Clinical trials
Aortic Stenosis Disease clinical trials
Below are recruiting aortic stenosis disease clinical trials, each written for real people, not researchers. We’re tracking 153 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07611968Recruiting
Physician-Modified Stent Grafts for Aortic Aneurysms
This trial tests a custom-made stent graft (a tube that reinforces the aorta from inside) for patients with large aortic aneurysms who may be too sick for traditional open surgery. The goal is to prevent rupture and complications while avoiding major surgery.
Jacksonville, FloridaAges 50 years+ - NCT07604402Recruiting
Aortic Valve Replacement Without On-Site Surgery
This study tests a catheter-based procedure to replace a narrowed aortic valve without traditional open-heart surgery. It's designed for patients who are at higher risk for surgery due to age, health conditions, or anatomy.
FerraraAges Any age - NCT07596394Recruiting
Registry of Catheter-Based Aortic Valve Replacements
This registry collects information about patients who receive a new valve inserted through a catheter (a thin tube) rather than open surgery. It tracks how well the procedure works and any side effects to help doctors understand the long-term safety and effectiveness of this less invasive approach.
Pavia, PaviaAges 18 years+ - NCT05961748Recruiting
Brain and heart illness registry for adults in China
This study is a registry that collects health information from adults who have certain new heart and/or brain conditions. It may help researchers understand how these problems occur together and improve future care planning.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05864456Recruiting
Study testing a new valve delivered through a blood vessel
This trial studies Prizvalve Pro™, a new transcatheter (catheter-based) aortic valve replacement, for people with severe aortic valve narrowing who are too high-risk for standard surgery. It may help your heart work better and improve symptoms by replacing the failing valve without open-heart surgery.
ShanghaiAges 65 years+ - NCT06286358Recruiting
Heart and aorta imaging study for valve disease
This study uses a special recording device to see if heart and aorta problems can be detected earlier. It may help people with aortic valve disease or enlarged aorta decide on treatment.
BrusselsAges 18 years+ - NCT06571175Enrolling by invitation
Measuring heart scarring in aortic stenosis patients
This study uses imaging to measure heart scarring in people with aortic stenosis, a condition where the heart valve is narrowed. It aims to better understand how scarring affects long-term outcomes.
Trondheim, TrøndelagAges 18–90 - NCT04414878Recruiting
Transcatheter aortic valve replacement for older, high-risk patients
This trial tests a new heart valve replacement done through a catheter (not open-heart surgery) in older adults with severe aortic valve narrowing. It’s mainly for people who are high-risk or not good candidates for standard surgery, to see if the new valve improves outcomes.
Beijing, Beijing MunicipalityAges 70 years+ - NCT03600662Recruiting
Heart valve reconstruction using your own tissue
This trial studies a surgery to repair the aortic valve using tissue taken from your body. It may help people with significant valve problems, by testing whether this reconstruction approach works and is safe.
Munich, BavariaAges 50 years+ - NCT06126367Recruiting
Study on lipoprotein(a) and clot breakdown in heart disease
This trial looks at how a type of fat in the blood called lipoprotein(a) and your body's ability to break down clots affect heart disease or heart valve disease. It is for people who are already taking certain cholesterol-lowering medicines or have severe aortic valve narrowing from calcium buildup.
StevenageAges 18 years+ - NCT06189976Recruiting
Can a quick heart pacing test after TAVI predict pacemaker need?
This study checks if a short, controlled heart pacing procedure right after your TAVI (a valve replacement) can tell doctors whether you might need a permanent pacemaker later. It aims to help avoid unnecessary pacemakers.
BrusselsAges 18 years+ - NCT06420830Recruiting
Study of a new heart valve in TAVR
This study follows patients with severe aortic stenosis who get a new heart valve (the SAPIEN 3 Ultra RESILIA) through a less invasive procedure (TAVR). Researchers want to see how well this valve works over time using special heart ultrasound tests.
