Clinical trials · California
Diabetes Mellitus clinical trials in California
We’re tracking 73 recruiting diabetes mellitus studies with a site in California — including Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT03460769Recruiting
Mixed meal test to study diabetes from pancreas conditions
This study uses a special blood-sugar test (a mixed meal) to better diagnose and understand diabetes related to pancreatic cancer or chronic pancreatitis, and to compare it with other diabetes types. It may help researchers find clearer ways to tell these diabetes causes apart and understand how they work.
Los Angeles, CaliforniaAges 30–84 - NCT05580536Recruiting
Text-message program for Arab Americans with type 2 diabetes
This study tests a diabetes support program designed for Arab Americans, using regular text messages and materials in Arabic and English. It may help people improve blood sugar control and stay engaged in their care.
El Cajon, CaliforniaAges 18 years+ - NCT07518004Recruiting
ROME GS System Study for diabetes glucose monitoring
This study tests the ROME GS System, a glucose monitoring device that measures blood sugar levels. The system includes a sensor placed under the skin and a transmitter worn on the body. If you have diabetes and want to help evaluate a new way to track your blood sugar, this trial may be for you.
Walnut Creek, CaliforniaAges 18 years+ - NCT07668388RecruitingPhase 2
Testing different doses of UBT251 for type 2 diabetes
This trial tests a new medicine, UBT251, to see how well it lowers blood sugar in people with type 2 diabetes. It compares different doses to find the best one for you.
Fountain Valley, CaliforniaAges 18–75 - NCT03746769RecruitingPhase 1/Phase 2
Testing gastrin to improve results of islet cell transplant
This trial looks at whether adding gastrin can improve outcomes after an islet cell transplant for people with type 1 diabetes. It may help some participants achieve better blood sugar control, but it also requires close follow-up and immune-suppressing medications to protect the new cells.
Duarte, CaliforniaAges 18–68 - NCT04428658Recruiting
Telehealth coaching for kids to improve blood sugar control
This trial tests whether extra diabetes coaching delivered through online video and online messages can lower blood sugar levels in children with type 1 diabetes. It may help your child improve diabetes control by combining real-time and non-real-time support.
Sacramento, CaliforniaAges 5–18 - NCT04786262RecruitingPhase 3
Study of VX-880 for long-standing type 1 diabetes
This Phase 3 trial tests how safe, tolerable, and effective VX-880 is for people with type 1 diabetes who have had it for many years. It may help reduce problems related to blood sugar swings, especially severe low blood sugar episodes.
San Francisco, CaliforniaAges 18–65 - NCT05124457RecruitingPhase 2
Detemir vs NPH insulin for diabetes in pregnancy
This Phase 2 study compares two types of insulin—insulin detemir vs NPH—to see which works better and is safe for controlling blood sugar during pregnancy. You may be invited if you are pregnant and need insulin for either pre-existing type 2 diabetes or gestational diabetes.
Los Angeles, CaliforniaAges 18 years+ - NCT06860516Recruiting
HLA Demographics Study in Adults With Type 1 Diabetes
This study (NCT06860516) is an observational trial of adults aged 18-55 with type 1 diabetes diagnosed within 6 months. It aims to collect demographic and HLA data.
San Francisco, CaliforniaAges 18–55 - NCT07415954RecruitingPhase 2
Testing a new diabetes medicine for blood sugar control
This study tests a new medicine, NNC0662-0419, in people with type 2 diabetes. You must be willing to lose a lot of weight (more than a quarter of your current weight) as part of the study to see if the medicine helps lower blood sugar.
Lancaster, CaliforniaAges 18–75 - NCT07076199RecruitingPhase 3
Weekly vs daily insulin for type 1 diabetes
This study tests a new once-weekly insulin (icodec) against a standard daily insulin (glargine), both taken with mealtime insulin. It aims to see which works better to control blood sugar in adults with type 1 diabetes.
Concord, CaliforniaAges 18 years+ - NCT07019649Enrolling by invitation
AYUDA program for younger Latinx adults with type 2 diabetes
This study tests a program called AYUDA, which sends helpful text messages and support to younger Latinx adults (ages 18–44) who were recently diagnosed with type 2 diabetes and are raising children. The goal is to see if this program helps manage diabetes better.
Pleasanton, CaliforniaAges 18–44 - NCT05752292Enrolling by invitation
Pregnant with gestational diabetes: share risk info to help
This study is testing how to share risk information during pregnancy in a way that helps patients feel more informed and empowered. It includes people currently pregnant with gestational diabetes and will ask about your preferences and understanding.
