Clinical trials
Aortic Stenosis Disease clinical trials
Below are recruiting aortic stenosis disease clinical trials, each written for real people, not researchers. We’re tracking 153 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06713889Recruiting
Study of heart valve disease and events
This study looks for biological markers in the blood that might help predict heart-related events in people with a narrowed aortic heart valve. It aims to improve care for those with this condition, whether or not they have a procedure called TAVI to replace the valve.
LyonAges 18 years+ - NCT02856620Recruiting
Study heart function and frailty in people with aortic valve narrowing
This study looks at how heart mechanics, blood markers, and frailty relate to symptoms and heart measurements in people with aortic stenosis (a stiff, narrowed heart valve). It may help doctors better understand who is at higher risk and how disease changes over time.
Montreal, QuebecAges 18 years+ - NCT04464655Recruiting
10-minute heart MRI protocol for people with heart conditions
This study uses a short, 10-minute heart MRI to check how well it works for people who need a clinically indicated heart scan. It may help streamline heart MRI testing, making exams faster while still providing useful heart information.
Montreal, QuebecAges 18 years+ - NCT03268135Recruiting
Study gene activity in people with heart failure or aortic stenosis
This trial looks at patterns in your blood or heart-related “gene activity” (transcriptome) after heart procedures. It may help doctors understand why some people with heart failure or aortic valve narrowing (stenosis) do better than others.
San Donato Milanese, MilanAges 40–75 - NCT06833762Recruiting
Predicting improvement after TAVI using exercise tests
This trial looks at whether a simple exercise test (called CPET) can help predict how much your heart function will improve after TAVI, a procedure to replace a narrowed heart valve. If you're scheduled for TAVI through your leg artery and are 18 or older, you might be able to join.
BarcelonaAges 18 years+ - NCT07370688RecruitingPhase 4
Iron infusion after TAVI for older adults
This trial tests whether giving iron infusions after a TAVI procedure can help patients with iron deficiency feel better and improve their quality of life. It is for older adults who have low iron levels and have already had a successful valve replacement.
Rotterdam, South HollandAges 65 years+ - NCT07626710Recruiting
How Heart Valve Replacement Affects Kidney Function
This study looks at whether a minimally invasive heart valve procedure (TAVI) affects how well your kidneys work. Researchers will track your kidney function before and after the procedure using blood tests to understand any changes.
Roma, RMAges 18 years+ - NCT03470246Recruiting
Wearable activity coaching after heart surgery
This study tests a personalized activity program and coaching after heart surgery, using wearable sensors to track movement. It may help you recover more safely and move in a goal-directed way during rehabilitation.
KuopioAges 30–90 - NCT05487612Recruiting
MiECC heart-lung machine vs standard bypass during heart surgery
This trial compares a newer heart-lung machine setup (MiECC) with the usual bypass technique during certain heart operations. It may help see whether MiECC changes outcomes like the need for blood transfusions or recovery after surgery.
TorontoAges 18–85 - NCT05862558Recruiting
Lithotripsy to open blocked, calcified artery for TAVR
This trial tests whether a treatment called intravascular lithotripsy (using sound waves from inside a blood vessel) can help widen severely calcified, narrowed iliac arteries so a TAVR procedure can be done through the groin. It may help some people who are considered “high risk” for access, based on CT scan findings.
Plano, TexasAges 18–90 - NCT07016477Recruiting
Heart CT study for TAVI planning
This study is a registry (a collection of information) for people who are about to have a TAVI heart valve procedure. It will see how a new type of CT scanner (the NAEOTOM Alpha) can help doctors plan the procedure better.
Charleston, South CarolinaAges 18 years+ - NCT07709858Recruiting
Outcomes after TAVR for severe aortic valve disease
This is a registry study that tracks how people do after a TAVR procedure for a severely narrowed aortic heart valve. It helps doctors learn more about long-term outcomes and improve care for future patients.
