Clinical trials
Chronic Postoperative Pain clinical trials
Below are recruiting chronic postoperative pain clinical trials, each written for real people, not researchers. We’re tracking 296 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07733128Recruiting
Pain relief with buprenorphine patch after lung surgery
This study tests a skin patch that releases buprenorphine, a pain medicine, to control pain after lung surgery. It may help reduce pain and the need for other pain medicines.
Santiago, Santiago MetropolitanAges 18 years+ - NCT07730216Recruiting
Ultrasound-Guided Knee Block Study for Knee Replacement
This study looks at whether using ultrasound to guide a numbing injection around the knee can improve pain control after knee replacement surgery. It aims to make recovery more comfortable.
Konya, KonyaAges 18 years+ - NCT07729488Recruiting
Nerve blocks for better recovery after lung surgery
This study compares two types of nerve blocks to see which one helps people recover better after lung surgery. It tests a block around the spine versus one near the shoulder blade to improve comfort and recovery.
Diyarbakır, Outside of the USAges 18–85 - NCT07689162RecruitingPhase 2
Long-acting vs standard numbing for nose surgery pain
This study compares two types of numbing medicine used during open rhinoplasty (nose surgery) to see which one controls pain better after surgery. One is a long-acting version (liposomal bupivacaine) and the other is the standard numbing medicine (bupivacaine).
St Louis, MissouriAges 18 years+ - NCT07695935Recruiting
Pain relief after hernia repair: nerve block vs low-dose morphine
This study compares two ways to manage pain after open inguinal hernia repair: a nerve block (injection near the abdominal muscles) versus a low-dose painkiller (morphine) given through the spinal needle. The goal is to find which method provides better relief with fewer side effects.
ÇorumAges 18–80 - NCT07681648Enrolling by invitationPhase 4
Nerve blocks vs local numbing for lumbar spine surgery
This study compares two types of nerve blocks (a longissimus plane block and a multifidus plane block) to a local numbing injection for pain control during lumbar spine surgery. It aims to find which method works best for patients having back surgery.
Aswān, Aswan GovernorateAges 18–65 - NCT07672418Recruiting
Pain relief after tonsil surgery: ibuprofen vs. ketorolac
This study compares two common pain relievers (ketorolac and ibuprofen) given after tonsil/adenoid surgery in teenagers. It aims to see which works better while keeping side effects low.
Houston, TexasAges 13–18 - NCT07676942Recruiting
Pain relief options after urethral surgery
This study compares two medications given during surgery to see which one better manages pain after urethral reconstruction. It aims to improve recovery and comfort after the procedure.
WarsawAges 18 years+ - NCT07668648Recruiting
Two nerve blocks for shoulder surgery pain relief
This study compares two types of nerve blocks to reduce pain after shoulder surgery. One block is placed near the neck (interscalene) and the other is placed further away (serratus posterior superior intercostal plane block). The goal is to see which works better and has fewer side effects.
Bursa, NilüferAges 18–75 - NCT07655323Recruiting
RISS vs. ESP Block for Gallbladder Surgery Pain
This study compares two types of nerve blocks (RISS and ESP) to manage pain after gallbladder removal surgery. It aims to find which block provides better pain relief.
Bursa, NilüferAges 18–75 - NCT07655336Recruiting
Nerve block comparisons for lung-sparing chest surgery
This trial compares two types of nerve blocks to manage pain during and after a type of lung surgery that removes only part of the lung. It aims to find which block provides better pain relief and recovery.
Bursa, NilüferAges 18–75 - NCT07659990Recruiting
Comparing two nerve blocks for mastectomy pain relief
This study compares two types of nerve blocks given before a mastectomy (breast removal surgery) to see which one provides better pain relief. If you are having a mastectomy on one side with lymph node removal, you may be able to join.
Bursa, NilüferAges 18–75 - NCT07653490Recruiting
Two anesthesia methods for gallbladder surgery
This study tests whether a numbing injection in the back (erector spinae plane block) helps reduce anesthesia needs during gallbladder surgery. It compares two anesthesia methods to see which works better for pain control and recovery.
