Clinical trials
Arthroplasty clinical trials
Below are recruiting arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 450 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07219888Enrolling by invitationPhase 4
Comparing suzetrigine and oxycodone for knee replacement pain
This study compares a new pain medicine called suzetrigine with a commonly used opioid, oxycodone, for pain after a knee replacement. The goal is to see which works better and has fewer side effects.
Louisville, KentuckyAges 21–89 - NCT07213622Enrolling by invitation
Smart glasses for numbing nerve block during knee replacement
This study tests if using smart glasses (like high-tech glasses that show a video) can help doctors give a more accurate numbing injection (nerve block) to the saphenous nerve for knee replacement surgery. The goal is to improve pain control after surgery.
Cleveland, OhioAges 18 years+ - NCT07212114RecruitingPhase 3
Comparing two numbing medicines for ankle replacement
This study compares two numbing medicines given during ankle replacement surgery to see which one works better for controlling pain after the operation. It may help you have less pain and need fewer pain pills afterward.
Atlanta, GeorgiaAges 18 years+ - NCT06943053Recruiting
Waterproof bandage study for knee replacement recovery
This study compares two types of waterproof bandages used after total knee replacement surgery to see which one works better at keeping the wound dry and clean.
Pathum Thani, Khlong luangAges 55 years+ - NCT07191067Recruiting
Study of NOVABLOC system for knee replacement pain
This trial tests a new device called the NOVABLOC system to see if it helps control pain during and after knee replacement surgery. It is for people with osteoarthritis who are having their first knee replacement on one knee.
Daphne, AlabamaAges 21 years+ - NCT07180979RecruitingPhase 4
Nerve blocks for pain relief after hip replacement
This trial compares three types of nerve blocks to find which provides the best pain relief after a hip replacement. It may help you have less pain and a smoother recovery.
PoznanAges 65–100 - NCT07155837Enrolling by invitation
TENS for pain after first knee replacement surgery
This study tests if a TENS device, which uses mild electrical pulses to relieve pain, helps people recover better after their first total knee replacement. It might reduce pain and improve movement.
Adana, AdanaAges 18 years+ - NCT07146685RecruitingPhase 4
Testing different strengths of numbing medicine for shoulder replacement
This study compares two different strengths of local anesthetic used in a nerve block for shoulder replacement surgery. The goal is to see if one strength helps reduce pain that can come back as the block wears off.
Charlottesville, VirginiaAges 18 years+ - NCT07153003Enrolling by invitationPhase 4
Tramadol and oxycodone vs oxycodone alone for joint pain
This trial tests if taking two pain relievers (tramadol and oxycodone) together works better than oxycodone alone to control pain after knee or hip replacement surgery. It aims to find a more effective way to manage pain with fewer side effects.
Rochester, MinnesotaAges 18 years+ - NCT07138898RecruitingPhase 2
Managing immune medications for shoulder replacement in rheumatology patients
This trial tests two ways of managing your immunosuppressant medication around the time of shoulder replacement surgery. The goal is to see if one approach leads to fewer infections while still controlling your rheumatic disease.
New York, New YorkAges 18 years+ - NCT06962046Recruiting
Can virtual reality improve knee replacement surgery results?
This trial tests if using virtual reality (VR) during knee replacement surgery can help improve your recovery. You wear a VR headset during the procedure to relax and distract you, which may lead to better outcomes.
BelfastAges 18–100 - NCT07130552Recruiting
Comparing two pain relief methods after knee replacement
This study tests two different nerve-block techniques to see which provides better pain control after total knee replacement surgery. The goal is to help you recover more comfortably.
KaramanAges 18–85 - NCT06963320RecruitingPhase 2
Preventing blood clots after knee replacement with H001
This trial tests whether an experimental capsule (H001) can prevent dangerous blood clots after knee replacement surgery. It is for people who are scheduled for a first-time total knee replacement and are willing to take the study drug instead of standard blood thinners.
Shanghai, Shanghai MunicipalityAges 18–74 - NCT06956950RecruitingPhase 2/Phase 3
Magnesium Added to Numbing Medicine for Hip Replacement Pain
This study tests whether adding magnesium sulfate to a numbing medicine (bupivacaine) can provide better pain relief after hip replacement surgery. The medicine is given as a shot in the back near the hip muscles.
Tanta, El-GharbiaAges 18 years+ - NCT07125833Recruiting
Cold therapy for shoulder replacement pain
This trial tests if freezing a nerve near the shoulder before surgery can reduce pain after a reverse total shoulder replacement. It may help you recover with less discomfort.
Rockwall, TexasAges 30–85 - NCT07124494Recruiting
Anesthesia type and recovery after knee replacement
This study compares two types of anesthesia for total knee replacement to see which helps with pain, movement, and satisfaction after surgery. If you are scheduled for a knee replacement and are willing to have a spinal or epidural anesthesia, you may be able to join.
Konya, MeramAges 18 years+ - NCT07101887Recruiting
Comparing two surgeries for thumb arthritis pain and function
This trial tests if a thumb joint replacement works better than the standard surgery for reducing pain and improving hand use in people with thumb arthritis (grades I to III).
BarcelonaAges Any age - NCT07098390Recruiting
Relaxation to Reduce Fear and Pain After Joint Replacement
This study tests whether a simple relaxation technique (progressive muscle relaxation) can help reduce fear of falling, pain, and anxiety after hip or knee replacement surgery. It may be a safe, drug-free way to feel better during recovery.
AnkaraAges 18 years+ - NCT06383936Recruiting
Knee replacement for active sports lovers
This study tests a new knee replacement designed for active people ages 40 to 65 who used to play sports but had to stop due to knee pain. It aims to see if the implant helps you return to your favorite activities.
BolognaAges 40–65 - NCT07058623Recruiting
Nurse-led telehealth vs in-person follow-up after knee replacement
This trial compares follow-up care with a nurse via video calls or phone versus in-person visits after your first total knee replacement. It aims to see if telehealth is as good as in-person for your recovery.
Hong KongAges 18 years+ - NCT07061223Enrolling by invitation
Comparing two nerve block methods for hip replacement surgery
This trial tests two types of nerve blocks (SFIB and PENG) to find which provides better anesthesia during total hip replacement. It may help you understand which pain control approach could work best for your surgery.
MoscowAges 50–75 - NCT07040878Recruiting
Antigravity treadmill after hip or knee replacement
This study tests whether walking on a special antigravity treadmill (which reduces weight on your joints) helps people recover faster after hip or knee replacement surgery. It's designed for people who are 60 or older and can walk on their own.
Trzebnica, Lower Silesian VoivodeshipAges 60–75 - NCT07043127Recruiting
Strength training after hip replacement with blood flow restriction
This trial tests a new kind of physical therapy after hip replacement. It combines strength exercises with a special technique called blood flow restriction to see if it helps you recover muscle strength faster.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT07015905RecruitingPhase 3
Study of REGN7508 vs. standard blood thinners after knee replacement
This trial compares a new blood thinner called REGN7508 to two standard blood thinners (apixaban and enoxaparin) to prevent blood clots after total knee replacement surgery. The goal is to see which is safer and more effective.
Sheffield, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for arthroplasty?
- Yes. Clin2 currently lists 450 recruiting arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.