Clinical trials
Cancer (Advanced Stage) clinical trials
Below are recruiting cancer (advanced stage) clinical trials, each written for real people, not researchers. We’re tracking 1,033 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07227038Recruiting
Living well with advanced breast cancer study
This study looks at a program called Living Well With Advanced Breast Cancer, which offers support to people with metastatic breast cancer and their caregivers. It aims to see how helpful the program is for different groups of people, including those who haven't tried it yet, those who cancelled, and those who finished it.
Columbus, OhioAges 18 years+ - NCT07250477RecruitingPhase 2
Guided immunotherapy for advanced lung cancer
This trial tests whether using a blood test to guide treatment can improve outcomes for people with advanced non-small cell lung cancer who are starting immunotherapy for the first time. Participants will receive standard immunotherapy tailored to their individual risk profile.
Sacramento, CaliforniaAges 18 years+ - NCT07276438Recruiting
Image-guided radiation therapy for localized prostate cancer
This trial tests a precise radiation technique that adapts to your body's daily changes. It may offer better outcomes for men with prostate cancer that hasn't spread outside the pelvic area.
Los Angeles, CaliforniaAges 18 years+ - NCT07284992RecruitingPhase 2
Comparing short vs long radiation with immunotherapy for rectal cancer
This trial tests whether a short course of radiation followed by an immunotherapy drug (PD-L1 inhibitor) plus chemotherapy works as well as or better than a longer radiation course for locally advanced rectal cancer. The goal is to shrink tumors before surgery.
Jinan, ShandongAges 18–80 - NCT05429970Recruiting
Reducing stress before ovarian cancer surgery with two medicines
This study tests whether giving two commonly used medicines before surgery—one that can lower stress on the body (a beta-blocker) and one that reduces inflammation (a COX-2 inhibitor)—can improve outcomes compared with standard care. It’s for people with advanced ovarian, fallopian tube, or primary peritoneal cancer who are having open surgery.
Basking Ridge, New JerseyAges 18 years+ - NCT07383441RecruitingPhase 3
Adding Biotherapy or Placebo to Standard Kidney Cancer Treatment
This trial tests whether adding a biotherapy (a special drug from a living source) or a placebo to standard treatments helps people with advanced kidney cancer. It may be a good option if your cancer hasn't been treated yet and you are in fairly good health.
Fayetteville, ArkansasAges 18 years+ - NCT01042379RecruitingPhase 2
Adaptive drug trial for newly diagnosed breast cancer
This study tests personalized, changing treatment plans (given before surgery) to find better options for your specific breast tumor. You may be asked for extra breast-tissue testing to help match you with the most suitable study drug(s).
Birmingham, AlabamaAges 18 years+ - NCT01000259Recruiting
Using stored tumor tissue after surgery for advanced ovarian cancer
This study looks at archived tumor tissue samples from people with advanced (stage III or IV) ovarian epithelial cancer who had surgery and standard “platinum/taxol” chemotherapy trials. It may help researchers understand the cancer better and improve future treatments.
Philadelphia, PennsylvaniaAges Any age - NCT01365169Recruiting
How activity level and daily function relate to cancer survival
This study looks at how physical activity (movement during the day) and a clinician-rated “day-to-day function” score relate to overall survival in people with certain cancers. It may help doctors understand who benefits most from activity-focused care and better monitoring.
Houston, TexasAges 18 years+ - NCT05136846RecruitingPhase 1
Papaverine with chemoradiation for stage II–III lung cancer
This early-phase trial tests whether adding papaverine to standard chemoradiation can improve treatment for stage II–III non-small cell lung cancer (and some limited stage IV cases). It aims to see if the combination is safe and tolerable while targeting the cancer with radiation and chemotherapy.
Duarte, CaliforniaAges 18 years+ - NCT06162221RecruitingPhase 1/Phase 2
Study of RAS inhibitors for advanced RAS-mutated lung cancer
This trial tests new drugs that target specific RAS mutations in advanced non-small cell lung cancer. It's for people whose cancer has a KRAS G12C, G12D, or other RAS mutation and who have already tried standard treatments.
