Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,060 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05545384RecruitingPhase 3
Immediate vs delayed azathioprine or rituximab for children with anti-MOG attacks
This Phase 3 trial tests whether starting anti-inflammatory treatment right away is better than waiting, using either azathioprine or rituximab, for children with anti-MOG antibody–related acute demyelinating episodes. It may help reduce future attacks and disability.
BesançonAges 6–17 - NCT05508971Recruiting
Personalized tonsil surgery for sleep apnea in children with Down syndrome
This study tests whether a personalized surgical approach can treat moderate to severe obstructive sleep apnea (OSA) in children with Down syndrome. The goal is to improve breathing during sleep and overall sleep health.
Aurora, ColoradoAges 2–17 - NCT05544721Enrolling by invitationPhase 4
Nerve-block pain study for thoracic outlet surgery
This trial tests whether a targeted numbing injection near the back helps reduce pain or improve comfort for people having first rib removal surgery for thoracic outlet syndrome. It’s a Phase 4 study, meaning it builds on earlier use of this pain-control approach to see how well it works in routine care.
Jacksonville, FloridaAges 18 years+ - NCT05528744Recruiting
Study genes and symptoms in ANKRD17-related CAGS
This study looks at how a specific gene change in ANKRD17 relates to the symptoms, brain/scan findings, and brain-cells in people with Chopra-Amiel-Gordon syndrome (CAGS). It may help families understand the condition better and connect gene results to what is seen clinically.
Boston, MassachusettsAges Any age - NCT03805477RecruitingPhase 2
Nintedanib for lung scarring after bone marrow transplant
This trial tests nintedanib to slow or improve bronchiolitis obliterans syndrome (BOS), a type of lung scarring, after a hematopoietic stem cell transplant. You may be considered if your breathing tests and scans show BOS, and if active infections and certain health risks are ruled out.
RiyadhAges 18 years+ - NCT05483010RecruitingPhase 2
Testing statins to treat low-risk blood disorders with abnormal blood counts
This Phase 2 trial studies whether a statin medicine can help people with CCUS (a bone-marrow condition with abnormal genetic mutations) or lower-risk MDS (a blood disorder) that causes persistent low blood counts. It aims to see if statins can improve blood-related outcomes while keeping you safe from side effects.
St Louis, MissouriAges 18 years+ - NCT05460520Recruiting
Test a therapy for Mal de Débarquement Syndrome symptoms
This trial studies a “DevRobust” treatment to reduce symptoms of Mal de Débarquement Syndrome (a persistent feeling of rocking or motion after travel or a trip). It may help by improving how your balance system responds and reducing day-to-day symptoms.
New York, New YorkAges 18–78 - NCT04323904Recruiting
Hantavirus registry for people with kidney or lung symptoms
This study is a registry, meaning it collects health information and possibly test results from people who have evidence of hantavirus infection along with specific illness symptoms. It may help researchers better understand how hantavirus affects the kidneys or the heart/lungs (and how to recognize it).
Cologne, North-Rhine WestfaliaAges Any age - NCT05419492RecruitingPhase 1/Phase 2
ETX101 for children with SCN1A Dravet syndrome
This early-phase study tests how safe ETX101 is and whether it can help reduce seizures in young children with Dravet syndrome caused by an SCN1A gene change. It mainly enrolls infants and children with a specific type of seizure history and genetic result.
San Francisco, CaliforniaAges 6 months–17 years - NCT05432648Recruiting
Fiber food introduction for children with short bowel syndrome
This trial tests if slowly adding fiber to the diet helps children with short bowel syndrome. It looks at how fiber affects digestion and overall health.
Philadelphia, PennsylvaniaAges 4 months–18 years - NCT05365035RecruitingPhase 2
Phase 2 trial for high-risk blood cancers with timed chemo
This study tests a mix of medicines (cladribine, low-dose cytarabine, and venetoclax) alternated with azacitidine and venetoclax to treat higher-risk CMML or MDS after prior treatment or when standard treatment may not work well. It may help by improving blood counts and controlling the disease.
Houston, TexasAges 18 years+ - NCT05374824Recruiting
Palliative surgery versus more seizure medicines for Lennox-Gastaut
This trial compares two treatment approaches for children with Lennox-Gastaut syndrome: palliative (comfort-focused) surgery versus adding more anti-seizure medicines. It aims to see which option works better for seizure control and day-to-day well-being.
