Clinical trials · Ohio
Cardiomyopathies clinical trials in Ohio
We’re tracking 34 recruiting cardiomyopathies studies with a site in Ohio — including Phase 1, Phase 1/Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Ohio
- NCT07052903RecruitingPhase 3
RNA therapy for ATTR amyloidosis with heart involvement
This trial tests an experimental RNA therapy (nucresiran) for people with transthyretin amyloidosis that causes heart problems (cardiomyopathy). It aims to lower the abnormal protein buildup to help heart function.
Cleveland, OhioAges 18–85 - NCT05180773RecruitingPhase 4
Bromocriptine for new postpartum heart weakness
This trial studies whether bromocriptine improves health outcomes in people recently diagnosed with peripartum cardiomyopathy (a weakened heart during late pregnancy or soon after delivery). You may be asked about timing after childbirth, heart strength tests, and whether you plan to keep breastfeeding.
Cleveland, OhioAges 18 years+ - NCT07606274RecruitingPhase 1/Phase 2
Study of NVC-001 for heart muscle disease caused by LMNA gene change
This trial tests an experimental drug called NVC-001 for people with a specific genetic heart condition (LMNA-related dilated cardiomyopathy) that causes the heart to become weak and enlarged. The goal is to see if the drug can help improve heart function.
Cincinnati, OhioAges 18 years+ - NCT06224660RecruitingPhase 1
Gene therapy for heart problems in Duchenne muscular dystrophy
This trial tests an experimental therapy for heart weakness caused by Duchenne muscular dystrophy. It aims to improve how heart cells handle calcium to protect heart function.
Columbus, OhioAges 18 years+ - NCT07210723RecruitingPhase 2/Phase 3
Study of danicamtiv for genetic and familial dilated cardiomyopathy
This trial tests if danicamtiv can improve heart function in people with dilated cardiomyopathy caused by certain genetic changes. It may help those who have stable symptoms but still need more treatment options.
Cincinnati, OhioAges 18 years+ - NCT05965258Recruiting
Classify mitral regurgitation using heart scans
This study uses heart imaging to better understand different types of mitral valve leak (mitral regurgitation) and how it relates to heart pumping function. Results may help doctors match people to the most appropriate care based on scan “patterns.”
Cleveland, OhioAges 18 years+ - NCT07218887RecruitingPhase 1/Phase 2
A study of ALXN2350 for BAG3-related heart muscle disease
This trial tests a new medicine, ALXN2350, for adults whose dilated cardiomyopathy (a weakened, enlarged heart) is caused by a mutation in the BAG3 gene. The goal is to see if it can help the heart pump better.
Cincinnati, OhioAges 18–70 - NCT06563895RecruitingPhase 3
Testing acoramidis to prevent ATTR amyloidosis in gene carriers
This trial tests a daily pill called acoramidis to see if it can prevent ATTR amyloidosis in people who carry a gene mutation but have no symptoms yet. It aims to stop the disease before it starts.
Cleveland, OhioAges 18–75 - NCT07081711Recruiting
Testing new heart MRI technology in volunteers
This study is testing a new way to take pictures of the heart using MRI. It is looking for healthy volunteers to help make sure the technology works correctly.
Cleveland, OhioAges 18 years+ - NCT05112237Recruiting
Study of children’s heart disease caused by MYBPC3 gene changes
This is an observational study that follows children under 18 with cardiomyopathy caused by certain MYBPC3 gene mutations. It aims to better understand how the disease changes over time, which may help future treatments be better targeted.
Middlefield, OhioAges birth–18 years - NCT05489705Recruiting
Real-world registry for mavacamten and other obstructive HCM treatments
This study collects real-world information about people with obstructive hypertrophic cardiomyopathy (HCM) who are being treated with mavacamten or other standard medicines. It aims to understand patient characteristics, treatment choices over time, and long-term outcomes.
Cincinnati, OhioAges 18 years+ - NCT05654272Recruiting
Testing CIRC imaging technology for people with heart problems
This study is developing and testing CIRC technologies using heart imaging. You may be able to join if you’re an adult with cardiovascular (heart) disease and can safely have the MRI scans.
Cleveland, OhioAges 18 years+ - NCT06128629RecruitingPhase 3
A study of NTLA-2001 for transthyretin amyloidosis with heart problems
This study tests a new treatment, NTLA-2001, for people with a type of heart disease called transthyretin amyloidosis with cardiomyopathy. It aims to see if the medicine can help improve heart function and quality of life.
