Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 793 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06574009RecruitingPhase 4
Better options for chronic cancer pain in veterans
This study tests if switching from long-term opioid painkillers to buprenorphine (a different type of pain medication) can provide better pain relief for veterans who have had cancer but are currently cancer-free. It aims to find a safer and more effective way to manage chronic pain.
Indianapolis, IndianaAges 18–99 - NCT06555107Recruiting
Pain before emergency surgery and long-term pain after
This study looks at whether pain you feel before emergency surgery affects long-term pain after the surgery. It may help doctors find ways to prevent chronic pain in patients who have emergency orthopedic (bone/joint) or abdominal (belly) surgery.
AmiensAges 18 years+ - NCT06544291RecruitingPhase 2
THC and CBD for pain and opioid use disorder
This study tests whether a combination of THC and CBD can help people who have both opioid use disorder and chronic low back pain. You would need to be on a stable dose of methadone and have used cannabis at least once in your life.
New Haven, ConnecticutAges 18–65 - NCT06512727Recruiting
Pain management study for Black older adults with long-term joint pain
This study tests two different approaches to help Black adults aged 50–92 manage chronic muscle or joint pain in their hips, knees, lower back, or ankles. It aims to find which method works better to reduce pain and improve daily life.
Gainesville, FloridaAges 50–92 - NCT06480786Recruiting
Spinal cord stimulator for diabetic nerve and artery pain
This study tests if a spinal cord stimulator (a device that sends mild electrical pulses to the spine) can relieve severe leg pain caused by diabetic nerve damage and poor blood flow. It may help people who have not found enough relief from other treatments.
Omaha, NebraskaAges 19–89 - NCT06471075Recruiting
Mindfulness for Pain Before Orthopedic Procedure
This study tests whether a short mindfulness (calm focus) exercise before an in-clinic orthopedic procedure can help reduce pain. If you are getting kyphoplasty or radiofrequency ablation at Tallahassee Orthopedic Center, this brief program might make your experience more comfortable.
Tallahassee, FloridaAges 18 years+ - NCT06407115Enrolling by invitation
Pain care support for rural patients
This study tests a nurse-led program to help people living in rural areas manage chronic pain. You'll work with a care manager who can support your pain treatment goals.
Winston-Salem, North CarolinaAges 18 years+ - NCT06387290RecruitingPhase 3
Mindfulness and pain management for chronic pain on opioids
This study tests whether adding mindfulness training to standard pain management visits can help people with chronic pain who are taking long-term opioids. It aims to improve pain relief and reduce opioid-related risks.
La Jolla, CaliforniaAges 18 years+ - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT06345872Recruiting
Better sleep to help reduce opioid use for chronic pain
This study tests a sleep improvement program to help people with chronic widespread pain reduce or stop their opioid pain medication. If you want to cut back on opioids and have trouble sleeping, this treatment might be a good fit.
Tampa, FloridaAges 18 years+ - NCT06350786Recruiting
Using a placebo to help reduce opioid pain medication
This trial tests whether a special placebo pill, given with your knowledge, can help you reduce your opioid pain medication. You'll work with your own doctor to safely lower your dose while taking the placebo.
Zurich, Canton of ZurichAges 18 years+ - NCT06299683Recruiting
Pain type and bladder pain syndrome treatment study
This study is testing if the type of pain you feel can help predict which treatments work best for interstitial cystitis (a condition that causes bladder pain and pressure). It may help match you with more effective care.
Franklin, TennesseeAges 18 years+ - NCT06208514Recruiting
Brief Pain Exposure Therapy for chronic pain conditions
This study tests a type of talk therapy called Brief Pain Exposure Therapy (BPET) for people with certain chronic pain conditions like fibromyalgia, lupus, or chronic low back pain. It aims to help reduce pain by changing how your brain responds to it.
Ann Arbor, MichiganAges 18 years+ - NCT06225817Recruiting
Can a placebo help with chronic jaw pain and sleep?
This study is testing whether a placebo (a pill with no medication) can help improve sleep and reduce pain for people with long-term jaw or face pain. Researchers want to see if just expecting relief can change how your body handles pain.
Baltimore, MarylandAges 18–88 - NCT06205342RecruitingEarly Phase 1
Stem cell treatment for chronic pancreatitis pain
This trial tests whether a new stem cell treatment can reduce the pain of chronic pancreatitis. It aims to improve your quality of life by easing long-term pain.
Charleston, South CarolinaAges 18–75 - NCT06123715RecruitingPhase 2
Vitamin C to reduce pain after knee replacement
This study tests whether taking vitamin C before and after knee replacement surgery can reduce long-term pain. You may be eligible if you are having knee replacement for osteoarthritis and are generally healthy.
Toronto, OntarioAges 18 years+ - NCT06058624Recruiting
Digital pain management program for veterans
This study tests a new digital program that helps veterans with long-term pain learn to accept and cope with it. You would use a computer at home to complete the program and share your feedback.
West Haven, ConnecticutAges 18 years+ - NCT06019793Enrolling by invitation
Recording brain signals during deep brain stimulation for pain
This study tests whether recording brain activity during deep brain stimulation (DBS) for chronic pain can help improve future treatments. It is for people with long-lasting, severe pain that hasn't been helped by other treatments.
Phoenix, ArizonaAges 22 years+ - NCT05963607Recruiting
Weighted blanket trial to reduce chronic pain
This study tests whether using a 15-pound weighted blanket can lower pain and improve sleep for Veterans with long-lasting, non-cancer musculoskeletal pain. It may help by reducing discomfort during rest and sleep.
San Diego, CaliforniaAges 18 years+ - NCT05925036RecruitingPhase 1
Cell therapy trial for pain from long-term pancreatitis
This Phase 1 study tests a new cell-based treatment to reduce pain caused by chronic pancreatitis. It’s designed mainly to check safety first, and it may help people with ongoing, opioid-stable pancreatic pain.
Charleston, South CarolinaAges 18–75 - NCT05920382Recruiting
Radiofrequency treatment for long-term knee pain after knee surgery
This trial studies whether a radiofrequency procedure can reduce chronic knee pain after knee replacement surgery. It may help people who still have bothersome pain between 6 months and 5 years after their operation, as long as their pain pattern and medications are stable.
Barcelona, CataloniaAges 18 years+ - NCT05689944Recruiting
Dance therapy for teens with chronic pain
This trial studies whether dance therapy can help reduce chronic pain in teens when usual pain treatments haven’t worked well. It may be helpful if you’re followed in a pain clinic and are able to participate in movement-based sessions.
BronAges 12–20 - NCT05612750Recruiting
Online therapy for chronic pain: CBT vs one-session relief
This study compares two online treatments for chronic pain: an 8-session cognitive behavioral therapy (CBT) program versus a single “empowered relief” session. It aims to see which approach helps people manage pain better over time.
Phoenix, ArizonaAges 18 years+ - NCT05477004Enrolling by invitation
Study of ketamine infusions for ongoing chronic pain
This study is observing people with chronic pain who are getting ketamine infusions at Stanford. You may help by completing email surveys about how you feel, which can help the team understand the treatment’s impact.
Stanford, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 793 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.