Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,015 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04653012Recruiting
Testing brain-activity recordings in people with drug-resistant epilepsy
This study looks at brain activity using electrodes placed inside the brain in people with focal, drug-resistant epilepsy before surgery. It may help doctors better map where seizures start and improve planning for treatment.
ParisAges 18 years+ - NCT04631042Recruiting
Study how the brain relates to impulsivity and compulsivity
This study looks at how brain function and structure relate to impulsive and compulsive behaviors. It may help researchers understand what drives these behaviors and who may benefit from future mental health treatments.
Bethesda, MarylandAges 6–80 - NCT04650932Recruiting
Study tests new stimulation settings for advanced Parkinson’s
This study looks at whether changing how deep brain stimulation (DBS) pulses are delivered can improve symptoms in people with advanced Parkinson’s disease. You may be eligible if you already have a specific Boston Scientific DBS device and have had it implanted for at least 3 months.
Sacramento, CaliforniaAges 18 years+ - NCT04621357Recruiting
Testing how brain swelling affects recovery after brain bleeding
This study looks at brain swelling (“cerebral edema”) after a spontaneous brain bleed and how it relates to outcomes. It mainly involves people who can have early care and MRI scans, to better understand what affects recovery.
LilleAges 18 years+ - NCT04493996Recruiting
Cognitive training before heart surgery to protect memory
This trial tests whether brain-focused cognitive training before elective heart surgery can help reduce memory and thinking problems afterward. If you qualify, you may do language-based thinking exercises and complete short brain tests around the time of surgery.
Bad NauheimAges 18 years+ - NCT04521881RecruitingPhase 3
Testing an antifibrinolytic for mild head injury in older adults
This study tests whether an anti-bleeding medicine (given to reduce unwanted clot breakdown) can improve outcomes after a mild head injury in people 50 and older. It is looking for patients who arrive quickly after injury and have certain symptoms like brief loss of consciousness, confusion, or nausea.
London, LondonAges 50 years+ - NCT04550377RecruitingPhase 2
Cannabidiol for PTSD, including PTSD after mild head injury
This Phase 2 study tests whether cannabidiol (CBD) can reduce PTSD symptoms, including in people who also had a mild traumatic brain injury (TBI). It’s meant to see if CBD is helpful and safe for PTSD symptoms over the study period.
New York, New YorkAges 18–70 - NCT04396873RecruitingPhase 1
PET brain scan study of inflammation markers in neurodegeneration
This Phase 1 study tests a PET scan to measure inflammation-related changes in the brain using a medication called ketoprofen. It may help researchers understand which people with certain brain diseases could benefit from treatments aimed at inflammation.
Bethesda, MarylandAges 18–99 - NCT04482660Enrolling by invitation
PET brain scan study of tau protein in ALFA volunteers
This study uses a special PET brain scan tracer to measure “tau” protein clumps in the brain. It’s meant to better understand brain changes in people who are already part of the ALFA research program, and may help researchers connect tau levels with memory and thinking.
Barcelona, BarcelonaAges 45 years+ - NCT04390009RecruitingEarly Phase 1
Whole-body PET scans in people with multiple sclerosis
This early study tests how whole-body PET-CT scans can be used in people with multiple sclerosis (and compares with healthy volunteers). It may help researchers understand what the scan can show in MS throughout the body.
Ladera Ranch, CaliforniaAges 25–55 - NCT04445649Recruiting
Find factors to help people regain consciousness after brain injury
This study looks at what predicts recovery of consciousness after certain serious brain injuries, such as stroke or traumatic brain injury. It may help clinicians better identify which patients are more likely to wake up and guide early rehabilitation and care.
Hessisch OldendorfAges 18–85 - NCT04479696Recruiting
Video coaching to ease anxiety during brain tumor radiation
This study tests a personalized video meant to reduce stress and anxiety for people getting radiation for brain tumors, and for their caregivers. You and your caregiver would complete short questionnaires before and after using the video support.
