Clinical trials
Circadian Rhythm clinical trials
Below are recruiting circadian rhythm clinical trials, each written for real people, not researchers. We’re tracking 69 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04893226Recruiting
Time-restricted eating for postmenopausal metabolic risk
This trial studies whether limiting when you eat each day can improve blood sugar and other health markers in postmenopausal women with prediabetes or metabolic risk factors. It may help your body’s metabolism if your sleep and daily routine can stay fairly consistent.
Lexington, KentuckyAges 45–65 - NCT05007834Recruiting
Study of sleep–hormone timing after chemotherapy-related missed periods
This study looks at how the body’s daily timing (circadian rhythms) may affect ovarian function and fertility after chemotherapy. It includes women who stopped having periods after chemotherapy and may help explain what to expect for post-cancer fertility.
LilleAges 25–35 - NCT07715721Recruiting
Acupuncture and Traditional Chinese Medicine for Sarcopenia and Sleep Problems in Older Adults
This study looks at how Traditional Chinese Medicine body types and sleep patterns relate to muscle loss (sarcopenia) in older adults, and tests whether acupoint stimulation (like acupuncture without needles) can help.
TainanAges 20 years+ - NCT04578249Recruiting
Blocking blue light at night after heart surgery
This trial tests whether reducing blue light at night after certain planned heart surgeries helps protect mood, thinking, and recovery. If you have no history of major mental health problems or organ problems, you may be able to join the study.
Morgantown, West VirginiaAges 45–75 - NCT04737200Recruiting
Overnight feeding to improve sleep in ICU heart surgery patients
This trial studies whether planned overnight nutrition (through a feeding tube) can reduce sleep problems and daily body-clock disruption while you’re in the ICU after certain heart surgery. It may help you get more restful sleep and better regular “wake–sleep” timing during recovery.
Boston, MassachusettsAges 18 years+ - NCT05829044Recruiting
How light exposure affects sleep and body clock by sex and age
This study looks at how non-visual light (light that isn’t just for seeing) affects your sleep timing and circadian rhythms, and whether the effects differ by sex and age. It may help researchers design better light-based or sleep-support strategies in the future.
Boston, MassachusettsAges 18–85 - NCT05277532Recruiting
Exercise and sleep timing for overweight type 1 diabetes
This trial studies whether changing daily sleep timing (circadian rhythm) and doing physical exercise can improve health outcomes in people who are overweight and have type 1 diabetes (or in some healthy people). It may help by seeing what combinations of routine and activity are most beneficial.
StockholmAges 18–50 - NCT05336084Recruiting
Study how sleep timing affects mood and thinking in teens
This study looks at how your body clock and sleep “pressure” affect reward feelings and thinking control. It may help researchers understand teen sleep patterns and how they connect to brain and behavior.
Pittsburgh, PennsylvaniaAges 13–18 - NCT05701969RecruitingEarly Phase 1
Melatonin for sleep during night shifts in residents
This early study tests whether melatonin can improve sleep patterns for doctors-in-training during overnight “night float” shifts. It may help you feel more rested and adjust to night work.
Charlottesville, VirginiaAges 18 years+ - NCT05866991Recruiting
Study tracking sleep and mood in depression
This study looks at people with a current episode of major depression and measures sleep and daily body-clock patterns, along with other mental health symptoms. They may help researchers better understand how sleep and mood changes relate, which could improve future care.
ParisAges Any age - NCT05977712Recruiting
Circadian rhythm factors in people with memory clinic concerns
This study looks at how daily body-clock timing (circadian rhythm) and other factors may relate to memory and thinking symptoms in memory clinic patients. You may be asked to wear a small device for about 9 days to track your daily patterns.
Paris, FranceAges 18 years+ - NCT05984979Recruiting
Breath rhythms in people with and without diabetes
This study looks at how your breath changes throughout the day in people with and without diabetes. Researchers want to find patterns in breath chemicals that could help understand diabetes better.
BernAges 18 years+ - NCT06052397Recruiting
Sleep and body clock markers for confusion after surgery
This trial tests whether sleep patterns and body clock signals can help predict confusion after major orthopedic surgery. You would wear a watch that tracks movement to see how your sleep relates to recovery.
Boston, MassachusettsAges 70 years+ - NCT06104280Recruiting
How opioid addiction meds affect sleep and eyes
This study tests how three common medications for opioid use disorder (methadone, buprenorphine, and naltrexone) affect eye function, sleep, and daily body rhythms. It may help find ways to improve treatment for opioid addiction.
Birmingham, AlabamaAges 18–80 - NCT06129942Recruiting
Light therapy for Parkinson's disease
This trial tests whether regular light therapy can help people with Parkinson's disease. It is designed for patients whose symptoms are at a moderate stage and whose medication has been stable for a month or more.
Suzhou, JiangsuAges 50–80 - NCT06226025RecruitingPhase 2
Melatonin for Bipolar Disorder in Night Owls
This trial tests whether giving melatonin at the right time can help people with bipolar disorder who are night owls improve their mood and sleep. You would take melatonin or a placebo each evening for a few weeks while tracking your symptoms on a phone app.
Ann Arbor, MichiganAges 18–60 - NCT06288568Recruiting
Night shift work and obesity risk study
This study looks at how night shift work affects weight and health in hospital and factory workers. They want to see if working nights changes your body's hormones and risk for obesity.
Vienna, State of ViennaAges 21 years+ - NCT06370962Recruiting
Sleep study for children with cystic fibrosis on Kaftrio-Kalydeco
This study looks at sleep and daily activity rhythms in children with cystic fibrosis who are taking a medication called Kaftrio-Kalydeco. It aims to understand if the medication affects sleep patterns and how to improve them.
BronAges 2–17 - NCT06384742Recruiting
Sleep help for nurses working night shifts
This study tests a program to help nurses and nursing staff who work night shifts improve their sleep. It's a 6-month online program that may help you sleep better and feel more rested.
Corvallis, OregonAges 18–65 - NCT06422741Recruiting
Grape seed extract for cholesterol in night shift workers
This study tests whether a grape seed extract supplement can help lower LDL (bad) cholesterol in people who work rotating night shifts. It is looking for healthy adults with moderately high cholesterol who are not taking cholesterol medicine.
Reus, TarragonaAges 18 years+ - NCT06473415Recruiting
Lormetazepam for sleep in the ICU
This trial tests whether a sleep medication called lormetazepam can improve sleep quality and brain activity in ICU patients who are on a breathing machine. It may help if you need sedation and are expected to stay in the ICU for at least two days.
Mitte, State of BerlinAges 18–100 - NCT06480305Recruiting
Evening snacks and pre-breakfast intake in healthy men
This study looks at how eating an evening snack before bed and having a small pre-breakfast meal affects sleep quality, heart rate, and stress levels in healthy men. It may help you understand how meal timing affects your body.
Islamabad, Punjab ProvinceAges 30–50 - NCT06502613Recruiting
Scoliosis and Sleep Cycle in Children
This study looks at how sleep timing (melatonin levels) might be linked to new cases of scoliosis in children. If you have scoliosis and are between 6 and 15, you may help researchers understand this connection.
Wenzhou, ZhejiangAges 6–15 - NCT06535178Recruiting
Sleep and heart health in fibromyalgia
This study looks at how sleep affects heart health in people with fibromyalgia (a condition causing widespread pain). Researchers will test if improving sleep can help your heart work better.
Portland, OregonAges 18–50
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Common questions
- Are there clinical trials for circadian rhythm?
- Yes. Clin2 currently lists 69 recruiting circadian rhythm studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a circadian rhythm trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a circadian rhythm trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.