Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,055 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05588063Recruiting
Device-based nerve stimulation for relapse-preventing kidney disease in kids
This trial tests whether a small non-surgical device can help keep children with steroid-sensitive nephrotic syndrome in remission. If it works, it could lower the chance of relapse (kidney flare-ups) and help maintain kidney health.
New Hyde Park, New YorkAges 3–17 - NCT05555771Recruiting
Kids with fainting episodes after arriving at the emergency room
This study looks at children and teens (ages 6–18) who recently fainted but are now back to normal, using a survey. It aims to better understand fainting episodes that happen before the emergency visit and how to evaluate them safely.
Vancouver, British ColumbiaAges 6–18 - NCT05585190Recruiting
Sit-stand desk study for people at diabetes risk
This trial tests whether using a sit-stand desk at work helps people who are overweight and at risk for diabetes. Participants may be asked to change how much they sit during the workday to improve health markers.
Milwaukee, WisconsinAges 18–79 - NCT05561153Enrolling by invitation
Study of knee movement issues in patellofemoral pain
This study looks at how the nerves and muscles are working in people with patellofemoral pain (pain around the kneecap). It may help researchers understand what drives the pain and how it might be treated.
AnkaraAges 18–40 - NCT05573542Enrolling by invitation
Study early Parkinson signs in people with IBS
This study looks for early clues of Parkinson’s disease in people who have IBS (irritable bowel syndrome), and compares them with people without IBS. The goal is to understand whether gut symptoms or test results can help spot Parkinson’s earlier.
ÖrebroAges 18–85 - NCT05583942Recruiting
Nerve stimulation trial for children with steroid-resistant kidney syndrome
This pilot study tests a device that stimulates nerves in the ear to help children with steroid-resistant nephrotic syndrome. It may improve urine protein and kidney-related outcomes for kids whose standard steroid treatment does not work.
New Hyde Park, New YorkAges 3–17 - NCT05577988RecruitingPhase 3
Genetic-guided weaker blood thinner vs stronger standard therapy
This study tests whether switching early to a weaker anti-platelet medicine based on your genetics can reduce bleeding problems in people at high risk for bleeding after a heart attack. It compares this approach to the usual strategy of staying on a stronger anti-platelet medicine.
Paris, IDFAges 18 years+ - NCT05575401Recruiting
Track surgery results in kids getting tonsil removal
This trial looks at how well a specific throat surgery technique works in children who are having their tonsils removed (with or without removing adenoids). It may help improve how doctors choose and perform surgery for safer, better recovery.
Murrieta, CaliforniaAges 3–17 - NCT05513417Enrolling by invitation
Digital pelvic health program for women with pelvic pain
This study tests a digital (phone/app-based) program to help women with pelvic pain or pelvic health symptoms. It may help by guiding pelvic-focused exercises and care, especially if you’re recovering from pelvic surgery or managing ongoing symptoms.
Draper, UtahAges 18–99 - NCT05537298Recruiting
Help for muscle recovery after serious ICU illness
This trial looks at how to improve muscle strength and function after a stay in the ICU for sepsis or acute respiratory failure. If you recover from the illness but your muscles become weak, this study may test an approach to help rebuild strength faster.
Birmingham, AlabamaAges 18 years+ - NCT05519683RecruitingPhase 2/Phase 3
Home electrical stimulation for constipation IBS pain
This trial tests whether a home device that uses mild skin electrical stimulation can reduce belly pain from IBS with constipation. It also checks whether the treatment is safe and helpful for symptom relief over the study period.
Ann Arbor, MichiganAges 18 years+ - NCT05527652Recruiting
Breathing tube device to help blocked upper airways in children
This study tests a self-supporting breathing tube placed through the nose during sleep to reduce upper airway blockage and improve breathing in children. It may help children who have sleep apnea symptoms, especially after tonsil/adenoid treatment or when tonsil removal isn’t possible.
Ann Arbor, MichiganAges 3–21 - NCT01962415RecruitingPhase 2
Reduced-intensity stem cell transplant for non-cancer disorders
This trial tests whether a gentler (reduced-intensity) conditioning treatment before a stem cell transplant works for non-cancer diseases. It uses specific donor stem cell matches and checks heart, lung, liver, and kidney function to help lower transplant stress while still aiming for benefit.
