Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,019 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05222594Recruiting
Brain language study using electrodes during epilepsy care
This study looks at how the brain processes language using recordings from electrodes placed during epilepsy treatment. If you’re already being considered for this type of brain monitoring, the study’s tasks may help researchers better understand language function in the brain.
Boston, MassachusettsAges 18–85 - NCT04994756Recruiting
Stroke and brain blood-vessel procedure registry study
This study collects information from people who undergo a procedure for a problem in brain or blood vessels (such as stroke-related vessel blockage). It does not test a new drug; it helps doctors understand outcomes and care patterns after these procedures.
Birmingham, AlabamaAges 1–120 - NCT05160129Recruiting
Deep brain stimulation for severe OCD using targeted electrodes
This study tests a deep brain stimulation (DBS) treatment device for adults with severe, long-lasting obsessive-compulsive disorder (OCD) that has not improved with standard treatments. It may help reduce OCD symptoms and improve daily functioning when medications and therapy have not worked.
New York, New YorkAges 18 years+ - NCT05184790Recruiting
Using imaging during radiation therapy to improve AI planning
This study tests how well an artificial intelligence system can use special X-ray images taken during certain radiation treatments to improve care. You may qualify if you’re having radiation for specific conditions and your treatment center uses the required imaging steps.
Saint Leonards, New South WalesAges 18 years+ - NCT05139277Recruiting
Using a imaging system during brain tumor surgery
This study tests the CONVIVO system to help surgeons see certain brain tumors during surgery. It may help make operations safer and more effective by improving how tumors are identified.
Lebanon, New HampshireAges 18 years+ - NCT05183152Recruiting
Non-invasive brain signal control for assistive devices
This study tests an assistive device that you control using signals from the brain and muscles without surgery. It may help people with movement problems communicate or operate devices using gentle, non-invasive sensing.
Austin, TexasAges 18–80 - NCT05151718Recruiting
Study of ependymoma treatment resistance in children
This trial looks at why ependymoma can resist (be harder to treat) after radiation or treatment. It studies children who are already being followed in specific existing programs, which may help researchers find better treatment approaches in the future.
ToulouseAges Up to 25 years - NCT05085210Recruiting
Brain stimulation to improve parts of lost vision
This study tests whether a noninvasive brain stimulation treatment (tRNS) plus visual training can improve visual field problems after a stroke. It may help some people regain better visual perception in the area they lost.
Boston, MassachusettsAges 18–80 - NCT05136846RecruitingPhase 1
Papaverine with chemoradiation for stage II–III lung cancer
This early-phase trial tests whether adding papaverine to standard chemoradiation can improve treatment for stage II–III non-small cell lung cancer (and some limited stage IV cases). It aims to see if the combination is safe and tolerable while targeting the cancer with radiation and chemotherapy.
Duarte, CaliforniaAges 18 years+ - NCT05101161Recruiting
Neurofeedback delivered through implanted brain stimulation
This study tests a brain “feedback” approach using electrodes already placed as part of standard medical care. It aims to see whether this method is safe and helpful for people undergoing deep brain stimulation after surgery.
Zurich, Canton of ZurichAges 18 years+ - NCT05124132Enrolling by invitation
Study of resilience and brain health after an earlier parent study
This trial looks at how resilience (how well people cope with stress) and brain health change over time in older adults who already joined an earlier study. You may be eligible if you participated in that “parent study.”
St Louis, MissouriAges 65 years+ - NCT05079464Recruiting
Exercise plus brain stimulation to improve memory in early impairment
This trial tests whether a supervised exercise program, paired with brain stimulation, can improve thinking and memory in people with early “vascular” cognitive problems (not dementia). It may help your brain function before memory loss becomes more severe.
Toronto, OntarioAges 50 years+ - NCT05120635Recruiting
Study brain signals tied to fear and anxiety in RNS patients
This study records electrical brain activity to understand how fear and anxiety work in people who already have an RNS (responsive neurostimulation) device placed. It may help researchers develop better ways to monitor and treat anxiety-related symptoms in the future.
