Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,015 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06188364RecruitingEarly Phase 1
Helping caregivers of traumatic brain injury patients
This trial tests if mobile health support (texts and calls) helps caregivers of people with traumatic brain injury after rehab. You may join as the main caregiver if you supervise daily care and have a smartphone or can get one.
Richmond, VirginiaAges 18 years+ - NCT06199479RecruitingPhase 1
Using imaging to tell real tumor growth from treatment effects
This trial uses special imaging to tell the difference between real brain tumor growth and a treatment reaction that looks like a tumor. It may help you and your doctor decide if a biopsy is needed.
Houston, TexasAges 18 years+ - NCT06194929RecruitingPhase 1/Phase 2
Drug combo for melanoma that spread to the brain
This trial tests a combination of two or three drugs (defactinib, avutometinib, with or without encorafenib) to shrink brain tumors that started from skin melanoma. It may be an option for people whose melanoma has a specific genetic change and who have already tried immunotherapy.
Iowa City, IowaAges 18 years+ - NCT06165653Recruiting
Guided meditation during radiation for brain tumors
This trial tests whether guided meditation can help people with brain tumors feel better during radiation therapy. You'll be randomly assigned to either meditation sessions or standard care, and researchers will see how it affects your well-being.
Salt Lake City, UtahAges 18 years+ - NCT06159335RecruitingPhase 3
PET/MR scan for brain metastasis imaging
This trial uses a special PET/MR scan with a radioactive tracer to help tell the difference between tumor regrowth and changes from radiation treatment in people with brain metastases. It may help doctors make better treatment decisions.
Madison, WisconsinAges 18 years+ - NCT06163820RecruitingPhase 1/Phase 2
Bevacizumab and immunotherapy with radiation for melanoma brain metastases
This trial tests a combination of a drug that stops blood vessel growth (bevacizumab), immunotherapy, and focused radiation to treat melanoma that has spread to the brain and is causing symptoms. The goal is to see if this approach shrinks tumors and improves outcomes.
Melbourne, VictoriaAges 18 years+ - NCT06136884RecruitingPhase 1
Study of AO-252 for advanced solid tumors with or without brain metastases
This trial tests an experimental oral pill (AO-252) that targets a protein called TACC3 in advanced solid tumors, including those that have spread to the brain. It is for people whose cancer has a specific genetic change (TP53 mutation) or who have prostate cancer, and who have already tried other treatments.
Detroit, MichiganAges 18 years+ - NCT06112093RecruitingPhase 1
Magnetic brain stimulation for headaches after a concussion
This study tests whether a non-invasive magnetic pulse treatment (repetitive transcranial magnetic stimulation) can help people with long-lasting headaches following a mild concussion. If you are 18 to 55 years old and have had daily headaches for at least 3 months after your head injury, this study may help find a new way to relieve your pain.
Syracuse, New YorkAges 18–55 - NCT06109909Recruiting
Brain training for light sensitivity after mild head injury
This study tests if a type of brain training called neurofeedback can help reduce sensitivity to light in people who have had a mild traumatic brain injury, also known as a concussion, at least 6 months ago.
Boston, MassachusettsAges 18–65 - NCT06115291Enrolling by invitation
Smell training study for adults with smell loss
This study tests whether a daily smell training routine can help improve your sense of smell. It is open to adults with any kind of smell loss or problem, including those with conditions like COVID-19 or head injury, but not certain brain diseases.
Kansas City, KansasAges 18–80 - NCT06117930Recruiting
Brain tumor and gut bacteria study
This study looks at how the bacteria in your gut might be linked to brain tumors. Researchers want to collect samples (like stool and tissue) during brain surgery to better understand this connection.
Jacksonville, FloridaAges 18 years+ - NCT03047369Recruiting
Myelin brain disorder research biobank for samples and data
This study collects brain-related medical information and biological samples to help researchers better understand leukodystrophies and other white-matter brain disorders. It may help future diagnosis and treatments by building a valuable “biobank” of patient data and samples.
