Clinical trials
Disc Degeneration clinical trials
Below are recruiting disc degeneration clinical trials, each written for real people, not researchers. We’re tracking 28 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04623593Recruiting
Study of cost and value of neck disc surgery
This study looks at how cost-effective (good value for the money) anterior neck disc surgery is for people with nerve or spinal cord symptoms. If you need this type of operation, it may help doctors better choose treatments and plan healthcare resources.
Maastricht, LimburgAges 18 years+ - NCT06778447Recruiting
Disc injection for chronic low back pain
This study tests whether injecting a special disc material (nucleus pulposus allograft) into the damaged discs of your lower back can safely reduce pain and improve function. It's for people with long-term, moderate to severe low back pain from disc disease that hasn't gotten better with other treatments.
Napa, CaliforniaAges 22–85 - NCT05305430Recruiting
Synergy cervical disc data study after neck surgery
This study collects real-world information about people who get the Synergy cervical disc implant after neck surgery for nerve or spinal cord pressure. It may help doctors understand how well the implant works in everyday care and what outcomes to expect.
Windsor, VictoriaAges 21 years+ - NCT06367855RecruitingPhase 4
Dexamethasone before spine surgery for pain control
This study tests whether giving a single dose of the steroid dexamethasone before minimally invasive spine surgery can help reduce pain and inflammation afterward. It is for people aged 50–80 who are having surgery on 1 or 2 levels of their lower back and have not had spine surgery before.
Pathum Thani, Changwat Pathum ThaniAges 50–80 - NCT07085247Recruiting
Role of bacteria in lower back disc disease
This trial looks at whether a specific bacteria, Cutibacterium acnes, is linked to disc problems in the lower back. If you're having surgery for a herniated disc, your tissue sample may help researchers understand the cause.
BrnoAges 18 years+ - NCT07127380Recruiting
Comparing two types of spine surgery for disc-related low back pain
This study compares two different surgery methods (Mini-TLIF and MIDLIF) for treating low back pain caused by worn-out discs in the lower back. The goal is to see which one offers better recovery, fewer complications, and lower costs.
Lodz, Łódź VoivodeshipAges 18 years+ - NCT07425613Recruiting
Neck movement before and after disc surgery
This study looks at how neck movement control changes after a common surgery (ACDF) for a damaged disc. It compares people having surgery with those who have neck pain but are not having surgery, to understand how the neck moves before and after treatment.
LjubljanaAges 18–65 - NCT07338877Enrolling by invitation
Stem cell therapy for disc-related low back pain
This trial tests a new treatment that uses your own stem cells to help heal damaged discs in your lower back. The stem cells are injected into the disc during a minimally invasive procedure to reduce pain and improve function.
Košice, Košice RegionAges 18 years+ - NCT05110833Enrolling by invitation
Study dosing effects during monitored neck or chest spine surgery
This trial studies whether different medication dosing during monitored neck or upper chest spine surgery leads to better outcomes. You might help doctors figure out the most effective dosing approach for this type of surgery.
Minneapolis, MinnesotaAges 18 years+ - NCT05971329Recruiting
Pilot study of bone graft for cervical disc wear and nerve symptoms
This trial tests a new bone graft product (ZetaFuse™) used during front-of-the-neck surgery to treat “wear and tear” in the cervical (neck) discs causing nerve problems. It may help relieve pain and nerve-related symptoms when other treatments haven’t worked.
Randwick, New South WalesAges 22–75 - NCT05745129Enrolling by invitation
AI tool for personalized care decisions in spine problems
This trial looks at using an artificial intelligence (AI) tool to help guide care choices for people with spine problems. It may help doctors assess whether you need surgery or a different approach, especially when disc herniation isn’t the main issue.
Oslo, NorgeAges 18–80 - NCT05299762Recruiting
INFUSE bone graft for lower back fusion: patient follow-up study
This study tracks patients who receive INFUSE bone graft during a specific type of lower back fusion surgery. It helps confirm how the device performs in real-world care and monitors safety and outcomes after surgery.
