Clinical trials
Colorectal Cancer (Locally Advanced or Metastatic) clinical trials
Below are recruiting colorectal cancer (locally advanced or metastatic) clinical trials, each written for real people, not researchers. We’re tracking 5,583 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06878664RecruitingPhase 3
Lu177-Dotatate vs standard care for slow-growing midgut neuroendocrine tumors
This trial tests whether a radioactive drug called Lu177-Dotatate (PRRT) works better than usual care for people with slow-growing, advanced midgut neuroendocrine tumors (NETs). It may help shrink or slow the growth of tumors when you also get somatostatin analog therapy.
Caen, CaenAges 18 years+ - NCT06879704Recruiting
Predicting breast cancer response to pre-surgery therapy with X-rays
This trial uses special imaging before and after treatment to see if it can predict how well triple-negative breast cancer responds to chemotherapy plus immunotherapy given before surgery. Participation could help doctors tailor future treatments.
RouenAges 18–75 - NCT06886347RecruitingPhase 1
New treatment for metastatic nasopharyngeal cancer before chemotherapy
This trial tests a new treatment for people with advanced nasopharyngeal cancer that has spread (stage IVb) and who have not yet had chemotherapy. It aims to see if the experimental treatment is safe and effective as a first option.
Hangzhou, ZhejiangAges 18–75 - NCT06896448Recruiting
Sleep apnea screening for head and neck cancer patients
This study tests a smartphone app (Apneal) to screen for sleep apnea in people who are being checked for head and neck cancer. It aims to find sleep problems early so they can be treated.
Caen, FranceAges 18 years+ - NCT06902272RecruitingPhase 2
Blood test to predict chemo-immunotherapy response in lung cancer
This trial tests whether a blood test (ctDNA) can help predict how well a combination of chemotherapy and immunotherapy (and sometimes radiation) works before surgery for non-small cell lung cancer. It aims to see if the blood test can detect small amounts of remaining cancer to guide further treatment.
Miami, FloridaAges 18 years+ - NCT06915727RecruitingPhase 3
Testing an imaging drug to see tumors in children having surgery
This study tests a special imaging drug called pafolacianine (Cytalux) that helps doctors see tumors more clearly during surgery. It is for children and teens who have a solid tumor in the body and are already scheduled for tumor removal or biopsy.
Rochester, MinnesotaAges 6 months–17 years - NCT06918184Recruiting
Exercise timing after breast cancer surgery
This study tests whether starting specific physical therapy exercises early or later after breast cancer surgery is better for recovery. It may help women who are at risk for arm and shoulder problems after surgery.
CairoAges 18–65 - NCT06927102Recruiting
Bringing back breast cancer patients lost to follow-up
This study looks at people with breast cancer who stopped coming to follow-up appointments. It aims to understand why they dropped out and help them re-engage with care.
Hyderabad, TelanganaAges 18 years+ - NCT06928818Recruiting
T-DM1 after T-DXd for advanced HER2-positive breast cancer
This trial looks at whether a different targeted therapy, T-DM1, can work for women with advanced HER2-positive breast cancer after they have already tried another targeted therapy called T-DXd (Enhertu). If you have progressed while on T-DXd and have not had more than three previous treatments for advanced cancer, you may be able to join.
SeoulAges 19 years+ - NCT06929650Recruiting
Radiofrequency ablation for low-risk thyroid cancer
This trial tests a procedure called radiofrequency ablation to treat small, low-risk thyroid cancer. If you have a small nodule (2 cm or less) that is confirmed as cancer or suspicious for cancer (Bethesda 5/6), this treatment may be an option instead of surgery.
Toronto, OntarioAges 18–100 - NCT06931717RecruitingPhase 3
Immunotherapy after lung cancer surgery for those not getting chemo
This trial tests if the drug cemiplimab can prevent non-small cell lung cancer from coming back after surgery. It's for people whose tumors have PD-L1 levels of at least 1% and who are not receiving standard chemotherapy after surgery.
ViennaAges 18 years+ - NCT06938360Recruiting
Breast-conserving surgery for central breast cancer study
This trial compares breast-conserving surgery (removing only the tumor and nearby tissue) to total mastectomy (removing the whole breast) for women with breast cancer in the central area of the breast. The goal is to see if the less extensive surgery works just as well.
Xi'an, ShaanxiAges 18–70 - NCT06956690RecruitingPhase 1/Phase 2
Testing HMBD-501 for HER3-positive advanced solid tumors
This trial tests a new drug, HMBD-501, for people with advanced solid tumors that have a specific protein called HER3. The goal is to see if the drug is safe and if it can help shrink or control the cancer.