SeoulAges 18 years+ - NCT04076150Recruiting
Testing a new valve placed through a blood vessel
This study checks whether an “investigational” transcatheter aortic valve is safe and works well for people with severe, calcified aortic stenosis (a stiff, narrowed heart valve). It may help improve valve function and symptoms, but you must meet specific heart, scan, and health-status requirements.
KrakowAges 70 years+ - NCT06047561Recruiting
Scottish Aortic Stenosis Imaging Study
This study looks at how aortic stenosis (a narrowing of the heart valve) changes over time using imaging and blood tests. It may help doctors better understand and treat this condition.
EdinburghAges 50 years+ - NCT06924151Recruiting
Surgery for Aortic Valve in Low Risk Patients
This trial tests if surgery to replace your aortic valve is safe and effective for people with severe aortic stenosis who are at low risk for complications. It compares surgery to another procedure to see which works best.
Nagoya, Aichi-kenAges Any age - NCT06817148Recruiting
TAVR vs surgery for bicuspid aortic valve disease
This study compares two treatments for severe aortic stenosis in people with a bicuspid aortic valve: transcatheter aortic valve replacement (TAVR, a less invasive procedure) and surgical aortic valve replacement (SAVR, open-heart surgery). The goal is to see which approach works better for this specific condition.
Los Angeles, CaliforniaAges 50 years+ - NCT07456280Recruiting
Early discharge after TAVI using heart monitoring
This study tests if patients who have mild heart electrical changes after TAVI can be sent home early with a portable heart monitor instead of staying in the hospital. It aims to see if this approach is safe and effective.
BarcelonaAges 18 years+ - NCT05552352Recruiting
VR training to help people prepare for aortic valve procedure
This trial tests whether virtual reality (VR) support helps patients feel more informed and prepared for an elective heart valve procedure (TAVI). It’s meant for people who already plan to have a valve replacement through the groin using a catheter, with pain medicines rather than full anesthesia.
Düsseldorf, North Rhine-WestphaliaAges 18 years+ - NCT06520774Recruiting
A new stent-graft system for treating aortic arch aneurysms
This trial tests a special stent-graft designed for aortic arch aneurysms or ulcers that need treatment near the heart. It might be an option if you are not a good candidate for open surgery.
BeijingAges 18–80 - NCT04861805Recruiting
Transcatheter aortic valve replacement study for high-risk seniors
This study tests a self-expanding artificial aortic valve placed through a blood vessel (no open-heart surgery) in older adults with severe aortic valve narrowing. It may help improve symptoms and heart function by treating the blocked valve.
Bahía BlancaAges 65 years+ - NCT07078383Recruiting
Study of the Rapidlink device for aorta repair
This trial tests a device called Rapidlink that helps repair blood vessels branching off the aorta during open heart surgery. It may be an option if you need open surgery to fix your thoracic aorta.
Los Angeles, CaliforniaAges 18 years+ - NCT06009588Recruiting
Comparing Two Heart Valve Types for Aortic Stenosis with Aorta Dilation
This trial tests two types of artificial heart valves—one that expands on its own and one expanded with a balloon—in people with a widened upper aorta. The goal is to see which works better for your condition.
Beijing, Beijing MunicipalityAges 65 years+ - NCT06215378RecruitingPhase 3
Protamine Sulfate to Reverse Heparin After TAVI
This trial tests whether giving protamine sulfate after a TAVI procedure (aortic valve replacement through the leg) to reverse the blood thinner heparin is safe and effective. It may help reduce bleeding risk for patients.
Paris, Île-de-France RegionAges 18 years+ - NCT07001800RecruitingPhase 2/Phase 3
Slowing aortic valve disease with ataciguat
This trial tests a new pill, ataciguat, to slow down the progression of moderate calcific aortic valve stenosis (a condition where your aortic valve stiffens). If you have moderate valve narrowing and meet the other criteria, participation could help find a way to delay needing surgery.
Birmingham, AlabamaAges 50 years+
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Common questions
- Are there clinical trials for aortic stenosis disease?
- Yes. Clin2 currently lists 153 recruiting aortic stenosis disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a aortic stenosis disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a aortic stenosis disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.