SeoulAges 18 years+ - NCT05997121Recruiting
Testing a new spinal implant for degenerative disc disease
This trial studies a new spinal implant system (Hexanium TLIF) for people with degenerative disc disease. It aims to see if the implant is safe and works well to help with back pain and stability.
BrugesAges 18 years+ - NCT07168603RecruitingPhase 1/Phase 2
Testing own disc cells for low back pain from a herniated disc
This trial tests whether your own disc cells (nucleus pulposus cells) can help heal a herniated disc and reduce pain. It is for people who have had low back pain for more than six weeks and are scheduled for disc surgery.
TaipeiAges 20 years+ - NCT07044206Recruiting
Comparing two bone graft materials for lumbar fusion surgery
This trial compares two types of bone graft materials (Magnetos Putty and GlassBone Putty) used in lower back fusion surgery for adults with degenerative disc disease. The goal is to see which material works better for helping the bones fuse together, which may reduce pain and improve function.
Montpellier, FranceAges 18–80 - NCT07489001Recruiting
Comparing opioid-free to standard anesthesia for back surgery
This study compares two types of anesthesia for lower back surgery: one that uses opioids and one that does not. The goal is to see which approach controls pain better with fewer side effects.
Istanbul, MaltepeAges 18–75 - NCT03076658Recruiting
Standing full-body X-rays from healthy adults
This trial is building a database of full-body standing X-rays in people who do not have spine problems or certain health conditions. If you qualify, your X-rays may help researchers study normal body alignment for future medical use.
Aurora, ColoradoAges 21–85 - NCT05066334RecruitingPhase 2
Back pain trial using your own stem cells in discs
This Phase 2 trial tests whether injecting your own stem cells into a few back discs can reduce chronic low back pain that has not improved with standard treatments. It may help by targeting disc-related (degenerative) wear seen on MRI, but it requires detailed MRI and blood test screening.
Roma, ItalyAges 18–65 - NCT05648474Recruiting
Nerve monitoring during a low-back fusion surgery
This study tests whether special nerve monitoring during a low-back fusion helps make surgery safer and the results easier to judge. It’s for people having a specific type of low-back fusion on one or two levels.
Carlsbad, CaliforniaAges 18 years+ - NCT06342765Recruiting
Safety of SpineVision posterior fixation systems in thoracolumbar spine
This trial checks how well the SpineVision Lumis, Plus, or Ulis spine fixation systems work and stay safe in the lower back and mid-back area. It is for people who already have one of these systems implanted.
BayonneAges 18 years+ - NCT07414745RecruitingPhase 3
Study of a bone graft for two-level lower back fusion
This trial tests a special material (rhBMP-2) placed inside a cage to help two nearby vertebrae in the lower back fuse together. It is for patients whose disc problems or deformity have not improved after at least 3 months of other treatments, and who have significant pain and limited function.
Kobe, HyōgoAges 18–80 - NCT07001969Enrolling by invitation
Percutaneous facet spine fixation for instability
This study tests a minimally invasive procedure to fix unstable vertebrae in the neck or lower back using a small incision. It may help people with spinal instability causing nerve symptoms or pressure on the spinal cord.
Cairo, ShoroukAges Any age - NCT04467944Recruiting
Lumbar fusion outcomes with arthritis in nearby spine segments
This study looks at how well lumbar fusion surgery works long-term when the joint just above or below (adjacent segment) already shows wear-and-tear. It may help predict who benefits most and guide treatment planning.
Beijing, Beijing MunicipalityAges 18–80 - NCT04469387Recruiting
Reduce adjacent back pain after lumbar surgery
This trial looks at whether a limited decompression (a careful nerve-space “freeing” procedure) can help prevent future problems in the spinal level next to your planned surgery. It targets people with spinal canal narrowing next to the surgery level but who do not yet have symptoms there.
Beijing, Beijing MunicipalityAges 18–80
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Common questions
- Are there clinical trials for disc degeneration?
- Yes. Clin2 currently lists 28 recruiting disc degeneration studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a disc degeneration trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a disc degeneration trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.