Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 793 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04673981Recruiting
Follow-up study for oral and throat cancer pain
This study looks at nerve-related symptoms and pain in the mouth and throat in people who have been treated for oral or oropharynx cancer. You may be able to take part if you’re within 1 to 5 years after treatment and can follow study steps.
Clermont-FerrandAges 18 years+ - NCT06076512Recruiting
Pain clinic safety trial for adults with chronic pain
This trial is testing whether a pain clinic can improve public health safety for adults who have chronic pain and also face social or emotional challenges. It aims to see if this kind of care helps people feel better and avoids opioid-related harms.
Surrey, British ColumbiaAges 20–99 - NCT07415941Recruiting
Mindfulness and nerve stimulation for back pain and depression
This trial tests if combining mindfulness-based meditation with a gentle nerve stimulation device (applied to the ear) can help people aged 50–85 with chronic low back pain and depression. The goal is to reduce pain and improve mood without changing your current medications.
Tallahassee, FloridaAges 50–85 - NCT06223503Recruiting
Pain support service study for veterans after surgery
This study tests a telehealth pain support program for veterans having orthopedic surgery. It aims to help manage pain after surgery and reduce the need for long-term opioid use.
Salt Lake City, UtahAges 18 years+ - NCT05843890Recruiting
Personalized pain guide for chronic low back pain
This study tests a tailored (personalized) pain guide to help people with long-lasting lower back pain. It may help by teaching strategies to reduce how pain interferes with daily life.
Ann Arbor, MichiganAges 18 years+ - NCT07650526Recruiting
Brain Stimulation for Nerve Pain Relief
This study tests two types of magnetic brain stimulation (aiTBS and rTMS) to treat long-lasting nerve pain. Researchers want to see which approach works better and develop a way to predict who will benefit most.
Boulogne-Billancourt, Île-de-France RegionAges 18–80 - NCT03877653Recruiting
Freedom-1 treatment for long-term knee pain in adults
This study tests a procedure called Freedom-1 to reduce long-term, limiting knee pain from knee arthritis. It may help if other non-surgical options didn’t work and you meet specific knee and health requirements.
Placentia, CaliforniaAges 18 years+ - NCT07328256Recruiting
Comparing two muscle relaxation techniques for neck pain relief
This study looks at two different gentle stretching methods to see which works better for relieving neck pain. It might help if you have had neck pain for a while and it limits your movement.
Islamabad, Punjab ProvinceAges 19–44 - NCT07166952Recruiting
Nerve Stimulation for Chronic Sacroiliac Joint Pain
This study tests whether the SPRINT system, a device that uses mild electrical pulses to block pain signals from the sacroiliac joint, can help people with chronic pain in that area. It aims to see if this treatment works well for those who have not improved with other therapies.
Charleston, South CarolinaAges 18 years+ - NCT07040605Recruiting
Neck exercises for chronic pain
This study tests a special set of exercises for your neck muscles to help with chronic neck pain. It focuses on strengthening deep muscles and improving how your body senses neck movement.
Cairo, Giza GovernorateAges 20–40 - NCT06472622RecruitingEarly Phase 1
Brain imaging study of pain and effort
This study uses brain scans to understand how people experience pain and effort. It compares healthy volunteers to people with ME/CFS to see if there are differences in brain activity.
Bethesda, MarylandAges 18–50 - NCT07818980Recruiting
An online pain management program for Canadian veterans
This study is testing an online pain management program designed for Canadian veterans. If you have chronic pain, joining could help you learn ways to manage pain from home.
Toronto, OntarioAges 18–80 - NCT06704490Recruiting
Chronic pain after planned cesarean section
This study looks at how common chronic pain is after a planned cesarean section and what factors might increase that risk. It could help doctors better prevent and manage long-term pain after delivery.
Wuhan, HubeiAges 20–50 - NCT06623669RecruitingPhase 2
Mobile program to reduce pain and improve health in older adults
This trial tests a mobile program to help reduce pain and improve health in older adults with knee or hip arthritis who are not very active. The program involves exercise and may help with weight management.
Winston-Salem, North CarolinaAges 65 years+ - NCT06384664Recruiting
Freezing Nerves to Reduce Pain After Chest Surgery
This study tests whether freezing a nerve (cryoablation) during chest surgery can reduce pain after the operation. It might help patients who are having their first chest surgery and have never used strong painkillers.
Ann Arbor, MichiganAges 18 years+ - NCT06183281Recruiting
Comparing two non-drug approaches for chronic pain
This study compares two different ways to help people manage chronic pain without using medications. Over 12 months, you'll use a smartphone app and learn strategies to feel better and have more control over your pain.
San Francisco, CaliforniaAges 18 years+ - NCT05989230Recruiting
Emotional awareness therapy for pain after orthopedic injury
This trial tests a therapy that helps people understand and express their emotions to manage long-term pain after a serious bone injury. It may help if you have had pain most days for at least three months following surgery for an orthopedic injury.
Baltimore, MarylandAges 18 years+ - NCT06796881Recruiting
Comparison of two therapies for long-term low back pain
This study compares two hands-on treatments for people with chronic low back pain. One uses special tools to massage tight muscles, while the other uses gentle pressure on muscle knots. Both aim to help you move better and feel less pain.
CairoAges 25–45 - NCT07306312Enrolling by invitation
How thoughts affect low back pain with manual therapy
This study looks at how your thoughts and feelings about your chronic low back pain affect your pain and ability to move, during a course of manual therapy (hands-on treatment by a therapist). It may help you understand if your mindset influences your recovery.
AthensAges 18–65 - NCT04144972Recruiting
Closed-loop deep brain stimulation for long-lasting nerve pain
This trial tests a “smart” deep brain stimulation device that senses your brain signals and adjusts treatment to reduce severe, long-lasting pain. It may help people whose pain has not improved with multiple pain medicines and surgery cannot fix the cause.
San Francisco, CaliforniaAges 22–80 - NCT06544525Recruiting
Pain test to predict physical therapy results for back pain
This trial tests whether a simple pain test can predict how much you will improve with physical therapy for chronic low back pain. It looks at how your body naturally handles pain, which may help tailor your treatment.
Fort Sam Houston, TexasAges 18–64 - NCT03270631Enrolling by invitation
Exercises and soft-tissue work for chronic low back pain
This study tests whether a combination of guided movement exercises and “fascial manipulation” (hands-on work on soft tissue) can help people with long-lasting low back pain. It may be an option if your back pain has not improved with non-surgery treatments or if you have post-surgery back pain.
OuluAges Any age - NCT07674836Recruiting
Comparing two nerve blocks for chronic pain after breast surgery
This study tests two types of nerve blocks (SPSIP and ESP blocks) to see which one works better for long-term pain after a single-sided breast surgery like mastectomy. It aims to find a safer, more effective way to manage chronic pain after surgery.
İzmit, KocaeliAges 18–65 - NCT05483816Recruiting
Sensory stimulation trial for nerve pain in people with neuropathy
This study tests a multi-sensory (multiple-sense) stimulation approach to see if it can help people with nerve-related pain in the legs/feet. You must be able to safely take part in MRI-related sessions and answer questions about pain and health history.
Zurich, Canton of ZurichAges 18–80
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Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 793 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.