Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,510 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07136714RecruitingPhase 4
Semaglutide for depression in people with overweight
This study tests whether a weekly injection of semaglutide (a medication used for weight loss and diabetes) can help reduce symptoms of depression in people who have major depressive disorder and are overweight or obese.
Hillerød, DenmarkAges 18–65 - NCT07146503Recruiting
Esketamine Nasal Spray for Treatment-Resistant Depression in Real Life
This study tests esketamine nasal spray (a fast-acting antidepressant) for people with treatment-resistant depression who haven't gotten better after trying at least two other antidepressants. It looks at how well the spray works in everyday doctor's offices, not just in research clinics.
Genova, GeAges 18–74 - NCT07172516RecruitingPhase 3
Study of azetukalner vs placebo for bipolar depression
This trial tests whether the study drug azetukalner can help reduce depression symptoms in people with bipolar I or II disorder who are currently having a depressive episode. You would be randomly assigned to receive either the drug or a placebo (inactive pill) to see which works better.
Tucson, ArizonaAges 18–74 - NCT07211750Recruiting
Integrated care for older adults with depression and multiple health conditions
This trial tests a new integrated care program for older adults who have depression or bipolar disorder along with at least two other long-term physical health problems. The program aims to bring together your doctors and psychiatrist to improve your overall health.
LeuvenAges 65 years+ - NCT07217223Recruiting
Home-based brain stimulation for treatment-resistant depression
This study tests whether a gentle brain stimulation technique called tDCS can help people with depression that hasn't improved with medication. It can be done at home using a special headset and an internet connection.
San Diego, CaliforniaAges 18–85 - NCT07246044Recruiting
Brain stimulation for teens with bipolar depression targeting S1
This trial tests a non-invasive brain stimulation technique (HD-tDCS) to see if it can help teens with bipolar disorder who are currently in a depressive episode. It aims to find a new treatment option for adolescent bipolar depression.
Nanjing, JiangsuAges 12–18 - NCT07258914Recruiting
Repetitive TMS for depression in adults with autism
This trial tests whether repetitive transcranial magnetic stimulation (rTMS) can safely and effectively treat major depression in adults who also have autism spectrum disorder. rTMS uses magnetic pulses to stimulate specific brain areas without surgery.
RennesAges 18–65 - NCT07266545RecruitingPhase 4
RNA markers for antidepressant response in depression
This study looks at how RNA might help predict which antidepressant works best for you. It tests two medications: vortioxetine and cariprazine, in people with major depressive disorder or bipolar depression.
Rochester, MinnesotaAges 18–65 - NCT07324070Recruiting
Adding TMS to ECT for hard-to-treat depression
This study tests whether adding TMS to ECT can better treat depression that hasn't improved with other treatments. It is for adults with moderate to severe major depression who haven't had these treatments recently.
Prague, CzechAges 18 years+ - NCT07380451Recruiting
Personalized therapy for depression with childhood trauma
This trial tests a flexible, personalized therapy program for adults with depression who also have a history of childhood trauma and personality challenges. It aims to see if this approach helps more than standard care, and you'll receive weekly therapy from a community clinic in Chile.
SantiagoAges 18–65 - NCT02752542RecruitingPhase 4
Personalized therapy and antidepressants for depression
This trial studies whether a personalized combination of talk therapy (CBT) and antidepressant medication works better for people with moderate to severe depression. It’s meant to match treatment choices to your situation and to see what helps most.
Halifax, Nova ScotiaAges 18 years+ - NCT03065335RecruitingPhase 1
Ketamine plus brain imaging to study response in depression
This early-stage study tests how ketamine given once and then repeatedly may change brain signals and related biomarkers in people with major depression. If you’re eligible, the team will use brain imaging and assessments to see who responds and why.
Bethesda, MarylandAges 18–65 - NCT07432815RecruitingPhase 4
Psoriasis with depression: methotrexate plus an antidepressant
This trial tests if adding an antidepressant (escitalopram) to standard methotrexate treatment works better than methotrexate alone for people who have both psoriasis and depression or anxiety. If you have moderate to severe psoriasis and also struggle with depression or anxiety, this study might offer a way to treat both conditions together.
Cairo, Cairo GovernorateAges 18–60 - NCT07454070Recruiting
Testing ear nerve stimulation for depression after a heart attack
This trial tests if a gentle, non-invasive ear stimulation device can help relieve depression in people who have had a heart attack and a stent placed. It aims to offer a drug-free option for those who choose not to take antidepressants or see a therapist.
Xi'an, ShaanxiAges 18 years+ - NCT07474363Recruiting
Depression differences between men and women
This study looks at how depression affects men and women differently, including symptoms, strength to cope (resilience), and feelings of stigma. It aims to understand these differences to improve treatment.
Eskişehir, EskişehirAges 18–65 - NCT07543328Recruiting
Light therapy added to antidepressants for depression with body symptoms
This study tests whether a special light treatment applied to the scalp (transcranial photobiomodulation) can help people with depression who aren't getting better with antidepressants alone. The light therapy is added to your current medication to see if it reduces both mood symptoms and physical complaints like pain or fatigue.
TaipeiAges 18–65 - NCT07576686Recruiting
AI-assisted therapy for depression and anxiety
This trial tests a computer-guided cognitive behavioral therapy (CBT)—a proven talk therapy approach—to help treat mild depression and anxiety. The program runs for 10 weeks with weekly sessions, and AI helps guide your therapist or the process itself.
NišAges 18 years+ - NCT07603804Recruiting
Accelerated Brain Stimulation for Treatment-Resistant Depression
This study tests an accelerated form of iTBS (a non-invasive brain stimulation technique) for depression that hasn't improved with antidepressant medications. The goal is to help people with major depression who haven't responded adequately to at least one antidepressant drug.
IstanbulAges 18–65 - NCT07398040Enrolling by invitation
Anti-inflammatory diet for anxiety and depression
This study tests whether following a personalized anti-inflammatory diet can help reduce symptoms of anxiety, depression, or stress. You would need to live in Zaragoza, speak Spanish, and already have a low-to-moderate Mediterranean diet score.
Zaragoza, ZaragozaAges 18 years+ - NCT07207239Enrolling by invitation
Brain stimulation for treatment-resistant depression
This trial is testing a type of brain stimulation therapy called theta-burst rTMS to see if it helps with depression that hasn't improved with standard treatments. It also uses brain scans to predict who might respond best.
Budapest, Pest CountyAges 18 years+ - NCT07146269Enrolling by invitation
Virtual reality and brain stimulation for depression
This study tests if combining virtual reality with a gentle brain stimulation method at home can help people with major depression. You would use a headset and small electrodes to receive treatment in your own home.
MunichAges 18–65 - NCT07064928Enrolling by invitation
Reducing HIV stigma in pregnancy and after birth
This study tests a program to reduce stigma related to HIV among pregnant women and new mothers. You may be eligible if you are living with HIV, are between 24 and 36 weeks pregnant, and plan to stay in the area for at least 6 months after your baby is born.
AccraAges 14 years+ - NCT07007247Enrolling by invitation
Digital aftercare for teens with depression after hospital discharge
This pilot study tests a digital program to support adolescents aged 12–17 with depression after they leave the hospital. It aims to help prevent relapse and improve well-being using a smartphone, tablet, or computer.
HamburgAges 12–17 - NCT06273982Enrolling by invitation
Telehealth for anxiety and depression in youth
This study tests whether a behavioral telehealth program can help teens and children with anxiety or depression. It is designed for patients in community health centers and includes support from a parent or guardian.
Portland, OregonAges 8–16
Hear when a new Depressed trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,510 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.