Clinical trials
Barrett Esophagus Adenocarcinoma clinical trials
Below are recruiting barrett esophagus adenocarcinoma clinical trials, each written for real people, not researchers. We’re tracking 23 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03961945Recruiting
Testing a new way to diagnose Barrett’s esophagus
This study tests minimally invasive, sample-based tests during an endoscopy to find Barrett’s esophagus and help sort it from esophageal cancer risk. It may help doctors spot changes earlier and more accurately using less invasive methods than standard tissue testing alone.
Scottsdale, ArizonaAges 18–90 - NCT06732388RecruitingPhase 2
Itraconazole with ablation to prevent esophageal cancer in Barrett's esophagus
This trial tests if adding the antifungal drug itraconazole to standard ablation therapy can help prevent esophageal cancer in people with high-risk Barrett's esophagus. You must have a confirmed diagnosis of Barrett's esophagus with low- or high-grade dysplasia or early-stage cancer, and be planning to have ablation treatment.
Kansas City, KansasAges 18 years+ - NCT04939051RecruitingPhase 2
Obeticholic acid to prevent Barrett’s esophagus worsening
This Phase 2 trial tests whether obeticholic acid (a medicine) can help stop Barrett’s esophagus from getting worse. You must already be taking acid-suppressing medicine and have non-cancer Barrett’s changes, and the study checks safety and whether the lining improves or stays stable.
Kansas City, KansasAges 18 years+ - NCT05642338Recruiting
Testing two sampling methods to monitor Barrett’s esophagus
This study compares two ways of taking tissue samples during endoscopy to check how Barrett’s esophagus is changing. The goal is to improve surveillance, especially for finding early precancer or early cancer changes.
Amsterdam, North HollandAges 18 years+ - NCT05745857RecruitingPhase 2
Scan for early esophagus cancer using infused antibody dyes
This Phase 2 study uses special drug dyes (bevacizumab and cetuximab, each tagged for imaging) during an esophagus scope to help doctors find very early abnormal cells, like low- or high-grade pre-cancer and superficial cancer. If you qualify, the goal is earlier detection and better targeting during diagnosis and treatment.
Groningen, Provincie GroningenAges 18 years+ - NCT05753748Recruiting
Compare watchful waiting vs endoscopy treatment for Barrett’s with low-grade dysplasia
This trial compares two approaches for people with Barrett’s esophagus and low-grade dysplasia: regular monitoring versus treatment done through an endoscopy. It aims to see which approach is safer and better at preventing progression to more serious changes in the esophagus.
Los Angeles, CaliforniaAges 18–89 - NCT06071845Recruiting
Testing a simpler sponge test for Barrett's esophagus
This study tests a new, less invasive way to collect cells from the esophagus using a small sponge on a string (called Cytosponge). It aims to see if this method can accurately detect Barrett's esophagus, a condition that can raise the risk of esophageal cancer.
Scottsdale, ArizonaAges 18–90 - NCT06803147Recruiting
Stopping Surveillance for Low-Risk Barrett's Esophagus
This study is testing whether it's safe to stop regular surveillance endoscopies for people with low-risk Barrett's esophagus. If you have a short Barrett's segment without any dysplasia, you may be able to avoid future procedures.
AmsterdamAges Any age - NCT06803927Recruiting
Detecting Barrett's esophagus with a non-endoscopic device
This trial tests a device that collects cells from the esophagus using a swallowed capsule, which may detect Barrett's esophagus without a standard endoscopy. It is for people who are already scheduled for an endoscopy.
Cordova, TennesseeAges 18 years+ - NCT05530343Recruiting
Two ways to sample tissue during Barrett’s follow-up
This study compares two tissue-collection methods during an endoscopy for Barrett’s esophagus to see which one detects concerning changes better. Your results could help improve how doctors check Barrett’s over time.
Gilbert, ArizonaAges 18–89 - NCT00288119Recruiting
Study genes in Barrett’s esophagus and esophageal cancer
This study looks at genetic (inherited) factors that may be linked to Barrett’s esophagus and esophageal cancer. It may help researchers understand why these conditions happen in some families and others do not.
Baltimore, MarylandAges 18 years+ - NCT00574327Recruiting
Barrett’s and reflux registry at the Kansas City VA
This study follows people with confirmed Barrett’s esophagus (with or without concerning cell changes) and people who have reflux symptoms, to better understand how these conditions progress. It may help by building a Barrett’s registry so doctors can learn which factors predict worsening over time.