Gilbert, ArizonaAges 18 years+ - NCT02600949Enrolling by invitationPhase 1
Peptide vaccine study for advanced pancreatic or colon cancer
This Phase 1 study tests a personalized vaccine made from a patient’s tumor to help the immune system recognize and attack cancer. It is for people with advanced pancreatic or colorectal cancer (often after surgery or while metastatic) and aims to see if the approach is safe and can help immune control of the cancer.
Houston, TexasAges 18 years+ - NCT07405086RecruitingPhase 4
Morning vs. afternoon immunotherapy for advanced solid tumors
This trial compares giving immunotherapy in the morning versus the afternoon to see if timing affects how well it works. It is for people with certain types of advanced or metastatic solid tumors who have not had this treatment before.
Portland, OregonAges 18 years+ - NCT07433660Recruiting
WellSpan Cancer Quality of Life Study
This study looks at quality of life in people recently diagnosed with cancer. It aims to understand how cancer and its treatment affect daily life and well-being.
Chambersburg, PennsylvaniaAges 18 years+ - NCT05098132RecruitingPhase 1/Phase 2
STK-012 drug for advanced lung cancer and other tumors
This trial tests STK-012 (alone and with other treatments) in people with advanced cancers, especially non-small cell lung cancer. It may help by activating the immune system to recognize and fight the tumor.
Tucson, ArizonaAges 18 years+ - NCT07584824Recruiting
Cancer Care Laws and Modern Technology Survey
This survey asks cancer patients, their relatives, and healthcare workers in the UK about how well current cancer care laws work with today's technology. Your feedback helps shape future cancer care policies and practices.
TruroAges 18 years+ - NCT07595874RecruitingPhase 2
New Immunotherapy Drugs Before Surgery for Advanced Colorectal Cancer
This trial tests two immunotherapy drugs (botensilimab and balstilimab) given before surgery to treat advanced colorectal cancer that can be removed. The goal is to help the immune system fight cancer cells and improve outcomes after surgery.
Goodyear, ArizonaAges 18 years+ - NCT07612891RecruitingPhase 1/Phase 2
Testing INV-6452 for advanced breast cancer and solid tumors
This study tests a new drug called INV-6452 to see if it is safe and can help control advanced cancers that have grown despite prior treatment. The drug targets specific cancer cell weaknesses, particularly in hormone-sensitive breast cancers without HER2 mutations.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07635147Recruiting
Decision Support Tool for Advanced Breast Cancer
This study tests a digital tool designed to help patients with advanced (stage IV) breast cancer make treatment decisions. The tool may help you understand your options and feel more confident discussing them with your doctor.
Brooklyn, New YorkAges 18 years+ - NCT07636200Recruiting
Managing Fear and Worry in Advanced Cancer
This study tests a new approach to help people with advanced cancer who feel significant fear about their cancer getting worse or coming back. The program uses writing and therapeutic techniques to help reduce this fear and related stress.
Aurora, ColoradoAges 18 years+ - NCT07645261RecruitingPhase 2
Lattice Radiation for Large Tumors When Other Treatments Won't Help
This trial tests a special type of focused radiation therapy (called SBRT-Lattice) for large tumors in patients who can't benefit from surgery, chemotherapy, or standard radiation. The radiation uses a lattice pattern designed to treat the tumor while protecting healthy tissue nearby.
São Paulo, São PauloAges 18 years+ - NCT07639268Enrolling by invitation
Support program for advanced cancer patients and their caregivers
This study tests a support program designed to help advanced cancer patients (stage III or IV) and their caregivers manage stress and emotional distress together. The program aims to improve coping and quality of life for both the patient and the person caring for them.
Ponce, PRAges 21–105 - NCT06883058Enrolling by invitation
CASA Program for Distressed Patients and Caregivers
This trial tests a program called CASA that helps both patients with advanced cancer and their caregivers cope with distress. If you or your loved one feel overwhelmed by worry or sadness, this support program may help you manage those feelings together.
Ponce, PRAges 21–105 - NCT05407844Enrolling by invitation
Community health worker program to improve palliative care
This study tests whether a community health worker can help people with advanced cancer get better palliative care support. Palliative care focuses on comfort, symptom relief, and support for patients and caregivers.
Birmingham, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for cancer (advanced stage)?
- Yes. Clin2 currently lists 1,033 recruiting cancer (advanced stage) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cancer (advanced stage) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cancer (advanced stage) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.