La Jolla, CaliforniaAges 18 years+ - NCT06958107Recruiting
Liquid biopsy study for sarcoma patients
This study uses a simple blood test (liquid biopsy) to look for tiny pieces of tumor DNA in people with sarcoma. It may help doctors learn more about the disease and guide treatment decisions, whether you are just diagnosed, being treated, or have finished treatment recently.
Charlotte, North CarolinaAges Any age - NCT06958432RecruitingPhase 2/Phase 3
Short-course radiation plus chemo and immunotherapy for rectal cancer
This trial tests a treatment plan that uses a short course of radiation to the lymph nodes-sparing area, followed by chemotherapy and an immunotherapy drug (PD-1 inhibitor) for people with a specific type of mid or low rectal cancer (pMMR/MSS). The goal is to see if this approach can shrink the tumor and improve outcomes without needing extensive surgery.
Guangzhou, GuangdongAges 18–75 - NCT06959615RecruitingPhase 1/Phase 2
Study of JAB-23E73 for KRAS-Altered Advanced Tumors
This trial tests an experimental pill (JAB-23E73) for people with advanced solid tumors that have a specific KRAS gene change. It aims to see if the drug can shrink or slow the growth of these cancers.
Hefei, AnhuiAges Any age - NCT06959706RecruitingPhase 1
Study of TGW101 for advanced solid tumors
This trial tests a new drug called TGW101 for people with certain advanced solid tumors that have not responded to standard treatments. The goal is to see if it is safe and may help shrink tumors.
Scottsdale, ArizonaAges 18 years+ - NCT06960720Recruiting
Weight lifting program for breast cancer fatigue
This trial tests whether a 3-month resistance exercise program (like lifting weights) can help reduce fatigue in women who have had breast cancer. You may be eligible if you were diagnosed with non-metastatic breast cancer 1-3 years ago and feel tired, even if only a little.
Morgantown, West VirginiaAges 18 years+ - NCT06961084RecruitingPhase 2
I-124 PET/CT scan for diagnosing thyroid cancer
This trial tests whether a new type of scan (I-124 PET/CT) can better detect thyroid cancer compared to standard scans. It may help doctors decide on the best treatment, such as radiation therapy or surgery.
San Francisco, CaliforniaAges 13 years+ - NCT06965101Recruiting
Single-session MRI-guided radiation for spinal cord compression
This trial tests whether one quick radiotherapy session on a special MRI machine (MRL) is as good as standard treatment for people with spinal cord compression caused by cancer that has spread. It aims to make treatment faster and easier for you.
ManchesterAges 18 years+ - NCT06966232RecruitingPhase 3
Using entecavir to prevent hepatitis B flare-up in gastrointestinal cancer patients
This trial tests whether giving the antiviral drug entecavir before or at the first sign of hepatitis B reactivation can prevent liver problems in gastrointestinal cancer patients who are inactive hepatitis B carriers and are starting chemotherapy or immunotherapy.
Guangzhou, GuangdongAges 18–75 - NCT06970119RecruitingPhase 1/Phase 2
Study of INR102 for advanced prostate cancer (Phase 1/2)
This trial tests a new investigational drug called INR102 for prostate cancer that has spread and stopped responding to standard treatments. It's given by injection, and the study will check if it's safe and if it can shrink or slow the cancer.
Wuxi, JiangsuAges 18 years+ - NCT06973564RecruitingPhase 1/Phase 2
JAB-23E73 for Advanced Solid Tumors with KRAS Changes
This trial tests a new drug called JAB-23E73 for people with advanced solid tumors that have a specific change in the KRAS gene. It may be an option if previous treatments have stopped working or are not suitable.
Rochester, MinnesotaAges 18 years+ - NCT06982677Recruiting
Improving health in early menopause after cancer
This study looks at ways to improve health and well-being in young women who went into early menopause after cancer treatment. It might help you feel better and manage menopausal symptoms like hot flashes, sleep problems, or mood changes.
Durham, North CarolinaAges 18–44
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Common questions
- Are there clinical trials for colorectal cancer (locally advanced or metastatic)?
- Yes. Clin2 currently lists 5,583 recruiting colorectal cancer (locally advanced or metastatic) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer (locally advanced or metastatic) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer (locally advanced or metastatic) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Breast Cancer
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Locally Advanced Colorectal Cancer
- Lung Cancer (Locally Advanced or Metastatic)
- Liver Cancer (Locally Advanced or Metastatic)
- Metastatic Colorectal Cancer
- Locally Advanced Rectal Cancer
- Metastatic Colorectal Cancer (CRC)
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.