Clinical trials · North Carolina
Diabetes Mellitus clinical trials in North Carolina
We’re tracking 42 recruiting diabetes mellitus studies with a site in North Carolina — including Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT06783309RecruitingPhase 1/Phase 2
Testing CNP-103 for newly diagnosed type 1 diabetes
This trial tests a new study drug called CNP-103 for people ages 12-35 who were recently diagnosed (within 6 months) with stage 3 type 1 diabetes. The goal is to see if the drug can help preserve the body's ability to make some insulin, potentially slowing the need for more insulin shots.
Durham, North CarolinaAges 12–35 - NCT07197788Enrolling by invitation
Continued access to the Endogenex device study for type 2 diabetes
This trial offers continued access to the Endogenex system for people who were in the sham (placebo) group of the ReCET study and have completed their 12-month visit. It tests a device that treats the duodenum to improve blood sugar control.
Raleigh, North CarolinaAges 22 years+ - NCT07228117Recruiting
Testing a new automated insulin pump for people with diabetes
This study tests a new automated insulin delivery system (a pump that helps manage blood sugar) in children and adults with diabetes. It aims to see if the system is safe and easy to use in daily life.
Arden, North CarolinaAges 7–85 - NCT07662213RecruitingPhase 3
Elecoglipron vs semaglutide for type 2 diabetes
This study tests an experimental diabetes pill (elecoglipron) to see if it works as well as a current medicine, semaglutide, for people with type 2 diabetes who also have heart risk factors. It aims to help better control blood sugar and weight.
Durham, North CarolinaAges 18 years+ - NCT05544266Recruiting
Study rare diabetes patterns to better guide diagnosis
This study looks at people who may have a “non-typical” form of diabetes, including rare genetic causes or unusual symptoms. It may help your care team understand what type of diabetes you have and whether specific genetic testing could explain it.
Chapel Hill, North CarolinaAges Any age - NCT06405373Recruiting
Coping skills program for type 1 diabetes distress
This study tests a program to help adults with type 1 diabetes who feel stressed or overwhelmed by their condition. You'll join virtual group sessions to learn coping skills and track how your distress changes over time.
Chapel Hill, North CarolinaAges 30 years+ - NCT07197775Enrolling by invitation
Endogenex PULSE Registry: Tracking long-term outcomes
This registry collects information from people with type 2 diabetes who have already been treated with the Endogenex System. It helps researchers learn how the treatment works over time.
Raleigh, North CarolinaAges 18 years+ - NCT07340320RecruitingPhase 2
CX11 tablets for type 2 diabetes
This trial tests an experimental drug called CX11 to see if it helps control blood sugar in people with type 2 diabetes who are already taking metformin. It may be an option for you if your blood sugar is not well controlled and you meet the health requirements.
Raleigh, North CarolinaAges 18–75 - NCT07527650RecruitingPhase 2
Testing HM15275 for Type 2 Diabetes Management
This study tests a new medication called HM15275 to help control blood sugar in people with type 2 diabetes. The trial will check if the medication works well and is safe when added to diet, exercise, or metformin treatment.
Morehead City, North CarolinaAges 18–75 - NCT07662109RecruitingPhase 3
Testing a new combo pill for type 2 diabetes
This study tests if a new medicine (elecoglipron) combined with dapagliflozin is safe and works better for adults with type 2 diabetes that isn't well controlled by diet or other medications.
Raleigh, North CarolinaAges 18 years+ - NCT07662135RecruitingPhase 3
A study of elecoglipron for type 2 diabetes with kidney problems
This trial tests a new medicine called elecoglipron to see if it helps control blood sugar in people with type 2 diabetes who also have reduced kidney function. You would continue taking your current SGLT2i medication (like dapagliflozin).
Kinston, North CarolinaAges 18 years+ - NCT07664553RecruitingPhase 3
Testing a new diabetes tablet for people on insulin
This trial tests a new once-daily tablet (elecoglipron) against a placebo to see if it can help improve blood sugar control in adults with type 2 diabetes who are already on insulin. It may offer an additional treatment option to help manage your diabetes.
Cary, North CarolinaAges 18 years+ - NCT05846802Recruiting
Gastroparesis and stomach symptoms registry for adults
This registry is for adults with long-lasting stomach emptying problems or related symptoms, helping researchers better understand patterns of nausea, pain, and fullness. You may be able to join if you meet specific symptom and test results, and can complete a stomach-emptying scan.
