Clinical trials
Bipolar Disorder I or II clinical trials
Below are recruiting bipolar disorder i or ii clinical trials, each written for real people, not researchers. We’re tracking 2,381 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05674617Recruiting
PTSD treatment for Veterans with serious mental illness
This trial tests a PTSD treatment approach for Veterans who also have a serious mental illness, aiming to improve day-to-day functioning. It includes Veterans who receive outpatient mental health care through the VA and have confirmed PTSD in the last month.
Baltimore, MarylandAges 18 years+ - NCT05757791RecruitingPhase 2
Testing an SGLT2 diabetes drug for depression
This Phase 2 trial tests whether an SGLT2 medicine (like empagliflozin) can reduce symptoms of major depression. It may help people with moderate-to-severe depression who are otherwise eligible for the study.
New York, New YorkAges 18–65 - NCT05765864Recruiting
Study of self-harm in at-risk teens
This study looks at self-harm and thoughts/behaviors related to safety in teenagers who are considered at higher risk. It may help researchers better understand what supports are needed for teens who self-harm without wanting to die.
LjubljanaAges 13–18 - NCT05786157Recruiting
Couples alcohol and safety support for drinking and relationship harm
This study tests a patient-focused approach to help couples where alcohol misuse and relationship physical harm may be happening. You may be asked to take part in sessions focused on safety, coping, and relationship communication, and some components may include controlled alcohol exposure.
Charleston, South CarolinaAges 21 years+ - NCT05797428Recruiting
Talk-based therapy to help teens cope with mood problems
This trial tests “logotherapy,” a type of counseling that helps people find meaning and purpose to cope with sadness or mood swings. It may help adolescents with mild to moderate-to-severe depression feel better and participate in structured therapy.
Kaohsiung City, Niaosong DistrictAges 15–24 - NCT05807139RecruitingPhase 1
Spironolactone for alcohol use disorder
This Phase 1 study tests whether spironolactone (a medicine that affects salt and hormone balance) is safe and potentially helpful in people with alcohol use disorder. You may be eligible if you are currently drinking heavily, have low alcohol withdrawal symptoms, and meet several lab and medication safety rules.
Baltimore, MarylandAges 21–99 - NCT05832489RecruitingPhase 3
EEG-MRI test of methylphenidate in adult attention symptoms
This Phase 3 study tests how methylphenidate affects brain signals and attention in adults with ADHD, and in adults with mood-related attention problems. It also includes healthy volunteers to compare brain responses during brain scanning.
StrasbourgAges 18–60 - NCT05843695Recruiting
Therapy study for PTSD and anxiety in veterans
This trial tests a psychotherapy approach to help veterans and service members who have PTSD and/or anxiety disorders. You may be randomly assigned to different therapy conditions, and the study aims to improve quality of life and reduce anxiety and PTSD symptoms.
Houston, TexasAges 18 years+ - NCT06075264RecruitingPhase 2
Artesunate ointment for high-grade vulvar lesions
This trial tests an artesunate ointment for women with high-grade vulvar lesions caused by HPV. It aims to see if the ointment can help the lesions heal or disappear without needing surgery.
Fort Myers, FloridaAges 18 years+ - NCT05859347Recruiting
Brain stimulation study for cannabis use disorder
This trial tests whether a treatment called repetitive transcranial magnetic stimulation (a non-surgical magnetic stimulation to the brain) can help people reduce or stop cannabis use. You may be eligible if you have cannabis use disorder and meet specific safety and symptom criteria.
Toronto, OntarioAges 18–65 - NCT05861752Recruiting
Study of sexual risk behaviors and mental health patterns
This case-control study looks at people with specific sexual behavior-related conditions (like certain paraphilias, compulsive sexual behavior, or sex during sleep) to understand factors linked with risk for sexual violence. The goal is to learn what patterns may be involved so better help and prevention strategies can be developed.
Stockholm, Stockholm CountyAges 18 years+ - NCT05870800RecruitingPhase 2
Study Immunotherapy and Chemotherapy Before Colon Surgery
This trial tests immunotherapy plus chemotherapy given before surgery for colon cancer that hasn’t spread. It aims to shrink or control the tumor and improve outcomes in people whose tumor has certain immune/biologic features.
