Clinical trials
Colorectal clinical trials
Below are recruiting colorectal clinical trials, each written for real people, not researchers. We’re tracking 1,227 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05244278Recruiting
AI tool that helps find and classify colon polyps during colonoscopy
This trial tests an artificial-intelligence (AI) software tool that helps doctors spot and categorize polyps in real time during a colonoscopy. It may help improve how accurately and quickly polyps are detected during routine and medical colon exams.
Montreal, QuebecAges 45–89 - NCT05064124Recruiting
Real-time healthcare system during colonoscopy for colon cancer
This study tests a new real-time healthcare system meant to improve how doctors find and monitor colon cancer risk during colonoscopy. You might be able to take part if you are scheduled for a non-emergency colonoscopy and meet other safety and medical criteria.
LondonAges 18 years+ - NCT05402696Recruiting
Study of advanced surgery care for colorectal tumors
This study follows adults who are referred for treatment of a specific type of colorectal tumor that involves the left side of the colon. It aims to improve care and outcomes for people needing advanced surgery.
Saint Cloud, MinnesotaAges 18 years+ - NCT04742881Recruiting
Laparoscopic colon surgery comparison for bowel tumors or disease
This trial studies a low-impact approach to colon or upper-rectum surgery using small cameras (laparoscopy) to see if it works well and is safe. You may be eligible if you are scheduled for a specific type of colon/rectal operation and can safely be monitored during the study.
BayonneAges 18 years+ - NCT03837782Enrolling by invitation
Surgery outcomes for early to mid-stage colon cancer
This study looks at how well surgery works for people with colorectal cancer that has not spread to distant organs. It mainly includes patients who can have the tumor completely removed and accurately staged using lymph node samples.
Tianjin, Tianjin MunicipalityAges 18–90 - NCT05428735Recruiting
Liver-first treatment study for colorectal cancer spread to liver
This trial studies a “liver-first” approach for colorectal cancer that has spread mainly to the liver, to see if it can help more people have the tumor(s) removed or treated. You may be eligible if your liver involvement is too extensive for immediate surgery but could become treatable after a specific plan.
New Haven, ConnecticutAges 18 years+ - NCT05334485RecruitingPhase 2/Phase 3
Pyridostigmine to treat slow bowel recovery after colorectal surgery
This trial tests whether pyridostigmine helps return bowel function faster after colorectal surgery when the gut is “stuck,” causing bloating and no gas or stool. It also checks safety and side effects compared with standard care.
Cleveland, OhioAges 18 years+ - NCT05062317RecruitingPhase 2
Blood test-guided chemotherapy after liver tumor removal
This trial uses a blood test (ctDNA, a sign of cancer cells shedding into the blood) to help guide chemotherapy after surgery to remove colorectal liver metastases. It may help patients get the right chemotherapy plan after their operation, potentially based on whether cancer material is still detectable.
Houston, TexasAges 18 years+ - NCT04367987Recruiting
Heart Rate Changes After Colorectal Surgery
This study measures how your heart rate varies after planned colorectal surgery to see if these changes can predict complications. Researchers will monitor your heart rhythm before and after your operation to understand whether certain patterns might warn of problems early.
NîmesAges 18 years+ - NCT04520737Recruiting
Exercise coaching during chemotherapy for liver metastases
This trial studies whether a “prehab” program—structured exercise and preparation—can help people keep up function while they are on chemotherapy for colorectal cancer that has spread to the liver. If you can safely exercise, the program may help you tolerate treatment and stay active.
TarragonaAges 18 years+ - NCT04220905Recruiting
Watching outcomes after removing large colon and duodenal polyps
This observational study follows people who have large polyps in the colon or duodenum that are removed during endoscopy. It aims to understand how safe and effective this approach is, and what outcomes patients have afterward.
White River Junction, VermontAges 18 years+ - NCT03692429RecruitingPhase 1
Testing new immune cells plus chemo for advanced colon cancer
This Phase 1 study tests CYAD-101, an immune-cell treatment made from donor T-cells, given with standard chemotherapy. It is for people with colon or rectal cancer that has spread and has not responded to prior treatments.
