Clinical trials · Maryland
Depression clinical trials in Maryland
We’re tracking 46 recruiting depression studies with a site in Maryland — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Maryland
- NCT07553637RecruitingPhase 2
ALTO-207 for Adults With Hard-to-Treat Depression
This study tests whether a new medication called ALTO-207 can help people with depression that hasn't improved with standard antidepressants. You may qualify if you've tried multiple antidepressants without enough relief and are willing to add this experimental treatment to your current medication.
Annapolis, MarylandAges 18–75 - NCT07149428Enrolling by invitation
Deep study of smell loss causes using brain scans
This study uses brain imaging and electrical recordings to understand the brain's role in smell loss from any cause—like COVID, sinus problems, or chemotherapy. You may be eligible if you have any degree of smell loss lasting under a year.
Bethesda, MarylandAges 18–99 - NCT05669703Recruiting
Tracking mood and activity patterns in bipolar disorder families
This study watches how a person’s mood and movement change over time, and how those patterns relate to bipolar disorder. It may help researchers better understand the condition in families and potentially improve future care.
Bethesda, MarylandAges 8–70 - NCT06034821Enrolling by invitationPhase 4
ECT vs. ketamine for suicidal depression in adults
This trial compares two treatments—ECT (electroconvulsive therapy, which uses electrical stimulation) and ketamine (a medicine given as a shot)—to see which works better for quickly reducing suicidal depression. It is for adults who are in a severe depressive episode with active suicidal thoughts.
Baltimore, MarylandAges 18–90 - NCT07220460RecruitingPhase 2
Study of an oral drug for bipolar depression
This trial tests an experimental pill (ABB-932) for people with bipolar I or II disorder who are currently in a depressive episode. The goal is to see if the drug is safe and helps improve mood.
Baltimore, MarylandAges 18–65 - NCT06748222RecruitingPhase 3
Online mindfulness program for breast cancer survivors
This trial tests a 6-week online mindfulness program to help breast cancer survivors manage mild to moderate depression. You may qualify if you finished active treatment within the last 5 years and can use a digital device.
Baltimore, MarylandAges 18–50 - NCT06326905Recruiting
Transplant help for kidney waitlist patients with barriers
This study helps people on the deceased donor kidney waitlist who have had setbacks like health issues, lack of support, or low income. It offers extra support to help you get ready for transplant.
Baltimore, MarylandAges 18–99 - NCT04877977Recruiting
Long-Term Follow-Up for People With Mood Disorders
This study follows people with mood disorders over a long time to better understand how symptoms and functioning change. You may be able to join if you already agreed to take part in an earlier mood/anxiety study and you meet basic participation needs.
Bethesda, MarylandAges 18–99 - NCT04201600Recruiting
Study how blood sugar swings affect thinking in prediabetes
This study looks at how “blood sugar variability” (how much glucose levels bounce around) may affect thinking and memory in people with prediabetes. You may be eligible if you’re older and don’t already have diabetes or conditions that can strongly affect the brain or blood vessels.
Baltimore, MarylandAges 50 years+ - NCT00018057RecruitingPhase 2
Brain study of pediatric anxiety disorders
This study looks at how the brain works in children and adults with anxiety disorders. It uses brain scans (fMRI) and other safe tests to understand anxiety better.
Bethesda, MarylandAges 8–65 - NCT05663034Recruiting
Compare CBT-I vs MBTI for sleep and trauma symptoms after TBI
This study compares two types of talk-based therapy to help veterans with long-lasting insomnia after a traumatic brain injury (TBI), and also looks at related post-trauma stress symptoms. It may help you improve sleep and reduce how much these symptoms affect daily life.
Bethesda, MarylandAges 18 years+ - NCT06605105Enrolling by invitationPhase 3
Long-term extension trial of CYB003 for depression
This long-term study is for people who already completed an earlier trial of the experimental drug CYB003 for major depression and who stayed on their regular antidepressant. It looks at the safety and effects of taking CYB003 again over many months.
