Clinical trials
Colorectal (Colon or Rectal) Cancer clinical trials
Below are recruiting colorectal (colon or rectal) cancer clinical trials, each written for real people, not researchers. We’re tracking 893 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03841799Recruiting
Study of gut bacteria and immune changes in colon tissue
This study looks at how gut bacteria and immune activity differ in normal, pre-cancer, and cancer colon tissue. It may help researchers understand what changes in the body are linked to colon growth and how they could be targeted in the future.
Lyon, LyonAges 18 years+ - NCT03925662RecruitingPhase 3
Mebendazole added to stage 4 colon cancer care
This trial studies whether adding mebendazole (an existing anti-parasite medicine) to standard treatment can improve outcomes for people with stage 4 colon cancer. You might qualify if you have stage 4 colorectal cancer and none of the key safety concerns.
CairoAges 18 years+ - NCT04842006Recruiting
Personalized treatment plan for rectal cancer before and after surgery
This trial looks at a personalized treatment approach for rectal cancer. It aims to guide the best chemotherapy and (if needed) radiotherapy before and after surgery, based on scans and specific test results.
Helsinki, UusimaaAges 18–100 - NCT04920032RecruitingPhase 1
Blood test–guided extra treatment for colon cancer recurrence risk
This Phase 1 study uses a blood test called ctDNA to decide whether and how to adjust treatment in people with colon cancer who still have a small amount of disease left after surgery. If your blood test remains positive, the trial aims to reduce recurrence risk by guiding treatment changes.
Orange, CaliforniaAges 18 years+ - NCT05041478Recruiting
Cold removal method for large colon polyps
This trial compares two cold endoscopic techniques to remove certain large, non-cancerous colon polyps with better control of bleeding and leftover tissue. You may be offered one of the two removal methods during your scheduled colonoscopy.
Westmead, New South WalesAges 18 years+ - NCT05202314Recruiting
Camrelizumab plus chemo after stent for left bowel cancer
This study tests whether adding camrelizumab (an immune therapy) to chemotherapy—after a stent is placed to open a blocked left-sided colon—improves outcomes. It’s meant for people whose cancer can still be removed with surgery after the blockage is treated.
Beijing, Beijing MunicipalityAges 18–80 - NCT05314400Recruiting
MRI with contrast for metastatic colon cancer liver lesions
This trial studies an MRI technique using a contrast dye (gadopetate/gadolinium) to better look at liver lesions that may be colon cancer spread. It may help doctors more accurately assess which liver tumors are present and guide next steps.
London, OntarioAges 18 years+ - NCT05365412Recruiting
Study of colon cancer in younger adults
This study looks at the clinic and lab features of colon cancer in people diagnosed at a young age. Your information from your diagnosis and treatment may help doctors understand how colon cancer differs by age.
Seongnam-si, Gyeonggi-doAges 18 years+ - NCT05524428Recruiting
Test to improve colorectal cancer screening at community clinics
This study tries to reduce barriers to colorectal cancer screening by using a repeated “test and improve” approach with clinic staff. If you work in roles that support screening at participating community health centers, you may be eligible to help implement and evaluate these changes.
Boston, MassachusettsAges 18 years+ - NCT05686499Recruiting
Colonoscopy training for early colorectal cancer detection
This trial supports training for healthcare professionals to improve screening and early diagnosis of colorectal cancer. It may help by building skills in safely performing colonoscopies and spotting cancer earlier.
Ile-Ife, Osun StateAges 18 years+ - NCT05706779RecruitingPhase 2
Encorafenib plus cetuximab before surgery for BRAF-mutated colon cancer
This trial tests whether giving encorafenib and cetuximab before surgery can shrink or control BRAF-mutated colon or upper rectal cancer and make surgery more effective. It also checks whether this approach is safe and helps patients do better overall.
ParisAges 18 years+ - NCT05861505RecruitingPhase 3
Treatment for new liver spread from colon cancer recurrence
This Phase 3 trial studies a treatment approach for people whose colorectal cancer has come back in the liver within 12 months and can be treated with local procedures. It aims to see whether the study treatment can improve outcomes compared with standard care for people with a limited number of liver tumors.
