Clinical trials
Cognitive clinical trials
Below are recruiting cognitive clinical trials, each written for real people, not researchers. We’re tracking 2,028 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04025398Recruiting
Computer training to improve thinking skills in adults with disability
This study tests whether a computer-based “cognitive remediation” program can improve thinking and daily functioning in adults with mild to moderate intellectual disability. It may help your attention and social thinking, alongside usual care.
Lyon, Auvergne-Rhône-AlpesAges 18–45 - NCT04109027Recruiting
Training program to improve thinking and memory for veterans
This trial tests an intensive skills-training program to help with thinking and memory problems after a mild-to-moderate traumatic brain injury (TBI). It’s designed for veterans who are at least 6 months past the injury and still notice cognitive symptoms that affect daily goals like work or school.
Sacramento, CaliforniaAges 21–60 - NCT04123314RecruitingEarly Phase 1
Psilocybin study for depression in mild memory or early Alzheimer’s
This early-phase study tests whether psilocybin (a psychedelic substance) can help with depression in people who have mild memory problems or early Alzheimer’s. The trial also closely monitors safety, thinking changes, mood, and blood pressure before and after dosing.
Baltimore, MarylandAges 18–85 - NCT04201600Recruiting
Study how blood sugar swings affect thinking in prediabetes
This study looks at how “blood sugar variability” (how much glucose levels bounce around) may affect thinking and memory in people with prediabetes. You may be eligible if you’re older and don’t already have diabetes or conditions that can strongly affect the brain or blood vessels.
Baltimore, MarylandAges 50 years+ - NCT04271527Recruiting
Compare two prostate biopsy guidance methods in men with PSA rise
This trial tests whether using a “cognitive” approach versus a software-guided approach to plan a prostate biopsy is just as effective. It may help improve how biopsies are targeted for men with PSA changes and/or abnormal prostate exams.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT04297020Recruiting
Checking brain health in breast cancer survivors
This study looks at differences in brain function in people who have had breast cancer, compared with certain people without that history. It’s testing how brain health changes after breast cancer and relates to mood, thinking, and daily functioning.
Los Angeles, CaliforniaAges 35–65 - NCT04335994Recruiting
Home sleep testing for people with memory trouble
This study looks at how well home sleep apnea testing works for people with cognitive impairment (memory/thinking problems) to help improve outcomes. You may be asked to do a home sleep test (and possibly an in-lab test) and will involve a caregiver if needed.
Toronto, OntarioAges Any age - NCT04343157RecruitingPhase 2
Image-guided focused radiation to protect thinking in brain metastases
This Phase 2 trial tests a brain radiation technique that aims to treat up to a few brain metastases while sparing areas important for thinking and memory. It may help people keep cognitive abilities better than with more brain-wide radiation approaches.
San Diego, CaliforniaAges 18 years+ - NCT04360200Recruiting
Study of thinking changes in older adults
This trial looks at people over age 50 who have mild thinking or memory problems but do not have dementia by standard clinical criteria. It tests how these early changes are characterized and measured using exams such as blood tests and brain scans, which may help improve understanding and future care.
Guangzhou, GuangdongAges 50 years+ - NCT04373564RecruitingPhase 4
Tracking brain and movement changes after repeated MRI contrast
This study looks at whether getting the MRI contrast dye multiple times over 5 years affects body movement and thinking skills. It compares people who had the dye repeatedly with people who have little or no exposure, using brain MRI scans and regular mental and movement testing.
Scottsdale, ArizonaAges 18–64 - NCT04390646RecruitingPhase 2/Phase 3
Hormone treatment to study thinking in Down syndrome
This trial studies whether a GnRH hormone treatment can improve thinking and memory in people with Down syndrome. It also checks safety and whether the treatment affects brain-related changes seen on MRI.
Lausanne, Canton of VaudAges 16–50 - NCT04463498Recruiting
Sleep school program for insomnia alongside mental health problems
This trial tests a group “sleep school” program to improve sleep when insomnia happens together with moderate to severe mental health symptoms. It may help you learn practical sleep strategies and improve sleep quality while you’re getting psychiatric care.
