Clinical trials
Lumbar Disc Degeneration clinical trials
Below are recruiting lumbar disc degeneration clinical trials, each written for real people, not researchers. We’re tracking 28 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04641039Recruiting
Study of scar differences after lumbar disc replacement
This study compares how postoperative scars look and behave after certain lumbar disc replacement surgery. It may help doctors choose approaches that reduce excessive scar-related problems after surgery.
Valencia, ValenciaAges 18–50 - NCT05299762Recruiting
INFUSE bone graft for lower back fusion: patient follow-up study
This study tracks patients who receive INFUSE bone graft during a specific type of lower back fusion surgery. It helps confirm how the device performs in real-world care and monitors safety and outcomes after surgery.
SeoulAges 18 years+ - NCT05997121Recruiting
Testing a new spinal implant for degenerative disc disease
This trial studies a new spinal implant system (Hexanium TLIF) for people with degenerative disc disease. It aims to see if the implant is safe and works well to help with back pain and stability.
BrugesAges 18 years+ - NCT06023719Recruiting
Study of Disc Care device for preventing repeat lumbar disc herniation
This trial tests a new device (Disc Care) implanted during surgery to repair a herniated disc in the lower back. It is designed to reduce the chance of the hernia coming back.
L'Hospitalet de Llobregat, BarcelonaAges 18–75 - NCT06367855RecruitingPhase 4
Dexamethasone before spine surgery for pain control
This study tests whether giving a single dose of the steroid dexamethasone before minimally invasive spine surgery can help reduce pain and inflammation afterward. It is for people aged 50–80 who are having surgery on 1 or 2 levels of their lower back and have not had spine surgery before.
Pathum Thani, Changwat Pathum ThaniAges 50–80 - NCT06462729RecruitingPhase 1/Phase 2
Testing a new bone graft for lower back fusion surgery
This trial tests a new bone graft material called LDGraft for people who need a single-level lower back fusion (anterior lumbar interbody fusion). It aims to see if the new graft is as good as or better than current options for helping bones heal together.
Fort Wayne, IndianaAges 22–80 - NCT06778447Recruiting
Disc injection for chronic low back pain
This study tests whether injecting a special disc material (nucleus pulposus allograft) into the damaged discs of your lower back can safely reduce pain and improve function. It's for people with long-term, moderate to severe low back pain from disc disease that hasn't gotten better with other treatments.
Napa, CaliforniaAges 22–85 - NCT07044206Recruiting
Comparing two bone graft materials for lumbar fusion surgery
This trial compares two types of bone graft materials (Magnetos Putty and GlassBone Putty) used in lower back fusion surgery for adults with degenerative disc disease. The goal is to see which material works better for helping the bones fuse together, which may reduce pain and improve function.
Montpellier, FranceAges 18–80 - NCT07085247Recruiting
Role of bacteria in lower back disc disease
This trial looks at whether a specific bacteria, Cutibacterium acnes, is linked to disc problems in the lower back. If you're having surgery for a herniated disc, your tissue sample may help researchers understand the cause.
BrnoAges 18 years+ - NCT07127380Recruiting
Comparing two types of spine surgery for disc-related low back pain
This study compares two different surgery methods (Mini-TLIF and MIDLIF) for treating low back pain caused by worn-out discs in the lower back. The goal is to see which one offers better recovery, fewer complications, and lower costs.
Lodz, Łódź VoivodeshipAges 18 years+ - NCT07489001Recruiting
Comparing opioid-free to standard anesthesia for back surgery
This study compares two types of anesthesia for lower back surgery: one that uses opioids and one that does not. The goal is to see which approach controls pain better with fewer side effects.
Istanbul, MaltepeAges 18–75 - NCT07338877Enrolling by invitation
Stem cell therapy for disc-related low back pain
This trial tests a new treatment that uses your own stem cells to help heal damaged discs in your lower back. The stem cells are injected into the disc during a minimally invasive procedure to reduce pain and improve function.
