Clinical trials · Minnesota
Cancer clinical trials in Minnesota
We’re tracking 556 recruiting cancer studies with a site in Minnesota — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Minnesota
- NCT06560021Enrolling by invitation
Random biopsies in inflammatory bowel disease surveillance
This trial looks at whether taking random biopsies during a routine colonoscopy is helpful for people with inflammatory bowel disease (IBD) who are at risk for colon cancer. It aims to understand if random biopsies can detect early signs of cancer or pre-cancer.
Rochester, MinnesotaAges 18 years+ - NCT06577441RecruitingPhase 2
Adding enasidenib to usual care for higher-risk MDS with IDH2 mutation
This trial tests whether adding enasidenib (a targeted pill) to the standard chemotherapy (cedazuridine-decitabine) works better than the chemotherapy alone for people with higher-risk myelodysplastic syndrome (MDS) whose cells have a specific change in the IDH2 gene.
Brainerd, MinnesotaAges 18 years+ - NCT07047872Recruiting
3D-printed breast form study for women after mastectomy
This study tests a custom 3D-printed external breast form for people who had a mastectomy without reconstruction. It aims to see if it improves comfort and satisfaction.
Rochester, MinnesotaAges 18 years+ - NCT06657222RecruitingPhase 1/Phase 2
Study of TUB-030 for advanced solid tumors
This trial tests a new drug called TUB-030 in people with advanced solid tumors that have not responded to other treatments. The goal is to see if it is safe and effective.
Rochester, MinnesotaAges 18 years+ - NCT06627647RecruitingPhase 3
Comparing two immunotherapy drugs for advanced lung cancer
This trial tests a new immunotherapy drug, rilvegostomig, against the standard pembrolizumab, both given with chemotherapy, as a first treatment for advanced non-squamous non-small cell lung cancer (NSCLC) that cannot be cured with surgery or radiation. It is for people whose tumors have high PD-L1 levels and do not have certain genetic mutations.
Duluth, MinnesotaAges 18 years+ - NCT07214532Recruiting
Using a blood test to guide breast cancer therapy
This study tests whether a blood test can help decide when to start additional hormone-blocking therapy for early-stage breast cancer. It aims to see if starting therapy only when the test detects cancer DNA is as effective as giving it to everyone.
Rochester, MinnesotaAges 18 years+ - NCT05001880RecruitingPhase 2
Chemo with or without immunotherapy for peritoneal mesothelioma
This study tests whether adding immunotherapy to standard chemotherapy helps people with peritoneal mesothelioma, a cancer in the lining of the abdomen. You may receive chemotherapy alone or with immunotherapy, and the goal is to improve cancer control.
Bemidji, MinnesotaAges 18 years+ - NCT06511141Recruiting
Nerve stimulation for men with overactive bladder
This study tests a nerve stimulation device placed near the tailbone to help men with overactive bladder symptoms. If you have bothersome urinary urgency or frequency, this treatment may offer relief without drugs.
Rochester, MinnesotaAges 18 years+ - NCT06926868RecruitingPhase 2/Phase 3
Study of a new drug versus chemotherapy for advanced triple-negative breast cancer
This trial tests a new investigational drug called izalontamab brengitecan against standard chemotherapy for people with advanced triple-negative breast cancer who cannot receive immunotherapy. The goal is to see if the new drug works better at shrinking or slowing the cancer.
Maple Grove, MinnesotaAges 18 years+ - NCT05675410RecruitingPhase 3
Testing two-drug treatment versus standard for Hodgkin lymphoma
This Phase 3 study compares today’s standard treatment for classic Hodgkin lymphoma with a new combination using brentuximab vedotin and nivolumab. The goal is to see which approach works better and is safe for newly diagnosed patients with early-stage disease.
Coon Rapids, MinnesotaAges 5–60 - NCT06172296RecruitingPhase 3
Dinutuximab plus transplant for high-risk neuroblastoma
This trial tests adding a targeted drug called dinutuximab to standard chemotherapy, surgery, and a stem cell transplant for children and young adults with a new diagnosis of high-risk neuroblastoma. The goal is to see if this combination helps more patients stay in remission.
Minneapolis, MinnesotaAges Up to 30 years - NCT07406633RecruitingPhase 2
KQB198 plus imatinib for advanced GIST
This trial tests a new drug called KQB198 combined with imatinib for people with advanced or metastatic gastrointestinal stromal tumor (GIST) that has a specific KIT or PDGFRA mutation. The goal is to see if this combination works better than imatinib alone as a first treatment.
Rochester, MinnesotaAges 18 years+ - NCT06584929Recruiting
Rural smoking cessation app study
This study tests a smartphone-based program to help people who smoke at least 5 cigarettes a day quit. It focuses on adults in rural areas who want to stop smoking using their own device.