Chicago, IllinoisAges Up to 26 years - NCT05395715Recruiting
Nerve stimulation study for cubital tunnel nerve compression
This study tests whether a specific type of electrical nerve stimulation (conditioning electrical stimulation) can improve outcomes for people with cubital tunnel syndrome. It is mainly for adults with more severe nerve damage based on specialist test results, and who have not had prior surgery for this problem.
Edmonton, AlbertaAges 18–79 - NCT05411718RecruitingPhase 2
Aspirin or naproxen to prevent cancer in Lynch syndrome
This trial tests whether daily aspirin or naproxen can “intercept” (stop) cancer from starting or coming back in people with Lynch syndrome who are currently cancer-free. Participants are randomly assigned to one of the two drugs, and neither the participant nor the team knows which one you’re taking.
Houston, TexasAges 18 years+ - NCT05410977Recruiting
Testing blood and stool for colon cancer in Lynch syndrome
This study collects blood and stool samples to see how well they can detect colorectal cancer or advanced growths in people with Lynch syndrome (an inherited colon cancer risk) or suspected Lynch syndrome. It may help find cancer or precancer earlier, which can improve next-step decisions.
Scottsdale, ArizonaAges 18 years+ - NCT05320198RecruitingPhase 1/Phase 2
Testing DISC-0974 for anemia in myelofibrosis or MDS
This trial tests an investigational drug called DISC-0974 for people with myelofibrosis or certain types of MDS who have low red blood cell counts (anemia). The goal is to see if this treatment can help improve anemia and reduce the need for blood transfusions.
Gilbert, ArizonaAges 18 years+ - NCT05354141RecruitingPhase 3
Tested treatment with tiny lung particles for moderate to severe ARDS
This Phase 3 trial studies an “extracellular vesicle” treatment in people with moderate to severe ARDS, a serious lung breathing problem. The goal is to see whether the treatment can improve outcomes compared with standard care.
Phoenix, ArizonaAges 18–75 - NCT05344716Recruiting
Erbium laser treatment for urethral pain in women
This trial tests whether an erbium:YAG laser can reduce urethral and lower pelvic pain that has lasted for at least 6 months. It may help people whose pain has not improved with at least one non-surgical treatment.
Frauenfeld, ThurgauAges 18 years+ - NCT05301361Enrolling by invitationPhase 1
Test of brain testing during stimulant treatment for ADHD
This trial checks whether a “NIH Toolbox” set of child-friendly tests can detect changes when stimulant medicine is used for ADHD. It may help doctors better measure how well stimulant treatment is working in people with intellectual disability.
Sacramento, CaliforniaAges 6–24 - NCT05308927Enrolling by invitation
Registry for children with Noonan syndrome on growth hormone
This trial is a real-world registry that collects information about children with Noonan syndrome who are treated with Norditropin (a growth hormone). It helps researchers understand how these children do over time in routine care.
AngersAges Any age - NCT05308264RecruitingPhase 1/Phase 2
R289 for lower-risk MDS that still needs blood support
This Phase 1/2 study tests R289 in adults with lower-risk myelodysplastic syndromes (MDS) whose disease keeps causing anemia and/or ongoing need for red blood cell transfusions. It may help reduce blood problems and treat MDS when standard options haven’t worked well enough or aren’t suitable.
Los Angeles, CaliforniaAges 18 years+ - NCT04522193Recruiting
Testing causes of dumping symptoms after esophagus repair
This study looks at how sugars move and how “dumping” symptoms happen in babies after surgery for an esophagus problem. It may help doctors understand what causes these symptoms and how to monitor them safely.
LilleAges 2 months–3 months - NCT02841553Recruiting
Online registry for Wolfram syndrome worldwide
This study builds an international online registry to learn how Wolfram syndrome (and related WFS1 conditions) changes over time. It may help researchers understand the disease course and improve future care by collecting health and family history data.
St Louis, MissouriAges birth+ - NCT04245397RecruitingPhase 1
Test drug SX-682 with decitabine for myelodysplastic syndrome
This Phase 1 trial tests whether SX-682 given alone or with decitabine can treat myelodysplastic syndrome (MDS) that has not responded well to prior therapy. It also studies safety and the best dose, which may help people who have limited treatment options.
Jacksonville, FloridaAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,060 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.