Clinical trials
Critically Ill clinical trials
Below are recruiting critically ill clinical trials, each written for real people, not researchers. We’re tracking 352 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05513456Recruiting
ICU doctors and trainees answer a fast online case survey
This study asks intensive care doctors (including trainees) to respond to short ICU case scenarios in a randomized survey. It aims to see whether people’s answers differ by gender and ethnicity, which could help improve fairness and education in ICU decision-making.
StockholmAges Any age - NCT05526105Recruiting
Ultrasound for stomach fluid in ICU patients
This trial tests using an ultrasound scan to estimate stomach fluid and volume in ICU patients. It may help clinicians better assess aspiration risk and prepare for safe anesthesia or procedures.
Lebanon, New HampshireAges 18–100 - NCT05536531Recruiting
NMES therapy to help prevent ICU muscle weakness
This trial tests whether a device that delivers small electrical pulses to muscles can help prevent breathing and muscle weakness in very sick ICU patients. It also looks at changes in blood markers that may relate to muscle weakness and recovery.
Santiago, Santiago MetropolitanAges 18 years+ - NCT05541029Recruiting
Music listening for children on breathing machines
This study tests whether listening to music can help children who are in the Pediatric Intensive Care Unit (PICU) and need a breathing machine. It looks at the “how it works” side—whether music changes things in the body or brain during intensive care.
Pittsburgh, PennsylvaniaAges 2 months–17 years - NCT05551325Recruiting
Resetting sleep timing for ICU patients to support recovery
This study tests a “sleep chronobundle,” a set of sleep and light-timing steps, to improve daily sleep-wake timing in people in the ICU on breathing or blood-pressure support. It also checks whether the body’s sleep rhythms are more aligned during critical illness and over time.
New Haven, ConnecticutAges 18 years+ - NCT05616130Recruiting
Study of abnormal blood immune activation after trauma or elective hip surgery
This study looks at how the body’s blood-related immune system “switches on” in unusual ways after a major injury or elective hip repair. The researchers hope this helps them understand who is at risk for complications and why, by measuring changes in your blood around the time of surgery or hospital treatment.
Gainesville, FloridaAges 18–100 - NCT05634135Recruiting
Testing breathing and blood-flow patterns in long-term ventilated ICU patients
This study looks at how well air moves through the lungs and how blood flows in different types of patients who have been on a breathing machine for a long time. It may help clinicians better understand these patterns during “weaning” (trying to come off the machine), which could improve care plans.
TaipeiAges 20 years+ - NCT05647135Recruiting
High-protein tube feeds for multiple trauma ICU patients
This trial studies whether very high protein tube-feeding helps critically ill adults with multiple injuries recover better in the ICU. It compares feeding approaches during the time you need breathing support.
BucharestAges 18 years+ - NCT05673408Recruiting
Check how well a blood pressure cuff reads in critically ill patients
This study tests whether a noninvasive blood pressure (NIBP) cuff gives accurate readings in people being cared for in intensive care or the operating room. It will compare the cuff’s numbers to blood pressure measured through an arterial line in different patient groups.
Jacksonville, FloridaAges Any age - NCT05713877RecruitingPhase 2
Melatonin to treat confusion in ICU patients
This Phase 2 trial tests whether melatonin can reduce delirium, a sudden confusion that can happen in the ICU. If you qualify, you may be given melatonin to see if it improves alertness and comfort during an expected longer ICU stay.
Montreal, QuebecAges 18 years+ - NCT05740735Recruiting
Testing sound-based brain signals to predict recovery after severe brain injury
This study checks how a brain responds to two kinds of sounds—neutral tones and emotional sounds—in people with a persistent disorder of consciousness after a serious event like stroke, head injury, or cardiac arrest. The goal is to see whether these brain “signal” tests can help doctors predict outcomes.
Paris, IDFAges 18 years+ - NCT05780099Recruiting
Study of patients treated in internal medicine clinics
This observational study follows people receiving care in Internal Medicine at San Raffaele Hospital to better understand what kinds of conditions they have. It does not test a new treatment, but your information may help improve future care.
