Clinical trials
Cardiac Surgery clinical trials
Below are recruiting cardiac surgery clinical trials, each written for real people, not researchers. We’re tracking 311 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04750616RecruitingPhase 2
NAD+ for heart injury prevention around non-emergency surgery
This Phase 2 trial studies whether adding NAD+ can reduce heart muscle injury around scheduled heart surgery. It may help protect the heart (and possibly kidneys) in people considered higher risk for complications.
San Francisco, CaliforniaAges 18 years+ - NCT04808401Recruiting
Testing how different oxygen levels affect surgery outcomes
This trial studies whether giving higher or lower oxygen during general anesthesia changes heart and lung outcomes after planned (non-emergency) non-heart surgery. It may help doctors choose safer oxygen settings during surgery for people at higher risk for heart problems.
BernAges 18 years+ - NCT04913649RecruitingPhase 4
IV iron for anemia after heart surgery in older adults
This trial tests whether giving iron through a vein after heart surgery helps treat postoperative anemia (low red blood cells) in people age 70 and older. It may improve recovery by correcting low iron levels after surgery.
BredaAges 70 years+ - NCT05014802Recruiting
MRI scans before heart surgery to predict post-surgery atrial fibrillation
This study uses an MRI scan before heart surgery to look for heart scarring that may predict who will develop atrial fibrillation afterward. Knowing the risk ahead of time could help doctors monitor you more closely and plan prevention.
Covington, LouisianaAges 40–120 - NCT05189262Recruiting
Study of blood changes during heart surgery bypass
This study looks at whether a machine used during heart surgery (cardiopulmonary bypass) causes red blood cells to break down. The goal is to better understand these blood changes and what they might mean for patients during and after surgery.
Baltimore, MarylandAges 18–88 - NCT05353348Recruiting
Program to treat mild anemia around heart surgery
This trial tests a combined treatment plan to improve anemia (low blood count/iron levels) before and around the time of major elective heart surgery. It may help reduce the need for blood transfusions and support safer recovery.
Hangzhou, ZhejiangAges 18 years+ - NCT05487612Recruiting
MiECC heart-lung machine vs standard bypass during heart surgery
This trial compares a newer heart-lung machine setup (MiECC) with the usual bypass technique during certain heart operations. It may help see whether MiECC changes outcomes like the need for blood transfusions or recovery after surgery.
TorontoAges 18–85 - NCT05573633Recruiting
Smartwatch test to detect irregular heartbeats after heart surgery
This study checks whether a smartwatch can spot an irregular heartbeat called atrial fibrillation soon after on-pump heart surgery. If the smartwatch works well, it could help clinicians find the problem earlier after surgery.
AmiensAges 18 years+ - NCT05632432Recruiting
Heart tissue grafts to help the heart after surgery
This trial tests whether transplanting tiny heart “micrografts” from the left heart chamber area can improve heart function after cardiac surgery. It is meant for people with weakened heart pumping and heart failure symptoms despite medicine.
Helsinki, UusimaaAges 18–75 - NCT05635227Recruiting
Medications during heart surgery to help control breathing and circulation
This study looks at whether giving dexamethasone and olanzapine during certain heart surgeries can improve how blood flow and ventilation (breathing support) are managed. It’s meant to see if these medicines help the body handle heart-lung bypass more safely.
CopenhagenAges 18 years+ - NCT05687292Recruiting
Decision tool to shorten breathing machine time in children
This study tests whether a computer “decision support” tool can help doctors safely reduce how long a child stays on a breathing machine after heart surgery. It may help children get off mechanical ventilation sooner and recover faster.
Boston, MassachusettsAges 1 day–12 years - NCT05849597RecruitingPhase 3
Dexmedetomidine to prevent delirium after open-heart surgery
This trial tests whether a sedating medicine called dexmedetomidine can reduce the risk of “delirium” (sudden confusion) in the intensive care unit after open-heart surgery. If you’re having certain heart operations, it may help protect your thinking and alertness during recovery.
