Clinical trials
Cortisol clinical trials
Below are recruiting cortisol clinical trials, each written for real people, not researchers. We’re tracking 39 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07361874Recruiting
Adrenal surgery vs semaglutide for mild cortisol excess
This study tests whether removing a small adrenal tumor or taking a diabetes/weight-loss medication (semaglutide) works better to improve health in people with mild hormone problems. It may help if you have an adrenal nodule causing slight cortisol overproduction or if you have obesity and related conditions.
Dallas, TexasAges 18 years+ - NCT07649317RecruitingPhase 1
Ketoconazole effects on cortisol rhythms in mild adrenal hormone changes
This study tests whether the drug ketoconazole can safely help regulate daily cortisol patterns in people with mild autonomous cortisol secretion (MACS), a condition where the adrenal glands make too much cortisol. It will compare how patients with MACS and healthy volunteers respond to the medication.
Bethesda, MarylandAges 18–100 - NCT07104812RecruitingPhase 2
Testing low-dose osilodrostat for mild cortisol excess
This study tests whether a low dose of the drug osilodrostat can help people with mild cortisol excess (MACS) caused by benign adrenal tumors. It may improve related health problems like high blood pressure, diabetes, or bone thinning.
Rochester, MinnesotaAges 18 years+ - NCT06896682Recruiting
Cortisol and weight regain after weight-loss surgery study
This study looks at how cortisol affects blood sugar drops after weight-loss surgery. It may help explain links between cortisol, obesity, and low blood sugar episodes.
EsbjergAges Any age - NCT07573163RecruitingPhase 2
Tirzepatide after adrenal surgery for mild cortisol condition
This trial tests if tirzepatide can help with weight and blood pressure after you have surgery to remove an adrenal gland that's making too much cortisol. It may be a good option if you still have health issues like high blood pressure or obesity after surgery.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05357456Recruiting
Study of brain and memory changes in cortisol-producing adrenal conditions
This study tracks thinking and brain changes over time in people with adrenal findings that produce too much cortisol (a stress hormone) on their own. It may help doctors understand how different treatments or watchful waiting affect the brain and cognition.
Nanjing, JiangsuAges 20–65 - NCT06344143Recruiting
Detecting mild hormone overproduction from adrenal tumors
This study looks for a mild form of hormone overproduction (called autonomous cortisol secretion) in people who have a benign growth on their adrenal gland. You will undergo a blood test to measure how well your body suppresses cortisol after taking a single dose of dexamethasone.
Cleveland, OhioAges 18 years+ - NCT07605156Recruiting
New imaging scan for rare adrenal hormone tumors
This study tests a special imaging scan (PET/CT) to help doctors identify adrenal tumors that produce too much of two hormones: aldosterone and cortisol. If you have both hormone imbalances confirmed by blood tests and are planning surgery to remove your adrenal gland, this scan may help your doctors see exactly where the tumor is.
BeijingAges 18–80 - NCT07268222RecruitingPhase 4
Comparing two drugs for metabolic autonomous cortisol secretion
This trial tests whether metyrapone or osilodrostat works better for people with MACS, a condition where the adrenal glands produce too much cortisol on their own. The goal is to help you and your doctor choose the best treatment.
AthensAges 18 years+ - NCT05759637Recruiting
Tests treatments for diabetes, weight, and high cortisol levels
This trial studies people who have type 2 diabetes and excess body weight, looking at how high cortisol (a stress hormone) may be involved. If you qualify, you may get a study treatment designed to improve diabetes and weight-related health by targeting cortisol-related pathways.
MilanAges 18–75 - NCT05969431Recruiting
Measuring hair cortisol to study stress in fathers of babies
This study looks at whether a father’s stress level over time can be estimated by measuring cortisol (a stress hormone) in hair. Results may help researchers better understand how chronic stress affects new families, especially when babies are born early or on time.
Cologne, Northrhine-westfaliaAges 1 day–1 week - NCT06513611Recruiting
Immune and hormone markers in acute coronary syndrome prognosis
This trial looks at how your body's immune system, hormones, and inflammation affect recovery after a heart attack or unstable angina. It may help doctors better predict outcomes for people with acute coronary syndrome.