Pleasanton, CaliforniaAges 18 years+ - NCT06296485Recruiting
Safer Aging with Diabetes Monitoring
This study tests a way to help older adults with type 2 diabetes who use insulin avoid dangerously low blood sugar. You would use a continuous glucose monitor and get support via email or internet to stay safe.
Fremont, CaliforniaAges 75 years+ - NCT05138432Recruiting
More fresh fruit and vegetables for kids with type 2 diabetes
This study tests whether giving families extra fresh fruits and vegetables helps children manage type 2 diabetes. It’s delivered through a “prescription” program and may support healthier eating habits.
San Diego, CaliforniaAges Up to 18 years - NCT06251323Recruiting
Better diabetes care with team support and technology
This study tests a new way to help adults with type 2 diabetes get better care. It includes a team of healthcare providers and uses technology to support your treatment.
Stanford, CaliforniaAges 18 years+ - NCT06445946RecruitingPhase 4
Metformin vs insulin for gestational diabetes
This study compares two common medicines (metformin pills and insulin shots) to see which works better for controlling blood sugar in pregnant women with gestational diabetes. The goal is to find the best treatment for both mom and baby, now and in the long term.
San Francisco, CaliforniaAges 18 years+ - NCT06453928Recruiting
Starting technology for high-risk type 1 diabetes
This study tests a new approach to help people with type 1 diabetes who have high blood sugar (A1c above 8.5%) and are not on an insulin pump. It looks at whether using diabetes technology can improve your glucose control.
Santa Monica, CaliforniaAges 18 years+ - NCT06964087RecruitingPhase 2
Testing OPT101 for type 1 diabetes
This trial tests an investigational drug called OPT101 in people with type 1 diabetes. It aims to see how the drug works in the body and whether it can help preserve insulin production, especially in those diagnosed recently or within the last 20 years.
Walnut Creek, CaliforniaAges 18–50 - NCT05762107RecruitingPhase 2
Drug ZT-01 to reduce low blood sugar at night
This Phase 2 study tests ZT-01 to help prevent night-time low blood sugar (hypoglycemia) in people with type 1 diabetes. It may help if you’ve had low blood sugar during sleep or are at high risk based on recent glucose monitoring.
San Carlos, CaliforniaAges 18–75 - NCT07224321RecruitingPhase 2
Inhaled insulin for youth with newly diagnosed type 1 diabetes
This study tests an inhaled insulin called Afrezza for teenagers and children who have just been diagnosed with type 1 diabetes. It aims to see if this new way of taking insulin can help manage blood sugar and fit into their lives.
Los Angeles, CaliforniaAges 6–17 - NCT07088068RecruitingPhase 3
Teplizumab for newly diagnosed type 1 diabetes
This study tests whether teplizumab can help keep the body making insulin in people recently diagnosed with type 1 diabetes. It is for children and young adults aged 1 to 25, and compares the drug against a placebo.
Huntington Beach, CaliforniaAges 1–25 - NCT07521475Recruiting
Fully Closed Loop Insulin Pump for Type 2 Diabetes
This study tests a new automated insulin pump system (Omnipod) that adjusts insulin doses on its own throughout the day for people with type 2 diabetes. The goal is to see if it helps keep blood sugar levels more stable while reducing the burden of manual insulin management.
Los Angeles, CaliforniaAges 18–75 - NCT05279729Recruiting
Mobile app coaching for people with diabetes
This study tests whether using a smartphone app can help people with type 2 diabetes manage their health. It focuses especially on low-income Hispanic/Latinx adults who regularly check blood sugar.
San Diego, CaliforniaAges 18–64
Diabetes Mellitus trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting diabetes mellitus studies listed above.
- University of California, San Francisco · 5 studies
- Diablo Clinical Research · 4 studies
- Headlands Research - AMCR Institute · 3 studies
- Ark Clinical Research · 2 studies
- Cedars-Sinai Medical Center · 2 studies
- City of Hope Comprehensive Cancer Center · 2 studies
- Kaiser Permanente Northern California · 2 studies
- Los Angeles Institute for Metabolic Research · 2 studies
What taking part in a diabetes mellitus study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Diabetes Mellitus trials in other states
Common questions
- Are there diabetes mellitus clinical trials in California?
- Yes. We're currently tracking 73 recruiting diabetes mellitus studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a diabetes mellitus study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a diabetes mellitus trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New diabetes mellitus studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.