Tampa, FloridaAges 18 years+ - NCT06756672Recruiting
Helping with recovery in laparoscopic colorectal surgery
This study looks at how a system called HPI (a way to track your body's response during surgery) might help people recover better after laparoscopic colorectal surgery. It is for people having this planned surgery who do not have serious heart or lung problems.
TaipeiAges 20 years+ - NCT07431723Recruiting
Magnetic magnets to connect the intestines during surgery
This trial is testing a new way to connect parts of the large or small intestine using magnets instead of staples or stitches. It may help people who need certain types of colon or rectal surgery recover with less pain and fewer complications.
SantiagoAges 18–75 - NCT06356558Recruiting
Making recovery programs easier for patients with limited health literacy
This study is testing ways to improve recovery programs for patients who may have trouble understanding health information. It aims to make these programs easier to follow, so patients can have better recovery after surgery.
Birmingham, AlabamaAges 18 years+ - NCT06317727Recruiting
Pulsed field ablation for removing colon polyps
This study tests a new way to remove colon polyps using short bursts of energy (pulsed field ablation) instead of standard methods. It may help people with polyps in the lower part of the colon that are not too large or complex.
LondonAges 18 years+ - NCT05643859Recruiting
Fiber supplement study for bowel health and gut bacteria
This study tests whether adding a dietary fiber supplement can change the bacteria in your colon (gut microbiome). You may be asked to take the fiber supplement during evaluation for a non-cancer rectal condition.
Portland, OregonAges 18 years+ - NCT06829355RecruitingPhase 2
Thymalfasin plus triple therapy for advanced colorectal cancer
This trial tests a combination of three drugs plus thymalfasin, an immune-boosting medicine, for people whose advanced colorectal cancer has not responded to at least two prior treatments. It's designed specifically for the common type of colorectal cancer (pMMR/MSS) to see if adding this immune therapy can help.
Beijing, ChinaAges 18–75 - NCT07608120Recruiting
Electrolyte drink with bowel cleansing solution for colonoscopy prep
This study tests whether combining an electrolyte beverage (a drink with salts and minerals) with polyethylene glycol—a standard bowel-cleaning solution—helps prepare your colon better for colonoscopy. The goal is to see if this combination makes the preparation easier to tolerate while still cleaning your bowel effectively.
Guangzhou, GuangdongAges 18–75 - NCT06308354Recruiting
Colorectal cancer data study at Xijing Hospital
This study collects and reviews medical records from patients diagnosed with colorectal adenocarcinoma at Xijing Hospital between 2013 and 2023. The goal is to build a dataset for future research—no new treatments or procedures are being tested.
Xi'an, ShaanxiAges 18–100 - NCT07623902Recruiting
Testing a Tongue Scan to Detect Colorectal Polyps
This study tests whether a new tongue-scanning tool called Gixam can help find advanced colorectal polyps in people with negative stool tests. If it works, it might offer a simpler screening option alongside colonoscopy.
Orlando, FloridaAges 45–84 - NCT06775951Recruiting
Colonoscopy use: a look at its impact
This trial studies how well colonoscopies are used in normal care. It aims to understand the medical and economic effects of doing colonoscopies for the right reasons.
BolognaAges 18 years+ - NCT07636174Enrolling by invitation
Text reminders to help you get colorectal cancer screening
This study tests whether text messages can help you remember and complete colorectal cancer screening tests like FIT or colonoscopy. You'll receive reminder texts before and after your doctor's visit to encourage you to get screened.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06228209Recruiting
Palliative care for advanced heart failure or cancer
This study tests whether adding a palliative care specialist to your regular care team can improve your quality of life if you have advanced heart failure or advanced lung or certain gastrointestinal cancers. It is for people who have been in the hospital recently and live in Manhattan.
New York, New YorkAges 18 years+
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Common questions
- Are there clinical trials for colorectal?
- Yes. Clin2 currently lists 1,227 recruiting colorectal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.