Houston, TexasAges 18–80 - NCT05872750Recruiting
Brain stimulation to reduce urges in gambling disorder
This trial tests a non-invasive brain stimulation technique (theta burst stimulation) to help reduce symptoms of gambling disorder. If you meet the criteria and can safely complete the sessions, you may be able to see whether this approach lowers gambling urges or related problems.
Taipei, Taipei CITYAges 18–65 - NCT05889624Recruiting
Study of treatments for childhood migraine headaches
This study looks at ways to help children and teens with migraine headaches by testing a care approach that includes access to evidence-based treatment. It may help if your child has frequent migraine headaches and is starting (or not already on) certain migraine-preventive medicines.
Birmingham, AlabamaAges 10–17 - NCT05899660Recruiting
Omega-3 for alcohol use disorder during withdrawal
This trial studies whether taking omega-3 supplements during a hospital alcohol-withdrawal program can improve recovery for people with alcohol use disorder. It may help by changing inflammation and how the body responds to stopping alcohol.
BrusselsAges 18–70 - NCT05913947RecruitingPhase 4
Lithium or cariprazine for bipolar depression
This trial compares lithium versus cariprazine to treat an episode of depression in people with bipolar disorder. It may help find which medicine works better and is safer during the acute (active) phase of depression.
AalborgAges 18–65 - NCT05913752RecruitingPhase 1/Phase 2
Test drug CMND-100 in people with alcohol use disorder
This early study tests the safety and dosing of CMND-100 in first-time participants, including people with alcohol use disorder (AUD) and some healthy volunteers. It may help researchers understand whether the drug is safe, and how it might affect alcohol use in AUD.
New Haven, ConnecticutAges 18–60 - NCT05930496Recruiting
Exercise after colorectal cancer to change gut bacteria
This study tests whether a structured exercise program can improve the makeup of gut microbiota (gut bacteria) in people who have finished treatment for stage II–III colorectal cancer. It may help learn how exercise supports recovery, and it involves remote or in-person sessions with gut-focused tracking.
Seattle, WashingtonAges 18–70 - NCT05934487Recruiting
Monitoring device trial for stable heart failure symptoms
This trial tests whether a wearable home monitoring system (myCordella™) can help people with moderate heart failure (NYHA class II or III) by tracking heart pressure and supporting follow-up care. It may help detect changes earlier so clinicians can adjust treatment sooner.
Phoenix, ArizonaAges 18 years+ - NCT05950581Recruiting
Twin-block braces with clear plates for jaw misalignment
This study tests a removable orthodontic device (twin-block with clear plates) to improve how the upper and lower jaws fit together in children. It may help if you have a specific “Class II” jaw pattern caused mainly by a lower jaw that sits back.
HamaAges 10–13 - NCT05973786RecruitingPhase 3
Six-week medicine boost for bipolar depression after first treatment fails
This trial tests whether a stronger, more active medication plan for six weeks helps people with bipolar depression who did not improve with their first prescribed treatment. It compares the intensified medication plan to usual care to see which approach works better.
InnsbruckAges 18 years+ - NCT05992272Recruiting
How cues affect drinking and smoking habits
This study looks at how certain cues (like seeing a drink or a cigarette) trigger cravings and behavior in people who drink alcohol or smoke. Understanding this may help improve addiction treatments.
BerlinAges 16–65 - NCT05995951Recruiting
Deep brain stimulation for severe OCD
This trial tests whether deep brain stimulation (a surgical implant that sends electrical pulses to part of your brain) can help people with severe obsessive-compulsive disorder (OCD) that has not improved with standard treatments.
Petah TikvaAges 18–75 - NCT05995769RecruitingPhase 2
Psilocybin therapy with talk therapy for alcohol problems
This trial tests whether psilocybin (the active ingredient in magic mushrooms), given with talk therapy, can help people who want to reduce their heavy drinking. It is for people with at least moderate alcohol use disorder who are motivated to change.
Calgary, AlbertaAges 22–65
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Common questions
- Are there clinical trials for bipolar disorder i or ii?
- Yes. Clin2 currently lists 2,381 recruiting bipolar disorder i or ii studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar disorder i or ii trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar disorder i or ii trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.