Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,015 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06810310RecruitingPhase 2
Psilocybin for motivation in opioid use disorder
This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid use disorder stay motivated in recovery. It uses brain scans to see how psilocybin affects brain areas linked to motivation.
Philadelphia, PennsylvaniaAges 18–60 - NCT06712004RecruitingPhase 2
Testing a new stroke drug: different doses for people who cannot get standard care
This trial tests a new medication (bevifibatide) to see which dose works best for people having an ischemic stroke who cannot get standard treatments like clot-busting drugs or a procedure to remove the clot. It aims to improve recovery by stopping clots from getting worse.
Guangzhou, GuangdongAges 18–80 - NCT06797661Recruiting
Brain lesion blood flow study before surgery
This study looks at how blood flow in the brain changes when there is a mass that can be removed with surgery. You would join before any treatment, which helps doctors understand the link between the brain lesion and blood vessel function.
BrusselsAges 18–90 - NCT06797752Recruiting
Stellate ganglion block and retina blood flow study
This trial looks at how a nerve block (stellate ganglion block) affects blood flow in the retina. It may help people who already get this block for conditions like complex regional pain syndrome understand eye effects.
Dallas, TexasAges 18 years+ - NCT06798740Recruiting
Study of brain aneurysm treatment with Sugita clipping devices
This study tracks people with brain aneurysms treated with a Sugita clipping device, watching how well it works and how they recover. It includes both ruptured and unruptured aneurysms, and follows standard care.
EssenAges 18 years+ - NCT06799429Recruiting
Exercise program for people with memory challenges
This trial tests whether a structured exercise program can help people with mild to moderate memory or thinking problems. You'll work with a trainer to improve your fitness and brain health.
Columbia, South CarolinaAges 18 years+ - NCT04250493Recruiting
Testing insulin resistance in multiple system atrophy
This study looks at how the body handles blood sugar (insulin resistance) in people with multiple system atrophy (MSA). Results may help doctors understand the disease better and explore new ways to monitor or treat it.
BordeauxAges 30 years+ - NCT05070013Recruiting
Brain stimulation to improve sleep in people with Parkinson’s disease
This study tests an adaptive brain stimulation device to help restore better sleep in people with Parkinson’s disease. You may be eligible if your Parkinson’s motor symptoms are severe despite best medical treatment and you are already being considered for a specific deep brain stimulation surgery.
Omaha, NebraskaAges 18–80 - NCT05909618RecruitingPhase 2
Crizanlizumab with nivolumab for brain-spread melanoma or glioblastoma
This Phase 2 study tests crizanlizumab alone or with nivolumab to treat people with certain brain tumors that have spread to the brain (melanoma) or glioblastoma. The goal is to see whether this approach can control the disease and improve outcomes.
Ramat Gan, IsraelAges 18 years+ - NCT06784388RecruitingEarly Phase 1
Deep brain stimulation for tough-to-treat depression
This early trial tests a personalized deep brain stimulation (DBS) approach for people with major depression that hasn't improved with at least two different antidepressants. DBS uses small electrodes placed in the brain to adjust mood-related circuits.
Hangzhou, ZhejiangAges 18–70 - NCT06790095Enrolling by invitationPhase 2
Testing Cyclosporine for Moderate to Severe Brain Injury
This study tests a drug called cyclosporine to see if it can help people with moderate to severe traumatic brain injury. You may be eligible if you have a brain injury seen on CT and can start treatment within 24 hours.
San Francisco, CaliforniaAges 18–65 - NCT06791837Recruiting
Brain blood flow and lactate in obesity study
This study looks at how blood flow and lactate (a chemical your body makes) in the brain differ between people with a healthy weight and those with obesity. It may help researchers understand how weight affects brain function.
Columbia, MissouriAges 18–45 - NCT06782464Recruiting
Freezing nerves for shoulder pain after stroke or brain injury
This trial tests if freezing certain nerves in the upper arm (cryoneurolysis) works as well as standard care for reducing shoulder pain and muscle tightness after a stroke or brain injury. It aims to improve function and ease caregiving tasks.
LuxembourgAges 18 years+ - NCT06432907Recruiting
Brain signal study during movement in epilepsy patients
This study records brain signals from electrodes already placed in your brain for medical reasons. It looks at how your brain controls movement, which could help develop future devices for people with paralysis.
MoscowAges 18–70 - NCT06779188RecruitingEarly Phase 1
Brain stimulation to improve balance in older adults
This trial tests whether a non-invasive brain stimulation technique called theta burst TMS can improve balance and brain connectivity in adults over 65 who have had recent falls. It involves MRI scans, 4 weeks of treatment, and follow-up tests.
Houston, TexasAges 65 years+ - NCT06515041Recruiting
Can museum visits boost brain health?
This study looks at whether visiting a museum can improve thinking and memory in healthy adults. You would visit the Caen Museum of Fine Arts and take some simple tests before and after.
CaenAges 18–65 - NCT06778135Recruiting
Brain cell study in Parkinson's DBS surgery
This trial studies how brain cells in a specific area (the prefrontal cortex) affect thinking and planning in people with Parkinson's disease who are getting deep brain stimulation (DBS) surgery. The goal is to learn more about brain function to improve future treatments.
Aurora, ColoradoAges 45–85 - NCT06776250RecruitingPhase 2
Tarlatamab for IDH-mutant brain tumors
This trial tests whether a new drug called tarlatamab is safe and effective for people with certain types of brain tumors that have an IDH mutation. You may be eligible if you have had up to 2 prior treatments after the tumor returned, and you are either having surgery to remove the tumor or the tumor cannot be removed.
Toronto, OntarioAges 18 years+ - NCT06781762Recruiting
Breast cancer hormone therapy and its effects on heart and brain
This study looks at how starting a common hormone therapy for breast cancer (aromatase inhibitors) affects your heart and brain health over the short term. It compares women starting this treatment to healthy women who are not on the therapy.
Toronto, OntarioAges Any age - NCT04852744Recruiting
Brain scan study in teens with borderline and/or PTSD
This study uses brain imaging (MRI) to compare brain patterns in teens with borderline personality disorder and those with PTSD, as well as teens without these mental health diagnoses. It may help researchers understand what brain differences go along with these conditions and how they relate to each other.
CaenAges 13–18 - NCT06761365Recruiting
Testing a new device for unruptured brain aneurysms
This trial tests a new device to block blood flow into unruptured brain aneurysms (balloon-like bulges). It is for adults whose aneurysm has not bled and fits specific size requirements. The goal is to see if the device is safe and works well.
SofiaAges 18–80 - NCT06771531Recruiting
Brain stimulation for foot sensation in older adults
This trial tests whether a gentle brain stimulation technique can improve feeling and steadiness in the feet of older adults who have numbness or reduced sensation. It aims to help with balance and walking.
Roslindale, MassachusettsAges 65 years+ - NCT06769464Recruiting
How the brain processes smell in epilepsy surgery patients
This study tests how your brain processes smells, using special recordings during brain surgery for epilepsy. It could help us understand how the brain handles odors.
Chicago, IllinoisAges 12–65 - NCT06769672Recruiting
Walking and thinking training with brain stimulation for stroke recovery
This study tests whether combining dual-task training (walking while doing a thinking task) with a gentle brain stimulation technique called tDCS can improve how stroke survivors move and think. It may help you walk safely while also paying attention to other tasks.
Hong KongAges 50 years+
Hear when a new Brain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,015 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.