Columbus, OhioAges 18–90 - NCT06311708Recruiting
PKP2-related heart condition natural history study
This study looks at how plakophilin 2 (PKP2)-related arrhythmogenic right ventricular cardiomyopathy (ARVC) progresses over time. You'll give blood samples to check for antibodies to a virus used in gene therapy, and help doctors understand the disease better.
Cleveland, OhioAges 14–65 - NCT07674758Recruiting
Understanding heart risk in Duchenne and Becker muscular dystrophy
This study looks at heart health in people with Duchenne or Becker muscular dystrophy to find better ways to predict and track heart problems. The goal is to improve future treatment trials.
Columbus, OhioAges Any age - NCT06679946Enrolling by invitationPhase 3
Study of Vutrisiran for heart condition from TTR amyloidosis
This study tests a drug called vutrisiran for people with a condition called transthyretin amyloidosis that affects the heart. It is for patients who have already been in certain earlier studies of patisiran or vutrisiran.
Columbus, OhioAges 18 years+ - NCT06461468Enrolling by invitation
AI study for hypertrophic cardiomyopathy using heart tests
This study uses artificial intelligence to analyze ECGs and echoes from people with hypertrophic cardiomyopathy (HCM) to improve how the disease is detected and managed. If you have HCM with a thickened heart wall and available heart tests, you may help train the AI.
Wooster, OhioAges 18 years+ - NCT05667493Enrolling by invitationPhase 3
Long-term safety follow-up for eplontersen in ATTR heart disease
This is a long-term study to check the safety of eplontersen over time in adults with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM). It is mainly for people who already took the study medication before, or who joined an earlier related study and are doing well.
Cleveland, OhioAges 18 years+ - NCT07207811RecruitingPhase 3
Study of coramitug for heart failure from ATTR amyloidosis
This study tests an investigational medicine called coramitug in people with heart failure caused by ATTR amyloidosis, a condition where abnormal protein builds up in the heart. The goal is to see if it can slow or improve heart function.
Cincinnati, OhioAges 18 years+ - NCT05034432RecruitingPhase 4
Test treatment for dangerous heart rhythm episodes in LVAD patients
This trial studies a procedure to fix abnormal heart rhythms (ventricular tachycardia or ventricular fibrillation) in people who have an LVAD and a defibrillator (ICD) or an alternative device. It may help prevent future dangerous rhythm episodes after LVAD treatment.
Cleveland, OhioAges 18 years+ - NCT04080492Recruiting
Quality of life study for heart disease patients
This study asks people with certain heart conditions to complete follow-up questionnaires to better understand how their quality of life changes over time. It may help improve how care plans are made and supported for patients and their families.
Cleveland, OhioAges 18–70 - NCT04504188Recruiting
Adjusting beta-blocker dose for women using a wearable defibrillator
This trial checks whether doctors can use a lower or adjusted dose of beta-blocker medicine in women who are wearing a wearable defibrillator (WCD). It aims to find an approach that’s safe and works while you’re using the device for about 3 months to protect your heart.
Cincinnati, OhioAges 18 years+ - NCT05427370Recruiting
Compare bypass or stent treatment in weak heart patients
This study compares two ways to restore blood flow to the heart—bypass surgery (CABG) or stent procedure (PCI)—in people with a weak pumping heart. It looks at which approach works best when the heart muscle is not pumping well and there are multiple blocked heart arteries.
Cleveland, OhioAges 18 years+ - NCT05489549Recruiting
Study of heart amyloid risk in people with TTR gene variants
This study looks at people who carry certain TTR gene variants, which can cause a specific type of heart amyloid buildup. It also includes people with symptoms, to understand how the condition develops and how it may be monitored.
Cleveland, OhioAges 30–80
Cardiomyopathies trials by city in Ohio
Where these studies are running in Ohio
Institutions with a site for the recruiting cardiomyopathies studies listed above.
- Cleveland Clinic · 12 studies
- The Christ Hospital · 5 studies
- University Hospitals Cleveland Medical Center · 4 studies
- The Ohio State University Wexner Medical Center · 3 studies
- Cincinnati Children's Hospital Medical Center · 2 studies
- Clinical Trial Site · 2 studies
- Nationwide Children's Hospital · 2 studies
- Cardiovascular Innovation Research Center
What taking part in a cardiomyopathies study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cardiomyopathies trials in other states
Common questions
- Are there cardiomyopathies clinical trials in Ohio?
- Yes. We're currently tracking 34 recruiting cardiomyopathies studies with a site in Ohio, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cardiomyopathies study in Ohio?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Ohio to take part?
- Not necessarily. These studies have a site in Ohio, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cardiomyopathies trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cardiomyopathies studies open in Ohio regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.