Košice, Košice RegionAges 18 years+ - NCT07001969Enrolling by invitation
Percutaneous facet spine fixation for instability
This study tests a minimally invasive procedure to fix unstable vertebrae in the neck or lower back using a small incision. It may help people with spinal instability causing nerve symptoms or pressure on the spinal cord.
Cairo, ShoroukAges Any age - NCT05527145Recruiting
Non-surgical spacer for spinal stenosis causing leg pain
This trial tests a minimally invasive (“through the skin”) procedure that places a small spacer between back bones to relieve lumbar spinal stenosis symptoms like leg pain when walking. It may help people who still need surgery based on their symptoms and MRI findings but may be treated without open surgery.
RomeAges 50–85 - NCT04273828Recruiting
Study of muscle changes in chronic low back pain surgery
This study looks at how muscle degeneration relates to nerve-related symptoms in people with chronic low back pain. You may be eligible if you’ve tried non-surgical care but still need surgery to relieve nerve pressure.
São Paulo, São PauloAges 18 years+ - NCT06704906Recruiting
Spine fusion surgery with a new bone graft material
This study tests a new bone graft material (Fibergraft BG Putty) used with a special screw system (Viper Prime) during spine fusion surgery. It is for adults with lower back problems who need 1 to 3 vertebrae fused, and who are not smokers or have a very low bone density.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT04467944Recruiting
Lumbar fusion outcomes with arthritis in nearby spine segments
This study looks at how well lumbar fusion surgery works long-term when the joint just above or below (adjacent segment) already shows wear-and-tear. It may help predict who benefits most and guide treatment planning.
Beijing, Beijing MunicipalityAges 18–80 - NCT05066334RecruitingPhase 2
Back pain trial using your own stem cells in discs
This Phase 2 trial tests whether injecting your own stem cells into a few back discs can reduce chronic low back pain that has not improved with standard treatments. It may help by targeting disc-related (degenerative) wear seen on MRI, but it requires detailed MRI and blood test screening.
Roma, ItalyAges 18–65 - NCT04469387Recruiting
Reduce adjacent back pain after lumbar surgery
This trial looks at whether a limited decompression (a careful nerve-space “freeing” procedure) can help prevent future problems in the spinal level next to your planned surgery. It targets people with spinal canal narrowing next to the surgery level but who do not yet have symptoms there.
Beijing, Beijing MunicipalityAges 18–80 - NCT06075979Recruiting
Microbes and spine health: a surgical study
This study looks at whether certain microbes (tiny living things) are linked to spine problems like herniated discs or narrow spinal canals. It involves people who need spine surgery, and the findings might help explain why some spines wear out faster.
Jinan, ShandongAges 18–85 - NCT07222787Recruiting
Testing a new spinal implant for lower back fusion
This trial tests a new spinal implant system (CORUS-LX) for fusing two lower back discs that are causing pain. It is meant for people with severe, long-lasting back or leg pain that hasn't improved with non-surgical treatments.
Scottsdale, ArizonaAges 18–80 - NCT06029764Recruiting
Extended fusion for spinal disc vacuum signs
This trial tests a surgery that fuses one extra spinal disc to treat a 'vacuum sign' (air pockets in the disc) that hasn't caused symptoms yet. It aims to prevent future problems in people with lumbar disc disease who need fusion surgery.
Beijing, Beijing MunicipalityAges 18–60 - NCT05648474Recruiting
Nerve monitoring during a low-back fusion surgery
This study tests whether special nerve monitoring during a low-back fusion helps make surgery safer and the results easier to judge. It’s for people having a specific type of low-back fusion on one or two levels.
Carlsbad, CaliforniaAges 18 years+ - NCT06011551Recruiting
Gel injection for painful lumbar discs
This trial tests a gel (HYDRAFIL-D) injected into painful discs in your lower back to see if it relieves pain. It's for people whose back pain hasn't improved with other treatments.
Birmingham, AlabamaAges 22–85
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Common questions
- Are there clinical trials for lumbar disc degeneration?
- Yes. Clin2 currently lists 28 recruiting lumbar disc degeneration studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lumbar disc degeneration trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lumbar disc degeneration trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.