IstanbulAges 18–65 - NCT06015165Recruiting
Pain control plan for complex anorectal surgery
This study tests a pain management plan led by anesthesiologists for people having complex anorectal surgery. The goal is to see if this approach can better control pain and improve recovery.
Beijing, Beijing MunicipalityAges 18–85 - NCT07626684Enrolling by invitation
Ice Pack After Minimally Invasive Hysterectomy Surgery
This study tests whether applying ice packs to the abdomen after a minimally invasive hysterectomy (removal of the uterus through the vagina) helps reduce pain and speed recovery. You would be randomly assigned to either receive ice pack treatment or standard care.
MuğlaAges 48–70 - NCT06270147RecruitingPhase 2
Timing of nerve blocks for weight loss surgery pain
This trial tests whether giving a nerve block before or after bariatric surgery works better for pain control. It could help you have less pain and use fewer painkillers after your procedure.
Hamilton, OntarioAges 18 years+ - NCT03596424Recruiting
Testing ketamine and dexmedetomidine during lung surgery
This trial studies whether the anesthesia medicines ketamine and dexmedetomidine can improve care during elective lung (video-assisted) surgery. It may help with comfort during and after the operation, depending on how these medicines affect pain and recovery.
Montreal, QuebecAges 18–80 - NCT07591207Recruiting
Pain relief patch after laparoscopic abdominal surgery
This trial tests whether a pain-relief patch (loxoprofen) works well and safely to reduce pain after common laparoscopic surgeries like gallbladder, appendix, or hernia repair. If it works, it could offer patients a non-invasive way to manage post-surgery pain.
Beijing, Beijing MunicipalityAges 18–64 - NCT07588230Recruiting
Nerve Block for Minimally Invasive Heart Valve Surgery Pain
This study tests a targeted nerve block (pain-numbing injection) to help manage pain after minimally invasive heart valve surgery. Researchers want to see if this technique reduces pain and the need for opioid medications during recovery.
Diyarbakır, Outside of the USAges 18–75 - NCT07577934Recruiting
Liposomal Bupivacaine for Pain Relief in Gallbladder Surgery
This trial tests a long-acting numbing medication (liposomal bupivacaine) injected around abdominal muscles during laparoscopic gallbladder removal to reduce pain after surgery. The goal is to see if it provides better pain control compared to standard approaches.
Tianjin, Tianjin MunicipalityAges 18–65 - NCT06479161RecruitingPhase 2
Oral tranexamic acid study for knee replacement patients
This trial tests if taking tranexamic acid (TXA) as a pill can reduce bleeding after total knee replacement surgery. It may help you if you have knee osteoarthritis and are scheduled for a first-time knee replacement.
Hartford, ConnecticutAges 18–89 - NCT07561333Recruiting
Pain Relief Methods for Knee Replacement Surgery
This study compares two different nerve-blocking anesthesia techniques to see which one controls pain better after knee replacement surgery. Both methods are designed to numb the area around your knee so you need less pain medication afterward.
Çorum, CentreAges 18–80 - NCT07557108Recruiting
Nerve Blocks to Improve Recovery After Heart Surgery
This study tests whether special numbing injections around nerves in the chest wall (fascial plane blocks) help patients recover better and have less pain after open-heart surgery. The goal is to see if this technique improves how you feel and function in the days after your operation.
Ordu, AltinorduAges 18–70 - NCT07525986RecruitingPhase 4
Pain control after laparoscopic colon surgery using a button-press system
This trial tests a new pain medication (anrikefon) that patients can control themselves by pressing a button after laparoscopic colon surgery. The goal is to see if it works better or safer than standard pain relief, especially for patients whose nerve blocks alone don't fully control pain.
Beijing, Beijing MunicipalityAges 18–75
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Common questions
- Are there clinical trials for chronic postoperative pain?
- Yes. Clin2 currently lists 296 recruiting chronic postoperative pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic postoperative pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic postoperative pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Postoperative Pain
- Postoperative Pain, Acute
- Postoperative Pain Management
- Total Knee Arthroplasty (Postoperative Pain)
- POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
- Postoperative Pain After Endodontic Treatment
- Postoperative Pain Following Knee Arthroplasty
- Postoperative Pain Management in Oral Surgery
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.