Minneapolis, MinnesotaAges 21 years+ - NCT05999994RecruitingPhase 2
Testing new drugs for children and young adults with cancer
This trial tests several experimental drugs for children and young adults with cancer. It aims to find safe and effective treatments by matching participants to one of several drug studies based on their cancer type and health.
Minneapolis, MinnesotaAges 1–39 - NCT04251052Recruiting
Compare two surgeries to lower ovarian cancer risk in BRCA1 carriers
This study compares two risk-reducing surgery plans for people with a BRCA1 genetic change to see which approach helps lower ovarian cancer risk. You may be asked to have the study procedure sooner or later depending on your chosen plan.
Burnsville, MinnesotaAges 35–50 - NCT05646316RecruitingPhase 3
Sentinel lymph node mapping to reduce leg swelling after surgery
This study tests whether a special way of finding lymph nodes during hysterectomy can lower the risk of long-term leg swelling or related dysfunction in people with stage I endometrial cancer. It compares standard lymph node assessment with sentinel lymph node mapping and looks at how this affects day-to-day leg functioning.
Edina, MinnesotaAges 18 years+ - NCT05232916RecruitingPhase 3
Vaccine for HER2-positive breast cancer after standard treatment
This trial tests a vaccine (GLSI-100) that may help prevent the return of HER2-positive breast cancer. It is given to patients who still had cancer cells after initial treatment with trastuzumab, or who had stage III disease and achieved a complete response.
Maple Grove, MinnesotaAges 18–100 - NCT06304168Recruiting
Blood, tissue, and urine tests to detect cancer early
This study is testing whether simple blood, tissue, and urine samples can help find cancer earlier and identify where it started. Participating could help improve future cancer detection for everyone.
Rochester, MinnesotaAges 18 years+ - NCT04269902RecruitingPhase 3
Early treatment check for high-risk CLL/SLL
This Phase 3 trial studies an early treatment approach for people with high-risk CLL or SLL who have not yet needed standard therapy. It aims to see if treating earlier can improve outcomes while keeping side effects manageable.
Burnsville, MinnesotaAges 18 years+ - NCT06693986RecruitingPhase 1
Virus therapy for pancreatic cancer
This trial tests a modified virus injected directly into pancreatic tumors using an endoscopy. It is designed to target and attack cancer cells while sparing healthy tissue, and may be an option for people whose cancer is still confined to the pancreas and nearby lymph nodes.
Minneapolis, MinnesotaAges 18 years+ - NCT06525740RecruitingPhase 4
Comparing two pain medicines for gynecologic cancer surgery
This trial compares two different pain medicines (methadone given by mouth or IV vs. hydromorphone given through a spinal injection) after surgery for gynecologic cancer. It aims to find which option provides better pain relief with fewer side effects.
Rochester, MinnesotaAges Any age - NCT06544811Recruiting
Smokefree Native: Smartphone quit support for American Indians
This trial tests a smartphone-based program to help American Indian adults quit smoking. If you are ready to try quitting and have daily access to a smartphone, you may be able to join for free support.
Minneapolis, MinnesotaAges 18 years+ - NCT06053333Recruiting
Social factors in liver, bile duct, and gallbladder cancer
This study looks at how social and economic factors (like income, housing, and support) affect people with liver, bile duct, or gallbladder cancer. The goal is to learn more about these factors to improve care and outcomes.
Rochester, MinnesotaAges 18 years+ - NCT06028022RecruitingPhase 2
Reishi mushroom for fatigue and joint/muscle pain in breast cancer
This trial tests whether a reishi mushroom extract can help reduce fatigue and joint or muscle pain in people with breast cancer who are taking aromatase inhibitors. If you have these symptoms, you may be able to join.
Albert Lea, MinnesotaAges 18 years+
Cancer trials by city in Minnesota
Where these studies are running in Minnesota
Institutions with a site for the recruiting cancer studies listed above.
- Mayo Clinic · 14 studies
- University of Minnesota Masonic Cancer Center · 6 studies
- Fairview Southdale Hospital · 5 studies
- Regions Hospital · 5 studies
- Abbott-Northwestern Hospital · 4 studies
- Fairview Northland Medical Center · 4 studies
- Mercy Hospital · 4 studies
- Park Nicollet Clinic - Saint Louis Park · 4 studies
What taking part in a cancer study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cancer trials in other states
Common questions
- Are there cancer clinical trials in Minnesota?
- Yes. We're currently tracking 556 recruiting cancer studies with a site in Minnesota, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cancer study in Minnesota?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Minnesota to take part?
- Not necessarily. These studies have a site in Minnesota, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cancer trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cancer studies open in Minnesota regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.