Los Angeles, CaliforniaAges 18–70 - NCT05101746Enrolling by invitationPhase 2/Phase 3
Nitric oxide to protect brain and kidneys in babies during heart surgery
This trial studies whether giving nitric oxide during heart-lung bypass surgery can help protect a baby’s brain and kidneys. If you qualify, the study team will check outcomes after surgery to see if benefits happen compared with usual care.
Nashville, TennesseeAges birth–1 year - NCT05085704Recruiting
Brain scans to study metabolism in healthy and diabetic people
This study uses MRI brain scans at different strengths to measure how the brain uses energy (metabolism) in health and in people with genetically confirmed G1D. It may help researchers understand brain energy changes related to metabolic disease and diabetes.
New York, New YorkAges 16–80 - NCT05115474RecruitingPhase 2
Screening brain MRI study for stage IV breast cancer
This trial checks whether taking screening brain MRI scans in people with stage IV breast cancer helps find brain involvement earlier. It may help guide treatment decisions for those who would otherwise only get brain imaging after symptoms start.
Clearwater, FloridaAges 18 years+ - NCT05079516Recruiting
Study how the brain learns using arm testing and brain stimulation
This study uses a reaching task and a brain stimulation method (TMS) to see which brain areas help sensory learning. It may help researchers understand how learning works in the brain and how to design better therapies, if needed.
Bloomington, IndianaAges 18–45 - NCT05090267Recruiting
Gut-brain treatments for alcohol use and memory changes
This study tests whether gut-brain–targeted treatments (including probiotics and stimulation of a nerve) can improve thinking and inflammation-related health in people who use alcohol. You may be able to join if you have memory/thinking problems and meet specific medical limits, including HIV immune system levels.
Coral Gables, FloridaAges 35–70 - NCT05129150Recruiting
Assessing brain function with an ultrasound in a day hospital
This trial studies brain function in people who are already going to a day hospital for memory and thinking assessments. It may help researchers better understand cognitive problems and improve how they are evaluated. You would likely be asked to complete an ultrasound exam of the brain and allow your information to be used for the study.
ToursAges Any age - NCT05014841Enrolling by invitation
Brain electrode study of speech across different languages
This study uses electrodes placed on the brain during surgery to understand how speech is represented in different languages. It may help doctors better map language areas and improve surgical planning for people having brain surgery.
San Francisco, CaliforniaAges 18–70 - NCT05013736Recruiting
Study to test recovery in babies with brain injury
This study looks at how well babies recover after certain types of brain injuries that happen around birth, such as stroke, bleeding, or lack of oxygen. You might join if your baby fits the specific age range and has a confirmed injury on brain imaging.
Madison, WisconsinAges birth–2 years - NCT05014399Recruiting
Study memory changes during chemotherapy for colorectal cancer
This study looks at cognitive (thinking and memory) changes in people with colorectal cancer who start certain chemotherapy drugs. It aims to understand how treatment affects the brain and may guide better monitoring or support during care.
Fort Wayne, IndianaAges 18 years+ - NCT05015881Enrolling by invitationPhase 2/Phase 3
Brain and heart scans in alcohol use disorder
This study uses special brain and heart scans to see how sugar (glucose) is used in people with alcohol use disorder compared with people without it. It may help researchers understand the brain–heart connection in alcohol use disorder.
Philadelphia, PennsylvaniaAges 21–65 - NCT05057702Recruiting
Personalized surgery-focused treatment plan for relapsed brain cancer
This study tests a personalized treatment plan for children and young adults whose medulloblastoma or ependymoma has come back. It aims to guide doctors using new tissue from surgery or biopsy after earlier treatments are fully finished.
Los Angeles, CaliforniaAges 1–39
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Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,019 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.