MilanAges 18 years+ - NCT05830669Recruiting
Remote preconditioning therapy for newly sick sepsis patients
This trial studies whether a “remote preconditioning” treatment given during early sepsis can help protect the kidneys and improve outcomes. It is for adults in the ICU very soon after sepsis begins.
MünsterAges 18 years+ - NCT05860894Recruiting
Study of new ICU atrial fibrillation
This trial looks at people who develop a new irregular heart rhythm called atrial fibrillation while in the intensive care unit (ICU). It tests an approach to help with that condition after critical illness, aiming to improve outcomes for those affected.
BesançonAges 18 years+ - NCT05865314Recruiting
Nutrition plus early therapy for adults in long ICU stays
This trial studies whether a planned nutrition plan, along with early physiotherapy (physical therapy), can improve outcomes for adults who expect to stay in the ICU for at least 7 days. It includes people who need feeding through a tube and/or special IV nutrition while on a breathing machine.
Geneva, Canton of GenevaAges 18 years+ - NCT05906472Recruiting
Feeding through a tube after tracheostomy in the ICU
This study tests a specific way of continuing tube feeding for people who need a tracheostomy after being on a breathing tube in the ICU. The goal is to see if this feeding approach is safe and beneficial for recovery.
Danbury, ConnecticutAges 18 years+ - NCT05952648Recruiting
Test for pneumonia in ICU using fast DNA testing
This study checks whether a fast “DNA test” can help diagnose hospital-acquired or ventilator-associated pneumonia in very sick patients with sepsis. If the test is accurate, it may help doctors start the right treatment sooner.
BolognaAges 18 years+ - NCT05985525Recruiting
Monitoring blood flow in ICU patients with severe infection or shock
This study monitors tiny blood vessels under the tongue using a non-invasive device to see how well blood flows in ICU patients on a breathing machine. Researchers hope to improve care for patients with serious infections or shock.
Winnipeg, ManitobaAges 18 years+ - NCT06021288Recruiting
Standard vs. lower dose dialysis for kidney failure in intensive care
This trial compares the usual dose of continuous dialysis with a lower dose to see if a lower dose is just as safe and effective for critically ill patients with sudden kidney failure.
MünsterAges 18 years+ - NCT06027684Recruiting
Intensive care decisions, survival, and dying well
This study talks to adults who have been in an intensive care unit (ICU) to understand their views on life-sustaining treatments, end-of-life wishes, and when they would want less or more care. It aims to improve how doctors and families make these hard decisions together.
ManchesterAges 18 years+ - NCT06032884Recruiting
Comparing two dialysis methods for severe kidney injury in ICU
This trial compares two ways to filter blood (intermittent hemodialysis and continuous renal replacement therapy) for patients in the intensive care unit with severe acute kidney injury. It aims to find which method works better for critically ill patients.
BobignyAges 18 years+ - NCT06034990Recruiting
ICU fluid use survey for Southeast Asian doctors
This survey asks doctors in Southeast Asian ICUs about how they use fluids (like IV fluids) for their patients. It's a simple questionnaire to understand current practices and help improve care.
Bangkok, BangkokAges 18–60 - NCT06039501Recruiting
The Family Perspectives Project Pilot Trial
This study looks at how to improve communication between families and the care team when a loved one is on a breathing machine in the intensive care unit. It may help families feel more supported and involved in care decisions.
Los Angeles, CaliforniaAges 18 years+ - NCT06109142Recruiting
Testing a special filter to clean blood in shock and kidney failure
This trial is testing a special blood filter (oXiris) to see if it helps remove harmful substances from the blood of people in the intensive care unit with shock and kidney failure. It may help improve blood pressure and reduce the need for strong medicines.
GarchesAges 6 years+
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Common questions
- Are there clinical trials for critically ill?
- Yes. Clin2 currently lists 352 recruiting critically ill studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a critically ill trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a critically ill trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.