Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,015 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05378035Recruiting
DOAC interruption study for Chinese people with atrial fibrillation
This trial studies how safely and effectively to pause a blood thinner (a DOAC) for about 48 hours before an elective procedure in people with atrial fibrillation. It may help confirm the best way to reduce bleeding risk without raising stroke risk.
Hong KongAges 18–80 - NCT05400174Recruiting
How blood pressure changes affect thinking and brain flow in Parkinson’s
This study measures how your blood pressure affects thinking skills and how blood flows in the brain in people with Parkinson’s. It may help researchers understand what blood-pressure changes could mean for cognition in Parkinson’s.
San Diego, CaliforniaAges 50 years+ - NCT05375617Recruiting
Study for newly diagnosed childhood cancers in Europe
This study follows children and teens with newly diagnosed certain leukemia (ALL) and certain favorable brain tumors to learn best care and outcomes. It may help your team compare standard treatments and monitor health over time.
New York, New YorkAges 3–21 - NCT05364749Recruiting
CT scan approach for people on blood thinners after head injury
This trial looks at a more targeted CT scan plan for people who are on blood thinners and have a head injury. It may help doctors decide who needs imaging right away and how to keep care safe and efficient.
Vancouver, British ColumbiaAges 16 years+ - NCT05401929Recruiting
TMS to reduce cannabis use in heavy users
This study tests whether transcranial magnetic stimulation (TMS) can help heavy cannabis users cut down or stop. TMS uses a magnetic coil on the scalp to gently stimulate parts of the brain involved in cravings and habits.
Durham, North CarolinaAges 18–65 - NCT05337618RecruitingPhase 2
Testing a medication approach to improve brain recovery after severe head injury
This Phase 2 trial is testing a combination medication strategy to improve outcomes after severe traumatic brain injury that needs emergency brain surgery soon after the injury. It may help by affecting how injured brain cells respond, aiming to improve survival or recovery.
Cincinnati, OhioAges 18–80 - NCT05335668Recruiting
Brain scan study of pain changes after stroke
This study looks at how brain wiring changes in people who have central post-stroke pain. It uses clinical checks and detailed brain scans (including a 7T MRI) to understand what may be driving the pain and how the brain changes over time.
BernAges 18–75 - NCT05323149RecruitingPhase 3
Dexamethasone for traumatic brain injury
This trial tests whether a medicine called dexamethasone, which reduces swelling, can improve recovery after a mild or moderate brain injury. It might help by decreasing pressure inside the skull.
Asyut, AssuitAges 18–65 - NCT05322239Recruiting
Brain stimulation study measuring resting brain activity
This trial tests how a specific brain stimulation method (theta burst stimulation) changes brain activity when you are resting. It may help researchers understand brain function changes, especially in people without certain mental or health risks.
Philadelphia, PennsylvaniaAges 18–60 - NCT05359653RecruitingPhase 1/Phase 2
Clemastine to study MRI changes in relapsing MS
This early-phase study tests whether clemastine (a drug being studied for “myelin repair”) changes how MS looks on special MRI scans. It may help researchers understand if the treatment supports restoring nerve covering in people with relapsing-remitting MS.
San Francisco, CaliforniaAges 18–55 - NCT05359562Recruiting
Hormones and OCD treatment approach on the brain
This study looks at how hormone changes and a specific OCD therapy method affect brain activity. It may help researchers understand why OCD symptoms and brain patterns differ between people and across time.
New York, New YorkAges 18–45 - NCT05317455RecruitingEarly Phase 1
Studying brain sugar changes in adults with risky low blood sugar
This early-stage study looks at how the brain uses sugar in people with type 1 diabetes who have had severe or hard-to-notice low blood sugar. It may help researchers understand the brain effects of low blood sugar and guide safer care.
New Haven, ConnecticutAges 18–55 - NCT05320822Recruiting
Rehab program study for recent mild concussion
This study tests a practical rehabilitation approach for people with a recent mild concussion (mTBI). You may be able to join if your injury happened recently and your symptoms match a “mild” concussion pattern on your medical record.
