Clinical trials
Bipolar Disorder Depression clinical trials
Below are recruiting bipolar disorder depression clinical trials, each written for real people, not researchers. We’re tracking 409 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07217223Recruiting
Home-based brain stimulation for treatment-resistant depression
This study tests whether a gentle brain stimulation technique called tDCS can help people with depression that hasn't improved with medication. It can be done at home using a special headset and an internet connection.
San Diego, CaliforniaAges 18–85 - NCT07105397Recruiting
AI assistant for managing depression
This study tests a conversational AI system designed to help manage depression. It may recommend treatment changes that are reviewed by a clinician, offering a new way to get support.
Fairfax, VirginiaAges 18–85 - NCT05232032RecruitingPhase 2
Brain scan and medication study for avoiding versus approaching
This Phase 2 study looks at how a medication affects brain activity and real-life mood or anxiety behaviors. It includes people with major depression or several anxiety disorders and also healthy volunteers, using questionnaires, a smartphone, and brain imaging.
Belmont, MassachusettsAges 18–45 - NCT05538910Recruiting
Study brain links between depression and substance use
This study uses brain imaging and questionnaires to understand how substance use and depression are connected in the brain. It may help researchers identify biological patterns that could guide better treatments in the future.
Baltimore, MarylandAges 18–60 - NCT05573074Recruiting
Light treatment trial for brain blood flow in depression
This study tests whether shining near-infrared light through the head can change brain blood flow and reduce depression symptoms. If you have major depression, you may be offered a non-drug, device-based approach to see how well it helps.
Boston, MassachusettsAges 18–65 - NCT06054321Recruiting
Depression medication study for adults 19 to 65
This study tests a new way of choosing antidepressants for people with major depression. It's designed for adults aged 19–65 who have moderate to severe depression and are either starting a new antidepressant or have been off psychiatric meds for at least a month.
GwangjuAges 19–65 - NCT06110897Recruiting
Resistance Exercise for Depression Trial
This study tests whether resistance exercise (like lifting weights) can help reduce depression symptoms. If you have major depression and are not already doing regular resistance training, you may be able to join.
Ames, IowaAges 18–65 - NCT06273527RecruitingPhase 2/Phase 3
Thinking skills training for mood and anxiety
This study tests whether a computerized training program can help people with mood, anxiety, or trauma-related disorders who struggle with repetitive negative thinking. If you are an outpatient and can have an MRI, this may be a good fit.
San Diego, CaliforniaAges 21–55 - NCT06274112Recruiting
Using brain stimulation to understand social motivation in depression or social anxiety
This study uses transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique, to explore how the brain processes social motivation in people with major depressive disorder or social anxiety disorder. Understanding these brain processes could help develop new treatments for social avoidance.
Auburn, AlabamaAges 25–50 - NCT07159061Recruiting
Brain training for depression using neurofeedback
This study tests whether a brain training technique called neurofeedback can help treat depression. By showing your brain activity in real time on a screen, you may learn to control the brain patterns linked to depression and feel better.
Philadelphia, PennsylvaniaAges 18–65 - NCT05797428Recruiting
Talk-based therapy to help teens cope with mood problems
This trial tests “logotherapy,” a type of counseling that helps people find meaning and purpose to cope with sadness or mood swings. It may help adolescents with mild to moderate-to-severe depression feel better and participate in structured therapy.
Kaohsiung City, Niaosong DistrictAges 15–24 - NCT04935619Recruiting
Testing cannabis abstinence effects in depression symptoms
This study looks at how stopping cannabis for a period of time may affect depression symptoms and thinking/memory. You might benefit by getting close monitoring of mood and cognition while researchers compare changes during cannabis abstinence.
Toronto, OntarioAges 18–55 - NCT05598034Recruiting
Brain stimulation with tDCS for moderate depression
This study tests whether a noninvasive brain stimulation called tDCS can improve depression symptoms. It also uses MRI scans, aiming to understand how brain changes may relate to symptom improvement.
Los Angeles, CaliforniaAges 20–55 - NCT05745194Recruiting
Mediterranean diet study for depression with inflammation
This study tests whether a Mediterranean-style diet can improve depression symptoms in people who have depression and higher inflammation in their blood. It may help by targeting nutrition-related inflammation that can worsen mood for some people.
Loures, Lisbon DistrictAges 18–70 - NCT06309472RecruitingPhase 2
Mirtazapine for depression in inflammatory bowel disease
This trial tests whether the antidepressant mirtazapine can help people with Crohn's disease or ulcerative colitis who also have moderate or severe depression. If you are at least 18 and your IBD treatment is stable, this study could see if this medication improves your mood without interfering with your gut condition.
LondonAges 18–125 - NCT06658795Recruiting
Can brain stimulation help older adults with depression and loneliness?
This study tests whether a gentle brain stimulation technique called tDCS (transcranial direct current stimulation) can reduce loneliness in older adults with depression. It involves wearing a headband during sessions and comparing results to a placebo group.
Guangzhou, GuangdongAges 60–80 - NCT06928428Enrolling by invitation
Online talk therapy for depression or anxiety
This study tests if a type of talk therapy called metacognitive therapy, delivered partly online, helps adults with depression or generalized anxiety. It aims to see if this blended approach works well in primary care.
Stockholm, Stockholm CountyAges 18 years+ - NCT07120880RecruitingPhase 3
Light therapy timing for depression with insomnia
This trial tests whether giving light therapy at a specific time of day can improve both depression and sleep problems. It is for adults with major depression and insomnia who are not currently on antidepressants.
ParisAges 18–65 - NCT05017311RecruitingPhase 4
Testing a depression medication plan using symptom predictions
This Phase 4 study tests an “optimized” medication approach for adults with major depressive disorder (unipolar depression) based on how you respond over time. It may help your care team choose treatments more effectively and reduce trial-and-error.
Calgary, AlbertaAges 18–65 - NCT06136546RecruitingPhase 2
Infliximab for depression with cognitive problems
This trial tests if a medicine called infliximab, given through an IV, can help improve thinking and memory problems in people with moderate to severe depression who also have high inflammation levels. It aims to see if lowering inflammation can ease both mood and cognitive symptoms.
Boston, MassachusettsAges 25–50 - NCT06610552Recruiting
Powerly: Preventing depression and anxiety after childbirth
This trial tests a science-based smartphone program to help prevent postpartum depression and anxiety. It is designed for pregnant women who are between 24 and 32 weeks along and have an iPhone.
ZurichAges 18 years+ - NCT06722781Recruiting
Online group therapy for common mental health conditions
This trial tests an online group therapy for people waiting for high intensity CBT. It aims to provide quicker support for conditions like depression, anxiety, and PTSD.
Doncaster, South YorkshireAges 17 years+ - NCT06816329Recruiting
Stress and depression risk study for teenage girls
This study looks at how stress affects teenage girls who may be at higher risk for depression due to a parent's history. It involves MRI scans and daily surveys on a cell phone.
Belmont, MassachusettsAges 13–15 - NCT07221929Recruiting
Exercise plus CBT for depression: The CBT+ Trial
This study tests whether adding exercise before standard talk therapy (CBT) helps treat depression more effectively than CBT alone. You will be asked to do moderate exercise and then receive CBT sessions over 8 weeks.
Madison, WisconsinAges 18–65
Hear when a new Bipolar Disorder Depression trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for bipolar disorder depression?
- Yes. Clin2 currently lists 409 recruiting bipolar disorder depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar disorder depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar disorder depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.