible if your ACL injury is recent and you’re having a specific type of graft surgery.
Chicago, IllinoisAges 18–60 - NCT04572256RecruitingEarly Phase 1
Montelukast after ACL surgery to protect knee cartilage
This early trial tests whether montelukast, a tablet used for allergies, can help protect knee cartilage after ACL surgery. It is specifically for people who have a meniscus injury along with their ACL tear.
Lexington, KentuckyAges 25–50 - NCT04183803Recruiting
Robot help to set the right position for ACL surgery
This study tests whether using a robot to help place the tunnel during ACL (knee ligament) reconstruction is better or more accurate than the usual approach. You may benefit if you need ACL surgery and your care team has robot experience.
AmiensAges 10 years+ - NCT03968913RecruitingEarly Phase 1
Biologic shot to prevent knee arthritis after ACL injury
This early-phase trial tests a biologic medicine (anakinra) given after an ACL injury to try to prevent or reduce later osteoarthritis (wear-and-tear arthritis). It enrolls young adults who recently tore their ACL and are planning a specific type of ACL reconstruction.
Los Angeles, CaliforniaAges 18–35 - NCT03896464Recruiting
Quadriceps tendon vs hamstring tendon for ACL surgery in teens
This trial compares using a quadriceps tendon graft versus a hamstring graft during ACL reconstruction in children and teens whose growth plates are still open. It aims to see which graft works better after ACL injury while accounting for ongoing bone growth.
Hamilton, OntarioAges 10–18 - NCT03552705RecruitingPhase 2
Tranexamic acid to reduce knee inflammation after ACL injury
This Phase 2 study tests whether tranexamic acid can reduce swelling and protect knee cartilage after an ACL injury. It may help by limiting bleeding-related inflammation in the injured joint soon after injury.
Stanford, CaliforniaAges 18–30 - NCT03365908Enrolling by invitation
Pain Management After ACL Reconstruction Surgery
This study looks at ways to manage pain in adults who are getting surgery to repair a torn ACL (a knee ligament). It may help improve comfort and recovery after ACL reconstruction.
Sacramento, CaliforniaAges 18–45 - NCT03441659Recruiting
ACL reconstruction recovery study using clinical outcome tracking
This study looks at outcomes after surgery to repair the ACL (a knee ligament that helps stabilize the joint). If you’re having ACL reconstruction, the trial may help doctors understand what factors lead to better recovery.
Bologna, ItaliaAges 18–60 - NCT03441165Recruiting
Measure knee looseness during ACL and meniscus surgery
This trial checks how loose the knee feels during surgery for ACL reconstruction, ACL revision, or meniscus transplantation. The goal is to better assess knee stability during the operation, which may help surgeons choose the best repair.
Bologna, ItaliaAges 14–65 - NCT02918734Recruiting
ACL surgery: compare two ways to secure the tendon graft
This study looks at two surgical methods to attach the tendon graft during ACL reconstruction, using either an Endobutton or metal interference screws. It may help patients by improving how securely the graft is fixed and how well recovery goes.
TrondheimAges 18–55 - NCT07190456Recruiting
Study on fear of movement after ACL surgery
This study looks at different types of fear people might feel after ACL surgery, especially when doing jumping tasks. It aims to help understand these fears better so rehab can be improved.
Caparica, AlmadaAges 18–35 - NCT06827483Enrolling by invitation
Balance and thinking test for young adults after ACL surgery
This study looks at how thinking skills affect balance in young adults who had ACL repair surgery in the past 5-7 months, compared to healthy young adults. You will do balance tasks and answer some questions.
Durham, North CarolinaAges 18–25 - NCT06193343Recruiting
Steps to prevent osteoarthritis after ACL surgery
This study tests whether increasing your daily steps after ACL reconstruction can help prevent knee osteoarthritis. It involves walking more and tracking your activity over time.
Athens, GeorgiaAges 16–40 - NCT05924178Recruiting
Pre-surgery rehab to improve healing after knee ligament injury
This study looks at whether doing physical therapy before surgery can improve tendon healing, bone density, and joint cushioning after ACL surgery or patellar dislocation surgery. It may help you recover better and faster by optimizing your knee before the operation.
BeijingAges 18–45 - NCT05412381RecruitingPhase 3
PRP after ACL injury to help prevent knee arthritis
This study tests whether PRP (platelet-rich plasma) given after an ACL injury and surgery can lower the chance of developing long-term knee arthritis. It may help protect the knee over time by targeting early healing after ACL reconstruction.
New York, New YorkAges 14–50 - NCT07578935Recruiting
Stability and Jump Training After ACL Surgery
This study compares two types of exercise programs for people who had ACL (knee ligament) reconstruction surgery 1-3 years ago. The goal is to see which training approach—focusing on balance and stability or on jumping and power—helps restore better knee function and strength.
Lahore, Punjab ProvinceAges 20–40 - NCT07683247Recruiting
Energy use during ACL reconstruction surgery
This study measures how much energy your body uses during ACL reconstruction surgery. It uses a special vest to track your heart rate and breathing, which may help surgeons understand how your body handles the operation.
LecceAges 16–49 - NCT06975306Recruiting
Bone Graft for Kneecap Defect in ACL Surgery
This study looks at how a bone graft used to fill a gap in the kneecap affects healing and recovery after ACL reconstruction. Researchers want to see if the graft helps the bone heal better and improves your knee function.
Phoenix, ArizonaAges 18–40 - NCT03096366Recruiting
Blood flow restriction rehab after ACL knee surgery
This trial studies whether a special exercise method that limits blood flow to the thigh (called blood flow restriction training) can improve quadriceps strength and function during recovery after arthroscopic ACL surgery. If you qualify, you would join a structured physical therapy program and follow the study’s rehab plan.
Houston, TexasAges 14–55
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Common questions
- Are there clinical trials for anterior cruciate ligament (acl) reconstruction?
- Yes. Clin2 currently lists 115 recruiting anterior cruciate ligament (acl) reconstruction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a anterior cruciate ligament (acl) reconstruction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a anterior cruciate ligament (acl) reconstruction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Anterior Cruciate Ligament Reconstruction
- Anterior Cruciate Ligament Reconstruction Rehabilitation
- ACL - Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament (ACL) Tear
- Anterior Cruciate Ligament Injuries
- Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament Tear
- Anterior Cruciate Ligament
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.