Charlotte, North CarolinaAges 18–85 - NCT07355270Recruiting
Radiofrequency vapor ablation for type 2 diabetes
This trial tests a new device that uses radiofrequency energy to treat the lining of the upper small intestine in people with type 2 diabetes. The goal is to see if this treatment is safe and helps improve blood sugar control.
Chapel Hill, North CarolinaAges 22–65 - NCT07654374RecruitingPhase 3
Study of a new pill for weight loss and diabetes
This study tests a new daily pill (aleniglipron) to help adults with excess weight and type 2 diabetes lose weight and improve blood sugar control. It may be a good fit if you have a BMI of 27 or higher and your diabetes is managed with A1c between 6.5% and 10%.
Charlotte, North CarolinaAges 18–79 - NCT07668388RecruitingPhase 2
Testing different doses of UBT251 for type 2 diabetes
This trial tests a new medicine, UBT251, to see how well it lowers blood sugar in people with type 2 diabetes. It compares different doses to find the best one for you.
Greensboro, North CarolinaAges 18–75 - NCT05026723Recruiting
Food plan to improve health for HIV and type 2 diabetes
This study tests whether a personalized “food as medicine” approach can help people manage health related to HIV and type 2 diabetes or prediabetes risk. If you struggle with having enough healthy food, the program may focus on practical ways to improve diet and support healthier blood sugar.
Chapel Hill, North CarolinaAges 18 years+ - NCT06860516Recruiting
HLA Demographics Study in Adults With Type 1 Diabetes
This study (NCT06860516) is an observational trial of adults aged 18-55 with type 1 diabetes diagnosed within 6 months. It aims to collect demographic and HLA data.
Chapel Hill, North CarolinaAges 18–55 - NCT07415954RecruitingPhase 2
Testing a new diabetes medicine for blood sugar control
This study tests a new medicine, NNC0662-0419, in people with type 2 diabetes. You must be willing to lose a lot of weight (more than a quarter of your current weight) as part of the study to see if the medicine helps lower blood sugar.
Greensboro, North CarolinaAges 18–75 - NCT07076199RecruitingPhase 3
Weekly vs daily insulin for type 1 diabetes
This study tests a new once-weekly insulin (icodec) against a standard daily insulin (glargine), both taken with mealtime insulin. It aims to see which works better to control blood sugar in adults with type 1 diabetes.
Greenville, North CarolinaAges 18 years+ - NCT06445946RecruitingPhase 4
Metformin vs insulin for gestational diabetes
This study compares two common medicines (metformin pills and insulin shots) to see which works better for controlling blood sugar in pregnant women with gestational diabetes. The goal is to find the best treatment for both mom and baby, now and in the long term.
Winston-Salem, North CarolinaAges 18 years+ - NCT07463209Recruiting
Diabetes education with continuous glucose monitoring for older adults
This study tests whether adding continuous glucose monitoring (CGM) to diabetes education helps older adults with diabetes manage their blood sugar better. You and a care partner will learn how to use CGM and support each other.
Chapel Hill, North CarolinaAges 65 years+ - NCT07054125Recruiting
CGM, education, and peer support for type 2 diabetes
This trial tests if using a continuous glucose monitor (a small sensor that tracks your blood sugar), combined with diabetes education and support from others with diabetes, can help people with type 2 diabetes better control their blood sugar. You may qualify if your blood sugar is not well controlled (A1c above 8%).
Asheville, North CarolinaAges 18 years+ - NCT05762107RecruitingPhase 2
Drug ZT-01 to reduce low blood sugar at night
This Phase 2 study tests ZT-01 to help prevent night-time low blood sugar (hypoglycemia) in people with type 1 diabetes. It may help if you’ve had low blood sugar during sleep or are at high risk based on recent glucose monitoring.
Morehead City, North CarolinaAges 18–75
Diabetes Mellitus trials by city in North Carolina
Where these studies are running in North Carolina
Institutions with a site for the recruiting diabetes mellitus studies listed above.
- Research Site · 5 studies
- University of North Carolina at Chapel Hill · 5 studies
- Accellacare · 2 studies
- Care Access · 2 studies
- Lucas Research · 2 studies
- M3 Wake Research · 2 studies
- PharmQuest Life Sciences LLC · 2 studies
- Physicians East · 2 studies
What taking part in a diabetes mellitus study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Diabetes Mellitus trials in other states
Common questions
- Are there diabetes mellitus clinical trials in North Carolina?
- Yes. We're currently tracking 42 recruiting diabetes mellitus studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a diabetes mellitus study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a diabetes mellitus trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New diabetes mellitus studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.