Clinical trials · California
Coronary artery disease clinical trials in California
We’re tracking 44 recruiting coronary artery disease studies with a site in California — including Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07223593RecruitingPhase 3
Orforglipron for peripheral artery disease with leg pain
This trial tests a new oral medication called orforglipron to see if it can improve walking distance in people with peripheral artery disease (PAD) who have leg pain when walking. It may be a good option if you have PAD and your walking is limited by leg cramping, not other health issues.
Los Angeles, CaliforniaAges 18 years+ - NCT07318610RecruitingPhase 3
Study of a new blood thinner in people with leg artery disease
This trial tests if a new blood-thinning drug (factor XI inhibitor) can prevent serious heart and leg problems in people who recently had a leg artery procedure. It compares the new drug to standard care for up to 3 years.
Los Angeles, CaliforniaAges 18 years+ - NCT06114615Recruiting
Remote monitoring after heart treatment to prevent future events
This trial tests whether digital tools can help monitor patients after a stent procedure to lower the chance of another heart problem. It aims to make follow-up care easier and more effective.
Sacramento, CaliforniaAges Any age - NCT02061436Recruiting
Chronic total occlusion procedure registry
This study collects data from patients who are having a procedure to open a completely blocked coronary artery. It may help improve future treatments for this condition.
San Diego, CaliforniaAges Any age - NCT06662500Recruiting
Shockwave balloon for hard heart blockages trial
This trial tests a new balloon catheter that uses sound waves to break up hard calcium blockages in heart arteries. It may be an option for people with stable chest pain or who have recovered from a recent heart attack, and who have a single, tough blockage.
La Jolla, CaliforniaAges 18 years+ - NCT01524276Recruiting
Registry to track outcomes of Medtronic medical devices
This is a follow-up registry that collects information from people who have (or will receive) an eligible Medtronic device. It helps the company and doctors better understand how the device works in real-world use.
Aliso Viejo, CaliforniaAges Any age - NCT05946629Recruiting
Drug-coated stent trial for narrowed heart arteries
This trial studies a drug-coated balloon (plus standard heart medicines) to treat a specific type of blockage in the heart arteries in people who need an intervention. It may help keep the artery open and prevent the narrowing from coming back, depending on how well you match the detailed heart and medication requirements.
Chula Vista, CaliforniaAges 18 years+ - NCT05427370Recruiting
Compare bypass or stent treatment in weak heart patients
This study compares two ways to restore blood flow to the heart—bypass surgery (CABG) or stent procedure (PCI)—in people with a weak pumping heart. It looks at which approach works best when the heart muscle is not pumping well and there are multiple blocked heart arteries.
Los Angeles, CaliforniaAges 18 years+ - NCT05618353RecruitingPhase 4
Colchicine before surgery to lower heart and inflammation complications
This trial tests whether taking colchicine around the time of surgery can reduce bad events after surgery in people at higher heart risk. It focuses on helping prevent complications related to inflammation after an operation.
Long Beach, CaliforniaAges 18 years+ - NCT06535854Recruiting
Prevail Stent Study for Heart Disease
This study tests a new type of stent for people with narrowed heart arteries causing chest pain or a recent mild heart attack. It aims to see if the stent is safe and effective in improving blood flow without serious side effects.
Stanford, CaliforniaAges 18 years+ - NCT01517425Enrolling by invitation
Using blood stem cells to study heart disease traits
This study uses your blood to create special lab cells (induced pluripotent stem cells) to better understand heart-related differences between people with coronary artery disease and generally healthy older adults. It may help researchers learn what biological traits are linked to heart risk and how those traits work.
La Jolla, CaliforniaAges 18 years+ - NCT02582021Recruiting
Study of treatments and imaging in women with angina or HFpEF
This trial studies how heart disease affects the heart using heart imaging, and looks at people with chest pain/angina or heart failure with preserved pumping strength (HFpEF). It may help doctors better understand what’s driving symptoms and how best to evaluate these conditions.
Los Angeles, CaliforniaAges 18 years+ - NCT05916950Recruiting
Study of a new treatment for blocked leg arteries
This trial studies a device-based treatment approach for people with blocked (narrowed or fully blocked) arteries in the thigh or behind the knee that reduce blood flow to the leg. It may help improve blood flow and walking ability, but you must meet specific artery and imaging requirements.
St. Helena, CaliforniaAges 18 years+ - NCT06424834RecruitingPhase 2/Phase 3
Targeted medicines for chest pain without blocked arteries
This study tests if specific heart medicines (like beta-blockers or calcium channel blockers) can help people with chest pain that is not caused by blocked arteries. It aims to treat the tiny blood vessels or spasms that may be the real cause of your pain.
Palo Alto, CaliforniaAges 18 years+ - NCT07062471Recruiting
Shockwave balloon treatment for hardened carotid arteries before stenting
This study tests a special balloon that uses sound waves to break up calcium buildup in the carotid artery (the main artery in your neck) before placing a stent. It's for people who are at high risk for traditional surgery and have heavy calcium deposits in their artery.
Rancho Mirage, CaliforniaAges 18 years+ - NCT06653387Recruiting
Testing a new carotid stent with blood-flow reversal for high-risk patients
This trial tests a new carotid stent system used with a special blood-flow reversal device to treat blocked carotid arteries. It is for people with high-risk conditions who might not be good candidates for traditional open surgery, and aims to see if the stent is safe and effective in preventing strokes.
Sacramento, CaliforniaAges 18–79 - NCT05055297Recruiting
Drug-coated balloon for severe leg artery blockage in lower legs
This trial studies a “drug-coated balloon” procedure to improve blood flow in people with severe, long-lasting poor circulation in the lower leg arteries. It may help reduce repeat blockage after treatment for selected artery lesions below the knee.
St. Helena, CaliforniaAges 18 years+ - NCT00573027Recruiting
Study of heart pain from small artery heart disease
This trial studies people who have chest pain (angina) due to problems with the heart’s small arteries, not a big blockage. It aims to test whether treatment approaches can help these patients by better understanding the cause of their heart-related symptoms.
Los Angeles, CaliforniaAges 18 years+ - NCT07613294RecruitingPhase 3
Testing lepodisiran to reduce heart plaque buildup
This study tests whether a new medicine called lepodisiran can shrink plaque in heart arteries for adults with high Lp(a) (a type of cholesterol linked to heart disease) who have had a heart event or are at serious risk. The trial uses CT scans to monitor changes in your arteries.
La Jolla, CaliforniaAges 45–80 - NCT07175038RecruitingPhase 2
Study of a new pill for pulmonary hypertension
This study tests a new pill, ROC-101, for people with pulmonary hypertension (high blood pressure in the lungs). It aims to see if the pill can improve symptoms and daily function.
Rancho Cordova, CaliforniaAges 18–80
Coronary artery disease trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting coronary artery disease studies listed above.
- Cedars-Sinai Medical Center · 4 studies
- The Lundquist Institute at Harbor-UCLA Medical Center · 3 studies
- Angel City Research Inc · 2 studies
- Scripps Health · 2 studies
- St. Helena Hospital · 2 studies
- University of California, Davis Medical Center · 2 studies
- University of California, San Francisco · 2 studies
- Valley Clinical Trials · 2 studies
What taking part in a coronary artery disease study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Coronary artery disease trials in other states
Common questions
- Are there coronary artery disease clinical trials in California?
- Yes. We're currently tracking 44 recruiting coronary artery disease studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a coronary artery disease study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a coronary artery disease trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New coronary artery disease studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.