Clinical trials
Diuretics clinical trials
Below are recruiting diuretics clinical trials, each written for real people, not researchers. We’re tracking 33 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06414759RecruitingPhase 4
Combination diuretic therapy for heart failure fluid overload
This trial tests a combination of water pills (diuretics) to help remove extra fluid in people hospitalized with acute decompensated heart failure (sudden worsening of heart failure). It aims to find a safe and effective way to reduce swelling and fluid buildup.
Giza, GZAges 18–65 - NCT07348510Recruiting
Diuretic Effect of Aminophylline and Furosemide in Heart Surgery Patients
This study is testing if a combination of two medicines (aminophylline and furosemide) can help the kidneys produce more urine after heart surgery. It may help reduce fluid buildup and protect kidney function.
CairoAges 18–65 - NCT04759274Recruiting
Personalized water pill dosing support for kidney and fluid overload
This trial tests a decision-support tool to help your care team safely adjust water pills (“diuretics”) when you have kidney disease and fluid buildup. It may help reduce swelling by guiding dosing using your home weight and blood pressure.
Dallas, TexasAges 18 years+ - NCT06092437Recruiting
Testing a personalized diuretic plan for acute heart failure
This trial is testing whether a diuretic (water pill) dose tailored to each patient works better for treating fluid buildup during a heart failure flare-up. It may help you get the right amount of medication faster and avoid complications.
Heerlen, LimburgAges 18 years+ - NCT06209359RecruitingPhase 1
Testing a second diuretic for heart failure patients
This trial tests whether adding a second type of diuretic (water pill) can help people with heart failure who don't respond well to their current diuretic. It aims to find better ways to manage fluid buildup.
New Haven, ConnecticutAges 18 years+ - NCT06841692Recruiting
Diuretic testing for moderate kidney disease
This study checks how well diuretics (water pills) work in people with moderate chronic kidney disease. It may help doctors understand how to better treat fluid buildup in patients.
Rotterdam, South HollandAges 18 years+ - NCT06921603Recruiting
Ultrasound-guided diuretics for heart failure
This trial tests whether using a bedside ultrasound to guide diuretic treatment improves outcomes in people hospitalized for worsening heart failure. It may help find the right dose of IV diuretics faster.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07369856Recruiting
Using urine sodium to guide diuretic dosing in heart failure
This trial uses a simple urine test to see if your current water pill dose is right for you. The goal is to find the best dose to reduce symptoms and avoid hospital visits.
Vancouver, British ColumbiaAges 18 years+ - NCT07320677Enrolling by invitation
Finding Heart Failure in People Taking Water Pills
This study is for people who take a type of water pill called a loop diuretic, but do not yet have a diagnosis of heart failure. The study will check a blood test to see if undiagnosed heart failure might be present.
Saint HelierAges 18 years+ - NCT05677100Recruiting
Aortix device for acute heart failure
This trial is testing a small pump placed in the aorta to help the kidneys remove extra fluid when standard IV diuretics aren't working well enough for severe heart failure. It may help you if you're hospitalized and still very congested (swollen, fluid buildup) despite strong water pills.
Phoenix, ArizonaAges 21 years+ - NCT05276219RecruitingPhase 4
Vasodilators or diuretics for acute heart failure
This trial compares two treatments for sudden heart failure symptoms like severe shortness of breath. It aims to see whether opening blood vessels or using a water pill works better to relieve congestion and improve breathing.
Copenhagen, CopenhagenAges 18 years+ - NCT06166654RecruitingPhase 4
Better water pill therapy for acute heart failure
This trial tests different water pill (diuretic) strategies for people hospitalized with acute heart failure and too much fluid. It is designed for patients who may not respond well to standard water pills, to find a more effective way to relieve symptoms.
Hvidovre, Capital Region of DenmarkAges 18 years+ - NCT02812212Recruiting
Test a kidney scan to spot early blockage in newborns
This study checks whether a specific kidney test (a renogram scan) can detect a significant urine blockage early in babies born with ureter-pelvic junction obstruction (a narrow connection between the kidney and ureter). It may help clinicians decide sooner which babies need closer follow-up or treatment.
