Clinical trials
Cardiac Valve Disease clinical trials
Below are recruiting cardiac valve disease clinical trials, each written for real people, not researchers. We’re tracking 131 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04882488Recruiting
Testing heart scan measurements in severe aortic valve narrowing
This trial compares two pressure-based measurements of blood flow in the coronary arteries with a PET heart scan in people with severe aortic valve stenosis. It may help doctors choose the most accurate way to assess blood flow and guide care during valve treatment.
Bad Oeynhausen, North Rhine-WestphaliaAges 65 years+ - NCT05628779Enrolling by invitation
Clip procedure to repair a leaking tricuspid valve
This trial studies a minimally invasive “edge-to-edge” clip procedure to reduce severe leakage of the tricuspid valve. It’s for people who still feel unwell despite standard treatments and may be too high-risk for open-heart surgery.
AmsterdamAges 18 years+ - NCT07466745Recruiting
New Pulmonary Valve Study for Kids Needing Replacement
This study tests a new type of replacement valve for children who need a new pulmonary valve (the valve between the heart and lungs). Researchers want to see if the valve works safely and well in real-world use.
Los Angeles, CaliforniaAges 1.5 years–16 years - NCT07042529Recruiting
Optimizing valve placement during TAVI
This trial is testing a better way to position a new heart valve during a TAVI procedure. The goal is to help the valve work as well as possible for people with severe aortic stenosis.
AalstAges 18 years+ - NCT07213531Recruiting
AI guidance for heart valve treatments
This trial uses artificial intelligence to improve outcomes for patients getting minimally invasive heart valve procedures. It looks at CT scans and ultrasound images to help doctors plan and perform treatments for the aortic, mitral, and tricuspid valves.
New York, New YorkAges 18 years+ - NCT04408430Recruiting
Valve replacement for severe mitral valve disease in high-risk adults
This trial tests a less-invasive way to treat severe mitral valve problems using a transcatheter valve. It may help people who are too high-risk for standard open-heart mitral surgery by improving symptoms and heart function.
Gilbert, ArizonaAges 18 years+ - NCT06557616Recruiting
CoolCryo system for treating atrial fibrillation during mitral valve surgery
This trial tests a new tool called CoolCryo that freezes heart tissue to treat atrial fibrillation while you have mitral valve surgery. If you are already having this surgery and also have AF, this device could correct both problems at once.
BydgoszczAges 18 years+ - NCT07133984Recruiting
Heart imaging study for patients with low heart function and coronary artery disease
This study uses cardiac MRI to look at the heart in people with weakened heart muscle and blocked heart arteries. It may help doctors improve treatments like bypass surgery or stents.
Brooklyn, New YorkAges 18 years+ - NCT07612553Recruiting
Imaging study of calcium buildup on heart valves
This research compares two types of heart imaging scans to better see calcium deposits on the mitral valve (a valve in your heart). Researchers hope this helps doctors plan valve procedures more safely and accurately.
Milan, MilanAges 18 years+ - NCT05139589Recruiting
Collecting data from adults with heart valve infection
This study collects information about adults who are treated in Amsterdam UMC for infective endocarditis (a serious infection of the heart valves). The goal is to better understand this condition—especially for people undergoing heart valve surgery—by comparing them to similar surgery patients who do not have an infection.
Amsterdam, North HollandAges 18 years+ - NCT07390903Recruiting
Heart function test for difficult bypass weaning
This trial studies whether a heart ultrasound test called GLS can help predict complications when patients are taken off the heart-lung machine after heart surgery. It aims to improve management for better outcomes.
RomeAges 18 years+ - NCT07217392Recruiting
Study on pacing the left bundle branch area of the heart
This study tests a new way to place a pacemaker lead in the left bundle branch area of the heart. It may help people who need a pacemaker to see if this approach is safe and works well.
Rio de Janeiro, Rio de JaneiroAges 18 years+ - NCT06286358Recruiting
Heart and aorta imaging study for valve disease
This study uses a special recording device to see if heart and aorta problems can be detected earlier. It may help people with aortic valve disease or enlarged aorta decide on treatment.
BrusselsAges 18 years+ - NCT07016477Recruiting
Heart CT study for TAVI planning
This study is a registry (a collection of information) for people who are about to have a TAVI heart valve procedure. It will see how a new type of CT scanner (the NAEOTOM Alpha) can help doctors plan the procedure better.
Charleston, South CarolinaAges 18 years+ - NCT05930899Recruiting
Study tissue and blood samples from heart disease patients
This study builds a biobank, meaning it collects and stores your health information, blood, and possibly heart-related samples to help researchers learn why heart conditions happen. You might join if you have certain heart diagnoses and are having cardiac surgery for a problem other than an aortic valve issue.
Montreal, QuebecAges 19 years+ - NCT07130994Recruiting
Testing a new less invasive mitral valve replacement (SATURN)
This trial tests a new, less invasive device called the SATURN system to replace a severely leaky mitral heart valve without open-heart surgery. It is for people who are too high-risk for traditional surgery and are willing to take blood thinners.
Los Angeles, CaliforniaAges 18 years+ - NCT07095829Recruiting
Predicting circulation after birth for severe pulmonary valve blockage
This study looks at babies with a severe heart defect where the pulmonary valve is blocked and the wall between the heart's lower chambers is intact. It aims to predict how well blood will flow after birth using ultrasound images taken during pregnancy.
MadridAges 4 months–6 months - NCT06938412Recruiting
Exercise and Fitbit for Afib patients
This study tests whether using a Fitbit activity tracker and a supportive exercise program helps people with AFib become more active. It may help you feel better and manage your heart rhythm.
New York, New YorkAges 18 years+ - NCT07799363Recruiting
Heart imaging test comparison for patients getting a new heart valve
This study compares two heart imaging scans to see if a newer CT scan works as well as an MRI for checking blood flow and heart tissue in people having a heart valve replacement. It may help improve care for patients with aortic stenosis.
Huddinge, Stockholm CountyAges 60 years+ - NCT07604402Recruiting
Aortic Valve Replacement Without On-Site Surgery
This study tests a catheter-based procedure to replace a narrowed aortic valve without traditional open-heart surgery. It's designed for patients who are at higher risk for surgery due to age, health conditions, or anatomy.
AndriaAges Any age - NCT07416279Recruiting
Can tiny bubbles replace catheters for heart pressure checks?
This trial tests if tiny ultrasound contrast bubbles can measure heart pressure, possibly replacing the need for catheter tubes. If you're already getting a heart catheterization, you may be able to join.
LondonAges 21–81 - NCT07661940RecruitingPhase 2
SP16 for kidney protection during heart surgery
This trial tests a drug called SP16 to see if it can prevent acute kidney injury in people with chronic kidney disease who are having elective heart surgery with a heart-lung machine. It aims to help preserve kidney function after surgery.
Erlangen, BavariaAges 18 years+ - NCT05631730RecruitingPhase 3
Flecainide plus metoprolol vs metoprolol alone for rhythm control
This trial studies whether adding flecainide to metoprolol can better reduce dangerous heart rhythm problems in people with mitral valve prolapse. It also checks safety and side effects compared with metoprolol alone.
OsloAges 18 years+ - NCT06077201Recruiting
Home-based heart rehab after valve procedure
This study tests a home-based exercise program using a mobile app and activity tracker for people who have had a heart valve procedure. It aims to help you safely recover and improve your fitness at home.
Nashville, TennesseeAges 18 years+
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Common questions
- Are there clinical trials for cardiac valve disease?
- Yes. Clin2 currently lists 131 recruiting cardiac valve disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cardiac valve disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cardiac valve disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.