Kansas City, MissouriAges 18 years+ - NCT03222635Recruiting
Follow-up for certain early esophageal cancer found by endoscopy
This study follows people whose early esophageal adenocarcinoma was found during an endoscopy (ER) sample. The goal is to better understand what follow-up tests are needed based on higher-risk features and to watch for spread or incomplete removal.
SydneyAges 18 years+ - NCT00587314Enrolling by invitation
Testing ablation treatment for Barrett’s with precancer changes
This trial studies whether an “ablation” procedure (destroying abnormal esophagus lining) works well for people with Barrett’s esophagus that has high-grade precancer changes or very early cancer. It may help find safer or more effective ways to prevent the condition from worsening.
Rochester, MinnesotaAges 18–90 - NCT05276791Recruiting
Compare two endoscopy removal methods for Barrett’s lesions
This study compares two ways doctors remove abnormal tissue in the esophagus during endoscopy: EMR versus ESD. It may help improve how safely and completely these lesions are removed, while also comparing outcomes between the two methods.
AmsterdamAges 18 years+ - NCT07212491Enrolling by invitation
New ways to detect early esophageal changes in Barrett's esophagus
This study tests a new, less invasive way to detect precancerous changes or early cancer in Barrett's esophagus. It uses a sponge or brush to collect cells from your esophagus during a routine endoscopy, which may help find problems earlier and avoid more invasive procedures.
Scottsdale, ArizonaAges 18–90 - NCT06687603Recruiting
Detecting Barrett's esophagus in people without heartburn
This study aims to screen for Barrett's esophagus in people who are getting a routine colonoscopy but do not have chronic heartburn. It uses a simple, non-invasive cell collection device (EsoCheck) to see if you might have Barrett's esophagus, which can increase the risk of esophageal cancer.
Aurora, ColoradoAges 50 years+ - NCT04867590Recruiting
EndoRotor vs radiofrequency treatment for Barrett’s esophagus
This study compares two endoscopic treatments to remove abnormal cells in Barrett’s esophagus and lower the chance of it worsening. If you qualify, you may be assigned to one of the two procedures and followed to see how well they work and how safe they are.
BesançonAges 18 years+ - NCT02427269Enrolling by invitation
Blood and tissue sample study for esophagus conditions
This study collects blood and biopsy tissue from people who are having an upper endoscopy at UNC for Barrett’s esophagus or esophageal cancer. The samples help researchers build a biorepository to study these conditions and support future research.
Chapel Hill, North CarolinaAges 18 years+ - NCT06523374Recruiting
Studying quality of life and cancer risk in Barrett's esophagus
This study looks at how Barrett's esophagus affects your quality of life and fear of cancer. It uses new tests to better predict who might develop esophageal cancer, so you can get the right care sooner.
Edegem, AntwerpenAges 18 years+ - NCT05688176Recruiting
Testing blood RNA markers for esophagus cancer and Barrett’s
This study looks for helpful “RNA markers” found in blood to improve diagnosis in people with Barrett’s esophagus or esophageal cancer. It may help doctors spot disease more reliably, but it requires specific health and treatment conditions and a planned biopsy blood sample process.
Ghent, Oost-VlaanderenAges 18 years+ - NCT05706025Enrolling by invitation
Testing a capsule to screen for Barrett’s and esophageal cancer
This study checks whether a swallowable capsule can help find signs of Barrett’s esophagus or esophageal cancer (or related risk) before or around an endoscopy. The goal is to see if this less invasive sampling method could improve screening.
Aurora, ColoradoAges 45 years+ - NCT06532734Recruiting
Barrett's Esophagus in people with purging eating disorders
This study checks if long-term purging (vomiting) in people with eating disorders can damage the tube that connects your mouth to your stomach (called the esophagus). The goal is to see how common Barrett's esophagus (a precancerous change) is in this group.
Denver, ColoradoAges 18–65
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Common questions
- Are there clinical trials for barrett esophagus adenocarcinoma?
- Yes. Clin2 currently lists 23 recruiting barrett esophagus adenocarcinoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a barrett esophagus adenocarcinoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a barrett esophagus adenocarcinoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.