Los Angeles, CaliforniaAges Any age - NCT04107285Recruiting
Study brain changes in people with lymphoma after CAR T
This study looks at how thinking and brain function change over time in people with lymphoma who receive CAR T therapy. It may help doctors understand side effects and better support patients during and after treatment.
New York, New YorkAges 18 years+ - NCT06099743Recruiting
Support program for people with brain tumors
This study tests a support program that helps people with brain tumors cope with their diagnosis and treatment. The program uses acceptance and commitment therapy, which focuses on accepting difficult emotions and committing to actions that improve well-being.
Boston, MassachusettsAges 18 years+ - NCT06090578Recruiting
Brain health check for adults in primary care
This trial tests a new brain health assessment tool in primary care clinics. It may help your doctor better detect thinking or memory changes early.
Pasadena, CaliforniaAges 18 years+ - NCT06058988RecruitingPhase 2
T-DXd for people with brain cancer
This trial tests a drug called Trastuzumab Deruxtecan (T-DXd) for people with brain tumors that are either glioblastoma or have spread from other cancers. Doctors will see if T-DXd can shrink tumors or slow their growth, and they will collect tumor tissue during surgery or biopsy to study how the drug works.
New York, New YorkAges 18 years+ - NCT06047379RecruitingPhase 1/Phase 2
Testing NEO212 for brain tumors and metastases
This trial tests a new drug called NEO212 for people with certain brain tumors (like astrocytoma or glioblastoma) or cancer that has spread to the brain from other parts of the body. The goal is to see if it is safe and if it can help shrink or control the tumors.
Beverly Hills, CaliforniaAges 18 years+ - NCT06032026RecruitingEarly Phase 1
Brain imaging study of tracer distribution in Parkinson's and related conditions
This study uses a special imaging tracer to see how it moves through the body and brain. It may help researchers understand brain changes in Parkinson's disease and related conditions.
Philadelphia, PennsylvaniaAges 40–80 - NCT06055790RecruitingEarly Phase 1
PET scan to find brain tumors from other cancers
This study tests a special PET/CT scan that uses a tracer called 18F-fluciclovine to find brain tumors that have spread from other cancers. It may help doctors see if this scan can better identify these tumors before treatment.
Tucson, ArizonaAges 18–99 - NCT06016387RecruitingPhase 2
Drug combo with radiation for HER2+ breast cancer spread to spinal lining
This trial tests a combination of three targeted drugs (tucatinib, trastuzumab, and capecitabine) along with radiation to the brain or spine for people whose HER2-positive breast cancer has spread to the lining of the brain or spinal cord. The goal is to see if this treatment is safe and effective.
Ottawa, OntarioAges 18 years+ - NCT05983185Recruiting
Prism adaptation therapy for right brain stroke recovery
This study tests whether prism adaptation therapy (wearing special glasses that shift how you see) can help improve attention and function after a right-brain stroke. You may be eligible if you recently had a first right-brain stroke and can sit up to take part in the therapy.
West Haven, ConnecticutAges 18 years+ - NCT05976490Recruiting
Support program for people newly diagnosed with brain cancer
This study tests a “NeuroPathways” support intervention for adults who are within 6 weeks of being diagnosed with a malignant (cancerous) brain tumor. It may help patients cope and navigate care during the early, stressful period after diagnosis.
Boston, MassachusettsAges 18 years+ - NCT05978557Recruiting
Brain tumor drug testing using live tissue samples
This trial uses a small piece of your brain tumor after surgery to test which drugs might work best for you. It helps doctors find the most effective treatment for your specific tumor.
Chapel Hill, North CarolinaAges Any age - NCT05979064Recruiting
Belly fat graft for recurrent brain tumor
This study tests if a piece of your own belly fat (omentum) placed in the brain during tumor surgery can help fight recurrent glioblastoma. It is for people who are already scheduled for surgery to remove their brain tumor.
New York, New YorkAges 18 years+
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Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,015 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.