Fort Liberty, North CarolinaAges 18–99 - NCT05265546RecruitingPhase 1
Psilocybin study of changes in how you see
This Phase 1 study tests whether psilocybin affects visual perception and how visual information is represented in the brain. It also studies safety and what brain/vision changes happen after the dose.
Berkeley, CaliforniaAges 21 years+ - NCT05285683RecruitingPhase 2
Study brain dopamine in people with chronic pain
This Phase 2 study looks at how a brain chemical called dopamine is involved in long-lasting pain. You may be able to join if you have chronic pain for over a year and your pain score is high enough, and if MRI and health checks are safe for you.
Rochester, New YorkAges 18 years+ - NCT05283265Recruiting
Study brain signals during language understanding
This study looks at brain activity while you do language tasks, to understand what brain signals are linked to understanding words. You may help researchers learn more about neurophysiological mechanisms of language comprehension using existing brain-monitoring care.
Birmingham, AlabamaAges 18 years+ - NCT05271240RecruitingPhase 3
Targeted brain-artery drug added to standard treatment for new GBM
This Phase 3 trial tests whether delivering a cancer drug directly into brain blood vessels, along with standard radiation and temozolomide, works better than standard treatment alone in newly diagnosed glioblastoma (GBM). The goal is to improve control of the tumor while comparing side effects between the two approaches.
New York, New YorkAges 18 years+ - NCT05266417RecruitingPhase 2
Nasal insulin plus glutathione for Parkinson’s symptoms
This Phase 2 study tests whether adding nasal insulin and glutathione can improve Parkinson’s disease symptoms and function. You would use study medicine through the nose while keeping your other treatments mostly the same during the trial.
Davie, FloridaAges 30 years+ - NCT05292794Recruiting
CereGate therapy for freezing of gait in Parkinson’s
This trial tests whether CereGate therapy can reduce “freezing of gait,” a walking problem, in people with Parkinson’s disease who already have deep brain stimulation (DBS). If you meet the device and medication stability requirements, the study may help your walking and movement symptoms measured during testing.
Redwood City, CaliforniaAges 21–80 - NCT05277519Recruiting
Rehab retraining for walking after stroke or brain injury
This study tests a rehab program aimed at improving how the brain learns movement, to help people walk more independently after a stroke or traumatic brain injury. It may help by targeting walking and movement control of the affected leg.
ParisAges 18–70 - NCT05241262RecruitingPhase 1
N-acetylcysteine for people with m.3243A>G and low brain glutathione
This trial tests whether the supplement N-acetylcysteine (NAC) can help people who have the m.3243A>G mitochondrial genetic change and low levels of a brain chemical called glutathione. The study aims to see if raising glutathione in the brain is safe and potentially beneficial for these patients.
New York, New YorkAges 18–80 - NCT05212272Recruiting
MRI plus cognitive testing during glioma chemoradiation
This study uses MRI scans and related brain/cognitive testing while you receive standard chemotherapy and radiation for a high-grade brain tumor. It aims to see how MRI measures and brain testing may relate to your treatment response or brain function.
Winston-Salem, North CarolinaAges 18 years+ - NCT05240352Recruiting
Personalized brain stimulation help for bipolar depression anhedonia
This study looks at using brain scans to better tailor transcranial direct current stimulation (a noninvasive brain stimulation) for people with bipolar depression who feel little pleasure. It aims to see whether matching the stimulation to your brain signals can improve symptoms like anhedonia.
Houston, TexasAges 18–50 - NCT05222594Recruiting
Brain language study using electrodes during epilepsy care
This study looks at how the brain processes language using recordings from electrodes placed during epilepsy treatment. If you’re already being considered for this type of brain monitoring, the study’s tasks may help researchers better understand language function in the brain.
Boston, MassachusettsAges 18–85
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Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,015 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.