Clinical trials
Colorectal (Colon or Rectal) Cancer clinical trials
Below are recruiting colorectal (colon or rectal) cancer clinical trials, each written for real people, not researchers. We’re tracking 867 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03925662RecruitingPhase 3
Mebendazole added to stage 4 colon cancer care
This trial studies whether adding mebendazole (an existing anti-parasite medicine) to standard treatment can improve outcomes for people with stage 4 colon cancer. You might qualify if you have stage 4 colorectal cancer and none of the key safety concerns.
CairoAges 18 years+ - NCT05202314Recruiting
Camrelizumab plus chemo after stent for left bowel cancer
This study tests whether adding camrelizumab (an immune therapy) to chemotherapy—after a stent is placed to open a blocked left-sided colon—improves outcomes. It’s meant for people whose cancer can still be removed with surgery after the blockage is treated.
Beijing, Beijing MunicipalityAges 18–80 - NCT04842006Recruiting
Personalized treatment plan for rectal cancer before and after surgery
This trial looks at a personalized treatment approach for rectal cancer. It aims to guide the best chemotherapy and (if needed) radiotherapy before and after surgery, based on scans and specific test results.
Helsinki, UusimaaAges 18–100 - NCT05861505RecruitingPhase 3
Treatment for new liver spread from colon cancer recurrence
This Phase 3 trial studies a treatment approach for people whose colorectal cancer has come back in the liver within 12 months and can be treated with local procedures. It aims to see whether the study treatment can improve outcomes compared with standard care for people with a limited number of liver tumors.
AmsterdamAges 18 years+ - NCT06204484Recruiting
MRD-guided Chemo Timing for Early Colon Cancer
This trial is for people with early-stage colon cancer (stage II high-risk or stage III low-risk) that is not MSI-H. It uses a blood test (MRD) to see if you can safely delay or skip extra chemotherapy after surgery, based on whether the test finds any leftover cancer cells.
Guangzhou, GuangdongAges 18–70 - NCT06057350Recruiting
Surgery versus endoscopy for early colon cancer with uncertain margins
This trial compares surgery versus an endoscopic procedure for people who had a colon polyp removed but some cancer cells may still be present at the edges. The goal is to see which approach leads to better outcomes and fewer side effects for early-stage colon cancer.
Oslo, AkershusAges 40 years+ - NCT02222844Recruiting
MRI checks for treatment planning in sigmoid colon cancer
This study uses MRI scans to better plan “curative” treatment (aimed at cure) for sigmoid colon cancer before surgery. It is for people who may still be deciding on the radical (major, curative) treatment plan and who can safely have an MRI.
Huntingdon, CambridgeshireAges 16 years+ - NCT07705880Recruiting
Predicting cancer in large flat colon polyps
This study tests a new tool to help doctors decide if a large, flat colorectal polyp might contain cancer. It involves doctors who use the tool during colonoscopy to better guide treatment.
GhentAges 18 years+ - NCT06646341Recruiting
Can scan findings predict colorectal cancer spread?
This study looks at whether signs of blood vessel involvement (called EMVI) seen on scans can predict if colorectal cancer spreads to other organs. You might join if you already had surgery to remove the cancer from the colon or rectum and any distant tumors, and your before-surgery scans are available for review.
Basingstoke, HampshireAges 16–100 - NCT06613165Recruiting
Short vs long treatment for stage II-III rectal cancer with dMMR
This trial tests how long you need a PD-1 immunotherapy before surgery for a specific type of rectal cancer (dMMR/MSI-H). It looks at whether a shorter or longer course works best. This could mean fewer side effects and a quicker path to surgery.
Xi'an, ShaanxiAges 18–80 - NCT07503847Enrolling by invitation
Colorectal Cancer Screening for Ages 40-49 with Family History
This trial helps people aged 40-49 who have a parent, sibling, or child with colorectal cancer decide on the best way to get screened. It aims to find the most effective screening method for those at higher risk.
