Clinical trials
Chronic Kidney Disease (Stages 4 and 5) clinical trials
Below are recruiting chronic kidney disease (stages 4 and 5) clinical trials, each written for real people, not researchers. We’re tracking 112 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05465044Recruiting
Twice-weekly dialysis for veterans starting kidney treatment
This study compares starting hemodialysis two times per week versus three times per week for veterans in their first year of dialysis. It aims to see if a less frequent schedule can be just as safe and effective for those who still make urine.
Long Beach, CaliforniaAges 18 years+ - NCT07592000RecruitingPhase 1/Phase 2
New Treatment for Type 1 Diabetes With Kidney Disease
This study tests a new experimental medication for people with type 1 diabetes who experience dangerous low blood sugar episodes and have early-stage kidney disease. The trial aims to help improve blood sugar control and reduce these risky episodes.
Miami, FloridaAges 18–70 - NCT05846581Recruiting
Dialysis graft registry for adults getting a new vascular graft
This registry follows adults with kidney failure who need a dialysis access connection in the arm using the GORE ACUSEAL graft. It helps track outcomes and safety over time while you receive standard dialysis care.
BielefeldAges 18 years+ - NCT05705414RecruitingEarly Phase 1
Amino acid supplement during dialysis to improve energy in kidney disease
This early-stage study tests whether taking amino acids during hemodialysis can help people with end-stage kidney disease feel better and maintain strength. It may help by supporting nutrition during dialysis, but it’s mainly meant to gather early safety and benefit information.
San Antonio, TexasAges 18–64 - NCT07754097Recruiting
Tracking your health at home for chronic kidney disease
This study tests if regularly tracking your blood pressure, diet, and medications through a mobile app can help monitor kidney disease progression. It aims to see if this self-management approach helps you stay healthier.
Daejeon, DJAges 19–84 - NCT05071131Recruiting
Inulin supplement to improve gut health in kidney disease
This trial studies whether taking inulin—a dietary fiber—can improve gut bacteria and the gut barrier in people with end-stage kidney disease on hemodialysis. It may help reduce gut-related problems that can affect overall health in kidney disease.
BerlinAges 18–75 - NCT06466785RecruitingPhase 3
Study of Efepoetin Alfa for anemia in kidney dialysis patients
This study tests a new drug called Efepoetin Alfa to treat anemia in people with chronic kidney disease who are on dialysis. The goal is to see if it can safely raise red blood cell levels and reduce the need for other anemia treatments.
YerevanAges 18 years+ - NCT07741279Recruiting
Enarodustat for anemia in chronic kidney disease patients
This study tests a daily pill that helps people with chronic kidney disease and anemia make more red blood cells, which may reduce the need for other anemia treatments. It is for patients who are not on dialysis and do not plan to start dialysis or have a kidney transplant within the next six months.
Shanghai, Shanghai MunicipalityAges 18–85 - NCT07544524Recruiting
Plant-Based Diet for Kidney Disease in Asian Adults
This study tests whether eating mostly plants (with some animal products) can safely help people with moderate kidney disease. Researchers will compare this diet to a standard kidney-friendly diet and see how it affects kidney function and overall health.
SingaporeAges 21–79 - NCT07187479Recruiting
Testing a new insulin approach for kidney disease and diabetes
This study tests a new approach to help your body use insulin better, which may improve blood sugar control and slow down kidney disease. It is for people with advanced chronic kidney disease and type 2 diabetes who are not yet on dialysis.
Phoenix, ArizonaAges 18 years+ - NCT07741292RecruitingPhase 4
Kidney health study for older adults not on dialysis
This study tests whether a traditional Chinese medicine called Niaoduqing Granules can help improve kidney function in people over 60 with chronic kidney disease. It may offer a new way to manage the condition without dialysis.
Shanghai, Shanghai MunicipalityAges 61 years+ - NCT06329622RecruitingPhase 3
Does Ketosteril help muscle loss in kidney disease?
This study tests whether a medicine called Ketosteril can improve muscle strength and function in people with moderate to severe chronic kidney disease (CKD) who also have sarcopenia (age-related muscle loss).