Pittsburgh, PennsylvaniaAges 2 months–55 years - NCT00389142Recruiting
Find genes linked to bladder pain and urinary symptoms
This study looks for genetic (inherited) causes of bladder pain syndrome (IC/BPS), using information from people who have typical urinary symptoms. It may help doctors understand why IC/BPS happens, which could guide better future care.
Boston, MassachusettsAges 1 year+ - NCT05462106RecruitingPhase 1/Phase 2
ACI-24.060 study for early Alzheimer’s in adults and Down syndrome
This Phase 1/2 study tests an Alzheimer’s treatment called ACI-24.060 to see if it affects the disease in people with early Alzheimer’s changes. It includes two groups: older adults with early symptoms and people with Down syndrome who also show Alzheimer’s-related changes on brain scans.
Phoenix, ArizonaAges 35–85 - NCT05473520RecruitingPhase 3
Doxycycline add-on therapy for lung improvement in tuberculosis
This Phase 3 trial tests whether adding doxycycline to standard TB medicine can improve lung function and reduce lung tissue damage. It aims to see if patients recover better by targeting the lung response to TB.
Kota Kinabalu, SabahAges 21 years+ - NCT05484570Recruiting
Study of how rare DNA repair disorders affect the body over time
This natural history study follows people with specific DNA repair disorders to better understand symptoms and how they change over time. It may help researchers plan future treatments by mapping what complications to expect and when.
Minneapolis, MinnesotaAges 6 months+ - NCT05463796Recruiting
Prevention and early detection for people at high cancer risk
This study looks at surveillance (watching closely), prevention, and early “interception” steps to lower the chance that cancer will develop or be found later. It is for people with genetic risk, past cancer treatment exposures, strong family history, or certain early pre-cancer or high-risk conditions.
Boston, MassachusettsAges Any age - NCT05437900RecruitingPhase 4
A heart test to guide stent placement using blood-flow measurements
This Phase 4 study tests a way to measure blood flow in heart arteries to help doctors choose the best stent plan. It may help improve safety and effectiveness for people having elective heart stent procedures for stable angina or certain heart attacks.
Aalst, Oost-VlaanderenAges 18–85 - NCT05444946Recruiting
Itraconazole alone versus with steroid pills for Aspergillus lung overlap
This trial compares itraconazole taken by mouth alone versus itraconazole plus steroid pills in people who have a mix of two Aspergillus lung conditions. It aims to see which approach works better to control symptoms and lung changes caused by Aspergillus infection.
Chandigarh, ChandigarhAges 15–90 - NCT05418010RecruitingPhase 2
Natalizumab treatment for early multiple sclerosis-like symptoms
This Phase 2 study tests natalizumab to treat people who have had a first episode of symptoms suggestive of multiple sclerosis. It aims to see whether the treatment can help after early “demyelination” changes are seen on brain MRI.
LondonAges 18–55 - NCT05449548Recruiting
Lenalidomide for severe mouth ulcers from Behçet’s
This trial studies lenalidomide to treat frequent, ongoing mouth ulcers caused by mucosal Behçet’s syndrome. It’s meant for people whose mouth sores keep coming back despite standard treatments like steroid medicines and other immune-suppressing drugs.
Beijing, Beijing MunicipalityAges 18–65 - NCT05444348Recruiting
Communication and care-planning support for blood cancer patients
This study tests an approach to help people with certain blood cancers and their main caregiver plan ahead and communicate more clearly about end-of-life care. It may help patients feel more supported and better prepared for difficult decisions.
AalborgAges 18 years+ - NCT05434598Recruiting
Whole-genome testing added to standard testing for MDS
This study checks whether adding whole-genome sequencing (a deeper look at DNA) alongside standard genomic tests helps in evaluating myelodysplastic syndrome (MDS). It aims to see if this extra testing is useful and acceptable during routine care—especially for people newly being worked up for MDS.
St Louis, MissouriAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,055 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.