Buenos AiresAges 21 years+ - NCT06635993Recruiting
Testing a PET scan for aldosterone and cortisol condition
This trial tests whether a special PET/CT scan (68Ga-Pentixafor) can accurately identify the subtype of primary aldosteronism in people who also have excess cortisol. It may help determine if surgery is the right treatment for you.
Chongqing, Chongqing MunicipalityAges Any age - NCT06833437Recruiting
New PET scan versus blood test for adrenal condition
This trial tests a special PET scan (68Ga-Pentixafor) to see if it can replace a more invasive blood test (AVS) for finding which adrenal gland is causing high blood pressure and high cortisol levels. It may help patients avoid a complicated procedure.
Chongqing, Chongqing MunicipalityAges 18–70 - NCT06955286Recruiting
Adrenal insufficiency after adrenal surgery in aldosteronism patients
This study looks at how often adrenal insufficiency happens after surgery for primary aldosteronism, especially in patients who also have an overproduction of cortisol. It helps doctors understand if extra hormone support is needed after surgery.
Chongqing, Chongqing MunicipalityAges 18–70 - NCT07247058RecruitingPhase 4
Testing Isturisa for mild cortisol excess from adrenal tumors
This study tests whether a drug called Isturisa (osilodrostat) can safely lower mild cortisol excess in people with adrenal tumors. It aims to help patients avoid the long-term effects of too much cortisol.
Baltimore, MarylandAges 18 years+ - NCT07764380Recruiting
Stress during pregnancy and its effects on mothers and babies
This study looks at how stress during pregnancy might affect stress hormones and genes in pregnant women. It aims to understand these effects to better support mothers and babies.
KahramanmaraşAges 18–49 - NCT07387419Recruiting
Steroid Hormone Rhythms in Adrenal Nodules
This study looks at how your body's natural steroid rhythms change when you have adrenal nodules. It compares people with non-secreting nodules to those with a mild hormone excess (MACS) to see if there are differences in daily cortisol patterns.
PessacAges 18 years+ - NCT07156370Recruiting
Saliva cortisol test for hard-to-control diabetes
This study checks if a simple saliva test can find high cortisol levels in people with hard-to-control type 2 diabetes. It aims to help doctors identify if cortisol problems are making diabetes worse.
ShanghaiAges 18–80 - NCT04127552Recruiting
Adrenal mass screening and hormone effects on health
This study looks at how an accidentally found adrenal growth may affect heart and metabolic health, especially if it causes extra cortisol production. It may help explain which people are at higher risk and what monitoring or treatment could be useful.
Rome, ItalyAges 18–80 - NCT04543253Recruiting
Recovery study after Cushing surgery for cortisol excess
This study looks at how people recover after surgery to treat Cushing syndrome and mild cortisol overproduction. It may help doctors understand what recovery looks like and how treatment affects cortisol levels and symptoms.
Rochester, MinnesotaAges 18 years+ - NCT04844684Recruiting
Study hormones and bile acids in women with obesity
This study looks at how cortisol and bile acids are processed in non-menopausal women with obesity. The goal is to understand metabolism differences and potentially guide future treatments or dietary/medication approaches.
LilleAges 18 years+ - NCT05149638Recruiting
Checking updated cortisol lab values for adrenal insufficiency
This study tests whether updated cortisol test numbers better identify adrenal insufficiency, a hormone condition where your body doesn’t make enough stress hormone. It may help doctors confirm the diagnosis and choose safer next steps for treatment.
The Bronx, New YorkAges 18 years+ - NCT05931549Recruiting
Brain and stress hormone study in severe anorexia
This study looks at cortisol (a stress hormone) and brain activity in people with anorexia nervosa, especially in the hippocampus and insula areas. It may help researchers understand what is going on in the brain and stress system, which could guide better treatments in the future.
OdenseAges 18–50
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Common questions
- Are there clinical trials for cortisol?
- Yes. Clin2 currently lists 39 recruiting cortisol studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cortisol trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cortisol trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.