ShanghaiAges Any age - NCT04185844Recruiting
Chronic kidney health study for Native American adults
This study follows Native American adults with kidney function changes (either moderately reduced kidney filtration or early urine protein). It aims to better understand kidney disease over time and what factors predict progress, which may help improve care for people like you.
Phoenix, ArizonaAges 21–80 - NCT04522622RecruitingPhase 4
Teriparatide for low bone turnover in advanced kidney disease
This trial tests teriparatide (a hormone-like bone medicine) to improve bone health in people with advanced chronic kidney disease who are at risk for weak, low-turnover bone. It may help by changing how quickly your bones break down and rebuild.
AalborgAges 18–120 - NCT04671771Recruiting
Testing a new graft for hemodialysis access in kidney failure
This study tests whether an “AV graft” implant works safely and well for people with end-stage kidney disease who need hemodialysis. It may help your dialysis access last and work better, compared with current expectations for AV grafts.
Phoenix, ArizonaAges 18–90 - NCT04708587Recruiting
Choosing the right anti-platelet duration for advanced kidney disease
This study looks at the best length of anti-platelet medicine (which helps prevent stent clots) after a new type of heart stent. It specifically focuses on people with advanced chronic kidney disease, where bleeding and clot risks can be higher.
SeoulAges 19–84 - NCT06712654RecruitingPhase 2
Testing AP306 for high phosphate in dialysis patients
This trial tests a new medication called AP306 for people on hemodialysis who have high blood phosphate. It aims to see if the drug is safe, tolerable, and helps lower phosphate levels.
Huntsville, AlabamaAges 18 years+ - NCT05149196Recruiting
Goal-directed fluid and blood pressure plan after kidney surgery
This trial tests a carefully tailored plan for managing blood pressure and fluid during and after kidney removal surgery, to help reduce kidney injury after surgery. It may be especially helpful if you’re having one kidney removed for cancer and your baseline heart/kidney risk is not too high.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05525507RecruitingPhase 1
Test early immune-tolerance treatment for matched kidney transplant patients
This Phase 1 study tests a treatment plan given after a kidney transplant to help the immune system stay calm and reduce the risk of rejection. Participants must have a well-functioning kidney transplant from a closely matched living donor and meet health and safety requirements.
Los Angeles, CaliforniaAges 18 years+ - NCT05679024RecruitingPhase 3
Apixaban to prevent stroke in atrial fibrillation and kidney failure
This trial tests apixaban (a blood thinner) to prevent stroke in people with atrial fibrillation or atrial flutter who have very poor kidney function or are on dialysis. If you qualify, you may help researchers find a safer way to lower stroke risk for this higher-risk group.
HelsinkiAges 18 years+ - NCT05944016RecruitingPhase 3
Dapagliflozin for early Alport kidney disease in teens and young adults
This trial tests dapagliflozin, a daily medicine, to slow kidney problems in people with early-stage chronic kidney disease caused by Alport syndrome. It may help protect kidney function and reduce worsening over time.
Heidelberg, Baden-WürttenbergAges 10–39 - NCT05970172RecruitingPhase 3
Roxadustat for anemia in kids with chronic kidney disease
This study tests roxadustat, a medicine that helps the body make more red blood cells, in children and teens with anemia caused by chronic kidney disease. It may help improve anemia and related blood counts, while also monitoring safety.
BrusselsAges 2–17 - NCT06155604RecruitingPhase 2
SGLT2 inhibitor for lupus nephritis with kidney disease
This study tests if an SGLT2 inhibitor can help protect kidney function in people who have lupus nephritis (kidney inflammation caused by lupus) and chronic kidney disease (CKD). The goal is to see if this medicine can slow down further kidney damage.
Hong KongAges 18 years+ - NCT06173323Recruiting
Improving decision-making for kidney disease patients and their caregivers
This study tests a program to help people with advanced chronic kidney disease (stage 4 CKD) and their caregiver work together on medical decisions. It aims to see if the program improves communication and partnership.
Birmingham, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for chronic kidney disease (stages 4 and 5)?
- Yes. Clin2 currently lists 112 recruiting chronic kidney disease (stages 4 and 5) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic kidney disease (stages 4 and 5) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic kidney disease (stages 4 and 5) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.