Québec, QuebecAges 18–80 - NCT07258706Enrolling by invitation
Study on TAVI results based on patient differences
This trial is for people with severe aortic stenosis who are already scheduled for TAVI (a procedure to replace a narrowed heart valve). It looks at how individual differences affect the procedure's outcomes.
VicenzaAges 18 years+ - NCT04414865Recruiting
Check a new heart valve treatment for older, high-risk patients
This study follows how the VitaFlow heart valve works in people age 70+ who have severe, narrowed aortic valves and cannot safely get open-heart valve surgery. It’s meant to see whether the device improves outcomes and is safe over time.
Shanghai, Shanghai MunicipalityAges 70 years+ - NCT06342635Recruiting
Study of Hydra Heart Valve in Copenhagen
This study is testing a new heart valve system called Hydra, used during a less invasive procedure called TAVI to replace a narrowed heart valve. It may help people with severe aortic stenosis who are already candidates for TAVI.
CopenhagenAges 18–99 - NCT06507579Recruiting
Aortic stenosis valve replacement study with Hydra device
This trial tests a new heart valve called Hydra for people with severe aortic stenosis who need a valve replacement through a leg artery. It aims to see how well the valve works in real-world patients.
Sheffield, YorkshireAges 18–99 - NCT05172973Recruiting
New valve procedure for failing aortic bioprosthetic valves
This trial studies whether a new transcatheter aortic valve (SAPIEN X4) is safe and works well in people whose previously implanted aortic valve is now failing. It may help reduce valve symptoms in higher-surgery-risk patients who are not good candidates for open-heart valve replacement.
Newport Beach, CaliforniaAges Any age - NCT07045233Enrolling by invitation
Using a brain protection device during TAVR to prevent stroke
This study tests if a special device placed during transcatheter aortic valve replacement (TAVR) can help prevent stroke. It is for adults with severe aortic stenosis who are already scheduled for TAVR.
BeijingAges 18 years+ - NCT06869954Recruiting
Bicuspid aortic valve repair: comparing two surgical techniques
This trial tests two different ways to repair a leaky bicuspid aortic valve (a valve with two flaps instead of three). The goal is to see which repair method works better. If you need surgery for a severely leaking valve and your valve is the right shape, you may be able to join.
Augsburg, BavariaAges 18 years+ - NCT04227002Recruiting
Study for people with aortic valve problems
This trial is for people with aortic valve disease (aortic valve narrowing, leakage, or a worn-out valve). It tests what the doctors learn from following these patients, and it may help improve future care.
HamburgAges 18 years+ - NCT04258488RecruitingPhase 4
Blood thinner pill vs warfarin after mechanical aortic valve
This study compares a blood thinner pill (a factor Xa inhibitor) with warfarin (vitamin K antagonist) in people who have had a mechanical aortic valve replacement. It looks at which option works better and is safer over the long term.
Bucheon-siAges 19 years+ - NCT05998694Recruiting
Monitoring a new aortic heart valve for safety and effectiveness
This trial tests how well a new replacement heart valve works and how safe it is. You might qualify if you need a planned first-time aortic valve replacement and are 60-70 years old (or younger if you cannot take blood thinners).
Kemerovo, Kemerovo OblastAges 60–70 - NCT06455787Recruiting
J-Valve study for leaky aortic valve patients
This study tests a new, less invasive device called J-Valve for people with severe aortic regurgitation (a leaky aortic valve). It is placed through a tube in the leg artery, avoiding open-heart surgery, and may help those who are at high risk for surgery.
Scottsdale, ArizonaAges 18 years+ - NCT04636684Recruiting
Study ATTR deposits in the aortic valve
This study looks at how common ATTR-related protein deposits are in the heart valve of people with age-related (degenerative) aortic stenosis. It may help doctors understand how important these deposits are and could guide future treatment decisions.
ToulouseAges 18–99
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Common questions
- Are there clinical trials for aortic stenosis disease?
- Yes. Clin2 currently lists 153 recruiting aortic stenosis disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a aortic stenosis disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a aortic stenosis disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.