Clinical trials
Bipolar Disorder Depression clinical trials
Below are recruiting bipolar disorder depression clinical trials, each written for real people, not researchers. We’re tracking 409 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05142683Recruiting
Test an integrated care plan for teens with depression
This study tests whether a structured, coordinated care pathway helps teens (and their caregivers) manage depression better than usual care. It aims to see if targeted treatment and follow-up improve depression symptoms over time.
Toronto, OntarioAges 13–18 - NCT05703256Recruiting
Brain training with feedback to help depression
This trial tests a type of brain training called amygdala neurofeedback to reduce depression symptoms. It may help by teaching your brain patterns to become less “stuck” in depression-related activity.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07462637Recruiting
Light therapy for depression in unipolar and bipolar disorder
This study tests how well light therapy works for moderate to severe depression in people with or without bipolar disorder. It includes a possible MRI brain scan to understand how light affects the brain. You must not have certain eye conditions or high suicide risk.
ParisAges 18–65 - NCT05754151Recruiting
Mobile therapy for anxiety and depression in adults 40+
This trial tests whether a phone or tablet version of cognitive behavioral therapy (CBT) can help people ages 40 and older with anxiety or depression. It may help you manage symptoms with skills you can use between sessions.
New York, New YorkAges 40 years+ - NCT05423275Recruiting
Light treatment to help you stop antidepressants safely
This study tests whether a “light and ion” treatment can help people with major depression (MDD) who are doing well on antidepressants safely reduce or stop them. You must be in remission and be willing to discontinue for reasons like side effects or personal preference.
Vancouver, British ColumbiaAges 19–65 - NCT03665831Recruiting
Deep TMS for depression and memory problems in older adults
This study tests a type of brain stimulation called Deep TMS to help reduce depression and improve or stabilize memory-related symptoms in older adults with Alzheimer’s disease. It’s mainly for people whose depression did not improve or could not be tolerated with antidepressant medicine.
Toronto, OntarioAges 60 years+ - NCT07193901RecruitingPhase 2
Nasal spray for depression with suicidal thoughts
This trial tests an experimental nasal spray for people with major depression who are currently having suicidal thoughts. It aims to see if the spray can quickly reduce depression and suicidal feelings.
BeijingAges 18–64 - NCT07197138Recruiting
TMS for depression with long COVID
This trial tests whether accelerated TMS (a brain stimulation treatment) can help people with depression who also have long COVID. It may be an option if your depression hasn't improved enough with medication alone.
Munich, BavariaAges 18–65 - NCT06892613Recruiting
Couples therapy for depression and anxiety in married couples
This trial compares two types of couples therapy (EFCT and BCT) to see which works better for depression and anxiety. If you and your spouse are feeling stressed, anxious, or low, this study may help you strengthen your relationship and improve your mood.
Istanbul, IstanbulAges 18–65 - NCT06537921Recruiting
Testing minocycline for depression with obesity
This trial tests whether adding the antibiotic minocycline to your current antidepressant helps people with both depression and obesity. It aims to see if reducing inflammation can improve mood.
LondonAges 18–65 - NCT07022184Recruiting
Lifestyle app for depression with GP support
This trial tests a lifestyle app to help people with depression who are under a GP's care. It looks at whether using the app alongside your usual treatment can improve your mood.
Nijmegen, GelderlandAges 18 years+ - NCT07554755Recruiting
Transcranial Stimulation for Teen Depression with Self-Injury
This trial tests a non-invasive brain stimulation treatment (TIS) for teenagers aged 12–22 with depression who injure themselves without wanting to die. The goal is to reduce depression symptoms and self-injury urges.
Hefei, AnhuiAges 12–22 - NCT05950698Recruiting
Study of obesity and bariatric surgery with mental and social factors
This study looks at how personal mental health and life circumstances relate to outcomes after bariatric (weight-loss) surgery. It may help the team understand what supports improve recovery and health after surgery.
Rio de Janeiro, Rio de Janeiro, BrazilAges 18–60 - NCT05866575Recruiting
Brain-modeling trial to predict depression treatment response
This trial uses computer modeling based on brain measurements to try to predict which depression treatment will work for you. It may help match you with the most effective option faster by understanding your motivation-related brain patterns.
La Tronche, IsèreAges 18 years+ - NCT06821646Enrolling by invitation
Brain responses in depression and autism with TMS and EEG
This study uses brain stimulation (TMS) and brain wave recording (EEG) to understand how the brain works in people with autism, depression, or both. It may help find better ways to treat these conditions.
TaipeiAges 20–50 - NCT06050070Recruiting
Using Real-Time Brain Imaging to Help Depression
This study tests whether real-time brain imaging (fMRI) can help people with depression learn to change their brain activity. You will receive feedback on your brain signals while thinking positive or neutral thoughts.
Ann Arbor, MichiganAges 18–55 - NCT07388004Recruiting
Comparing two group therapies for depression
This trial compares two types of group therapy for major depression: one that focuses on changing your expectations about the future, and another that helps you reconnect with rewarding activities. The goal is to see which approach works better for reducing depression symptoms.
Marburg, HesseAges 18–80 - NCT07216404RecruitingPhase 2
Psilocybin therapy for depression in lung cancer patients
This trial tests whether a psychedelic-assisted therapy can help treat major depression in people with non-small cell lung cancer. If you have moderate to severe depression and are receiving cancer treatment, you may be able to join.
Columbus, OhioAges 18 years+ - NCT06725277Recruiting
Observing ketamine and Spravato for depression
This study follows people who are already taking or about to start IV ketamine or Spravato® for hard-to-treat depression. Researchers want to learn more about how these treatments work in real life.
Milford, ConnecticutAges Any age - NCT06788249RecruitingEarly Phase 1
Ketamine for treatment-resistant depression brain study
This trial tests whether a single dose of ketamine can quickly improve depression by studying brain chemical changes using MRI. It's for people with treatment-resistant depression who haven't used ketamine before.
Philadelphia, PennsylvaniaAges 25–65 - NCT04923685Recruiting
Study looks at blood markers linked to childhood trauma and suicide risk
This study checks whether tiny genetic signals in blood (microRNAs) are linked to childhood maltreatment and thoughts or risk of suicide, especially in people with major depression. It may help researchers understand biological clues that could someday guide better care.
Birmingham, AlabamaAges 18–60 - NCT05004987RecruitingPhase 4
Study brain and blood changes in older adults with depression
This study looks at how a brain protein linked to Alzheimer’s disease changes over time in older adults who have major depression but no major memory problems. It involves brain scans, blood and urine tests, and a spinal fluid sample to better understand the connection between depression and brain aging.
New York, New YorkAges 60 years+ - NCT05240352Recruiting
Personalized brain stimulation help for bipolar depression anhedonia
This study looks at using brain scans to better tailor transcranial direct current stimulation (a noninvasive brain stimulation) for people with bipolar depression who feel little pleasure. It aims to see whether matching the stimulation to your brain signals can improve symptoms like anhedonia.
Houston, TexasAges 18–50 - NCT05327699RecruitingEarly Phase 1
Ketamine study for depression with reduced pleasure
This early-phase study tests whether ketamine can help people with major depression who have trouble feeling pleasure. It also studies how the brain may change in response to stress, to better understand who might respond to treatment.
Atlanta, GeorgiaAges 18–65
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Common questions
- Are there clinical trials for bipolar disorder depression?
- Yes. Clin2 currently lists 409 recruiting bipolar disorder depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar disorder depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar disorder depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.