AmsterdamAges 18 years+ - NCT05970133Recruiting
Robotic surgery vs laparoscopy for left colon cancer
This trial compares two ways to remove left-sided colon cancer and take the specimen out through the anus (without a large external incision). It may help find which approach is safer and more effective for curing Stage I–III disease.
TaipeiAges 18 years+ - NCT06014372RecruitingPhase 2
Envafolimab before surgery for advanced rectal cancer
This trial tests envalolimab (an immunotherapy) alone or with chemo (CAPEOX) before surgery for locally advanced rectal cancer. It aims to shrink the tumor and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT06024837Recruiting
Testing spectral CT for colorectal cancer spread to liver or belly
This study tests a new type of CT scan (spectral CT) to see how well it detects colorectal cancer that has spread to the liver or belly lining. It may help doctors better plan surgery to remove all the cancer.
Saint-EtienneAges Any age - NCT06057350Recruiting
Surgery versus endoscopy for early colon cancer with uncertain margins
This trial compares surgery versus an endoscopic procedure for people who had a colon polyp removed but some cancer cells may still be present at the edges. The goal is to see which approach leads to better outcomes and fewer side effects for early-stage colon cancer.
Oslo, AkershusAges 40 years+ - NCT06204484Recruiting
MRD-guided Chemo Timing for Early Colon Cancer
This trial is for people with early-stage colon cancer (stage II high-risk or stage III low-risk) that is not MSI-H. It uses a blood test (MRD) to see if you can safely delay or skip extra chemotherapy after surgery, based on whether the test finds any leftover cancer cells.
Guangzhou, GuangdongAges 18–70 - NCT06271941Recruiting
Reducing polyp return after large colon polyp removal
This trial is testing a standard way to remove large polyps from the colon and checking if it helps prevent them from coming back. It's for people who have a large non-cancerous polyp that needs to be taken out during a colonoscopy.
Montreal, QuebecAges 18 years+ - NCT06287814Recruiting
Blood test to detect leftover cancer DNA in colorectal cancer patients
This study uses a simple blood test (liquid biopsy) to look for tiny bits of tumor DNA remaining after colorectal cancer surgery. It aims to see if the test can help predict whether the cancer will come back, especially in people with stage III cancer who will receive chemotherapy.
Montpellier, HéraultAges 18 years+ - NCT06575127RecruitingPhase 2
Three-drug chemo plus targeted therapy for advanced colorectal cancer
This trial tests a combination of three chemotherapy drugs plus a targeted therapy as a first treatment for advanced colorectal cancer. The goal is to see if this strong drug mix can shrink tumors better than standard approaches.
Cairo, Cairo GovernorateAges 18–65 - NCT06613165Recruiting
Short vs long treatment for stage II-III rectal cancer with dMMR
This trial tests how long you need a PD-1 immunotherapy before surgery for a specific type of rectal cancer (dMMR/MSI-H). It looks at whether a shorter or longer course works best. This could mean fewer side effects and a quicker path to surgery.
Xi'an, ShaanxiAges 18–80 - NCT06630624RecruitingPhase 1/Phase 2
IP-001 with ablation for colorectal liver metastases
This trial tests whether adding the drug IP-001 to tumor ablation (microwave or irreversible electroporation) helps control colorectal cancer that has spread to the liver. The goal is to find the best dose and see how the immune system responds.
Amsterdam, North HollandAges 18 years+ - NCT06646341Recruiting
Can scan findings predict colorectal cancer spread?
This study looks at whether signs of blood vessel involvement (called EMVI) seen on scans can predict if colorectal cancer spreads to other organs. You might join if you already had surgery to remove the cancer from the colon or rectum and any distant tumors, and your before-surgery scans are available for review.
Basingstoke, HampshireAges 16–100 - NCT06696534Recruiting
Patient views on colorectal cancer screening methods
This study asks people aged 50–69 about their experience and preferences with different screening methods for colorectal cancer. It aims to improve screening programs by understanding what patients prefer.
LisbonAges 50–69
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Common questions
- Are there clinical trials for colorectal (colon or rectal) cancer?
- Yes. Clin2 currently lists 893 recruiting colorectal (colon or rectal) cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal (colon or rectal) cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal (colon or rectal) cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.