Clinical trials
Aortic Stenosis Disease clinical trials
Below are recruiting aortic stenosis disease clinical trials, each written for real people, not researchers. We’re tracking 153 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07201363Recruiting
Inflammation and scarring markers after TAVI
This study looks at markers of inflammation and scarring in people who develop heart rhythm problems after having a TAVI procedure (a minimally invasive valve replacement). It may help doctors understand and predict these complications.
Rijeka, CroatiaAges 18 years+ - NCT07462624Recruiting
Comparing treatments for a failing surgical aortic valve
This trial compares two ways to treat a failing aortic valve that was replaced with a tissue valve during surgery: another surgical replacement or a less invasive catheter-based valve-in-valve procedure. It is for people with low to intermediate surgical risk who are between 18 and 75 years old.
Leipzig, SaxonyAges 18–75 - NCT04029844Recruiting
Transcatheter valve replacement for older adults with severe aortic stenosis
This study tests a new “through-a-vein” heart valve procedure for people age 75+ with severe aortic valve narrowing that causes symptoms. It aims to see if the new valve can be safely implanted and improve outcomes in higher-surgery-risk patients.
LilleAges 75 years+ - NCT05603026Recruiting
MRI study for people getting a valve replacement
This study uses MRI (a type of scan) in people who are scheduled for a catheter-based aortic valve replacement through the groin. It aims to see how well MRI can work for these patients and potentially improve care planning around the procedure.
Cleveland, OhioAges 18–105 - NCT04973579Recruiting
Stent plus heart surgery for high risk carotid patients
This trial looks at whether doing carotid artery stenting at the same time as heart surgery is safe and effective for people at high risk of stroke around the time of surgery. It targets people with significant carotid narrowing who also need heart surgery for specific heart problems.
KrakowAges 18 years+ - NCT06935110Recruiting
Windpipe repair with donated aortic patch
This trial tests whether a special patch made from donated tissue (aorta) can help repair damaged or missing parts of the windpipe. It is for people with serious windpipe problems who cannot have standard surgery.
TaipeiAges 18 years+ - NCT06861361Recruiting
Surgery versus transcatheter valve replacement in younger patients
This trial compares two ways to replace a narrowed aortic heart valve in patients aged 65 to 75. It aims to find which approach—surgical valve replacement or a catheter-based procedure—works better for people in this age group.
GrazAges 65–75 - NCT07309029Recruiting
ECMO support during high-risk TAVR heart valve procedure
This trial tests whether placing patients on ECMO (a heart-lung support machine) before a high-risk TAVR valve replacement can improve safety and outcomes. It is for people who are at very high risk due to low blood pressure, severe heart or lung problems, or complex valve anatomy.
Detroit, MichiganAges 18–100 - NCT06559332Recruiting
Heart artery checks during aortic valve replacement
This study tests different ways to check for blocked heart arteries in patients getting a new aortic valve through a tube in the leg. It aims to find the best approach to guide treatment.
BernAges 70 years+ - NCT06991517Recruiting
TAVR sizing study for bicuspid aortic valve patients
This study tests a special sizing method (ABC algorithm) to help doctors select the right valve for people with a bicuspid aortic valve. It aims to improve outcomes for those getting a Sapien 3 valve through a catheter (TAVR).
St Leonards, New South WalesAges Any age - NCT05805111Recruiting
BeGraft stents for blocked aorta and iliac arteries
This trial tests a specific stent system (BeGraft) to improve blood flow through the aorta and iliac arteries in people with symptomatic peripheral artery disease. It may help reduce symptoms and improve leg circulation, based on the study device’s ability to fit your artery anatomy.
BerlinAges 18–99 - NCT02860364Recruiting
Checking different cooling levels during part of heart surgery
This trial compares two cooling temperatures during an “aortic hemiarch” operation to see which approach is safer and better for brain protection. It may help guide surgeons on the best cooling strategy for some planned heart surgeries.