BergenAges 18–80 - NCT04556227Recruiting
Exercise and memory training after ICU delirium
This study tests whether combining gentle cycling while lying down with tablet-based memory exercises can improve recovery after ICU delirium. It may help people regain thinking and comfort after a hospital stay.
Kansas City, MissouriAges 45–64 - NCT04583800Recruiting
Tracking heart failure risk and memory change in diabetes
This study follows adults with type 2 diabetes to see who may develop heart problems and who may have memory or thinking changes over time. It may help doctors better predict risk and plan earlier support.
LilleAges 18 years+ - NCT04632628Recruiting
Online sleep coaching for insomnia in dementia caregivers
This trial tests an online form of cognitive behavioral therapy (a structured skills-based program) to improve insomnia for people caring for someone with dementia. It may help reduce trouble falling asleep, staying asleep, or waking too early.
Columbia, MissouriAges 18 years+ - NCT04658290Recruiting
Sleep apnea screening and memory test study
This study looks at how common obstructive sleep apnea is and whether it’s linked to thinking and memory problems. It may help clarify which people with sleep apnea might be more likely to have cognitive difficulties.
Hong Kong, Please SelectAges 40–74 - NCT04724499Recruiting
High-intensity interval exercise during chemo to improve brain function
This trial tests whether high-intensity interval training (short bursts of harder exercise with recovery) during chemotherapy can improve thinking and memory in women with early-stage breast cancer. Participants may join an exercise program supervised at a hospital or at home, with many health and brain-related check-ins.
Boston, MassachusettsAges 18 years+ - NCT04754906Recruiting
Study how thinking abilities affect planning movement
This study looks at how well people can plan and control movements, and whether thinking ability affects that process. It compares healthy younger adults, healthy older adults, and older adults with mild cognitive problems.
DijonAges 18 years+ - NCT04761328Recruiting
Study fear of cancer coming back and stopping immunotherapy
This study looks at fear of cancer coming back and how people feel about stopping immunotherapy (cancer treatment that helps the immune system). You may be able to join if you’re an adult with a cancer history that included immunotherapy, and if you can safely participate.
Pittsburgh, PennsylvaniaAges 21 years+ - NCT04831385Recruiting
CBT-I sleep therapy to improve blood sugar in older adults
This study tests whether a structured therapy for insomnia (CBT-I) can help improve blood sugar control in older adults with type 2 diabetes. It targets people who have both high blood sugar levels and troublesome insomnia, aiming to see if better sleep improves glycemic measurements.
Hong KongAges 60 years+ - NCT04855825Recruiting
Wearable robotic exoskeleton to improve walking and thinking in MS
This study tests a wearable robotic exoskeleton to help people with multiple sclerosis walk better and improve thinking/problem-solving. You would use the device during supervised sessions and take brief thinking and movement checks to see if it’s safe and helpful for you.
West Orange, New JerseyAges 18–75 - NCT04897334Recruiting
Brain stimulation plus rehab to improve thinking after stroke
This study tests whether a noninvasive brain stimulation treatment, combined with rehabilitation, can improve thinking and other “neurocognition” problems after a recent stroke. It may help people whose thinking has been affected by stroke within the past month.
Philadelphia, PennsylvaniaAges 18–90 - NCT04765137RecruitingPhase 2
Atorvastatin to improve brain blood flow in mild memory decline
This Phase 2 study tests whether the cholesterol medicine atorvastatin can improve how well blood vessels in the brain respond in people with mild cognitive impairment (MCI). It may help brain circulation and possibly slow thinking and memory problems.
Baltimore, MarylandAges 60–95 - NCT00018057RecruitingPhase 2
Brain study of pediatric anxiety disorders
This study looks at how the brain works in children and adults with anxiety disorders. It uses brain scans (fMRI) and other safe tests to understand anxiety better.
Bethesda, MarylandAges 8–65
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Common questions
- Are there clinical trials for cognitive?
- Yes. Clin2 currently lists 2,028 recruiting cognitive studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.