Houston, TexasAges 18 years+ - NCT04475640Recruiting
Genetic testing study for cancer patients in different ethnic groups
This study looks at cancer-related inherited gene changes using blood samples. It may help patients and doctors understand cancer risk and guide treatment planning, especially across different ethnic communities.
Scottsdale, ArizonaAges 18 years+ - NCT04373564RecruitingPhase 4
Tracking brain and movement changes after repeated MRI contrast
This study looks at whether getting the MRI contrast dye multiple times over 5 years affects body movement and thinking skills. It compares people who had the dye repeatedly with people who have little or no exposure, using brain MRI scans and regular mental and movement testing.
Scottsdale, ArizonaAges 18–64 - NCT04354077Recruiting
Deep brain stimulation for opioid addiction
This study tests whether deep brain stimulation (DBS), a surgical treatment that uses electrical pulses to target specific brain areas, can help reduce cravings and relapse in people with opioid use disorder who haven't found relief from other treatments.
Pittsburgh, PennsylvaniaAges 22–65 - NCT04297020Recruiting
Checking brain health in breast cancer survivors
This study looks at differences in brain function in people who have had breast cancer, compared with certain people without that history. It’s testing how brain health changes after breast cancer and relates to mood, thinking, and daily functioning.
Los Angeles, CaliforniaAges 35–65 - NCT04274283Recruiting
Study of brain tumor samples and blood tests
This trial studies newly diagnosed or progressing brain tumors (grade 2–4 gliomas) to better understand the disease using tumor tissue and blood samples. It may help doctors learn which treatments could work best for different tumor types by matching tumor material to blood results.
BirminghamAges 16 years+ - NCT04278118Recruiting
Proton radiation study for non-cancer brain tumor types
This trial tests a radiation plan that gives treatment in fewer, larger “fractions” using proton beams (or sometimes photon beams) for certain non-cancer brain tumor types. It aims to see how well this approach works while keeping side effects manageable.
Atlanta, GeorgiaAges 18 years+ - NCT04267003Recruiting
Brain stimulation study for thinking and brain chemistry in schizophrenia
This study tests whether a brain stimulation approach can improve thinking (cognition) in people with schizophrenia and how it changes brain electrical signals and a brain chemical called GABA. It may help researchers understand new ways to support thinking and symptoms.
Sacramento, CaliforniaAges 18–47 - NCT04258774Enrolling by invitation
Breathing challenge during MRI to test brain blood-flow signals
This study uses a breathing challenge while you’re in an MRI to see how blood flow signals in the brain change. It may help researchers better understand how brain imaging signals respond to breathing and oxygen/carbon dioxide levels.
St Louis, MissouriAges 18 years+ - NCT04322734Recruiting
Blood tests study immune and metabolism markers in neurodevelopment
This study looks for biological “signals” in blood—related to the immune system and metabolism—to better understand conditions like autism and other brain or development-related disorders. It may help researchers find markers that could guide future diagnosis or treatment.
Phoenix, ArizonaAges Up to 18 years - NCT04290130Enrolling by invitation
Study brain signals during audiovisual speech in neurosurgery patients
This study measures brain activity to understand how your brain combines what you see and hear during speech. It may help scientists build better ways to understand and treat problems with speech processing.
Philadelphia, PennsylvaniaAges 21–65 - NCT04165746Recruiting
Early care program for very young children in foster systems
This study looks at how an early support program affects the development of infants who are newly entering institutional care or foster care in the São Paulo area. It may help families and caregivers support healthy growth during a critical first period.
São Paulo, São PauloAges Up to 2 years - NCT04192955RecruitingPhase 3
Aspirin before and after brain aneurysm coiling
This trial tests if taking aspirin before and after a procedure to fix an unruptured brain aneurysm (coiling) helps prevent complications. Aspirin is a common blood thinner that might reduce the risk of blood clots or other problems after the procedure.
Calgary, AlbertaAges 18 years+
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Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,015 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.