Boston, MassachusettsAges 18 years+ - NCT04234841Recruiting
Study of outcomes after aortic valve replacement
This study follows adults who are having aortic valve replacement (through surgery or a catheter) to see how often certain outcomes happen after the procedure. You may be asked for blood tests and scans at set times, and some people may also be offered a special CT scan.
Stevenage, HertforshireAges 18 years+ - NCT07194265Recruiting
A study of the DurAVR heart valve for aortic stenosis
This trial tests a new heart valve called DurAVR for people with severe aortic stenosis (a narrowed aortic valve) who need a valve replacement. It compares the new valve to standard valves to see if it is safe and works well.
Copenhagen, Capital Region of DenmarkAges 18 years+ - NCT04552275RecruitingPhase 1
Biomarker study during valve replacement for older adults
This Phase 1 study looks at changes in the body’s “biomarkers” (measurable signs in blood/medical tests) in older people who are getting a specific type of valve replacement. Results may help doctors better monitor or understand outcomes after this valve procedure.
Boston, MassachusettsAges 65 years+ - NCT05493657Recruiting
Aspirin vs clopidogrel after TAVR valve procedure
This trial compares aspirin and clopidogrel (two blood-thinning medicines) after TAVR to see which is safer or more effective for preventing clots. You may be able to join if you recently had a TAVR for severe aortic valve narrowing and can follow the study plan.
SeoulAges 19 years+ - NCT05866640RecruitingEarly Phase 1
Testing a filter to reduce debris during TAVR
This early feasibility study tests a device filter system used during a TAVR procedure to help protect the brain and other organs from debris that can break free. It looks mainly at whether the filter can be safely placed and delivered as planned.
TbilisiAges 22 years+ - NCT05172960Recruiting
Study of a new heart valve for severe aortic stenosis
This trial tests a new version of a heart valve (SAPIEN X4) placed without open-heart surgery. It's for people with severe aortic stenosis who have symptoms like shortness of breath or chest pain.
La Jolla, CaliforniaAges Any age - NCT06828770Recruiting
Minima stent system long-term safety study
This study checks the safety of the Minima Stent System over time. It is for people who need a stent to keep their blood vessel open. The study wants to see how the device works in real-world use.
Los Angeles, CaliforniaAges Any age - NCT07035847Recruiting
Transaxillary TAVR guided by ultrasound only
This trial is testing a new way to replace your aortic valve using a small tube through your armpit, guided only by ultrasound (echocardiography) instead of X-rays. It may be an option if you have severe aortic stenosis and are a good fit for this less invasive approach.
Beijing, Beijing MunicipalityAges Any age - NCT06049654Recruiting
Comparing Allegra and Sapien valves for valve-in-valve procedure
This trial tests two different replacement heart valves (Allegra and Sapien) to see which works better for people who need a new valve placed inside a previously implanted surgical valve. It aims to help patients with a failing biological aortic valve who are already scheduled for this procedure.
AlessandriaAges 18 years+ - NCT03549559Recruiting
Heart imaging study in healthy people and specific conditions
This study uses heart imaging to look at changes in the heart muscle. It includes healthy volunteers and people with diabetes or aortic stenosis, to understand differences seen on scans.
Boston, MassachusettsAges 18–85 - NCT05093764Recruiting
Test how well debris is captured during valve-in-valve TAVR
This trial studies a device and a technique meant to capture debris during a repeat aortic valve procedure (valve-in-valve TAVR). It may help doctors understand if the approach reduces risk from material that can break loose during the procedure.
Kansas City, MissouriAges 18 years+ - NCT05308888RecruitingPhase 2
PET scan study of heart inflammation after aortic valve replacement
This Phase 2 trial uses a PET scan to study how local inflammation inside the heart affects the heart’s electrical wiring after a minimally invasive aortic valve procedure. The results may help doctors better predict or prevent rhythm and conduction problems after treatment.
BrestAges 18 years+
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Common questions
- Are there clinical trials for aortic stenosis disease?
- Yes. Clin2 currently lists 153 recruiting aortic stenosis disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a aortic stenosis disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a aortic stenosis disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.