KamenitzAges 18 years+ - NCT05886517Recruiting
Transcatheter aortic valve in patients too high-risk for surgery
This trial looks at placing a new aortic valve through the groin (transfemoral) without needing on-site heart surgery for people who are considered very high risk for standard open-heart valve surgery. It aims to measure early outcomes to see how safe and effective this approach is for frail or complex patients.
Acquaviva delle Fonti, BariAges 75–120 - NCT05972356Recruiting
How heart relaxation affects outcomes in heart surgery
This study looks at whether a measurement of how well the heart relaxes helps predict outcomes after heart surgery. It focuses on patients treated in Amsterdam UMC and uses care data to understand who may be at higher or lower risk.
Amsterdam, North HollandAges 18 years+ - NCT06012760Recruiting
Can iron and vitamin C reduce transfusions during heart surgery?
This trial is testing whether giving iron plus vitamin C before heart surgery can reduce the need for blood transfusions. It is for people with low iron and anemia who are scheduled for bypass or valve surgery.
Hangzhou, ZhejiangAges 18 years+ - NCT06054360Recruiting
Predicting irregular heartbeat after heart bypass surgery
This study uses an ultrasound test of the heart's right atrium to see if it can predict who will develop an irregular heartbeat (atrial fibrillation) after planned coronary bypass surgery. If you are scheduled for this surgery and have no history of atrial fibrillation, you may be able to join.
AmiensAges 18 years+ - NCT06096116RecruitingPhase 3
Trial of a blood product for heparin resistance during heart surgery
This study tests a blood-derived medicine (antithrombin) to help people who do not respond well to the blood thinner heparin during heart surgery. It aims to make surgery safer by improving blood thinning.
Stanford, CaliforniaAges 18–85 - NCT06133842Recruiting
Brain blood flow and confusion after surgery study
This trial looks at how well the brain controls its own blood flow during non-cardiac surgeries. It aims to see if problems with this regulation are linked to confusion after surgery (delirium).
Boston, MassachusettsAges 60 years+ - NCT06258681Recruiting
Breathing exercise device for recovery after heart surgery
This trial tests a new breathing exercise device designed to help your lungs recover after heart surgery. It may make your breathing easier and speed up your return to daily activities.
Istanbul, IstanbulAges 40–65 - NCT06271265RecruitingPhase 1
Testing EXPAREL for pain after heart surgery in children
This study tests a long-acting pain medicine (EXPAREL) given during heart surgery to see how it works in young children. The goal is to help control pain after surgery with fewer side effects.
Indianapolis, IndianaAges birth–6 years - NCT06291714Recruiting
Non-invasive blood pressure prediction during major surgery
This trial tests a new, non-invasive way to predict drops in blood pressure during major hip, knee, pelvis, or spine surgery. The goal is to help doctors prevent low blood pressure, which can lead to complications.
GiessenAges 45 years+ - NCT06322810Recruiting
Pain relief methods for open heart surgery: ESP vs PIFB
This study compares two ways to manage pain after open-heart surgery. It looks at using an injection near the spine (ESP block) versus a needle placed through the chest wall (PIFB) to help reduce pain and the need for strong pain medicines.
Taichung, TaiwanAges 18 years+ - NCT06361238RecruitingPhase 3
Liraglutide to prevent confusion after heart surgery in seniors with diabetes
This trial is testing if liraglutide, a diabetes medication, can prevent delirium (sudden confusion) in older adults with type 2 diabetes who are having planned heart surgery. If you qualify, you may help find a new way to protect brain function after surgery.
Nanjing, JiangsuAges 60 years+ - NCT06401616RecruitingPhase 4
Stopping blood thinners after heart surgery for atrial fibrillation
This trial tests whether it is safe for patients with atrial fibrillation to stop taking blood thinners after they have had heart surgery, including closure of the left atrial appendage. The goal is to see if these patients can avoid long-term medication without increasing the risk of stroke.
Copenhagen, Capital RegionAges 18 years+
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Common questions
- Are there clinical trials for cardiac surgery?
- Yes. Clin2 currently lists 311 recruiting cardiac surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cardiac surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cardiac surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.