Rockville, MarylandAges 18–85 - NCT05859204Enrolling by invitation
Exercise groups to improve mental health in hospital
This study tests whether joining structured exercise groups while you’re an inpatient in a psychiatric unit can improve mood, mental wellbeing, and overall comfort. It’s designed to be adjustable for different mobility needs and to be safe for participating patients.
Baltimore, MarylandAges 18 years+ - NCT05538910Recruiting
Study brain links between depression and substance use
This study uses brain imaging and questionnaires to understand how substance use and depression are connected in the brain. It may help researchers identify biological patterns that could guide better treatments in the future.
Baltimore, MarylandAges 18–60 - NCT06744790Recruiting
Predicting breathing trouble after surgery with a new sensor
This trial tests a new sensor that monitors your breathing to predict if you might have trouble after surgery. It is for people who are staying overnight in the hospital and getting extra oxygen through a face mask.
Baltimore, MarylandAges 18 years+ - NCT06994988Recruiting
Smart band-aid study for chronic pain in women
This trial tests a special band-aid that measures chronic pain. Women with chronic pain or healthy women may join to help researchers learn how this device works.
Bethesda, MarylandAges 18 years+ - NCT07097545Recruiting
Social media, exercise, and mindfulness for college students
This study tests whether limiting social media to a few minutes daily and doing brief exercise or mindfulness activities for two weeks can improve well-being. It is for Johns Hopkins students who use social media a lot and currently exercise an hour or less each day.
Baltimore, MarylandAges 18 years+ - NCT07227337Recruiting
Being safe, healthy, and empowered for immigrant women
This study tests a program to help immigrant women who have faced violence and feel symptoms of PTSD or depression. It aims to improve your safety, health, and wellbeing.
Baltimore, MarylandAges 18 years+ - NCT07228520Recruiting
Pain and strength study for depression and frailty
This trial tests a program to help people with chronic pain, depression, and weakness build strength and coping skills. It may help you if pain limits your daily activities and you feel down or frail.
Baltimore, MarylandAges 50 years+ - NCT07317271Recruiting
Virtual reality for burn symptoms
This trial tests a virtual reality program to help with symptoms like pain, trouble sleeping, and itching after a burn injury. You can join from home using your own device.
Baltimore, MarylandAges 18 years+ - NCT00024635Recruiting
Understanding Mood and Anxiety Disorders Study
This research study evaluates people with mood disorders (like depression or bipolar disorder), anxiety disorders, or people without these conditions to better understand how these conditions develop and affect the brain. Researchers will ask questions and may do other assessments to learn more.
Bethesda, MarylandAges 3–99 - NCT02543983RecruitingPhase 2
Brain scan and ketamine study for suicidal thoughts
This trial studies how ketamine affects the brain in people dealing with suicidal thoughts or an active suicide crisis. It uses questionnaires, consent testing, and brain imaging to look for biological changes that may relate to symptom improvement.
Bethesda, MarylandAges 18–70
Depression trials by city in Maryland
Where these studies are running in Maryland
Institutions with a site for the recruiting depression studies listed above.
- National Institutes of Health Clinical Center · 6 studies
- Johns Hopkins University · 5 studies
- Johns Hopkins Bayview Medical Center · 2 studies
- Walter Reed National Military Medical Center · 2 studies
- Baltimore VA Geriatric Research Education and Clinical Center (GRECC)
- Central Maryland Radiation Oncology
- Kaiser Permanente - Largo Medical Center
- Kaiser Permanente Gaithersburg Medical Center
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Depression trials in other states
Common questions
- Are there depression clinical trials in Maryland?
- Yes. We're currently tracking 46 recruiting depression studies with a site in Maryland, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study in Maryland?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Maryland to take part?
- Not necessarily. These studies have a site in Maryland, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open in Maryland regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.