TaipeiAges 40–49 - NCT07478731RecruitingPhase 2
Combination therapy for advanced rectal cancer before surgery
This trial tests a new drug called SHR-1701 combined with standard chemotherapy and radiation for people with locally advanced rectal cancer. The goal is to shrink the tumor before surgery, making it easier to remove completely.
Wuhan, HubeiAges 18–75 - NCT06787625Recruiting
Growing tumor models from colorectal cancer and liver metastases
This study takes samples from colorectal cancer that has spread to the liver and grows them in the lab. The goal is to create models that can help researchers understand the cancer better and find new treatments.
RomeAges 18 years+ - NCT07470658Enrolling by invitation
Surveillance after positive FIT and normal colonoscopy
This trial studies the best way to follow up with people who had a positive FIT stool test (high blood level) but a normal colonoscopy. It aims to find the right schedule for future screening to catch any problems early.
TaipeiAges 45–74 - NCT07433673RecruitingPhase 2
Gemcitabine, cisplatin, nab-paclitaxel, and cemiplimab for locally advanced bile duct cancer
This trial tests a combination of four drugs to see if they shrink locally advanced bile duct or gallbladder cancer that cannot be removed surgically. It is for people who have not had prior treatment for this cancer.
New York, New YorkAges 18 years+ - NCT06822634Recruiting
Advanced imaging for rectal cancer treatment response
This trial uses advanced MRI scans to see how well rectal cancer is responding to radiotherapy. It may help doctors better understand which treatments work best for patients with more advanced disease.
GlasgowAges 18 years+ - NCT07345676Recruiting
Helping patients complete colorectal cancer screening
This trial is testing a simple program to help people who are due for colorectal cancer screening to complete their test. It's for patients at Cornell Scott Hill Health who either haven't finished a screening order or had an abnormal stool test without follow-up.
New Haven, ConnecticutAges 45–75 - NCT07284992RecruitingPhase 2
Comparing short vs long radiation with immunotherapy for rectal cancer
This trial tests whether a short course of radiation followed by an immunotherapy drug (PD-L1 inhibitor) plus chemotherapy works as well as or better than a longer radiation course for locally advanced rectal cancer. The goal is to shrink tumors before surgery.
Jinan, ShandongAges 18–80 - NCT05686499Recruiting
Colonoscopy training for early colorectal cancer detection
This trial supports training for healthcare professionals to improve screening and early diagnosis of colorectal cancer. It may help by building skills in safely performing colonoscopies and spotting cancer earlier.
Ile-Ife, Osun StateAges 18 years+ - NCT07276529Recruiting
Magnet procedure safety trial for colon surgery patients
This trial tests a new magnet device to connect sections of the colon after surgery. It may be an option for people who need part of their colon removed and are otherwise in good health.
Orlando, FloridaAges 22 years+ - NCT05041478Recruiting
Cold removal method for large colon polyps
This trial compares two cold endoscopic techniques to remove certain large, non-cancerous colon polyps with better control of bleeding and leftover tissue. You may be offered one of the two removal methods during your scheduled colonoscopy.
Westmead, New South WalesAges 18 years+ - NCT07213193Recruiting
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RomaAges 18 years+ - NCT07168876Recruiting
A blood test to screen for colon cancer
This trial studies a new blood test that looks for specific markers of colon cancer. If it works well, it could offer an easier way to screen for the disease without a colonoscopy.
Mendoza, Mendoza ProvinceAges 45–75 - NCT07148297Recruiting
Blood test for colorectal cancer detection
This study tests a new blood test that might help detect colorectal cancer. If you're already planning a colonoscopy or colorectal surgery, your participation could help improve early detection.
MendozaAges 45–75
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Common questions
- Are there clinical trials for colorectal (colon or rectal) cancer?
- Yes. Clin2 currently lists 867 recruiting colorectal (colon or rectal) cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal (colon or rectal) cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal (colon or rectal) cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.