BordeauxAges 4 weeks–2 months - NCT07372040RecruitingPhase 2
Adding a Water Pill for Heart Failure in the Hospital
This trial tests if adding a diuretic (water pill) called acetazolamide to usual care can help you get rid of extra fluid faster while you are in the hospital for worsening heart failure.
TantaAges 18 years+ - NCT06799910Recruiting
Optimizing fluid balance with bioelectrical impedance during dialysis in ICU
This trial tests a method to better manage fluid levels in critically ill patients who are receiving a type of dialysis (CVVH) for kidney failure. It uses a device (bioelectrical impedance) to measure fluid in the body, which may help doctors give the right amount of fluids more safely.
SalouëlAges 18 years+ - NCT06094816RecruitingPhase 4
Brain MRI study on salt and blood pressure
This study uses MRI scans to look at how the brain controls salt and blood pressure. It is for people aged 40–60 with normal to slightly high blood pressure, who have no major health conditions.
Newark, DelawareAges 40–60 - NCT07577596RecruitingPhase 4
Continuous Furosemide Infusion for Heart Failure Fluid Overload
This study tests whether giving furosemide (a water pill) as a continuous IV drip works better than standard doses for patients hospitalized with heart failure and fluid buildup. The goal is to help your body get rid of excess fluid more effectively.
RandersAges 18 years+ - NCT04934228RecruitingPhase 1
Study targeting inflammation in people with obesity and high blood pressure
This Phase 1 study looks at a treatment aimed at reducing “inflammation patterns” that are common in obesity and insulin resistance. If you meet specific health and lab criteria, you may be asked to visit a research lab and provide blood samples to see how the treatment affects your body.
Kansas City, KansasAges 18–79 - NCT05323487RecruitingPhase 1
Study why water pills (diuretics) stop working in heart failure
This Phase 1 study looks at why “water pills” sometimes stop relieving fluid overload in people with heart failure. It may help researchers understand the causes of diuretic resistance and improve future treatment for fluid management.
New Haven, ConnecticutAges 18 years+ - NCT05620784RecruitingPhase 3
Loop water pills during surgery to go home sooner after HoLEP
This trial tests whether giving a “loop diuretic” water pill during surgery can help people after HoLEP go home the same day more often. It’s mainly looking to improve discharge timing while keeping you safe.
Chicago, IllinoisAges 18–89 - NCT05732727RecruitingPhase 3
Stronger BP lowering using diuretics in kidney disease
This Phase 3 trial compares a plan that uses diuretics (water pills) to lower blood pressure more, versus usual blood pressure care, in people with uncontrolled hypertension and moderate-to-severe chronic kidney disease. It may help your blood pressure control while monitoring safety closely because kidney function changes how medicines work.
AngersAges 18 years+ - NCT05753059RecruitingPhase 1
Study why some water pills stop working in heart failure
This Phase 1 study looks at why “water pills” (diuretics) like bumetanide may not remove fluid as expected in people with heart failure. The results may help clinicians improve treatment strategies for fluid control in the future.
New Haven, ConnecticutAges 18 years+ - NCT06218199RecruitingPhase 4
Diuretics vs. blood pressure meds for HeartLogic alerts
This trial compares two treatments—diuretics (water pills) and a blood pressure medication called sacubitril/valsartan—to see which works better when your heart device sends an alert. It's for people with a Boston Scientific heart device that has HeartLogic alerting turned on.
Huntsville, AlabamaAges 19 years+ - NCT06381934Recruiting
New tests for low sodium from thiazide pills
This study looks at new ways to quickly check how well low sodium (caused by a common water pill called thiazide) is being treated in the hospital. If you have low sodium and take a thiazide pill, this trial may help doctors find better treatment methods.
BaselAges 18 years+
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Common questions
- Are there clinical trials for diuretics?
- Yes. Clin2 currently lists 33 recruiting diuretics studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a diuretics trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a diuretics trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.